RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000101871	Gene ID	4281	Accession	7095
Symbol	MID1	Alias	OS;FXY;OSX;GBBB;OGS1;XPRF;BBBG1;GBBB1;MIDIN;RNF59;ZNFXY;TRIM18	Full Name	midline 1
Status	Confidence	Length	388345 bases	Strand	Minus strand
Position	X : 10445310 - 10833654	RNA binding domain	SPRY
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000502171	SPRY	PF00622	1.4e-17	1
ENSP00000508663	SPRY	PF00622	4e-17	1
ENSP00000509730	SPRY	PF00622	4e-17	1
ENSP00000509925	SPRY	PF00622	4e-17	1
ENSP00000312678	SPRY	PF00622	4.3e-17	1
ENSP00000370156	SPRY	PF00622	4.3e-17	1
ENSP00000370157	SPRY	PF00622	4.3e-17	1
ENSP00000370162	SPRY	PF00622	4.3e-17	1
ENSP00000370164	SPRY	PF00622	4.3e-17	1
ENSP00000414521	SPRY	PF00622	4.3e-17	1
ENSP00000501707	SPRY	PF00622	4.7e-17	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
29062069	Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex.	Susann Schweiger	2017-10-23	Scientific reports
27774050	Regulation of mRNA Translation by MID1: A Common Mechanism of Expanded CAG Repeat RNAs.	Nadine Griesche	2016-01-01	Frontiers in cellular neuroscience
18949047	Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A.	Beatriz Aranda-Orgillés	2008-01-01	PloS one
32283114	The MID1 gene product in physiology and disease.	Rossella Baldini	2020-07-15	Gene
37062072	CAG-Repeat RNA Hairpin Folding and Recruitment to Nuclear Speckles with a Pivotal Role of ATP as a Cosolute.	Alexander Hautke	2023-05-03	Journal of the American Chemical Society
24913494	A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling.	Andrea Köhler	2014-06-09	Molecular cancer
27625393	Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases.	Magdalena Jazurek	2016-11-02	Nucleic acids research
18005432	Alternative polyadenylation signals and promoters act in concert to control tissue-specific expression of the Opitz Syndrome gene MID1.	Jennifer Winter	2007-11-15	BMC molecular biology
18172692	The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex.	Beatriz Aranda-Orgillés	2008-03-01	Human genetics

Name	Transcript ID	bp	Protein	Translation ID
MID1-208	ENST00000453318	6393	667aa	ENSP00000414521
MID1-202	ENST00000380779	6044	667aa	ENSP00000370156
MID1-203	ENST00000380780	6195	667aa	ENSP00000370157
MID1-201	ENST00000317552	6168	667aa	ENSP00000312678
MID1-207	ENST00000413894	6095	667aa	ENSP00000391154
MID1-205	ENST00000380785	6092	667aa	ENSP00000370162
MID1-206	ENST00000380787	5973	667aa	ENSP00000370164
MID1-204	ENST00000380782	3352	552aa	ENSP00000370159
MID1-222	ENST00000691943	3436	631aa	ENSP00000508663
MID1-220	ENST00000690004	3473	629aa	ENSP00000509730
MID1-218	ENST00000689773	3452	629aa	ENSP00000509925
MID1-213	ENST00000675073	2369	718aa	ENSP00000501707
MID1-212	ENST00000674917	1365	371aa	ENSP00000502171
MID1-209	ENST00000479925	858	No protein	-
MID1-216	ENST00000687008	2439	489aa	ENSP00000508734
MID1-221	ENST00000691913	1141	No protein	-
MID1-211	ENST00000616003	1927	540aa	ENSP00000484712
MID1-214	ENST00000675358	557	48aa	ENSP00000502220
MID1-210	ENST00000610939	1839	No protein	-
MID1-215	ENST00000686012	2250	No protein	-
MID1-217	ENST00000689180	1248	No protein	-
MID1-223	ENST00000693721	1992	No protein	-
MID1-219	ENST00000689988	1056	No protein	-
MID1-224	ENST00000707197	1364	No protein	-
MID1-225	ENST00000707198	1305	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
3576	Cholesterol, HDL	2.84798923929218E-7	17903299
6264	Erythrocyte Indices	5.6512429342198E-7	17903294
9781	Echocardiography	2.38083448696652E-6	17903301
105657	Neuropsychological Tests	1E-7	19734545

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000226	involved_in microtubule cytoskeleton organization	1	TAS	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0005819	located_in spindle	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005874	located_in microtubule	1	IDA	Homo_sapiens(9606)	Component
GO:0005875	part_of microtubule associated complex	1	TAS	Homo_sapiens(9606)	Component
GO:0005881	colocalizes_with cytoplasmic microtubule	1	IDA	Homo_sapiens(9606)	Component
GO:0007026	involved_in negative regulation of microtubule depolymerization	1	IEA	Homo_sapiens(9606)	Process
GO:0007389	involved_in pattern specification process	1	TAS	Homo_sapiens(9606)	Process
GO:0008017	enables microtubule binding	1	IMP	Homo_sapiens(9606)	Function
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0016740	enables transferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0019899	enables enzyme binding	1	IPI	Homo_sapiens(9606)	Function
GO:0031625	enables ubiquitin protein ligase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0032874	involved_in positive regulation of stress-activated MAPK cascade	1	IMP	Homo_sapiens(9606)	Process
GO:0034451	located_in centriolar satellite	1	IDA	Homo_sapiens(9606)	Component
GO:0035372	involved_in protein localization to microtubule	1	IMP	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042803	enables protein homodimerization activity	1	IDA	Homo_sapiens(9606)	Function
GO:0051219	enables phosphoprotein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0070507	involved_in regulation of microtubule cytoskeleton organization	1	IBA	Homo_sapiens(9606)	Process