Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases SARS-COV-2
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000100804 Gene ID 5693 Accession 9542
Symbol PSMB5 Alias MB1;LMPX Full Name proteasome 20S subunit beta 5
Status Confidence Length 18688 bases Strand Minus strand
Position 14 : 23016543 - 23035230 RNA binding domain N.A.
Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
35617426 Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Eun Ha Kong 2022-05-31 Proceedings of the National Academy of Sciences of the United States of America

Transcripts

Name Transcript ID bp Protein Translation ID
PSMB5-206 ENST00000555895 444 118aa ENSP00000451816
PSMB5-202 ENST00000361611 1044 263aa ENSP00000355325
PSMB5-205 ENST00000493471 1117 203aa ENSP00000452424
PSMB5-204 ENST00000460922 729 84aa ENSP00000451286
PSMB5-203 ENST00000425762 900 160aa ENSP00000395206
PSMB5-201 ENST00000334454 796 77aa ENSP00000334973

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000502part_of proteasome complex2IDA,NASHomo_sapiens(9606)Component
GO:0004175enables endopeptidase activity1IBAHomo_sapiens(9606)Function
GO:0004298enables threonine-type endopeptidase activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus3HDA,IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005839part_of proteasome core complex2IDA,ISSHomo_sapiens(9606)Component
GO:0006508acts_upstream_of_or_within proteolysis1IDAHomo_sapiens(9606)Process
GO:0006979involved_in response to oxidative stress1IEAHomo_sapiens(9606)Process
GO:0008233enables peptidase activity1IDAHomo_sapiens(9606)Function
GO:0010498involved_in proteasomal protein catabolic process1IBAHomo_sapiens(9606)Process
GO:0019774part_of proteasome core complex, beta-subunit complex2IBA,ISSHomo_sapiens(9606)Component
GO:0043161involved_in proteasome-mediated ubiquitin-dependent protein catabolic process1NASHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component

Expression