Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000087250 Gene ID 4504 Accession 7408
Symbol MT3 Alias GIF;GIFB;GRIF;ZnMT3 Full Name metallothionein 3
Status Confidence Length 2012 bases Strand Plus strand
Position 16 : 56589074 - 56591085 RNA binding domain N.A.
Summary This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
MT3-202 ENST00000561640 514 113aa ENSP00000455353
MT3-203 ENST00000565838 421 81aa ENSP00000455980
MT3-201 ENST00000200691 406 68aa ENSP00000200691
MT3-204 ENST00000566451 1550 No protein -
MT3-206 ENST00000570176 579 92aa ENSP00000457164
MT3-205 ENST00000566576 448 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001666involved_in response to hypoxia1IDAHomo_sapiens(9606)Process
GO:0001934involved_in positive regulation of protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0005507enables copper ion binding2IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1IEAHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005741located_in mitochondrial outer membrane1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005840located_in ribosome1IEAHomo_sapiens(9606)Component
GO:0005874located_in microtubule1IEAHomo_sapiens(9606)Component
GO:0006112involved_in energy reserve metabolic process1ISSHomo_sapiens(9606)Process
GO:0006829involved_in zinc ion transport1ISSHomo_sapiens(9606)Process
GO:0006882involved_in intracellular zinc ion homeostasis2IBA,ISSHomo_sapiens(9606)Process
GO:0008021located_in synaptic vesicle1ISSHomo_sapiens(9606)Component
GO:0008270enables zinc ion binding1IDAHomo_sapiens(9606)Function
GO:0010273involved_in detoxification of copper ion1IBAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IDAHomo_sapiens(9606)Process
GO:0010977involved_in negative regulation of neuron projection development1TASHomo_sapiens(9606)Process
GO:0016209enables antioxidant activity1NASHomo_sapiens(9606)Function
GO:0016234located_in inclusion body1IDAHomo_sapiens(9606)Component
GO:0019430involved_in removal of superoxide radicals1IDAHomo_sapiens(9606)Process
GO:0030003involved_in intracellular monoatomic cation homeostasis2NAS,TASHomo_sapiens(9606)Process
GO:0030295enables protein kinase activator activity1IDAHomo_sapiens(9606)Function
GO:0030308involved_in negative regulation of cell growth2IDA,IMPHomo_sapiens(9606)Process
GO:0030424located_in axon1IEAHomo_sapiens(9606)Component
GO:0030517involved_in negative regulation of axon extension1IDAHomo_sapiens(9606)Process
GO:0030949involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0032095involved_in regulation of response to food1ISSHomo_sapiens(9606)Process
GO:0032148involved_in activation of protein kinase B activity1IDAHomo_sapiens(9606)Process
GO:0033210involved_in leptin-mediated signaling pathway1ISSHomo_sapiens(9606)Process
GO:0034599involved_in cellular response to oxidative stress1IEPHomo_sapiens(9606)Process
GO:0034614involved_in cellular response to reactive oxygen species1IDAHomo_sapiens(9606)Process
GO:0043197located_in dendritic spine1IEAHomo_sapiens(9606)Component
GO:0043524involved_in negative regulation of neuron apoptotic process1ISSHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription2IDA,ISSHomo_sapiens(9606)Process
GO:0046870enables cadmium ion binding1IDAHomo_sapiens(9606)Function
GO:0046872enables metal ion binding1IBAHomo_sapiens(9606)Function
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0050821involved_in protein stabilization1IDAHomo_sapiens(9606)Process
GO:0051354involved_in negative regulation of oxidoreductase activity1IDAHomo_sapiens(9606)Process
GO:0070374involved_in positive regulation of ERK1 and ERK2 cascade3IBA,IDA,ISSHomo_sapiens(9606)Process
GO:0071276involved_in cellular response to cadmium ion1IBAHomo_sapiens(9606)Process
GO:0071280involved_in cellular response to copper ion1IBAHomo_sapiens(9606)Process
GO:0071294involved_in cellular response to zinc ion1IBAHomo_sapiens(9606)Process
GO:0071456involved_in cellular response to hypoxia1IEPHomo_sapiens(9606)Process
GO:0097450located_in astrocyte end-foot1IEAHomo_sapiens(9606)Component
GO:1990748involved_in cellular detoxification1IDAHomo_sapiens(9606)Process
GO:2000296involved_in negative regulation of hydrogen peroxide catabolic process1IEAHomo_sapiens(9606)Process
GO:2000376involved_in positive regulation of oxygen metabolic process1ISSHomo_sapiens(9606)Process

Expression