RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000093000	Gene ID	10762	Accession	8065
Symbol	NUP50	Alias	NPAP60;NPAP60L	Full Name	nucleoporin 50
Status	Confidence	Length	24093 bases	Strand	Plus strand
Position	22 : 45163925 - 45188017	RNA binding domain	N.A.
Summary	The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
36670122	Integrative genetic analysis illuminates ALS heritability and identifies risk genes.	Salim Megat	2023-01-20	Nature communications

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
NUP50-201	ENST00000347635	5151	468aa	ENSP00000345895
NUP50-203	ENST00000407019	2059	440aa	ENSP00000385555
NUP50-207	ENST00000424634	579	45aa	ENSP00000415062
NUP50-204	ENST00000417702	584	8aa	ENSP00000394450
NUP50-219	ENST00000497960	986	No protein	-
NUP50-213	ENST00000461437	531	No protein	-
NUP50-210	ENST00000434760	763	30aa	ENSP00000388426
NUP50-208	ENST00000430547	537	76aa	ENSP00000397960
NUP50-215	ENST00000484186	431	No protein	-
NUP50-211	ENST00000445721	443	10aa	ENSP00000398297
NUP50-218	ENST00000493456	478	No protein	-
NUP50-202	ENST00000396096	1895	440aa	ENSP00000379403
NUP50-212	ENST00000461194	550	No protein	-
NUP50-209	ENST00000432340	551	4aa	ENSP00000400465
NUP50-205	ENST00000419387	1018	30aa	ENSP00000391987
NUP50-206	ENST00000422489	543	178aa	ENSP00000416264
NUP50-216	ENST00000486184	821	No protein	-
NUP50-217	ENST00000491860	493	No protein	-
NUP50-214	ENST00000469163	3507	No protein	-

Gene Model

Click here to download ENSG00000093000's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
25651	Arteries	6.4090000E-006	-
25657	Arteries	3.0010000E-006	-
59044	Pulmonary Disease, Chronic Obstructive	1.1240000E-005	22837378

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000093000's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005635	located_in nuclear envelope	1	IDA	Homo_sapiens(9606)	Component
GO:0005643	part_of nuclear pore	1	NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006606	involved_in protein import into nucleus	1	IBA	Homo_sapiens(9606)	Process
GO:0006913	involved_in nucleocytoplasmic transport	1	NAS	Homo_sapiens(9606)	Process
GO:0031965	located_in nuclear membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0051028	involved_in mRNA transport	1	IEA	Homo_sapiens(9606)	Process

Expression