Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-2Dengue
Drug Drug
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000100823 Gene ID 328 Accession 587
Symbol APEX1 Alias APE;APX;APE1;APEN;APEX;HAP1;REF1 Full Name apurinic/apyrimidinic endodeoxyribonuclease 1
Status Confidence Length 2582 bases Strand Plus strand
Position 14 : 20455191 - 20457772 RNA binding domain Exo_endo_phos
Summary The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000216714 Exo_endo_phos PF03372 4.2e-21 1
ENSP00000381111 Exo_endo_phos PF03372 4.2e-21 1
ENSP00000451979 Exo_endo_phos PF03372 4.2e-21 1
ENSP00000451327 Exo_endo_phos PF03372 9.8e-16 1
ENSP00000452460 Exo_endo_phos PF03372 1.4e-14 1
ENSP00000416414 Exo_endo_phos PF03372 1e-13 1
ENSP00000451060 Exo_endo_phos PF03372 9.8e-08 1
ENSP00000452418 Exo_endo_phos PF03372 1.2e-07 1
ENSP00000451170 Exo_endo_phos PF03372 1.6e-07 1
ENSP00000452137 Exo_endo_phos PF03372 6.7e-07 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34529719 Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line. V Daria Kim 2021-01-01 PloS one

Transcripts

Name Transcript ID bp Protein Translation ID
APEX1-210 ENST00000555414 1437 318aa ENSP00000451979
APEX1-206 ENST00000553681 899 263aa ENSP00000451327
APEX1-208 ENST00000554813 654 No protein -
APEX1-213 ENST00000556296 571 No protein -
APEX1-218 ENST00000557344 671 146aa ENSP00000452137
APEX1-209 ENST00000555306 898 No protein -
APEX1-205 ENST00000553555 1603 No protein -
APEX1-201 ENST00000216714 1453 318aa ENSP00000216714
APEX1-202 ENST00000398030 1387 318aa ENSP00000381111
APEX1-207 ENST00000554325 568 49aa ENSP00000450604
APEX1-217 ENST00000557181 566 107aa ENSP00000452304
APEX1-211 ENST00000555839 952 242aa ENSP00000452460
APEX1-216 ENST00000557159 1803 No protein -
APEX1-204 ENST00000553368 304 41aa ENSP00000451491
APEX1-212 ENST00000556054 773 174aa ENSP00000451170
APEX1-214 ENST00000557054 888 14aa ENSP00000452212
APEX1-220 ENST00000557592 640 172aa ENSP00000451060
APEX1-219 ENST00000557365 831 No protein -
APEX1-215 ENST00000557150 740 162aa ENSP00000452418
APEX1-203 ENST00000438886 451 150aa ENSP00000416414

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000100823homo_sapiensENSP0000036412623.938214.2857homo_sapiensENSP0000021671438.993723.2704
ENSG00000100823homo_sapiensENSP00000517342100100homo_sapiensENSP00000216714100100

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000100823homo_sapiensENSP0000021671499.056698.4277nomascus_leucogenysENSNLEP0000001325999.056698.4277
ENSG00000100823homo_sapiensENSP0000021671410099.6855pan_paniscusENSPPAP0000003169610099.6855
ENSG00000100823homo_sapiensENSP0000021671499.371198.4277pongo_abeliiENSPPYP0000003020099.371198.4277
ENSG00000100823homo_sapiensENSP0000021671410099.6855pan_troglodytesENSPTRP0000001034410099.6855
ENSG00000100823homo_sapiensENSP0000021671410098.7421gorilla_gorillaENSGGOP0000004404296.951295.7317
ENSG00000100823homo_sapiensENSP0000021671487.735877.3585ornithorhynchus_anatinusENSOANP0000004901483.783873.8739
ENSG00000100823homo_sapiensENSP0000021671492.767386.1635sarcophilus_harrisiiENSSHAP0000001587291.900385.3583
ENSG00000100823homo_sapiensENSP0000021671491.823986.7924notamacropus_eugeniiENSMEUP0000001325692.993687.8981
ENSG00000100823homo_sapiensENSP0000021671493.396289.3082dasypus_novemcinctusENSDNOP0000002112090.548886.5854
ENSG00000100823homo_sapiensENSP0000021671487.106984.9057erinaceus_europaeusENSEEUP0000001143596.180693.75
ENSG00000100823homo_sapiensENSP0000021671466.666758.805echinops_telfairiENSETEP0000001358478.518569.2593
