Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000112658 Gene ID 6722 Accession 11291
Symbol SRF Alias MCM1 Full Name serum response factor
Status Confidence Length 10238 bases Strand Plus strand
Position 6 : 43171269 - 43181506 RNA binding domain N.A.
Summary This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000785part_of chromatin1IEAHomo_sapiens(9606)Component
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding2IDA,ISSHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific1IBAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific3IDA,IGI,ISSHomo_sapiens(9606)Function
GO:0001569involved_in branching involved in blood vessel morphogenesis1IEAHomo_sapiens(9606)Process
GO:0001666involved_in response to hypoxia1IEPHomo_sapiens(9606)Process
GO:0001707involved_in mesoderm formation1IEAHomo_sapiens(9606)Process
GO:0001764involved_in neuron migration1IEAHomo_sapiens(9606)Process
GO:0001829acts_upstream_of_or_within trophectodermal cell differentiation1IDAHomo_sapiens(9606)Process
GO:0001947involved_in heart looping1ISSHomo_sapiens(9606)Process
GO:0002011involved_in morphogenesis of an epithelial sheet1IEAHomo_sapiens(9606)Process
GO:0002042involved_in cell migration involved in sprouting angiogenesis1IMPHomo_sapiens(9606)Process
GO:0003700enables DNA-binding transcription factor activity2IDA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1TASHomo_sapiens(9606)Component
GO:0006366involved_in transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0007160involved_in cell-matrix adhesion1IEAHomo_sapiens(9606)Process
GO:0007507involved_in heart development1ISSHomo_sapiens(9606)Process
GO:0007616involved_in long-term memory1IEAHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IEAHomo_sapiens(9606)Process
GO:0008306involved_in associative learning1IEAHomo_sapiens(9606)Process
GO:0009636involved_in response to toxic substance1TASHomo_sapiens(9606)Process
GO:0009725involved_in response to hormone1IDAHomo_sapiens(9606)Process
GO:0010669involved_in epithelial structure maintenance1IEAHomo_sapiens(9606)Process
GO:0010736enables serum response element binding2IBA,IDAHomo_sapiens(9606)Function
GO:0021766involved_in hippocampus development1IEAHomo_sapiens(9606)Process
GO:0022028involved_in tangential migration from the subventricular zone to the olfactory bulb1IEAHomo_sapiens(9606)Process
GO:0030036involved_in actin cytoskeleton organization1ISSHomo_sapiens(9606)Process
GO:0030155involved_in regulation of cell adhesion1IEAHomo_sapiens(9606)Process
GO:0030168involved_in platelet activation1IEAHomo_sapiens(9606)Process
GO:0030220involved_in platelet formation1IEAHomo_sapiens(9606)Process
GO:0030336involved_in negative regulation of cell migration1IEAHomo_sapiens(9606)Process
GO:0030878involved_in thyroid gland development1IEAHomo_sapiens(9606)Process
GO:0031490enables chromatin DNA binding1IEAHomo_sapiens(9606)Function
GO:0034097involved_in response to cytokine2IMP,NASHomo_sapiens(9606)Process
GO:0035855involved_in megakaryocyte development1IEAHomo_sapiens(9606)Process
GO:0035912involved_in dorsal aorta morphogenesis1IEAHomo_sapiens(9606)Process
GO:0042803enables protein homodimerization activity1IPIHomo_sapiens(9606)Function
GO:0042826enables histone deacetylase binding1IEAHomo_sapiens(9606)Function
GO:0043149involved_in stress fiber assembly1IEAHomo_sapiens(9606)Process
GO:0043589involved_in skin morphogenesis1IEAHomo_sapiens(9606)Process
GO:0045059involved_in positive thymic T cell selection1IEAHomo_sapiens(9606)Process
GO:0045214involved_in sarcomere organization1IEAHomo_sapiens(9606)Process
GO:0045597acts_upstream_of_or_within positive regulation of cell differentiation1IDAHomo_sapiens(9606)Process
GO:0045773involved_in positive regulation of axon extension1IEAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II5IBA,IDA,IGI,ISSHomo_sapiens(9606)Process
GO:0045987involved_in positive regulation of smooth muscle contraction1IDAHomo_sapiens(9606)Process
GO:0046016involved_in positive regulation of transcription by glucose1IEAHomo_sapiens(9606)Process
GO:0046716involved_in muscle cell cellular homeostasis1ISSHomo_sapiens(9606)Process
GO:0046847involved_in filopodium assembly1IEAHomo_sapiens(9606)Process
GO:0048538involved_in thymus development1IEAHomo_sapiens(9606)Process
GO:0048666involved_in neuron development1TASHomo_sapiens(9606)Process
GO:0048675involved_in axon extension1IEAHomo_sapiens(9606)Process
GO:0048821involved_in erythrocyte development1IEAHomo_sapiens(9606)Process
GO:0051091involved_in positive regulation of DNA-binding transcription factor activity2IDA,IMPHomo_sapiens(9606)Process
GO:0051150involved_in regulation of smooth muscle cell differentiation1TASHomo_sapiens(9606)Process
GO:0051491involved_in positive regulation of filopodium assembly1IEAHomo_sapiens(9606)Process
GO:0055003involved_in cardiac myofibril assembly1IEAHomo_sapiens(9606)Process
GO:0060055involved_in angiogenesis involved in wound healing1TASHomo_sapiens(9606)Process
GO:0060218involved_in hematopoietic stem cell differentiation1IEAHomo_sapiens(9606)Process
GO:0060261involved_in positive regulation of transcription initiation by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0060292involved_in long-term synaptic depression1IEAHomo_sapiens(9606)Process
GO:0060324involved_in face development1IEAHomo_sapiens(9606)Process
GO:0060347involved_in heart trabecula formation1IEAHomo_sapiens(9606)Process
GO:0060379involved_in cardiac muscle cell myoblast differentiation1IGIHomo_sapiens(9606)Process
GO:0060425involved_in lung morphogenesis1IEAHomo_sapiens(9606)Process
GO:0060532involved_in bronchus cartilage development1IEAHomo_sapiens(9606)Process
GO:0060534involved_in trachea cartilage development1IEAHomo_sapiens(9606)Process
GO:0060947involved_in cardiac vascular smooth muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0061029involved_in eyelid development in camera-type eye1IEAHomo_sapiens(9606)Process
GO:0061145involved_in lung smooth muscle development1IEAHomo_sapiens(9606)Process
GO:0061436involved_in establishment of skin barrier1IEAHomo_sapiens(9606)Process
GO:0061629enables RNA polymerase II-specific DNA-binding transcription factor binding1IEAHomo_sapiens(9606)Function
GO:0070830involved_in bicellular tight junction assembly1IEAHomo_sapiens(9606)Process
GO:0070878enables primary miRNA binding1ISSHomo_sapiens(9606)Function
GO:0071333involved_in cellular response to glucose stimulus1IEAHomo_sapiens(9606)Process
GO:0090009involved_in primitive streak formation1IEAHomo_sapiens(9606)Process
GO:0090136involved_in epithelial cell-cell adhesion1IEAHomo_sapiens(9606)Process
GO:0090398involved_in cellular senescence1IMPHomo_sapiens(9606)Process
GO:0140297enables DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:1900222involved_in negative regulation of amyloid-beta clearance1IMPHomo_sapiens(9606)Process
GO:1902894involved_in negative regulation of miRNA transcription1ISSHomo_sapiens(9606)Process
GO:1902895involved_in positive regulation of miRNA transcription2IGI,ISSHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function

Expression