RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000103657	Gene ID	8925	Accession	4867
Symbol	HERC1	Alias	p532;p619;MDFPMR	Full Name	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Status	Confidence	Length	225331 bases	Strand	Minus strand
Position	15 : 63608618 - 63833948	RNA binding domain	SPRY
Summary	This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000390158	SPRY	PF00622	1.1e-17	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
HERC1-201	ENST00000443617	15197	4861aa	ENSP00000390158
HERC1-206	ENST00000559996	443	No protein	-
HERC1-202	ENST00000558324	828	152aa	ENSP00000453196
HERC1-212	ENST00000561348	588	No protein	-
HERC1-215	ENST00000561436	551	No protein	-
HERC1-213	ENST00000561359	551	47aa	ENSP00000453603
HERC1-210	ENST00000560897	539	26aa	ENSP00000452671
HERC1-204	ENST00000559715	495	165aa	ENSP00000452654
HERC1-214	ENST00000561400	2215	691aa	ENSP00000453937
HERC1-211	ENST00000560983	457	No protein	-
HERC1-209	ENST00000560519	591	No protein	-
HERC1-205	ENST00000559886	2462	No protein	-
HERC1-203	ENST00000558532	581	153aa	ENSP00000453086
HERC1-208	ENST00000560462	647	145aa	ENSP00000452969
HERC1-207	ENST00000560316	577	20aa	ENSP00000453010

Gene Model

Click here to download ENSG00000103657's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
59812	Hypertension	1.2276459E-005	-
90646	Corneal Pachymetry	1E-6	21835309

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000103657's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004842	enables ubiquitin-protein transferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005085	enables guanyl-nucleotide exchange factor activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005737	located_in cytoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IEA	Homo_sapiens(9606)	Component
GO:0006914	involved_in autophagy	1	IEA	Homo_sapiens(9606)	Process
GO:0010507	involved_in negative regulation of autophagy	1	IEA	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0016567	involved_in protein ubiquitination	1	IEA	Homo_sapiens(9606)	Process
GO:0021702	involved_in cerebellar Purkinje cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0022038	involved_in corpus callosum development	1	IEA	Homo_sapiens(9606)	Process
GO:0031175	involved_in neuron projection development	1	IEA	Homo_sapiens(9606)	Process
GO:0050885	involved_in neuromuscular process controlling balance	1	IEA	Homo_sapiens(9606)	Process

Expression