ENSG00000100823homo_sapiensENSP0000021671496.226493.7107echinops_telfairiENSETEP0000000396696.226493.7107
ENSG00000100823homo_sapiensENSP0000021671499.056698.1132callithrix_jacchusENSCJAP0000001786499.056698.1132
ENSG00000100823homo_sapiensENSP0000021671499.056698.4277cercocebus_atysENSCATP0000000445399.056698.4277
ENSG00000100823homo_sapiensENSP0000021671498.742198.1132macaca_fascicularisENSMFAP0000000582098.742198.1132
ENSG00000100823homo_sapiensENSP0000021671498.742198.1132macaca_mulattaENSMMUP0000004487198.742198.1132
ENSG00000100823homo_sapiensENSP0000021671498.427797.7987macaca_nemestrinaENSMNEP0000002710398.119197.4922
ENSG00000100823homo_sapiensENSP0000021671499.056698.4277papio_anubisENSPANP0000001457199.056698.4277
ENSG00000100823homo_sapiensENSP0000021671499.056698.4277mandrillus_leucophaeusENSMLEP0000003600899.056698.4277
ENSG00000100823homo_sapiensENSP0000021671472.012670.7547tursiops_truncatusENSTTRP0000000743097.446895.7447
ENSG00000100823homo_sapiensENSP0000021671496.855394.6541vulpes_vulpesENSVVUP0000001223596.855394.6541
ENSG00000100823homo_sapiensENSP0000021671496.855394.3396mus_spretusMGP_SPRETEiJ_P003819897.160994.6372
ENSG00000100823homo_sapiensENSP0000021671497.798796.2264equus_asinusENSEASP0000502564071.990770.8333
ENSG00000100823homo_sapiensENSP0000021671495.28393.0818capra_hircusENSCHIP0000000328195.28393.0818
ENSG00000100823homo_sapiensENSP0000021671478.616473.5849capra_hircusENSCHIP0000001296087.10881.5331
ENSG00000100823homo_sapiensENSP0000021671496.540994.0252loxodonta_africanaENSLAFP0000001775396.540994.0252
ENSG00000100823homo_sapiensENSP0000021671497.798796.2264panthera_leoENSPLOP0000001084397.798796.2264
ENSG00000100823homo_sapiensENSP0000021671497.169895.5975ailuropoda_melanoleucaENSAMEP0000000572197.169895.5975
ENSG00000100823homo_sapiensENSP0000021671453.144746.8553bos_indicus_hybridENSBIXP0000503779684.079674.1294
ENSG00000100823homo_sapiensENSP0000021671495.597593.7107bos_indicus_hybridENSBIXP0000501568595.597593.7107
ENSG00000100823homo_sapiensENSP0000021671497.484394.6541oryctolagus_cuniculusENSOCUP0000000434997.484394.6541
ENSG00000100823homo_sapiensENSP0000021671497.798796.2264equus_caballusENSECAP0000006815071.990770.8333
ENSG00000100823homo_sapiensENSP0000021671497.484395.283canis_lupus_familiarisENSCAFP0084503160444.412643.4097
ENSG00000100823homo_sapiensENSP0000021671498.113296.5409panthera_pardusENSPPRP0000002083698.113296.5409
ENSG00000100823homo_sapiensENSP0000021671492.138489.3082marmota_marmota_marmotaENSMMMP0000000445396.381693.4211
ENSG00000100823homo_sapiensENSP0000021671494.339691.5094marmota_marmota_marmotaENSMMMP0000000110896.46393.5691
ENSG00000100823homo_sapiensENSP0000021671495.911993.3962balaenoptera_musculusENSBMSP0001001200095.911993.3962
ENSG00000100823homo_sapiensENSP0000021671496.540994.3396cavia_porcellusENSCPOP0000003212596.540994.3396
ENSG00000100823homo_sapiensENSP0000021671497.798796.2264felis_catusENSFCAP0000002970271.990770.8333
ENSG00000100823homo_sapiensENSP0000021671497.169895.283ursus_americanusENSUAMP0000001296097.169895.283
ENSG00000100823homo_sapiensENSP0000021671492.767386.1635monodelphis_domesticaENSMODP0000000883892.187585.625
ENSG00000100823homo_sapiensENSP0000021671495.597593.7107bison_bison_bisonENSBBBP0000000173895.597593.7107
ENSG00000100823homo_sapiensENSP0000021671495.597593.0818monodon_monocerosENSMMNP0001501320995.597593.0818
ENSG00000100823homo_sapiensENSP0000021671496.226494.3396sus_scrofaENSSSCP0000005945196.226494.3396
ENSG00000100823homo_sapiensENSP0000021671497.169895.283microcebus_murinusENSMICP0000004154497.169895.283
