RBPWorld - a comprehensive database of RNA Binding Proteins

Welcome to

RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000110344	Gene ID	9354	Accession	12499
Symbol	UBE4A	Alias	E4;UFD2;UBOX2;NEDHMS	Full Name	ubiquitination factor E4A
Status	Confidence	Length	39612 bases	Strand	Plus strand
Position	11 : 118359600 - 118399211	RNA binding domain	N.A.
Summary	This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
UBE4A-201	ENST00000252108	6088	1066aa	ENSP00000252108
UBE4A-202	ENST00000431736	6061	1073aa	ENSP00000387362
UBE4A-203	ENST00000545354	2149	538aa	ENSP00000438918

Gene Model

Click here to download ENSG00000110344's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
65313	HIV-1	2E-6	21897333
65314	Body Fat Distribution	2E-6	21897333

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000110344's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000151	part_of ubiquitin ligase complex	1	IEA	Homo_sapiens(9606)	Component
GO:0000209	involved_in protein polyubiquitination	1	IBA	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0030433	involved_in ubiquitin-dependent ERAD pathway	1	IBA	Homo_sapiens(9606)	Process
GO:0034450	enables ubiquitin-ubiquitin ligase activity	1	IBA	Homo_sapiens(9606)	Function

Expression