RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000111671	Gene ID	84727	Accession	29522
Symbol	SPSB2	Alias	SSB2;GRCC9	Full Name	splA/ryanodine receptor domain and SOCS box containing 2
Status	Confidence	Length	11353 bases	Strand	Minus strand
Position	12 : 6870935 - 6882287	RNA binding domain	SPRY
Summary	This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000431037	SPRY	PF00622	3.1e-19	1
ENSP00000428338	SPRY	PF00622	3.2e-19	1
ENSP00000430872	SPRY	PF00622	3.2e-19	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
SPSB2-204	ENST00000523102	1205	263aa	ENSP00000430872
SPSB2-205	ENST00000524270	1203	263aa	ENSP00000428338
SPSB2-203	ENST00000519357	1496	267aa	ENSP00000431037
SPSB2-201	ENST00000432205	679	82aa	ENSP00000428458
SPSB2-202	ENST00000437851	404	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
71333	Colorectal Neoplasms	4E-11	26965516

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	2	IDA,IEA	Homo_sapiens(9606)	Process
GO:0019005	part_of SCF ubiquitin ligase complex	1	IBA	Homo_sapiens(9606)	Component
GO:0035556	involved_in intracellular signal transduction	1	IEA	Homo_sapiens(9606)	Process
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:1990756	enables ubiquitin ligase-substrate adaptor activity	1	IPI	Homo_sapiens(9606)	Function