ENSG00000100823homo_sapiensENSP0000021671478.930873.2704octodon_degusENSODEP0000000880584.797378.7162
ENSG00000100823homo_sapiensENSP0000021671496.540994.6541octodon_degusENSODEP0000000218096.845494.9527
ENSG00000100823homo_sapiensENSP0000021671475.786272.956octodon_degusENSODEP0000000637989.591186.2454
ENSG00000100823homo_sapiensENSP0000021671496.226494.0252jaculus_jaculusENSJJAP0000000772296.226494.0252
ENSG00000100823homo_sapiensENSP0000021671482.704480.5031jaculus_jaculusENSJJAP0000001953291.637689.1986
ENSG00000100823homo_sapiensENSP0000021671489.622684.5912jaculus_jaculusENSJJAP0000000220389.622684.5912
ENSG00000100823homo_sapiensENSP0000021671492.452888.9937ovis_aries_rambouilletENSOARP0002000207285.714382.5073
ENSG00000100823homo_sapiensENSP0000021671495.28393.0818ovis_aries_rambouilletENSOARP0002001608795.28393.0818
ENSG00000100823homo_sapiensENSP0000021671497.169895.283ursus_maritimusENSUMAP0000001232997.169895.283
ENSG00000100823homo_sapiensENSP0000021671495.28393.0818ochotona_princepsENSOPRP0000001279695.583693.3754
ENSG00000100823homo_sapiensENSP0000021671495.597593.0818delphinapterus_leucasENSDLEP0000000224795.597593.0818
ENSG00000100823homo_sapiensENSP0000021671495.911993.3962physeter_catodonENSPCTP0000502954195.911993.3962
ENSG00000100823homo_sapiensENSP0000021671495.911993.3962mus_caroliMGP_CAROLIEiJ_P003648096.214593.6908
ENSG00000100823homo_sapiensENSP0000021671496.855394.3396mus_musculusENSMUSP0000004260297.160994.6372
ENSG00000100823homo_sapiensENSP0000021671496.226494.3396dipodomys_ordiiENSDORP0000000150596.226494.3396
ENSG00000100823homo_sapiensENSP0000021671419.182418.8679mustela_putorius_furoENSMPUP0000001801057.547256.6038
ENSG00000100823homo_sapiensENSP0000021671499.056697.7987aotus_nancymaaeENSANAP0000002482699.056697.7987
ENSG00000100823homo_sapiensENSP0000021671486.163581.4465saimiri_boliviensis_boliviensisENSSBOP0000003017889.250884.3648
ENSG00000100823homo_sapiensENSP0000021671499.056698.1132saimiri_boliviensis_boliviensisENSSBOP0000000458099.056698.1132
ENSG00000100823homo_sapiensENSP0000021671468.23966.9811vicugna_pacosENSVPAP0000000471492.73591.0256
ENSG00000100823homo_sapiensENSP0000021671499.056698.1132chlorocebus_sabaeusENSCSAP0000001273999.056698.1132
ENSG00000100823homo_sapiensENSP0000021671499.056698.1132chlorocebus_sabaeusENSCSAP0000001272499.056698.1132
ENSG00000100823homo_sapiensENSP0000021671494.025291.8239tupaia_belangeriENSTBEP0000000551494.620392.4051
ENSG00000100823homo_sapiensENSP0000021671495.28393.0818mesocricetus_auratusENSMAUP0000001414195.886193.6709
ENSG00000100823homo_sapiensENSP0000021671495.911993.0818phocoena_sinusENSPSNP0000001656295.911993.0818
ENSG00000100823homo_sapiensENSP0000021671496.855394.9686camelus_dromedariusENSCDRP0000500243196.855394.9686
ENSG00000100823homo_sapiensENSP0000021671497.484394.6541carlito_syrichtaENSTSYP0000003466997.484394.6541
ENSG00000100823homo_sapiensENSP0000021671497.798796.2264panthera_tigris_altaicaENSPTIP0000001586297.798796.2264
ENSG00000100823homo_sapiensENSP0000021671492.767389.9371rattus_norvegicusENSRNOP0000006867393.354490.5063
ENSG00000100823homo_sapiensENSP0000021671497.169895.283prolemur_simusENSPSMP0000000024097.169895.283
ENSG00000100823homo_sapiensENSP0000021671496.540992.1384microtus_ochrogasterENSMOCP0000001413396.845492.429
ENSG00000100823homo_sapiensENSP0000021671496.855393.7107peromyscus_maniculatus_bairdiiENSPEMP0000002145397.160994.0063
ENSG00000100823homo_sapiensENSP0000021671495.597593.7107bos_mutusENSBMUP0000001605295.597593.7107
