Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000100697 Gene ID 23405 Accession 17098
Symbol DICER1 Alias DCR1;GLOW;MNG1;aviD;Dicer;HERNA;RMSE2;Dicer1e;K12H4.8-LIKE Full Name dicer 1, ribonuclease III
Status Confidence Length 71783 bases Strand Minus strand
Position 14 : 95086228 - 95158010 RNA binding domain ResIII , DEAD , Ribonucleas_3_3 , PAZ , Dicer_dimer , Ribonuclease_3
Summary This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000502591 DEAD PF00270 5.2e-12 1
ENSP00000502591 ResIII PF04851 4.4e-12 2
ENSP00000501988 DEAD PF00270 2.6e-11 1
ENSP00000501988 Dicer_dimer PF03368 1.3e-24 2
ENSP00000501988 ResIII PF04851 1.6e-11 3
ENSP00000501988 PAZ PF02170 1.6e-35 4
ENSP00000452556 DEAD PF00270 5.5e-11 1
ENSP00000452556 Dicer_dimer PF03368 3e-24 2
ENSP00000452556 ResIII PF04851 3.5e-11 3
ENSP00000452556 PAZ PF02170 3.6e-35 4
ENSP00000452556 Ribonuclease_3 PF00636 8e-44 5
ENSP00000512841 DEAD PF00270 5.5e-11 1
ENSP00000512841 Dicer_dimer PF03368 3e-24 2
ENSP00000512841 ResIII PF04851 3.5e-11 3
ENSP00000512841 PAZ PF02170 3.6e-35 4
ENSP00000512841 Ribonuclease_3 PF00636 8e-44 5
ENSP00000512839 DEAD PF00270 5.9e-11 1
ENSP00000512839 Dicer_dimer PF03368 3.2e-24 2
ENSP00000512839 ResIII PF04851 3.8e-11 3
ENSP00000512839 PAZ PF02170 3.8e-35 4
ENSP00000512839 Ribonuclease_3 PF00636 2.6e-61 5
ENSP00000512839 Ribonuclease_3 PF00636 2.6e-61 6
ENSP00000512839 Ribonucleas_3_3 PF14622 1.3e-18 7
ENSP00000512976 DEAD PF00270 5.9e-11 1
ENSP00000512976 Dicer_dimer PF03368 3.2e-24 2
ENSP00000512976 ResIII PF04851 3.8e-11 3
ENSP00000512976 PAZ PF02170 3.8e-35 4
ENSP00000512976 Ribonuclease_3 PF00636 2.6e-61 5
ENSP00000512976 Ribonuclease_3 PF00636 2.6e-61 6
ENSP00000512976 Ribonucleas_3_3 PF14622 1.3e-18 7
ENSP00000512838 DEAD PF00270 5.9e-11 1
ENSP00000512838 Dicer_dimer PF03368 3.2e-24 2
ENSP00000512838 ResIII PF04851 3.8e-11 3
ENSP00000512838 PAZ PF02170 3.8e-35 4
ENSP00000512838 Ribonuclease_3 PF00636 2.4e-61 5
ENSP00000512838 Ribonuclease_3 PF00636 2.4e-61 6
ENSP00000512838 Ribonucleas_3_3 PF14622 1.3e-18 7
ENSP00000512977 DEAD PF00270 5.9e-11 1
ENSP00000512977 Dicer_dimer PF03368 3.2e-24 2
ENSP00000512977 ResIII PF04851 3.8e-11 3
ENSP00000512977 PAZ PF02170 3.8e-35 4
ENSP00000512977 Ribonuclease_3 PF00636 2.4e-61 5
ENSP00000512977 Ribonuclease_3 PF00636 2.4e-61 6
ENSP00000512977 Ribonucleas_3_3 PF14622 1.3e-18 7
ENSP00000451041 DEAD PF00270 6e-11 1
ENSP00000451041 Dicer_dimer PF03368 3.2e-24 2
ENSP00000451041 ResIII PF04851 3.8e-11 3
ENSP00000451041 PAZ PF02170 3.9e-35 4
ENSP00000451041 Ribonuclease_3 PF00636 2.3e-61 5
ENSP00000451041 Ribonuclease_3 PF00636 2.3e-61 6
ENSP00000451041 Ribonucleas_3_3 PF14622 1.2e-18 7
ENSP00000444719 DEAD PF00270 6.1e-11 1
ENSP00000444719 Dicer_dimer PF03368 3.3e-24 2
ENSP00000444719 ResIII PF04851 3.9e-11 3
ENSP00000444719 PAZ PF02170 3.8e-35 4
ENSP00000444719 Ribonuclease_3 PF00636 1.8e-61 5
ENSP00000444719 Ribonuclease_3 PF00636 1.8e-61 6
ENSP00000444719 Ribonucleas_3_3 PF14622 1.4e-18 7
ENSP00000512840 DEAD PF00270 6.3e-11 1
ENSP00000512840 Dicer_dimer PF03368 3.4e-24 2
ENSP00000512840 ResIII PF04851 4e-11 3
ENSP00000512840 PAZ PF02170 4.1e-35 4
ENSP00000512840 Ribonuclease_3 PF00636 4.7e-69 5
ENSP00000512840 Ribonuclease_3 PF00636 4.7e-69 6
ENSP00000512840 Ribonucleas_3_3 PF14622 1e-23 7
ENSP00000343745 DEAD PF00270 6.6e-11 1
ENSP00000343745 Dicer_dimer PF03368 2.9e-24 2
ENSP00000343745 ResIII PF04851 4.2e-11 3
ENSP00000343745 PAZ PF02170 4.2e-35 4
ENSP00000343745 Ribonuclease_3 PF00636 5.4e-69 5
ENSP00000343745 Ribonuclease_3 PF00636 5.4e-69 6
ENSP00000343745 Ribonucleas_3_3 PF14622 1.1e-23 7
ENSP00000376783 DEAD PF00270 6.6e-11 1
ENSP00000376783 Dicer_dimer PF03368 2.9e-24 2
ENSP00000376783 ResIII PF04851 4.2e-11 3
ENSP00000376783 PAZ PF02170 4.2e-35 4
ENSP00000376783 Ribonuclease_3 PF00636 5.4e-69 5
ENSP00000376783 Ribonuclease_3 PF00636 5.4e-69 6
ENSP00000376783 Ribonucleas_3_3 PF14622 1.1e-23 7
ENSP00000433060 DEAD PF00270 6.6e-11 1
ENSP00000433060 Dicer_dimer PF03368 2.9e-24 2
ENSP00000433060 ResIII PF04851 4.2e-11 3
ENSP00000433060 PAZ PF02170 4.2e-35 4
ENSP00000433060 Ribonuclease_3 PF00636 5.4e-69 5
ENSP00000433060 Ribonuclease_3 PF00636 5.4e-69 6
ENSP00000433060 Ribonucleas_3_3 PF14622 1.1e-23 7
ENSP00000433926 DEAD PF00270 6.6e-11 1
ENSP00000433926 Dicer_dimer PF03368 2.9e-24 2
