RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000100567	Gene ID	5684	Accession	9532
Symbol	PSMA3	Alias	HC8;PSC3	Full Name	proteasome 20S subunit alpha 3
Status	Confidence	Length	27170 bases	Strand	Plus strand
Position	14 : 58244843 - 58272012	RNA binding domain	N.A.
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
36607951	Long Noncoding RNA PSMA3 Antisense RNA 1 Promotes Cell Proliferation, Migration, and Invasion in Pancreatic Ductal Adenocarcinoma Via Targeting MicroRNA-154-5p to Positively Modulate Karyopherin Subunit Alpha 4.	Jiancheng Bi	2022-09-01	Pancreas

Name	Transcript ID	bp	Protein	Translation ID
PSMA3-201	ENST00000216455	955	255aa	ENSP00000216455
PSMA3-207	ENST00000554812	1279	No protein	-
PSMA3-203	ENST00000553665	925	No protein	-
PSMA3-211	ENST00000557087	654	36aa	ENSP00000451461
PSMA3-209	ENST00000555931	606	54aa	ENSP00000452437
PSMA3-206	ENST00000554456	435	No protein	-
PSMA3-202	ENST00000412908	908	248aa	ENSP00000390491
PSMA3-208	ENST00000555743	640	No protein	-
PSMA3-213	ENST00000557508	814	180aa	ENSP00000452056
PSMA3-210	ENST00000556321	500	No protein	-
PSMA3-204	ENST00000553677	363	83aa	ENSP00000450573
PSMA3-205	ENST00000554207	570	No protein	-
PSMA3-212	ENST00000557290	730	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000502	part_of proteasome complex	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	4	HDA,IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005839	part_of proteasome core complex	1	IDA	Homo_sapiens(9606)	Component
GO:0010498	involved_in proteasomal protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0019773	part_of proteasome core complex, alpha-subunit complex	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0031625	enables ubiquitin protein ligase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	NAS	Homo_sapiens(9606)	Process
GO:0045202	is_active_in synapse	1	IBA	Homo_sapiens(9606)	Component
GO:0052548	involved_in regulation of endopeptidase activity	1	IMP	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component