ENSG00000100823homo_sapiensENSP0000021671496.540994.0252mus_spicilegusENSMSIP0000002293596.845494.3218
ENSG00000100823homo_sapiensENSP0000021671495.28392.1384cricetulus_griseus_chok1gshdENSCGRP0000101681195.583692.429
ENSG00000100823homo_sapiensENSP0000021671498.113295.9119pteropus_vampyrusENSPVAP0000001011497.595.3125
ENSG00000100823homo_sapiensENSP0000021671496.855394.6541myotis_lucifugusENSMLUP0000002117496.2594.0625
ENSG00000100823homo_sapiensENSP0000021671492.767384.9057vombatus_ursinusENSVURP0001002599092.476584.6395
ENSG00000100823homo_sapiensENSP0000021671496.855394.0252rhinolophus_ferrumequinumENSRFEP0001002507297.160994.3218
ENSG00000100823homo_sapiensENSP0000021671496.855394.9686neovison_visonENSNVIP0000001716797.160995.2681
ENSG00000100823homo_sapiensENSP0000021671495.597593.7107bos_taurusENSBTAP0000000355995.597593.7107
ENSG00000100823homo_sapiensENSP0000021671496.855394.3396heterocephalus_glaber_femaleENSHGLP0000003127687.749385.4701
ENSG00000100823homo_sapiensENSP0000021671499.371198.4277rhinopithecus_bietiENSRBIP0000002886298.136697.205
ENSG00000100823homo_sapiensENSP0000021671453.459150.3145canis_lupus_dingoENSCAFP0002002950294.444488.8889
ENSG00000100823homo_sapiensENSP0000021671497.484395.283canis_lupus_dingoENSCAFP0002001796197.484395.283
ENSG00000100823homo_sapiensENSP0000021671497.484395.5975sciurus_vulgarisENSSVLP0000500225897.484395.5975
ENSG00000100823homo_sapiensENSP0000021671492.138485.8491phascolarctos_cinereusENSPCIP0000003131391.849585.5799
ENSG00000100823homo_sapiensENSP0000021671496.226492.1384procavia_capensisENSPCAP0000000963896.5392.429
ENSG00000100823homo_sapiensENSP0000021671475.786270.1258nannospalax_galiliENSNGAP0000002308883.680677.4306
ENSG00000100823homo_sapiensENSP0000021671495.28393.0818nannospalax_galiliENSNGAP0000000276495.28393.0818
ENSG00000100823homo_sapiensENSP0000021671496.855394.6541chinchilla_lanigeraENSCLAP0000000131896.855394.6541
ENSG00000100823homo_sapiensENSP0000021671489.937188.0503cervus_hanglu_yarkandensisENSCHYP0000002249795.652293.6455
ENSG00000100823homo_sapiensENSP0000021671494.968693.0818cervus_hanglu_yarkandensisENSCHYP0000002251794.968693.0818
ENSG00000100823homo_sapiensENSP0000021671490.56686.478cervus_hanglu_yarkandensisENSCHYP0000002367990.56686.478
ENSG00000100823homo_sapiensENSP0000021671496.540995.283catagonus_wagneriENSCWAP0000000860896.540995.283
ENSG00000100823homo_sapiensENSP0000021671496.540993.7107ictidomys_tridecemlineatusENSSTOP0000000906696.540993.7107
ENSG00000100823homo_sapiensENSP0000021671484.591282.3899otolemur_garnettiiENSOGAP0000001908693.728291.2892
ENSG00000100823homo_sapiensENSP0000021671497.169894.3396otolemur_garnettiiENSOGAP0000001195097.169894.3396
ENSG00000100823homo_sapiensENSP0000021671499.371198.4277cebus_imitatorENSCCAP0000003003299.371198.4277
ENSG00000100823homo_sapiensENSP0000021671488.050384.9057cebus_imitatorENSCCAP0000002806591.803388.5246
ENSG00000100823homo_sapiensENSP0000021671496.226493.3962urocitellus_parryiiENSUPAP0001000994396.226493.3962
ENSG00000100823homo_sapiensENSP0000021671491.823989.6226moschus_moschiferusENSMMSP0000001165795.424893.1373
ENSG00000100823homo_sapiensENSP0000021671488.050386.1635mus_pahariMGP_PahariEiJ_P008460196.885894.8097
ENSG00000100823homo_sapiensENSP0000021671496.855395.283propithecus_coquereliENSPCOP0000001922996.855395.283
ENSG00000100823homo_sapiensENSP0000021671455.031438.3648caenorhabditis_elegansR09B3.1a.260.763942.3611
ENSG00000100823homo_sapiensENSP0000021671468.553552.2013drosophila_melanogasterFBpp028868030.878223.5127