ENSP00000433926 ResIII PF04851 4.2e-11 3
ENSP00000433926 PAZ PF02170 4.2e-35 4
ENSP00000433926 Ribonuclease_3 PF00636 5.4e-69 5
ENSP00000433926 Ribonuclease_3 PF00636 5.4e-69 6
ENSP00000433926 Ribonucleas_3_3 PF14622 1.1e-23 7
ENSP00000435681 DEAD PF00270 6.6e-11 1
ENSP00000435681 Dicer_dimer PF03368 2.9e-24 2
ENSP00000435681 ResIII PF04851 4.2e-11 3
ENSP00000435681 PAZ PF02170 4.2e-35 4
ENSP00000435681 Ribonuclease_3 PF00636 5.4e-69 5
ENSP00000435681 Ribonuclease_3 PF00636 5.4e-69 6
ENSP00000435681 Ribonucleas_3_3 PF14622 1.1e-23 7
ENSP00000437256 DEAD PF00270 6.6e-11 1
ENSP00000437256 Dicer_dimer PF03368 2.9e-24 2
ENSP00000437256 ResIII PF04851 4.2e-11 3
ENSP00000437256 PAZ PF02170 4.2e-35 4
ENSP00000437256 Ribonuclease_3 PF00636 5.4e-69 5
ENSP00000437256 Ribonuclease_3 PF00636 5.4e-69 6
ENSP00000437256 Ribonucleas_3_3 PF14622 1.1e-23 7
ENSP00000502730 DEAD PF00270 6.6e-11 1
ENSP00000502730 Dicer_dimer PF03368 2.9e-24 2
ENSP00000502730 ResIII PF04851 4.2e-11 3
ENSP00000502730 PAZ PF02170 4.2e-35 4
ENSP00000502730 Ribonuclease_3 PF00636 5.4e-69 5
ENSP00000502730 Ribonuclease_3 PF00636 5.4e-69 6
ENSP00000502730 Ribonucleas_3_3 PF14622 1.1e-23 7
ENSP00000512843 ResIII PF04851 0.00011 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
32297952 Uncovering the cellular capacity for intensive and specific feedback self-control of the argonautes and MicroRNA targeting activity. Degeng Wang 2020-05-21 Nucleic acids research
29399544 Micromanaging Glucose Tolerance and Diabetes. Negar Saliani 2017-12-01 Advanced pharmaceutical bulletin
37494452 Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas. A Raisa Reyes-Castro 2023-07-28 Science advances
26087193 Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma. Vieira Resende Gabriela GR de 2015-09-08 Oncotarget
33112812 Metformin decreases miR-122, miR-223 and miR-29a in women with polycystic ovary syndrome. Bækgaard Pernille Udesen 2020-11-01 Endocrine connections
21858095 Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. Yoshinari Ando 2011-01-01 PloS one
35935529 Bioinformatic Tools for the Identification of MicroRNAs Regulating the Transcription Factors in Patients with β-Thalassemia. S Sumayakausar Kalaigar 2022-01-01 Bioinformatics and biology insights
26990999 Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence. Nicole N Noren 2016-06-01 Aging cell
37394005 Accelerated export of Dicer1 from lipid-challenged hepatocytes buffers cellular miRNA-122 levels and prevents cell death. Diptankar Bandyopadhyay 2023-08-01 The Journal of biological chemistry
32714280 Rare Germline DICER1 Variants in Pediatric Patients With Cushing's Disease: What Is Their Role? Idoia I LaPiscina Martínez 2020-01-01 Frontiers in endocrinology
25658360 Sensing viral RNAs by Dicer/RIG-I like ATPases across species. Simona Paro 2015-02-01 Current opinion in immunology
26688807 Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population. Ewa Osuch-Wojcikiewicz 2015-01-01 BioMed research international
19219043 A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. A Sonia Melo 2009-03-01 Nature genetics
34695450 Amyloid peptide exerts a rapid induction of Dicer1 protein in neuron via reducing phosphorylation. Yan Wang 2021-12-01 Neurochemistry international
23690119 Microsatellite instability and TARBP2 mutation study in upper urinary tract urothelial carcinoma. Shuting Bai 2013-06-01 American journal of clinical pathology
32051563 Conserved chromosomal functions of RNA interference. J Michael Gutbrod 2020-05-01 Nature reviews. Genetics
35336787 Small but Mighty-Exosomes, Novel Intercellular Messengers in Neurodegeneration. Meena Kumari 2022-03-08 Biology
25115815 Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells. P Liliana Cantini 2014-08-13 Molecular cancer
35736218 PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing. Swetha Rajasekaran 2022-07-08 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
DICER1-208 ENST00000529720 10374 1922aa ENSP00000433926
DICER1-214 ENST00000674628 10483 1922aa ENSP00000502730
DICER1-201 ENST00000343455 10384 1922aa ENSP00000343745
DICER1-225 ENST00000696920 10287 No protein -
DICER1-209 ENST00000531162 10453 1922aa ENSP00000433060
DICER1-226 ENST00000696921 11130 No protein -
DICER1-215 ENST00000675540 10356 1090aa ENSP00000501988
