Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000108559 Gene ID 4927 Accession 8067
Symbol NUP88 Alias FADS4 Full Name nucleoporin 88
Status Confidence Length 60497 bases Strand Minus strand
Position 17 : 5359668 - 5420164 RNA binding domain N.A.
Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
NUP88-214 ENST00000700529 4626 732aa ENSP00000515034
NUP88-206 ENST00000573169 1195 No protein -
NUP88-212 ENST00000576708 800 110aa ENSP00000461334
NUP88-215 ENST00000700530 2270 657aa ENSP00000515035
NUP88-216 ENST00000700531 5220 711aa ENSP00000515036
NUP88-217 ENST00000700532 5185 699aa ENSP00000515037
NUP88-218 ENST00000700533 5175 368aa ENSP00000515038
NUP88-219 ENST00000700534 5235 441aa ENSP00000515039
NUP88-220 ENST00000700535 5246 712aa ENSP00000515040
NUP88-221 ENST00000700536 5283 169aa ENSP00000515041
NUP88-222 ENST00000700537 5253 449aa ENSP00000515042
NUP88-203 ENST00000572019 5474 151aa ENSP00000515043
NUP88-223 ENST00000700538 5682 721aa ENSP00000515044
NUP88-224 ENST00000700539 3329 435aa ENSP00000515045
NUP88-225 ENST00000700540 3683 475aa ENSP00000515046
NUP88-226 ENST00000700541 3465 368aa ENSP00000515047
NUP88-227 ENST00000700542 3549 704aa ENSP00000515048
NUP88-228 ENST00000700543 3534 688aa ENSP00000515049
NUP88-201 ENST00000225696 3900 757aa ENSP00000225696
NUP88-207 ENST00000573584 3611 741aa ENSP00000458954
NUP88-229 ENST00000700544 3438 610aa ENSP00000515050
NUP88-230 ENST00000700545 2909 229aa ENSP00000515051
NUP88-209 ENST00000574855 434 No protein -
NUP88-231 ENST00000700546 2023 646aa ENSP00000515052
NUP88-208 ENST00000574087 548 No protein -
NUP88-213 ENST00000576862 788 No protein -
NUP88-211 ENST00000575976 599 No protein -
NUP88-210 ENST00000574867 2081 No protein -
NUP88-202 ENST00000570937 2671 98aa ENSP00000515053
NUP88-232 ENST00000700547 2346 No protein -
NUP88-233 ENST00000700548 321 No protein -
NUP88-205 ENST00000572809 771 153aa ENSP00000459370
NUP88-204 ENST00000572290 615 128aa ENSP00000459979

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000055involved_in ribosomal large subunit export from nucleus1IBAHomo_sapiens(9606)Process
GO:0000056involved_in ribosomal small subunit export from nucleus1IBAHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005635located_in nuclear envelope1IDAHomo_sapiens(9606)Component
GO:0005643part_of nuclear pore3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006406involved_in mRNA export from nucleus1IBAHomo_sapiens(9606)Process
GO:0006606involved_in protein import into nucleus1IBAHomo_sapiens(9606)Process
GO:0006913involved_in nucleocytoplasmic transport1NASHomo_sapiens(9606)Process
GO:0017056enables structural constituent of nuclear pore1IEAHomo_sapiens(9606)Function

Expression