ENSG00000100823homo_sapiensENSP0000021671464.779950.3145ciona_intestinalisENSCINP0000001662065.814751.1182
ENSG00000100823homo_sapiensENSP0000021671474.528362.5786petromyzon_marinusENSPMAP0000000800880.33967.4576
ENSG00000100823homo_sapiensENSP0000021671461.006349.6855eptatretus_burgeriENSEBUP0000000053774.903561.0039
ENSG00000100823homo_sapiensENSP0000021671477.67366.3522latimeria_chalumnaeENSLACP0000000977478.662467.1974
ENSG00000100823homo_sapiensENSP0000021671478.616467.6101lepisosteus_oculatusENSLOCP0000001909478.864467.8233
ENSG00000100823homo_sapiensENSP0000021671477.04465.7233danio_rerioENSDARP0000006737379.032367.4194
ENSG00000100823homo_sapiensENSP0000021671477.67366.3522carassius_auratusENSCARP0000012917377.187565.9375
ENSG00000100823homo_sapiensENSP0000021671477.67365.7233carassius_auratusENSCARP0000003447572.43461.2903
ENSG00000100823homo_sapiensENSP0000021671477.67366.3522carassius_auratusENSCARP0000000967473.731362.9851
ENSG00000100823homo_sapiensENSP0000021671476.729666.3522astyanax_mexicanusENSAMXP0000005237878.205167.6282
ENSG00000100823homo_sapiensENSP0000021671478.616466.9811ictalurus_punctatusENSIPUP0000000845080.385868.4887
ENSG00000100823homo_sapiensENSP0000021671477.04466.3522esox_luciusENSELUP0000002279871.847561.8768
ENSG00000100823homo_sapiensENSP0000021671476.415166.0377electrophorus_electricusENSEEEP0000000274977.884667.3077
ENSG00000100823homo_sapiensENSP0000021671476.100664.7799oncorhynchus_kisutchENSOKIP0000507778069.740659.366
ENSG00000100823homo_sapiensENSP0000021671476.100664.7799oncorhynchus_mykissENSOMYP0000002303269.740659.366
ENSG00000100823homo_sapiensENSP0000021671476.100664.7799oncorhynchus_mykissENSOMYP0000002099469.740659.366
ENSG00000100823homo_sapiensENSP0000021671476.100664.7799salmo_salarENSSSAP0000001340870.348859.8837
ENSG00000100823homo_sapiensENSP0000021671475.786264.4654salmo_salarENSSSAP0000016877070.058159.593
ENSG00000100823homo_sapiensENSP0000021671475.471764.4654salmo_truttaENSSTUP0000009900869.767459.593
ENSG00000100823homo_sapiensENSP0000021671476.100664.7799salmo_truttaENSSTUP0000000623370.348859.8837
ENSG00000100823homo_sapiensENSP0000021671473.899461.3208gadus_morhuaENSGMOP0000000848875.806462.9032
ENSG00000100823homo_sapiensENSP0000021671476.415166.6667fundulus_heteroclitusENSFHEP0000000787265.322656.9892
ENSG00000100823homo_sapiensENSP0000021671477.987466.3522poecilia_reticulataENSPREP0000002113779.742867.8457
ENSG00000100823homo_sapiensENSP0000021671477.67366.0377xiphophorus_maculatusENSXMAP0000003501075.766964.4172
ENSG00000100823homo_sapiensENSP0000021671477.04466.3522oryzias_latipesENSORLP0000001549478.778167.8457
ENSG00000100823homo_sapiensENSP0000021671477.358565.4088cyclopterus_lumpusENSCLMP0000502075378.594266.4537
ENSG00000100823homo_sapiensENSP0000021671478.301967.6101oreochromis_niloticusENSONIP0000001521680.064369.1318
ENSG00000100823homo_sapiensENSP0000021671477.987466.9811haplochromis_burtoniENSHBUP0000002448480.258968.932
ENSG00000100823homo_sapiensENSP0000021671477.987467.2956astatotilapia_callipteraENSACLP000000271108069.0323
ENSG00000100823homo_sapiensENSP0000021671476.729663.8365sparus_aurataENSSAUP0001002660365.945954.8649
ENSG00000100823homo_sapiensENSP0000021671477.67366.0377lates_calcariferENSLCAP0001005668270.773660.1719
ENSG00000100823homo_sapiensENSP0000021671477.358566.6667xenopus_tropicalisENSXETP0000004543067.768658.4022
ENSG00000100823homo_sapiensENSP0000021671482.704472.0126chrysemys_picta_belliiENSCPBP0000001270382.704472.0126
ENSG00000100823homo_sapiensENSP0000021671476.100667.2956sphenodon_punctatusENSSPUP0000000060485.211375.3521