DICER1-203 ENST00000526495 10315 1922aa ENSP00000437256
DICER1-227 ENST00000696922 12694 No protein -
DICER1-228 ENST00000696923 10197 1789aa ENSP00000512976
DICER1-229 ENST00000696924 10167 1790aa ENSP00000512977
DICER1-217 ENST00000696733 10006 1790aa ENSP00000512838
DICER1-218 ENST00000696734 10081 1789aa ENSP00000512839
DICER1-205 ENST00000527416 691 No protein -
DICER1-202 ENST00000393063 7423 1922aa ENSP00000376783
DICER1-216 ENST00000675995 7157 522aa ENSP00000502591
DICER1-230 ENST00000696925 9929 No protein -
DICER1-204 ENST00000527414 6179 1922aa ENSP00000435681
DICER1-219 ENST00000696735 2822 No protein -
DICER1-211 ENST00000541352 5621 1829aa ENSP00000444719
DICER1-212 ENST00000556045 6161 1802aa ENSP00000451041
DICER1-220 ENST00000696736 6509 1868aa ENSP00000512840
DICER1-206 ENST00000527554 665 No protein -
DICER1-210 ENST00000532939 5989 1715aa ENSP00000452556
DICER1-221 ENST00000696737 5815 1715aa ENSP00000512841
DICER1-222 ENST00000696738 1967 No protein -
DICER1-231 ENST00000696926 2654 No protein -
DICER1-213 ENST00000556681 310 No protein -
DICER1-232 ENST00000696927 2052 No protein -
DICER1-233 ENST00000696928 5081 No protein -
DICER1-207 ENST00000529206 1286 No protein -
DICER1-223 ENST00000696739 2025 No protein -
DICER1-224 ENST00000696740 1188 133aa ENSP00000512843

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
37552Platelet Function Tests5.3900000E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000100697

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000100697homo_sapiensENSP0000034374599.843999.6878nomascus_leucogenysENSNLEP0000002103299.843999.6878
ENSG00000100697homo_sapiensENSP0000034374510099.8959pan_paniscusENSPPAP0000002400910099.8959
ENSG00000100697homo_sapiensENSP0000034374599.791999.7399pongo_abeliiENSPPYP0000000694999.791999.7399
ENSG00000100697homo_sapiensENSP0000034374599.94899.8959pan_troglodytesENSPTRP0000004662899.94899.8959
ENSG00000100697homo_sapiensENSP0000034374510099.948gorilla_gorillaENSGGOP0000000369910099.948
ENSG00000100697homo_sapiensENSP0000034374595.785691.7274ornithorhynchus_anatinusENSOANP0000001906295.835591.7751
ENSG00000100697homo_sapiensENSP0000034374596.826293.2882sarcophilus_harrisiiENSSHAP0000001413196.775993.2397
ENSG00000100697homo_sapiensENSP0000034374561.810660.0416notamacropus_eugeniiENSMEUP0000000057666.554664.6499
ENSG00000100697homo_sapiensENSP0000034374574.089572.5286choloepus_hoffmanniENSCHOP0000000189383.912882.145
ENSG00000100697homo_sapiensENSP0000034374596.51493.8606dasypus_novemcinctusENSDNOP0000000323596.363693.7143
ENSG00000100697homo_sapiensENSP0000034374550.208147.7107erinaceus_europaeusENSEEUP0000000359651.742649.1689
ENSG00000100697homo_sapiensENSP0000034374579.396572.3205echinops_telfairiENSETEP0000000892588.055480.2077
ENSG00000100697homo_sapiensENSP0000034374599.635899.0635callithrix_jacchusENSCJAP0000005120399.635899.0635
ENSG00000100697homo_sapiensENSP0000034374599.739999.2716cercocebus_atysENSCATP0000001480299.843899.375
ENSG00000100697homo_sapiensENSP0000034374598.335197.5026macaca_fascicularisENSMFAP0000006143993.610792.8182
ENSG00000100697homo_sapiensENSP0000034374598.335197.6587macaca_mulattaENSMMUP0000007264093.983193.3366
ENSG00000100697homo_sapiensENSP0000034374599.739999.2716macaca_nemestrinaENSMNEP0000000460499.843899.375
ENSG00000100697homo_sapiensENSP0000034374599.739999.1675papio_anubisENSPANP0000001315899.429598.8589
ENSG00000100697homo_sapiensENSP0000034374599.687899.2716mandrillus_leucophaeusENSMLEP0000002119399.791799.375
ENSG00000100697homo_sapiensENSP0000034374592.559890.7388tursiops_truncatusENSTTRP0000001238192.60890.786
ENSG00000100697homo_sapiensENSP0000034374598.335196.8783vulpes_vulpesENSVVUP0000002568296.923195.4872
ENSG00000100697homo_sapiensENSP0000034374595.681692.5598mus_spretusMGP_SPRETEiJ_P003478496.484893.3368
ENSG00000100697homo_sapiensENSP0000034374597.606795.8377equus_asinusENSEASP0000503155997.657595.8876
ENSG00000100697homo_sapiensENSP0000034374597.866895.8897capra_hircusENSCHIP0000001511997.866895.8897
ENSG00000100697homo_sapiensENSP0000034374597.554696.3059loxodonta_africanaENSLAFP0000001141698.167596.911
ENSG00000100697homo_sapiensENSP0000034374597.086495.4214panthera_leoENSPLOP0000002829296.985595.3222
