Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000112759 Gene ID 2030 Accession 11003
Symbol SLC29A1 Alias AUG;ENT1;hENT1 Full Name solute carrier family 29 member 1 (Augustine blood group)
Status Confidence Length 14590 bases Strand Plus strand
Position 6 : 44219553 - 44234142 RNA binding domain N.A.
Summary This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
53794Chlorine4.8780000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001504involved_in neurotransmitter uptake1ISSHomo_sapiens(9606)Process
GO:0005326enables neurotransmitter transmembrane transporter activity2IDA,ISSHomo_sapiens(9606)Function
GO:0005337enables nucleoside transmembrane transporter activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005886is_active_in plasma membrane3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0006139involved_in nucleobase-containing compound metabolic process1TASHomo_sapiens(9606)Process
GO:0006805involved_in xenobiotic metabolic process1TASHomo_sapiens(9606)Process
GO:0006836involved_in neurotransmitter transport1IDAHomo_sapiens(9606)Process
GO:0006855involved_in xenobiotic transmembrane transport1TASHomo_sapiens(9606)Process
GO:0007595involved_in lactation1IEAHomo_sapiens(9606)Process
GO:0015207enables adenine transmembrane transporter activity1IDAHomo_sapiens(9606)Function
GO:0015208enables guanine transmembrane transporter activity1IDAHomo_sapiens(9606)Function
GO:0015210enables uracil transmembrane transporter activity1IDAHomo_sapiens(9606)Function
GO:0015211enables purine nucleoside transmembrane transporter activity2IDA,ISSHomo_sapiens(9606)Function
GO:0015212enables cytidine transmembrane transporter activity1IDAHomo_sapiens(9606)Function
GO:0015213enables uridine transmembrane transporter activity1IDAHomo_sapiens(9606)Function
GO:0015389enables pyrimidine- and adenosine-specific:sodium symporter activity1IDAHomo_sapiens(9606)Function
GO:0015851involved_in nucleobase transport1IDAHomo_sapiens(9606)Process
GO:0015853involved_in adenine transport1IDAHomo_sapiens(9606)Process
GO:0015858involved_in nucleoside transport1IDAHomo_sapiens(9606)Process
GO:0015860involved_in purine nucleoside transmembrane transport2IDA,ISSHomo_sapiens(9606)Process
GO:0015861involved_in cytidine transport1IDAHomo_sapiens(9606)Process
GO:0015862involved_in uridine transport3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016323located_in basolateral plasma membrane1IDAHomo_sapiens(9606)Component
GO:0016324located_in apical plasma membrane1IDAHomo_sapiens(9606)Component
GO:0032238involved_in adenosine transport2IDA,ISSHomo_sapiens(9606)Process
GO:0035340involved_in inosine transport1IDAHomo_sapiens(9606)Process
GO:0035344involved_in hypoxanthine transport1IDAHomo_sapiens(9606)Process
GO:0035364involved_in thymine transport1IDAHomo_sapiens(9606)Process
GO:0060079involved_in excitatory postsynaptic potential1IEAHomo_sapiens(9606)Process
GO:0071333involved_in cellular response to glucose stimulus1IEAHomo_sapiens(9606)Process
GO:0071456involved_in cellular response to hypoxia1IEAHomo_sapiens(9606)Process
GO:0072531involved_in pyrimidine-containing compound transmembrane transport1IMPHomo_sapiens(9606)Process
GO:0098793located_in presynapse1IEAHomo_sapiens(9606)Component
GO:0098794located_in postsynapse1IEAHomo_sapiens(9606)Component
GO:0150104involved_in transport across blood-brain barrier1NASHomo_sapiens(9606)Process
GO:1901642involved_in nucleoside transmembrane transport2IDA,IMPHomo_sapiens(9606)Process
GO:1903716involved_in guanine transmembrane transport1IDAHomo_sapiens(9606)Process
GO:1903791involved_in uracil transmembrane transport1IDAHomo_sapiens(9606)Process
GO:1904082involved_in pyrimidine nucleobase transmembrane transport1IDAHomo_sapiens(9606)Process
GO:1904823involved_in purine nucleobase transmembrane transport1IDAHomo_sapiens(9606)Process

Expression