ENSG00000100823homo_sapiensENSP0000021671483.018971.6981crocodylus_porosusENSCPRP0000501866151.764744.7059
ENSG00000100823homo_sapiensENSP0000021671482.075568.5535laticauda_laticaudataENSLLTP0000001511183.12169.4268
ENSG00000100823homo_sapiensENSP0000021671482.389968.5535notechis_scutatusENSNSUP0000000301583.174669.2064
ENSG00000100823homo_sapiensENSP0000021671480.817667.2956pseudonaja_textilisENSPTXP0000002404586.53272.0539
ENSG00000100823homo_sapiensENSP0000021671456.918246.8553anas_platyrhynchos_platyrhynchosENSAPLP0000001842062.847251.7361
ENSG00000100823homo_sapiensENSP0000021671430.503121.6981gallus_gallusENSGALP0001000011755.747139.6552
ENSG00000100823homo_sapiensENSP0000021671434.591230.8176meleagris_gallopavoENSMGAP0000001644382.706873.6842
ENSG00000100823homo_sapiensENSP0000021671445.28335.5346serinus_canariaENSSCAP0000000815570.93655.665
ENSG00000100823homo_sapiensENSP0000021671471.698159.1195parus_majorENSPMJP0000001803267.256655.4572
ENSG00000100823homo_sapiensENSP0000021671482.389969.8113anolis_carolinensisENSACAP0000002995882.649870.0315
ENSG00000100823homo_sapiensENSP0000021671477.67366.9811neolamprologus_brichardiENSNBRP0000000678172.861462.8319
ENSG00000100823homo_sapiensENSP0000021671480.817666.3522naja_najaENSNNAP0000001781575.146261.6959
ENSG00000100823homo_sapiensENSP0000021671455.660444.9686podarcis_muralisENSPMRP0000001914753.153242.9429
ENSG00000100823homo_sapiensENSP0000021671444.968635.5346geospiza_fortisENSGFOP0000001333174.869159.1623
ENSG00000100823homo_sapiensENSP0000021671471.069257.8616taeniopygia_guttataENSTGUP0000002091973.615659.9349
ENSG00000100823homo_sapiensENSP0000021671476.100665.7233erpetoichthys_calabaricusENSECRP0000000395177.564166.9872
ENSG00000100823homo_sapiensENSP0000021671477.67366.6667kryptolebias_marmoratusENSKMAP0000002855879.677468.3871
ENSG00000100823homo_sapiensENSP0000021671483.647869.4969salvator_merianaeENSSMRP0000000836384.444470.1587
ENSG00000100823homo_sapiensENSP0000021671477.04466.6667oryzias_javanicusENSOJAP0000001625878.525667.9487
ENSG00000100823homo_sapiensENSP0000021671474.842864.7799amphilophus_citrinellusENSACIP0000001369080.405469.5946
ENSG00000100823homo_sapiensENSP0000021671477.987464.7799dicentrarchus_labraxENSDLAP0000501313272.727360.4106
ENSG00000100823homo_sapiensENSP0000021671476.415164.4654amphiprion_perculaENSAPEP0000003019978.640866.343
ENSG00000100823homo_sapiensENSP0000021671477.04466.3522oryzias_sinensisENSOSIP0000001593372.058862.0588
ENSG00000100823homo_sapiensENSP0000021671452.830246.8553gopherus_evgoodeiENSGEVP0000502011084.848575.2525
ENSG00000100823homo_sapiensENSP0000021671482.389971.3836gopherus_evgoodeiENSGEVP0000502005882.389971.3836
ENSG00000100823homo_sapiensENSP0000021671482.704471.6981chelonoidis_abingdoniiENSCABP0000001203782.704471.6981
ENSG00000100823homo_sapiensENSP0000021671477.04465.0943seriola_dumeriliENSSDUP0000002249378.778166.5595
ENSG00000100823homo_sapiensENSP0000021671474.213861.6352cottoperca_gobioENSCGOP0000004966769.822557.9882
ENSG00000100823homo_sapiensENSP0000021671477.04465.0943gasterosteus_aculeatusENSGACP0000002576978.778166.5595
ENSG00000100823homo_sapiensENSP0000021671477.358564.7799cynoglossus_semilaevisENSCSEP0000002739379.099766.2379
ENSG00000100823homo_sapiensENSP0000021671477.987466.9811poecilia_formosaENSPFOP000000040468068.7097
ENSG00000100823homo_sapiensENSP0000021671477.04466.9811myripristis_murdjanENSMMDP0000505262775.384665.5385
ENSG00000100823homo_sapiensENSP0000021671478.930866.3522sander_luciopercaENSSLUP0000001287280.707467.8457