ENSG00000100697homo_sapiensENSP0000034374598.022996.7222ailuropoda_melanoleucaENSAMEP0000000684897.971996.6719
ENSG00000100697homo_sapiensENSP0000034374594.016691.8835bos_indicus_hybridENSBIXP0000503636290.440488.3884
ENSG00000100697homo_sapiensENSP0000034374539.125937.2529oryctolagus_cuniculusENSOCUP0000000934291.595687.2107
ENSG00000100697homo_sapiensENSP0000034374597.554695.8897equus_caballusENSECAP0000004352697.554695.8897
ENSG00000100697homo_sapiensENSP0000034374598.23196.8262canis_lupus_familiarisENSCAFP0084500454396.820595.4359
ENSG00000100697homo_sapiensENSP0000034374596.930395.2654panthera_pardusENSPPRP0000000535196.930395.2654
ENSG00000100697homo_sapiensENSP0000034374595.109393.4443marmota_marmota_marmotaENSMMMP0000000152798.332496.6111
ENSG00000100697homo_sapiensENSP0000034374597.918896.2539balaenoptera_musculusENSBMSP0001000326497.918896.2539
ENSG00000100697homo_sapiensENSP0000034374597.138495.7336cavia_porcellusENSCPOP0000000380798.108396.6894
ENSG00000100697homo_sapiensENSP0000034374597.138495.5255felis_catusENSFCAP0000003958697.037495.4262
ENSG00000100697homo_sapiensENSP0000034374595.057293.6524ursus_americanusENSUAMP0000001484297.700596.2567
ENSG00000100697homo_sapiensENSP0000034374596.982393.2882monodelphis_domesticaENSMODP0000005995397.032893.3368
ENSG00000100697homo_sapiensENSP0000034374597.970996.2019bison_bison_bisonENSBBBP0000001474097.970996.2019
ENSG00000100697homo_sapiensENSP0000034374597.658795.5775monodon_monocerosENSMMNP0001502197797.709595.6273
ENSG00000100697homo_sapiensENSP0000034374596.774293.7565sus_scrofaENSSSCP0000003530397.178794.1484
ENSG00000100697homo_sapiensENSP0000034374599.011497.8148microcebus_murinusENSMICP0000001778699.011497.8148
ENSG00000100697homo_sapiensENSP0000034374598.074996.358octodon_degusENSODEP0000001155697.871296.1578
ENSG00000100697homo_sapiensENSP0000034374596.46293.1322jaculus_jaculusENSJJAP0000000596796.46293.1322
ENSG00000100697homo_sapiensENSP0000034374597.866895.6296ovis_aries_rambouilletENSOARP0002001452896.51194.3048
ENSG00000100697homo_sapiensENSP0000034374597.294595.8897ursus_maritimusENSUMAP0000000495197.905896.4921
ENSG00000100697homo_sapiensENSP0000034374590.790888.5536ochotona_princepsENSOPRP0000001343290.790888.5536
ENSG00000100697homo_sapiensENSP0000034374597.658795.6296delphinapterus_leucasENSDLEP0000000284597.709595.6793
ENSG00000100697homo_sapiensENSP0000034374598.387196.41physeter_catodonENSPCTP0000502848298.387196.41
ENSG00000100697homo_sapiensENSP0000034374595.577592.0916mus_caroliMGP_CAROLIEiJ_P003325096.329392.8159
ENSG00000100697homo_sapiensENSP0000034374596.097892.872mus_musculusENSMUSP0000004367696.398893.1628
ENSG00000100697homo_sapiensENSP0000034374596.045893.8085dipodomys_ordiiENSDORP0000000582196.548194.2992
ENSG00000100697homo_sapiensENSP0000034374597.554695.8377mustela_putorius_furoENSMPUP0000000309998.064896.3389
ENSG00000100697homo_sapiensENSP0000034374599.687899.2716aotus_nancymaaeENSANAP0000001148099.687899.2716
ENSG00000100697homo_sapiensENSP0000034374599.687899.2716saimiri_boliviensis_boliviensisENSSBOP0000002438699.687899.2716
ENSG00000100697homo_sapiensENSP0000034374589.906388.0333vicugna_pacosENSVPAP0000000633490.187988.309
ENSG00000100697homo_sapiensENSP0000034374599.635899.2196chlorocebus_sabaeusENSCSAP0000000691099.739699.3229
ENSG00000100697homo_sapiensENSP0000034374586.940784.7555tupaia_belangeriENSTBEP0000001074491.863789.5547
ENSG00000100697homo_sapiensENSP0000034374596.774294.3288mesocricetus_auratusENSMAUP0000000858697.026694.5749
ENSG00000100697homo_sapiensENSP0000034374597.762795.6816phocoena_sinusENSPSNP0000000398397.813695.7314
ENSG00000100697homo_sapiensENSP0000034374597.970996.1498camelus_dromedariusENSCDRP0000500209797.919996.0998
ENSG00000100697homo_sapiensENSP0000034374591.415288.0853carlito_syrichtaENSTSYP0000000189895.230491.7615
ENSG00000100697homo_sapiensENSP0000034374596.878395.1613panthera_tigris_altaicaENSPTIP0000000643496.878395.1613
ENSG00000100697homo_sapiensENSP0000034374596.35893.4443rattus_norvegicusENSRNOP0000001440596.558993.6392
ENSG00000100697homo_sapiensENSP0000034374599.115598.0749prolemur_simusENSPSMP0000003500999.115598.0749
ENSG00000100697homo_sapiensENSP0000034374596.930394.589microtus_ochrogasterENSMOCP0000002120797.233894.8852
ENSG00000100697homo_sapiensENSP0000034374555.046852.0812sorex_araneusENSSARP0000000019754.989652.027
