RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000089053	Gene ID	51433	Accession	15713
Symbol	ANAPC5	Alias	APC5	Full Name	anaphase promoting complex subunit 5
Status	Confidence	Length	91652 bases	Strand	Minus strand
Position	12 : 121308245 - 121399896	RNA binding domain	ANAPC5
Summary	This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000437857	ANAPC5	PF12862	4.9e-33	1
ENSP00000437857	ANAPC5	PF12862	4.9e-33	2
ENSP00000415061	ANAPC5	PF12862	6e-33	1
ENSP00000415061	ANAPC5	PF12862	6e-33	2
ENSP00000439875	ANAPC5	PF12862	1e-32	1
ENSP00000439875	ANAPC5	PF12862	1e-32	2
ENSP00000261819	ANAPC5	PF12862	1.1e-32	1
ENSP00000261819	ANAPC5	PF12862	1.1e-32	2
ENSP00000440800	ANAPC5	PF12862	1.1e-12	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ANAPC5-203	ENST00000422342	1141	No protein	-
ANAPC5-209	ENST00000535641	2627	No protein	-
ANAPC5-214	ENST00000539079	1715	396aa	ENSP00000437857
ANAPC5-204	ENST00000441917	2147	643aa	ENSP00000415061
ANAPC5-205	ENST00000534976	3165	No protein	-
ANAPC5-218	ENST00000541887	2400	742aa	ENSP00000439875
ANAPC5-201	ENST00000261819	2574	755aa	ENSP00000261819
ANAPC5-208	ENST00000535482	2077	421aa	ENSP00000438754
ANAPC5-219	ENST00000544314	1508	No protein	-
ANAPC5-221	ENST00000545218	1328	No protein	-
ANAPC5-202	ENST00000366333	923	No protein	-
ANAPC5-207	ENST00000535472	1048	No protein	-
ANAPC5-213	ENST00000538334	6149	No protein	-
ANAPC5-206	ENST00000535463	265	No protein	-
ANAPC5-212	ENST00000538223	292	No protein	-
ANAPC5-215	ENST00000539612	654	No protein	-
ANAPC5-217	ENST00000541652	753	No protein	-
ANAPC5-220	ENST00000544442	915	217aa	ENSP00000440800
ANAPC5-210	ENST00000536416	677	No protein	-
ANAPC5-216	ENST00000539871	704	216aa	ENSP00000445191
ANAPC5-211	ENST00000536837	509	44aa	ENSP00000441508
ANAPC5-222	ENST00000545801	1281	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005680	part_of anaphase-promoting complex	4	IBA,IDA,IPI,NAS	Homo_sapiens(9606)	Component
GO:0005819	located_in spindle	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0007049	involved_in cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0007346	involved_in regulation of mitotic cell cycle	1	NAS	Homo_sapiens(9606)	Process
GO:0019903	enables protein phosphatase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0031145	involved_in anaphase-promoting complex-dependent catabolic process	2	IBA,NAS	Homo_sapiens(9606)	Process
GO:0045842	involved_in positive regulation of mitotic metaphase/anaphase transition	1	IBA	Homo_sapiens(9606)	Process
GO:0051301	involved_in cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0051445	involved_in regulation of meiotic cell cycle	1	NAS	Homo_sapiens(9606)	Process
GO:0070979	involved_in protein K11-linked ubiquitination	2	IBA,IDA	Homo_sapiens(9606)	Process