ENSG00000100823homo_sapiensENSP0000021671476.729664.4654amphiprion_ocellarisENSAOCP0000000606278.964466.343
ENSG00000100823homo_sapiensENSP0000021671482.704472.327terrapene_carolina_triunguisENSTMTP0000000874482.704472.327
ENSG00000100823homo_sapiensENSP0000021671476.100664.4654hucho_huchoENSHHUP0000001657677.564165.7051
ENSG00000100823homo_sapiensENSP0000021671476.415164.7799hucho_huchoENSHHUP0000002032377.884666.0256
ENSG00000100823homo_sapiensENSP0000021671477.04466.0377betta_splendensENSBSLP0000002203960.493851.8519
ENSG00000100823homo_sapiensENSP0000021671472.32761.3208pygocentrus_nattereriENSPNAP0000003274772.32761.3208
ENSG00000100823homo_sapiensENSP0000021671477.67366.3522anabas_testudineusENSATEP0000006294977.91866.5615
ENSG00000100823homo_sapiensENSP0000021671463.52245.9119ciona_savignyiENSCSAVP0000001214766.666748.1848
ENSG00000100823homo_sapiensENSP0000021671439.937125.4717saccharomyces_cerevisiaeYBL019W24.423115.5769
ENSG00000100823homo_sapiensENSP0000021671477.67365.7233seriola_lalandi_dorsalisENSSLDP0000002983479.677467.4194
ENSG00000100823homo_sapiensENSP0000021671475.471762.5786labrus_bergyltaENSLBEP0000001331777.170463.9871
ENSG00000100823homo_sapiensENSP0000021671477.987467.2956pundamilia_nyerereiENSPNYP000000317408069.0323
ENSG00000100823homo_sapiensENSP0000021671477.67366.6667mastacembelus_armatusENSMAMP0000005489972.011761.8076
ENSG00000100823homo_sapiensENSP0000021671476.415164.7799stegastes_partitusENSSPAP0000000059078.387166.4516
ENSG00000100823homo_sapiensENSP0000021671476.100664.7799oncorhynchus_tshawytschaENSOTSP0000500300170.348859.8837
ENSG00000100823homo_sapiensENSP0000021671476.100664.4654acanthochromis_polyacanthusENSAPOP0000003042974.233162.8834
ENSG00000100823homo_sapiensENSP0000021671477.67364.7799nothobranchius_furzeriENSNFUP0001500583079.421266.2379
ENSG00000100823homo_sapiensENSP0000021671476.100665.7233cyprinodon_variegatusENSCVAP0000003220878.064567.4194
ENSG00000100823homo_sapiensENSP0000021671476.100664.4654denticeps_clupeoidesENSDCDP0000004534378.827466.7752
ENSG00000100823homo_sapiensENSP0000021671477.04464.4654larimichthys_croceaENSLCRP0000504487779.032366.129
ENSG00000100823homo_sapiensENSP0000021671476.100663.522takifugu_rubripesENSTRUP0000001012377.070164.3312
ENSG00000100823homo_sapiensENSP0000021671476.415165.7233hippocampus_comesENSHCOP0000002234278.13567.2026
ENSG00000100823homo_sapiensENSP0000021671477.04465.4088cyprinus_carpio_carpioENSCCRP0000017229571.847560.9971
ENSG00000100823homo_sapiensENSP0000021671476.729666.6667cyprinus_carpio_carpioENSCCRP0000013255969.121860.0567
ENSG00000100823homo_sapiensENSP0000021671455.660443.0818coturnix_japonicaENSCJPP0000500158641.943132.4645
ENSG00000100823homo_sapiensENSP0000021671477.67366.6667poecilia_latipinnaENSPLAP0000002564279.677468.3871
ENSG00000100823homo_sapiensENSP0000021671477.04465.4088sinocyclocheilus_grahamiENSSGRP0000008849671.847560.9971
ENSG00000100823homo_sapiensENSP0000021671475.471764.4654sinocyclocheilus_grahamiENSSGRP0000005634073.394562.6911
ENSG00000100823homo_sapiensENSP0000021671477.987467.2956maylandia_zebraENSMZEP000050189078069.0323
ENSG00000100823homo_sapiensENSP0000021671475.157263.2075tetraodon_nigroviridisENSTNIP0000000849477.597465.2597
ENSG00000100823homo_sapiensENSP0000021671477.04465.4088paramormyrops_kingsleyaeENSPKIP0000001770178.025566.242
ENSG00000100823homo_sapiensENSP0000021671475.786262.8931scleropages_formosusENSSFOP0001500298277.741964.5161
ENSG00000100823homo_sapiensENSP0000021671476.729665.4088leptobrachium_leishanenseENSLLEP0000000880078.205166.6667