ENSG00000100697homo_sapiensENSP0000034374596.201993.6524peromyscus_maniculatus_bairdiiENSPEMP0000001427596.907894.3396
ENSG00000100697homo_sapiensENSP0000034374598.022996.2019bos_mutusENSBMUP0000002741098.022996.2019
ENSG00000100697homo_sapiensENSP0000034374596.201993.0281mus_spicilegusENSMSIP0000001403096.503193.3194
ENSG00000100697homo_sapiensENSP0000034374596.774294.4329cricetulus_griseus_chok1gshdENSCGRP0000100606597.026694.6792
ENSG00000100697homo_sapiensENSP0000034374587.981386.4724pteropus_vampyrusENSPVAP0000000455590.865189.3068
ENSG00000100697homo_sapiensENSP0000034374597.606795.1613myotis_lucifugusENSMLUP0000000364297.555995.1118
ENSG00000100697homo_sapiensENSP0000034374596.618193.1322vombatus_ursinusENSVURP0001001134196.618193.1322
ENSG00000100697homo_sapiensENSP0000034374597.762795.3694rhinolophus_ferrumequinumENSRFEP0001001157297.711995.3198
ENSG00000100697homo_sapiensENSP0000034374597.762796.0978neovison_visonENSNVIP0000000686897.711996.0478
ENSG00000100697homo_sapiensENSP0000034374598.074996.2539bos_taurusENSBTAP0000001708098.074996.2539
ENSG00000100697homo_sapiensENSP0000034374598.022996.6701heterocephalus_glaber_femaleENSHGLP0000004262497.364396.0207
ENSG00000100697homo_sapiensENSP0000034374599.687899.2716rhinopithecus_bietiENSRBIP0000000460599.791799.375
ENSG00000100697homo_sapiensENSP0000034374598.387196.9823canis_lupus_dingoENSCAFP0002001779198.335996.9319
ENSG00000100697homo_sapiensENSP0000034374597.762795.8897sciurus_vulgarisENSSVLP0000500191797.661195.79
ENSG00000100697homo_sapiensENSP0000034374595.629692.2997phascolarctos_cinereusENSPCIP0000002380596.533693.1723
ENSG00000100697homo_sapiensENSP0000034374577.211275.4943procavia_capensisENSPCAP0000001022577.372375.6517
ENSG00000100697homo_sapiensENSP0000034374595.889793.7045nannospalax_galiliENSNGAP0000000679796.847194.64
ENSG00000100697homo_sapiensENSP0000034374597.970996.0978bos_grunniensENSBGRP0000002634798.021996.1478
ENSG00000100697homo_sapiensENSP0000034374598.595296.8262chinchilla_lanigeraENSCLAP0000002188996.437794.7074
ENSG00000100697homo_sapiensENSP0000034374591.987589.6982cervus_hanglu_yarkandensisENSCHYP0000003579496.61294.2076
ENSG00000100697homo_sapiensENSP0000034374597.502695.5775catagonus_wagneriENSCWAP0000002751697.705995.7768
ENSG00000100697homo_sapiensENSP0000034374597.346595.9417ictidomys_tridecemlineatusENSSTOP0000002343998.266896.8487
ENSG00000100697homo_sapiensENSP0000034374592.715991.155otolemur_garnettiiENSOGAP0000000959697.430395.79
ENSG00000100697homo_sapiensENSP0000034374599.687899.1675cebus_imitatorENSCCAP0000001848299.687899.1675
ENSG00000100697homo_sapiensENSP0000034374596.253994.3288urocitellus_parryiiENSUPAP0001000423292.315490.4691
ENSG00000100697homo_sapiensENSP0000034374597.970996.0978moschus_moschiferusENSMMSP0000001040896.465294.6209
ENSG00000100697homo_sapiensENSP0000034374599.635899.3236rhinopithecus_roxellanaENSRROP0000001543199.739699.4271
ENSG00000100697homo_sapiensENSP0000034374595.993893.1322mus_pahariMGP_PahariEiJ_P008336596.799693.914
ENSG00000100697homo_sapiensENSP0000034374598.855497.7627propithecus_coquereliENSPCOP0000002175098.855497.7627
ENSG00000100697homo_sapiensENSP0000034374549.94834.2352caenorhabditis_elegansK12H4.8.150.261834.4503
ENSG00000100697homo_sapiensENSP0000034374553.121736.9407drosophila_melanogasterFBpp008371745.39831.5696
ENSG00000100697homo_sapiensENSP0000034374559.781542.7679ciona_intestinalisENSCINP0000001711761.378243.9103
ENSG00000100697homo_sapiensENSP0000034374535.015630.8012petromyzon_marinusENSPMAP0000001000375.279666.2192
ENSG00000100697homo_sapiensENSP0000034374573.15362.1228eptatretus_burgeriENSEBUP0000002240568.318858.0175
ENSG00000100697homo_sapiensENSP0000034374586.888780.333callorhinchus_miliiENSCMIP0000003302487.115380.5425
ENSG00000100697homo_sapiensENSP0000034374591.571384.8075latimeria_chalumnaeENSLACP0000000941291.523784.7634
ENSG00000100697homo_sapiensENSP0000034374587.669181.1134lepisosteus_oculatusENSLOCP0000001039687.943681.3674
ENSG00000100697homo_sapiensENSP0000034374584.183177.0031clupea_harengusENSCHAP0000004665581.965674.9747
ENSG00000100697homo_sapiensENSP0000034374585.067678.564danio_rerioENSDARP0000004588087.667680.9651
ENSG00000100697homo_sapiensENSP0000034374585.067678.512carassius_auratusENSCARP0000005866186.875780.1807
