Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000103257 Gene ID 8140 Accession 11063
Symbol SLC7A5 Alias E16;CD98;LAT1;4F2LC;MPE16;D16S469E Full Name solute carrier family 7 member 5
Status Confidence Length 39485 bases Strand Minus strand
Position 16 : 87830023 - 87869507 RNA binding domain N.A.
Summary Enables L-leucine transmembrane transporter activity; L-tryptophan transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Is integral component of membrane. Part of amino acid transport complex; apical plasma membrane; and microvillus membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
SLC7A5-203 ENST00000565644 3983 241aa ENSP00000454323
SLC7A5-201 ENST00000261622 4556 507aa ENSP00000261622
SLC7A5-202 ENST00000563489 780 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
37672Platelet Function Tests1.2148600E-005-
51939Child Development Disorders, Pervasive3.9000000E-005-
92972Metabolism9E-2624816252

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0002720acts_upstream_of positive regulation of cytokine production involved in immune response1TASHomo_sapiens(9606)Process
GO:0003333involved_in amino acid transmembrane transport1IBAHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005765located_in lysosomal membrane1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane2IDA,TASHomo_sapiens(9606)Component
GO:0009925located_in basal plasma membrane1ISSHomo_sapiens(9606)Component
GO:0010507involved_in negative regulation of autophagy1IEAHomo_sapiens(9606)Process
GO:0010629acts_upstream_of negative regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0014850involved_in response to muscle activity1IEAHomo_sapiens(9606)Process
GO:0015171enables amino acid transmembrane transporter activity3IDA,IMP,ISSHomo_sapiens(9606)Function
GO:0015173enables aromatic amino acid transmembrane transporter activity1IGIHomo_sapiens(9606)Function
GO:0015175enables neutral L-amino acid transmembrane transporter activity3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0015179enables L-amino acid transmembrane transporter activity1IBAHomo_sapiens(9606)Function
GO:0015190enables L-leucine transmembrane transporter activity2IDA,IMPHomo_sapiens(9606)Function
GO:0015196enables L-tryptophan transmembrane transporter activity1IDAHomo_sapiens(9606)Function
GO:0015297enables antiporter activity1IDAHomo_sapiens(9606)Function
GO:0015349enables thyroid hormone transmembrane transporter activity1IDAHomo_sapiens(9606)Function
GO:0015804involved_in neutral amino acid transport3IBA,IDA,ISSHomo_sapiens(9606)Process
GO:0015818involved_in isoleucine transport1IDAHomo_sapiens(9606)Process
GO:0015820involved_in leucine transport1IDAHomo_sapiens(9606)Process
GO:0015821involved_in methionine transport1IDAHomo_sapiens(9606)Process
GO:0015823involved_in phenylalanine transport2IDA,IGIHomo_sapiens(9606)Process
GO:0015824involved_in proline transport1IDAHomo_sapiens(9606)Process
GO:0015827involved_in tryptophan transport1IDAHomo_sapiens(9606)Process
GO:0015828involved_in tyrosine transport1IDAHomo_sapiens(9606)Process
GO:0015829involved_in valine transport1IDAHomo_sapiens(9606)Process
GO:0016020located_in membrane2HDA,IDAHomo_sapiens(9606)Component
GO:0016323located_in basolateral plasma membrane1ISSHomo_sapiens(9606)Component
GO:0016324located_in apical plasma membrane2IDA,ISSHomo_sapiens(9606)Component
GO:0031528located_in microvillus membrane1IDAHomo_sapiens(9606)Component
GO:0032328involved_in alanine transport1IDAHomo_sapiens(9606)Process
GO:0032729acts_upstream_of positive regulation of type II interferon production1IMPHomo_sapiens(9606)Process
GO:0032740acts_upstream_of positive regulation of interleukin-17 production1IMPHomo_sapiens(9606)Process
GO:0032753acts_upstream_of positive regulation of interleukin-4 production1IMPHomo_sapiens(9606)Process
GO:0042149involved_in cellular response to glucose starvation1IEAHomo_sapiens(9606)Process
GO:0042605enables peptide antigen binding1ISSHomo_sapiens(9606)Function
GO:0042908involved_in xenobiotic transport1IMPHomo_sapiens(9606)Process
GO:0043231located_in intracellular membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0055093involved_in response to hyperoxia1IEAHomo_sapiens(9606)Process
GO:0060252involved_in positive regulation of glial cell proliferation1IEAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070327involved_in thyroid hormone transport1IDAHomo_sapiens(9606)Process
GO:0071222involved_in cellular response to lipopolysaccharide1IEAHomo_sapiens(9606)Process
GO:0089718involved_in amino acid import across plasma membrane3IDA,IMP,ISSHomo_sapiens(9606)Process
GO:0097421involved_in liver regeneration1IEAHomo_sapiens(9606)Process
GO:0098591located_in external side of apical plasma membrane1ISSHomo_sapiens(9606)Component
GO:0098713involved_in leucine import across plasma membrane2IDA,IMPHomo_sapiens(9606)Process
GO:0150104involved_in transport across blood-brain barrier1NASHomo_sapiens(9606)Process
GO:1902024involved_in L-histidine transport1IDAHomo_sapiens(9606)Process
GO:1903577involved_in cellular response to L-arginine1IEAHomo_sapiens(9606)Process
GO:1903801involved_in L-leucine import across plasma membrane2IDA,IMPHomo_sapiens(9606)Process
GO:1904556involved_in L-tryptophan transmembrane transport1IDAHomo_sapiens(9606)Process
GO:1905460involved_in negative regulation of vascular associated smooth muscle cell apoptotic process1IEAHomo_sapiens(9606)Process
GO:1905534involved_in positive regulation of leucine import across plasma membrane1IEAHomo_sapiens(9606)Process
GO:1990184part_of amino acid transport complex1IDAHomo_sapiens(9606)Component

Expression