ENSG00000100823homo_sapiensENSP0000021671473.899462.8931leptobrachium_leishanenseENSLLEP0000004005375.079963.8978
ENSG00000100823homo_sapiensENSP0000021671477.987465.4088scophthalmus_maximusENSSMAP0000005618478.48165.8228
ENSG00000100823homo_sapiensENSP0000021671477.358566.3522oryzias_melastigmaENSOMEP0000003308779.099767.8457

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000723involved_in telomere maintenance1IDAHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region1ICHomo_sapiens(9606)Component
GO:0003677enables DNA binding1IDAHomo_sapiens(9606)Function
GO:0003684enables damaged DNA binding1IDAHomo_sapiens(9606)Function
GO:0003691enables double-stranded telomeric DNA binding1IDAHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IDAHomo_sapiens(9606)Function
GO:0003714enables transcription corepressor activity1TASHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003906enables DNA-(apurinic or apyrimidinic site) endonuclease activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0004519enables endonuclease activity1IDAHomo_sapiens(9606)Function
GO:0004520enables DNA endonuclease activity1TASHomo_sapiens(9606)Function
GO:0004523enables RNA-DNA hybrid ribonuclease activity1TASHomo_sapiens(9606)Function
GO:0004528enables phosphodiesterase I activity1TASHomo_sapiens(9606)Function
GO:0004844enables uracil DNA N-glycosylase activity1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IDAHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum1TASHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0005840located_in ribosome1TASHomo_sapiens(9606)Component
GO:0006281involved_in DNA repair1IDAHomo_sapiens(9606)Process
GO:0006284involved_in base-excision repair2IBA,IDAHomo_sapiens(9606)Process
GO:0006287involved_in base-excision repair, gap-filling1TASHomo_sapiens(9606)Process
GO:0006308involved_in DNA catabolic process1IDAHomo_sapiens(9606)Process
GO:0006310involved_in DNA recombination1IEAHomo_sapiens(9606)Process
GO:0008081enables phosphoric diester hydrolase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0008296enables 3-5-DNA exonuclease activity1IDAHomo_sapiens(9606)Function
GO:0008309enables double-stranded DNA exodeoxyribonuclease activity1IDAHomo_sapiens(9606)Function
GO:0008311enables double-stranded DNA 3-5 DNA exonuclease activity1IBAHomo_sapiens(9606)Function
GO:0008408enables 3-5 exonuclease activity2IDA,TASHomo_sapiens(9606)Function
GO:0016491enables oxidoreductase activity1IDAHomo_sapiens(9606)Function
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0016890enables site-specific endodeoxyribonuclease activity, specific for altered base1IDAHomo_sapiens(9606)Function
GO:0031490enables chromatin DNA binding1IDAHomo_sapiens(9606)Function
GO:0042981involved_in regulation of apoptotic process1IDAHomo_sapiens(9606)Process
GO:0043488involved_in regulation of mRNA stability1IMPHomo_sapiens(9606)Process
GO:0045454involved_in cell redox homeostasis1IEAHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IDAHomo_sapiens(9606)Function
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0052720enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity1IDAHomo_sapiens(9606)Function
GO:0080111involved_in DNA demethylation1IDAHomo_sapiens(9606)Process
GO:0090580enables phosphodiesterase activity, acting on 3-phosphoglycolate-terminated DNA strands1IDAHomo_sapiens(9606)Function
GO:0097698involved_in telomere maintenance via base-excision repair1IDAHomo_sapiens(9606)Process
GO:0140431enables DNA-(abasic site) binding1IMPHomo_sapiens(9606)Function

Expression