ENSG00000100697homo_sapiensENSP0000034374585.119778.616carassius_auratusENSCARP0000002412286.698580.0742
ENSG00000100697homo_sapiensENSP0000034374584.131177.8876astyanax_mexicanusENSAMXP0000001101886.470680.0535
ENSG00000100697homo_sapiensENSP0000034374582.882476.6909ictalurus_punctatusENSIPUP0000000745884.824378.4878
ENSG00000100697homo_sapiensENSP0000034374584.547377.4714esox_luciusENSELUP0000007310982.908275.9694
ENSG00000100697homo_sapiensENSP0000034374584.131177.2112electrophorus_electricusENSEEEP0000003299086.19479.1045
ENSG00000100697homo_sapiensENSP0000034374574.193667.9501oncorhynchus_kisutchENSOKIP0000505340486.634379.3439
ENSG00000100697homo_sapiensENSP0000034374584.651477.7836oncorhynchus_kisutchENSOKIP0000511525376.456870.2538
ENSG00000100697homo_sapiensENSP0000034374583.350776.2747oncorhynchus_mykissENSOMYP0000007433080.705373.8539
ENSG00000100697homo_sapiensENSP0000034374584.391377.4194oncorhynchus_mykissENSOMYP0000005236976.94570.5882
ENSG00000100697homo_sapiensENSP0000034374583.662876.5869salmo_salarENSSSAP0000000553185.486478.2562
ENSG00000100697homo_sapiensENSP0000034374583.714976.9511salmo_salarENSSSAP0000007582480.651674.1353
ENSG00000100697homo_sapiensENSP0000034374584.235277.3153salmo_truttaENSSTUP0000011510581.356874.6734
ENSG00000100697homo_sapiensENSP0000034374583.714976.743salmo_truttaENSSTUP0000006346874.353168.1608
ENSG00000100697homo_sapiensENSP0000034374582.049975.3382gadus_morhuaENSGMOP0000002884482.869276.0904
ENSG00000100697homo_sapiensENSP0000034374577.211269.8231fundulus_heteroclitusENSFHEP0000001514182.766374.8466
ENSG00000100697homo_sapiensENSP0000034374582.830476.2227poecilia_reticulataENSPREP0000001796085.591478.7634
ENSG00000100697homo_sapiensENSP0000034374582.518276.3788xiphophorus_maculatusENSXMAP0000001579385.268878.9247
ENSG00000100697homo_sapiensENSP0000034374582.986576.4828oryzias_latipesENSORLP0000001382484.480977.8602
ENSG00000100697homo_sapiensENSP0000034374582.934476.0666cyclopterus_lumpusENSCLMP0000502052383.411876.5044
ENSG00000100697homo_sapiensENSP0000034374583.454777.0552oreochromis_niloticusENSONIP0000001310284.77878.277
ENSG00000100697homo_sapiensENSP0000034374583.97577.2633haplochromis_burtoniENSHBUP0000001689684.6877.9119
ENSG00000100697homo_sapiensENSP0000034374583.87177.0552astatotilapia_callipteraENSACLP0000001161384.57577.702
ENSG00000100697homo_sapiensENSP0000034374584.027177.5754sparus_aurataENSSAUP0001004940084.422477.9404
ENSG00000100697homo_sapiensENSP0000034374584.027177.4194lates_calcariferENSLCAP0001000900185.179378.481
ENSG00000100697homo_sapiensENSP0000034374588.865882.5702xenopus_tropicalisENSXETP0000008277690.227183.8352
ENSG00000100697homo_sapiensENSP0000034374596.097892.4558chrysemys_picta_belliiENSCPBP0000001314296.147892.5039
ENSG00000100697homo_sapiensENSP0000034374596.097892.2997sphenodon_punctatusENSSPUP0000002129096.197992.3958
ENSG00000100697homo_sapiensENSP0000034374596.045891.9355crocodylus_porosusENSCPRP0000501313895.945991.8399
ENSG00000100697homo_sapiensENSP0000034374593.964689.0219laticauda_laticaudataENSLLTP0000002004192.095987.2514
ENSG00000100697homo_sapiensENSP0000034374593.912689.0219notechis_scutatusENSNSUP0000001239594.108489.2075
ENSG00000100697homo_sapiensENSP0000034374593.808588.9178pseudonaja_textilisENSPTXP0000002686294.004289.1032
ENSG00000100697homo_sapiensENSP0000034374596.201992.5078anas_platyrhynchos_platyrhynchosENSAPLP0000001223096.25292.556
ENSG00000100697homo_sapiensENSP0000034374595.889791.9355gallus_gallusENSGALP0001002491195.939691.9833
ENSG00000100697homo_sapiensENSP0000034374562.070858.2726meleagris_gallopavoENSMGAP0000001394790.515984.9772
ENSG00000100697homo_sapiensENSP0000034374595.837792.2477serinus_canariaENSSCAP0000000989895.887692.2957
ENSG00000100697homo_sapiensENSP0000034374595.889792.1956parus_majorENSPMJP0000002292895.939692.2436
ENSG00000100697homo_sapiensENSP0000034374594.328889.334anolis_carolinensisENSACAP0000001296294.525689.5203
ENSG00000100697homo_sapiensENSP0000034374580.38574.0375neolamprologus_brichardiENSNBRP0000002932882.664576.137
ENSG00000100697homo_sapiensENSP0000034374593.548488.9178naja_najaENSNNAP0000000351793.841389.1962
ENSG00000100697homo_sapiensENSP0000034374595.369490.1665podarcis_muralisENSPMRP0000000416495.468890.2604
