RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000083544	Gene ID	81550	Accession	20612
Symbol	TDRD3	Alias	NA	Full Name	tudor domain containing 3
Status	Confidence	Length	177422 bases	Strand	Plus strand
Position	13 : 60396457 - 60573878	RNA binding domain	TUDOR , SMN
Summary	Enables chromatin binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in chromatin organization and positive regulation of transcription, DNA-templated. Located in Golgi apparatus; cytosol; and nucleoplasm. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000196169	SMN	PF06003	8.9e-08	1
ENSP00000196169	TUDOR	PF00567	4.3e-10	2
ENSP00000367126	SMN	PF06003	8.9e-08	1
ENSP00000367126	TUDOR	PF00567	4.3e-10	2
ENSP00000498191	SMN	PF06003	8.9e-08	1
ENSP00000498191	TUDOR	PF00567	4.3e-10	2
ENSP00000477993	SMN	PF06003	9.1e-08	1
ENSP00000477993	TUDOR	PF00567	4.3e-10	2
ENSP00000367113	SMN	PF06003	1.5e-07	1
ENSP00000367113	TUDOR	PF00567	5e-10	2

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
28176834	Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor.	Sakurako Goto-Ito	2017-02-08	Scientific reports
18632687	TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.	Isabelle Goulet	2008-10-01	Human molecular genetics
29471495	Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.	Lifeng Huang	2018-04-06	Nucleic acids research
28039324	Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction.	Muzammil Ahmad	2017-03-17	Nucleic acids research
30456381	CARM1 methylates MED12 to regulate its RNA-binding ability.	Donghang Cheng	2018-10-01	Life science alliance
24507716	Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.	Yanzhong Yang	2014-02-06	Molecular cell
36690626	The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer.	Guozhen Gao	2023-01-23	Nature communications
27582462	DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3.	Ee-Lu Grace Siaw	2016-09-20	Proceedings of the National Academy of Sciences of the United States of America
27257063	RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.	Muzammil Ahmad	2016-07-27	Nucleic acids research
32511318	Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses.	Reddisiva K Prasanth	2020-03-27	bioRxiv : the preprint server for biology

Name	Transcript ID	bp	Protein	Translation ID
TDRD3-201	ENST00000196169	3019	651aa	ENSP00000196169
TDRD3-207	ENST00000484389	1863	116aa	ENSP00000432703
TDRD3-204	ENST00000377894	2484	651aa	ENSP00000367126
TDRD3-202	ENST00000377881	2645	744aa	ENSP00000367113
TDRD3-209	ENST00000648252	3388	651aa	ENSP00000498191
TDRD3-208	ENST00000621840	2497	650aa	ENSP00000477993
TDRD3-203	ENST00000377882	660	129aa	ENSP00000367114
TDRD3-205	ENST00000463109	723	No protein	-
TDRD3-206	ENST00000471710	3234	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
2752	Intra-Abdominal Fat	3.5134738807879E-6	17903300
2760	Intra-Abdominal Fat	3.86651629084462E-6	17903300
24667	Muscle, Skeletal	4.6420000E-005	-
24684	Muscle, Skeletal	7.8630000E-005	-
24685	Muscle, Skeletal	7.0130000E-005	-
34131	Anatomy	8.2715030E-005	-
100571	Menopause	1E-10	22267201

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000083544

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000083544	homo_sapiens	ENSP00000367113	98.9247	98.6559	nomascus_leucogenys	ENSNLEP00000019334	98.9247	98.6559
ENSG00000083544	homo_sapiens	ENSP00000367113	99.7312	99.0591	pan_paniscus	ENSPPAP00000002404	99.7312	99.0591
ENSG00000083544	homo_sapiens	ENSP00000367113	99.5968	99.328	pongo_abelii	ENSPPYP00000006153	99.5968	99.328
ENSG00000083544	homo_sapiens	ENSP00000367113	99.7312	99.328	pan_troglodytes	ENSPTRP00000063356	99.7312	99.328
ENSG00000083544	homo_sapiens	ENSP00000367113	97.8495	97.8495	gorilla_gorilla	ENSGGOP00000050740	99.726	99.726
