RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000102098	Gene ID	10389	Accession	10581
Symbol	SCML2	Alias	NA	Full Name	Scm polycomb group protein like 2
Status	Confidence	Length	115376 bases	Strand	Minus strand
Position	X : 18239313 - 18354688	RNA binding domain	RBR
Summary	This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000499630	RBR	PF17208	4.7e-11	1
ENSP00000251900	RBR	PF17208	1.2e-10	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
24986859	Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.	Roberto Bonasio	2014-07-01	eLife
30137219	A rapidly evolved domain, the SCML2 DNA-binding repeats, contributes to chromatin binding of mouse SCML2†.	So Maezawa	2019-02-01	Biology of reproduction
25251851	Regulation of transcription by long noncoding RNAs.	Roberto Bonasio	2014-01-01	Annual review of genetics
33067435	Analysis of protein-DNA interactions in chromatin by UV induced cross-linking and mass spectrometry.	Alexandra Stützer	2020-10-16	Nature communications

Name	Transcript ID	bp	Protein	Translation ID
SCML2-201	ENST00000251900	4162	700aa	ENSP00000251900
SCML2-203	ENST00000420857	2432	124aa	ENSP00000407315
SCML2-204	ENST00000491988	807	No protein	-
SCML2-205	ENST00000665583	1514	345aa	ENSP00000499630
SCML2-202	ENST00000398048	1334	138aa	ENSP00000381126

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003682	enables chromatin binding	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0009653	involved_in anatomical structure morphogenesis	1	IMP	Homo_sapiens(9606)	Process
GO:0031519	part_of PcG protein complex	1	IDA	Homo_sapiens(9606)	Component
GO:0042393	enables histone binding	1	IBA	Homo_sapiens(9606)	Function
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	IBA	Homo_sapiens(9606)	Process