ENSG00000100697homo_sapiensENSP0000034374595.837792.2477geospiza_fortisENSGFOP0000000786695.887692.2957
ENSG00000100697homo_sapiensENSP0000034374595.629691.9355taeniopygia_guttataENSTGUP0000001303695.480591.7922
ENSG00000100697homo_sapiensENSP0000034374586.368479.5005erpetoichthys_calabaricusENSECRP0000003142187.552780.5907
ENSG00000100697homo_sapiensENSP0000034374577.055270.8117kryptolebias_marmoratusENSKMAP0000000205788.259881.1085
ENSG00000100697homo_sapiensENSP0000034374593.548488.2414salvator_merianaeENSSMRP0000001774394.086988.7493
ENSG00000100697homo_sapiensENSP0000034374582.362176.3788oryzias_javanicusENSOJAP0000003605084.023477.9193
ENSG00000100697homo_sapiensENSP0000034374579.916873.4131amphilophus_citrinellusENSACIP0000000110184.581577.6982
ENSG00000100697homo_sapiensENSP0000034374584.131177.6795dicentrarchus_labraxENSDLAP0000507238384.971178.4551
ENSG00000100697homo_sapiensENSP0000034374583.87177.1592amphiprion_perculaENSAPEP0000003213684.663977.8887
ENSG00000100697homo_sapiensENSP0000034374583.142676.6389oryzias_sinensisENSOSIP0000002069582.712276.2422
ENSG00000100697homo_sapiensENSP0000034374594.849190.8429pelodiscus_sinensisENSPSIP0000001222595.49591.4615
ENSG00000100697homo_sapiensENSP0000034374595.733692.0395gopherus_evgoodeiENSGEVP0000500225795.783492.0875
ENSG00000100697homo_sapiensENSP0000034374595.785692.2477chelonoidis_abingdoniiENSCABP0000001197895.835592.2957
ENSG00000100697homo_sapiensENSP0000034374584.443377.5234seriola_dumeriliENSSDUP0000003007485.107578.1332
ENSG00000100697homo_sapiensENSP0000034374583.87177.1072cottoperca_gobioENSCGOP0000001958284.931578.0822
ENSG00000100697homo_sapiensENSP0000034374595.733692.5598struthio_camelus_australisENSSCUP0000000696095.833392.6562
ENSG00000100697homo_sapiensENSP0000034374596.201992.4037anser_brachyrhynchusENSABRP0000000456196.25292.4519
ENSG00000100697homo_sapiensENSP0000034374582.986575.7544gasterosteus_aculeatusENSGACP0000002660083.903276.5913
ENSG00000100697homo_sapiensENSP0000034374583.350775.8064cynoglossus_semilaevisENSCSEP0000002679882.919375.4141
ENSG00000100697homo_sapiensENSP0000034374582.934476.1707poecilia_formosaENSPFOP0000000876785.698978.7097
ENSG00000100697homo_sapiensENSP0000034374584.963678.2518myripristis_murdjanENSMMDP0000501429285.58778.826
ENSG00000100697homo_sapiensENSP0000034374584.079177.1072sander_luciopercaENSSLUP0000004958584.342477.3486
ENSG00000100697homo_sapiensENSP0000034374596.201992.3517strigops_habroptilaENSSHBP0000501407396.25292.3998
ENSG00000100697homo_sapiensENSP0000034374583.558877.2112amphiprion_ocellarisENSAOCP0000001815684.393177.9821
ENSG00000100697homo_sapiensENSP0000034374596.201992.5598terrapene_carolina_triunguisENSTMTP0000000064696.25292.608
ENSG00000100697homo_sapiensENSP0000034374583.92376.743hucho_huchoENSHHUP0000008909086.580879.1734
ENSG00000100697homo_sapiensENSP0000034374583.142676.1707hucho_huchoENSHHUP0000000238985.500378.3307
ENSG00000100697homo_sapiensENSP0000034374583.142676.3788betta_splendensENSBSLP0000004592784.238377.3853
ENSG00000100697homo_sapiensENSP0000034374585.431878.9282pygocentrus_nattereriENSPNAP0000000188586.557779.9684
ENSG00000100697homo_sapiensENSP0000034374583.714976.795anabas_testudineusENSATEP0000002022684.550777.5617
ENSG00000100697homo_sapiensENSP0000034374541.207131.7378ciona_savignyiENSCSAVP0000001041364.811849.9182
ENSG00000100697homo_sapiensENSP0000034374581.061473.8814seriola_lalandi_dorsalisENSSLDP0000001525385.369977.8082
ENSG00000100697homo_sapiensENSP0000034374583.454777.1072labrus_bergyltaENSLBEP0000001173083.979177.5916
ENSG00000100697homo_sapiensENSP0000034374583.97577.3153pundamilia_nyerereiENSPNYP0000002381384.6877.9643
ENSG00000100697homo_sapiensENSP0000034374583.87177.0031mastacembelus_armatusENSMAMP0000002510784.886877.9358
ENSG00000100697homo_sapiensENSP0000034374583.454777.2112stegastes_partitusENSSPAP0000002286184.912778.5601
ENSG00000100697homo_sapiensENSP0000034374579.552672.3205oncorhynchus_tshawytschaENSOTSP0000500815883.506375.9148
ENSG00000100697homo_sapiensENSP0000034374575.130167.6899oncorhynchus_tshawytschaENSOTSP0000502689980.715572.7222
ENSG00000100697homo_sapiensENSP0000034374583.97577.4194acanthochromis_polyacanthusENSAPOP0000003239284.768978.1513
ENSG00000100697homo_sapiensENSP0000034374596.201992.5598aquila_chrysaetos_chrysaetosENSACCP0002000360696.25292.608