ENSG00000083544	homo_sapiens	ENSP00000367113	86.0215	76.0753	ornithorhynchus_anatinus	ENSOANP00000043482	70.7182	62.5414
ENSG00000083544	homo_sapiens	ENSP00000367113	90.7258	83.871	sarcophilus_harrisii	ENSSHAP00000014026	90.4826	83.6461
ENSG00000083544	homo_sapiens	ENSP00000367113	66.6667	61.0215	notamacropus_eugenii	ENSMEUP00000009232	76.0736	69.6319
ENSG00000083544	homo_sapiens	ENSP00000367113	68.2796	64.7849	choloepus_hoffmanni	ENSCHOP00000011372	82.8711	78.6297
ENSG00000083544	homo_sapiens	ENSP00000367113	94.3548	88.4409	dasypus_novemcinctus	ENSDNOP00000001555	94.4818	88.5599
ENSG00000083544	homo_sapiens	ENSP00000367113	75.4032	71.2366	erinaceus_europaeus	ENSEEUP00000001999	86.3077	81.5385
ENSG00000083544	homo_sapiens	ENSP00000367113	57.6613	52.0161	echinops_telfairi	ENSETEP00000005170	75.2632	67.8947
ENSG00000083544	homo_sapiens	ENSP00000367113	93.9516	91.6667	callithrix_jacchus	ENSCJAP00000080975	90.1936	88
ENSG00000083544	homo_sapiens	ENSP00000367113	98.5215	97.5806	cercocebus_atys	ENSCATP00000010517	98.5215	97.5806
ENSG00000083544	homo_sapiens	ENSP00000367113	86.1559	85.2151	macaca_fascicularis	ENSMFAP00000010598	98.4639	97.3886
ENSG00000083544	homo_sapiens	ENSP00000367113	97.4462	96.2366	macaca_mulatta	ENSMMUP00000065102	96.1538	94.9602
ENSG00000083544	homo_sapiens	ENSP00000367113	98.5215	97.1774	macaca_nemestrina	ENSMNEP00000000460	98.5215	97.1774
ENSG00000083544	homo_sapiens	ENSP00000367113	98.3871	97.4462	papio_anubis	ENSPANP00000049535	98.3871	97.4462
ENSG00000083544	homo_sapiens	ENSP00000367113	53.0914	52.5538	mandrillus_leucophaeus	ENSMLEP00000031083	97.5309	96.5432
ENSG00000083544	homo_sapiens	ENSP00000367113	77.957	74.7312	tursiops_truncatus	ENSTTRP00000009552	89.0937	85.4071
ENSG00000083544	homo_sapiens	ENSP00000367113	95.0269	90.8602	vulpes_vulpes	ENSVVUP00000040942	88.4856	84.6058
ENSG00000083544	homo_sapiens	ENSP00000367113	93.2796	85.7527	mus_spretus	MGP_SPRETEiJ_P0039244	93.4051	85.8681
ENSG00000083544	homo_sapiens	ENSP00000367113	93.414	88.5753	equus_asinus	ENSEASP00005038836	87.5315	82.9975
ENSG00000083544	homo_sapiens	ENSP00000367113	90.7258	85.4839	capra_hircus	ENSCHIP00000021807	88.5827	83.4646
ENSG00000083544	homo_sapiens	ENSP00000367113	63.9785	59.543	loxodonta_africana	ENSLAFP00000002264	94.2574	87.7228
ENSG00000083544	homo_sapiens	ENSP00000367113	96.371	91.6667	panthera_leo	ENSPLOP00000015124	96.371	91.6667
ENSG00000083544	homo_sapiens	ENSP00000367113	88.7097	84.543	ailuropoda_melanoleuca	ENSAMEP00000000083	95.2381	90.7648
ENSG00000083544	homo_sapiens	ENSP00000367113	91.2634	86.5591	bos_indicus_hybrid	ENSBIXP00005021951	89.1076	84.5144
ENSG00000083544	homo_sapiens	ENSP00000367113	96.1021	93.0107	oryctolagus_cuniculus	ENSOCUP00000012265	96.2315	93.1359
ENSG00000083544	homo_sapiens	ENSP00000367113	93.5484	88.8441	equus_caballus	ENSECAP00000000532	88.5496	84.0967
ENSG00000083544	homo_sapiens	ENSP00000367113	93.0107	88.0376	canis_lupus_familiaris	ENSCAFP00845027906	86.7168	82.0802
ENSG00000083544	homo_sapiens	ENSP00000367113	94.6237	90.457	panthera_pardus	ENSPPRP00000016054	96.4384	92.1918
ENSG00000083544	homo_sapiens	ENSP00000367113	94.2204	90.0538	marmota_marmota_marmota	ENSMMMP00000019505	93.3422	89.2144
ENSG00000083544	homo_sapiens	ENSP00000367113	96.371	92.3387	balaenoptera_musculus	ENSBMSP00010021968	96.371	92.3387
ENSG00000083544	homo_sapiens	ENSP00000367113	86.9624	82.9301	cavia_porcellus	ENSCPOP00000009373	93.4971	89.1618
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	91.9355	felis_catus	ENSFCAP00000018213	96.5054	91.9355
ENSG00000083544	homo_sapiens	ENSP00000367113	89.9194	85.2151	ursus_americanus	ENSUAMP00000022058	95.9828	90.9613
ENSG00000083544	homo_sapiens	ENSP00000367113	60.0806	55.6452	ursus_americanus	ENSUAMP00000011985	93.125	86.25
ENSG00000083544	homo_sapiens	ENSP00000367113	93.8172	90.0538	bison_bison_bison	ENSBBBP00000028146	93.8172	90.0538