ENSG00000100697homo_sapiensENSP0000034374582.362176.2227cyprinodon_variegatusENSCVAP0000001700885.24578.8907
ENSG00000100697homo_sapiensENSP0000034374585.79678.7201denticeps_clupeoidesENSDCDP0000000472387.341180.1377
ENSG00000100697homo_sapiensENSP0000034374583.92377.1072larimichthys_croceaENSLCRP0000500207583.879477.0671
ENSG00000100697homo_sapiensENSP0000034374595.889792.1436ficedula_albicollisENSFALP0000000263195.939692.1916
ENSG00000100697homo_sapiensENSP0000034374582.986575.4943hippocampus_comesENSHCOP0000001263885.294177.5936
ENSG00000100697homo_sapiensENSP0000034374584.911678.3038cyprinus_carpio_carpioENSCCRP0000008662288.025981.1758
ENSG00000100697homo_sapiensENSP0000034374584.859578.4079cyprinus_carpio_carpioENSCCRP0000004101887.079680.4592
ENSG00000100697homo_sapiensENSP0000034374595.785691.9875coturnix_japonicaENSCJPP0000500229995.339291.5588
ENSG00000100697homo_sapiensENSP0000034374582.778476.2227poecilia_latipinnaENSPLAP0000002330284.492877.8014
ENSG00000100697homo_sapiensENSP0000034374583.038576.2747sinocyclocheilus_grahamiENSSGRP0000007585086.223779.2004
ENSG00000100697homo_sapiensENSP0000034374585.119778.3559sinocyclocheilus_grahamiENSSGRP0000008099786.928880.0213
ENSG00000100697homo_sapiensENSP0000034374583.87177.0552maylandia_zebraENSMZEP0000502270184.57577.702
ENSG00000100697homo_sapiensENSP0000034374582.414275.4943tetraodon_nigroviridisENSTNIP0000000813082.629175.6912
ENSG00000100697homo_sapiensENSP0000034374584.703477.6795paramormyrops_kingsleyaeENSPKIP0000000182785.369778.2905
ENSG00000100697homo_sapiensENSP0000034374586.420478.4599scleropages_formosusENSSFOP0001501676186.510478.5417
ENSG00000100697homo_sapiensENSP0000034374587.044780.5411leptobrachium_leishanenseENSLLEP0000003820188.191981.6025
ENSG00000100697homo_sapiensENSP0000034374582.726375.4422scophthalmus_maximusENSSMAP0000003852482.554575.2856
ENSG00000100697homo_sapiensENSP0000034374582.830476.3788oryzias_melastigmaENSOMEP0000003295485.729779.0522

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1IBAHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding2IDA,IMPHomo_sapiens(9606)Function
GO:0004386enables helicase activity1IEAHomo_sapiens(9606)Function
GO:0004521enables RNA endonuclease activity3IDA,IMP,TASHomo_sapiens(9606)Function
GO:0004525enables ribonuclease III activity4EXP,IBA,IDA,TASHomo_sapiens(9606)Function
GO:0004530enables deoxyribonuclease I activity1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006309involved_in apoptotic DNA fragmentation1IBAHomo_sapiens(9606)Process
GO:0010586involved_in miRNA metabolic process1TASHomo_sapiens(9606)Process
GO:0010626involved_in negative regulation of Schwann cell proliferation1ISSHomo_sapiens(9606)Process
GO:0010629acts_upstream_of negative regulation of gene expression2IMPHomo_sapiens(9606)Process
GO:0014040involved_in positive regulation of Schwann cell differentiation1ISSHomo_sapiens(9606)Process
GO:0016078involved_in tRNA catabolic process1TASHomo_sapiens(9606)Process
GO:0016442NOT part_of RISC complex2IDAHomo_sapiens(9606)Component
GO:0019904enables protein domain specific binding1IPIHomo_sapiens(9606)Function
GO:0021675involved_in nerve development1ISSHomo_sapiens(9606)Process
GO:0030422involved_in siRNA processing4IBA,IDA,IMP,TASHomo_sapiens(9606)Process
GO:0031054involved_in pre-miRNA processing2IBA,IDAHomo_sapiens(9606)Process
GO:0031643involved_in positive regulation of myelination1ISSHomo_sapiens(9606)Process
GO:0032290involved_in peripheral nervous system myelin formation1ISSHomo_sapiens(9606)Process
GO:0032720involved_in negative regulation of tumor necrosis factor production1IMPHomo_sapiens(9606)Process
GO:0035196involved_in miRNA processing3IDA,IMP,ISSHomo_sapiens(9606)Process
GO:0035197enables siRNA binding1IDAHomo_sapiens(9606)Function
GO:0038061involved_in NIK/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0048812involved_in neuron projection morphogenesis1ISSHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1IDAHomo_sapiens(9606)Component
GO:0070578part_of RISC-loading complex2IDA,IPIHomo_sapiens(9606)Component
GO:0070883contributes_to pre-miRNA binding2IDAHomo_sapiens(9606)Function
GO:0070922involved_in RISC complex assembly1IDAHomo_sapiens(9606)Process
GO:0098795involved_in global gene silencing by mRNA cleavage1IMPHomo_sapiens(9606)Process

Expression