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	93.0107	monodon_monoceros	ENSMMNP00015027584	96.5054	93.0107
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	91.9355	sus_scrofa	ENSSSCP00000061758	96.3758	91.8121
ENSG00000083544	homo_sapiens	ENSP00000367113	97.4462	93.414	microcebus_murinus	ENSMICP00000016462	97.4462	93.414
ENSG00000083544	homo_sapiens	ENSP00000367113	79.0323	74.328	octodon_degus	ENSODEP00000019718	92.891	87.3618
ENSG00000083544	homo_sapiens	ENSP00000367113	91.5323	87.2312	octodon_degus	ENSODEP00000000693	92.4016	88.0597
ENSG00000083544	homo_sapiens	ENSP00000367113	90.5914	84.0054	jaculus_jaculus	ENSJJAP00000024093	92.4554	85.7339
ENSG00000083544	homo_sapiens	ENSP00000367113	94.2204	89.1129	ovis_aries_rambouillet	ENSOARP00020004158	86.7574	82.0545
ENSG00000083544	homo_sapiens	ENSP00000367113	90.1882	85.6183	ursus_maritimus	ENSUMAP00000019875	93.7151	88.9665
ENSG00000083544	homo_sapiens	ENSP00000367113	75.2688	71.6398	ochotona_princeps	ENSOPRP00000007207	86.2866	82.1264
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	92.6075	delphinapterus_leucas	ENSDLEP00000010324	96.5054	92.6075
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	92.4731	physeter_catodon	ENSPCTP00005009311	96.5054	92.4731
ENSG00000083544	homo_sapiens	ENSP00000367113	93.1452	86.1559	mus_caroli	MGP_CAROLIEiJ_P0037502	93.1452	86.1559
ENSG00000083544	homo_sapiens	ENSP00000367113	92.3387	84.9462	mus_musculus	ENSMUSP00000129019	92.463	85.0606
ENSG00000083544	homo_sapiens	ENSP00000367113	93.9516	89.2473	dipodomys_ordii	ENSDORP00000021572	93.9516	89.2473
ENSG00000083544	homo_sapiens	ENSP00000367113	81.3172	76.6129	mustela_putorius_furo	ENSMPUP00000009554	87.3016	82.2511
ENSG00000083544	homo_sapiens	ENSP00000367113	69.6237	66.129	aotus_nancymaae	ENSANAP00000020274	93.8406	89.1304
ENSG00000083544	homo_sapiens	ENSP00000367113	95.0269	92.8763	aotus_nancymaae	ENSANAP00000026284	97.249	95.0481
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	94.3548	saimiri_boliviensis_boliviensis	ENSSBOP00000011965	98.3562	96.1644
ENSG00000083544	homo_sapiens	ENSP00000367113	84.9462	80.2419	vicugna_pacos	ENSVPAP00000010944	97.0814	91.7051
ENSG00000083544	homo_sapiens	ENSP00000367113	98.5215	97.8495	chlorocebus_sabaeus	ENSCSAP00000013665	98.5215	97.8495
ENSG00000083544	homo_sapiens	ENSP00000367113	94.2204	88.0376	mesocricetus_auratus	ENSMAUP00000012201	94.094	87.9195
ENSG00000083544	homo_sapiens	ENSP00000367113	96.371	92.7419	phocoena_sinus	ENSPSNP00000025895	96.371	92.7419
ENSG00000083544	homo_sapiens	ENSP00000367113	84.9462	80.3763	camelus_dromedarius	ENSCDRP00005024834	97.0814	91.8587
ENSG00000083544	homo_sapiens	ENSP00000367113	92.4731	90.3226	carlito_syrichta	ENSTSYP00000002079	96.2238	93.986
ENSG00000083544	homo_sapiens	ENSP00000367113	94.6237	90.1882	panthera_tigris_altaica	ENSPTIP00000000990	96.4384	91.9178
ENSG00000083544	homo_sapiens	ENSP00000367113	90.5914	82.9301	rattus_norvegicus	ENSRNOP00000086500	92.0765	84.2896
ENSG00000083544	homo_sapiens	ENSP00000367113	96.2366	91.9355	prolemur_simus	ENSPSMP00000026827	95.2128	90.9574
ENSG00000083544	homo_sapiens	ENSP00000367113	92.7419	87.0968	microtus_ochrogaster	ENSMOCP00000013048	92	86.4
ENSG00000083544	homo_sapiens	ENSP00000367113	81.8548	76.7473	sorex_araneus	ENSSARP00000002746	93.9815	88.1173
ENSG00000083544	homo_sapiens	ENSP00000367113	93.9516	87.3656	peromyscus_maniculatus_bairdii	ENSPEMP00000003152	93.9516	87.3656
ENSG00000083544	homo_sapiens	ENSP00000367113	83.4677	79.5699	bos_mutus	ENSBMUP00000032154	95.3917	90.937
ENSG00000083544	homo_sapiens	ENSP00000367113	92.6075	85.0806	mus_spicilegus	ENSMSIP00000015839	92.7322	85.1952
ENSG00000083544	homo_sapiens	ENSP00000367113	93.0107	86.1559	cricetulus_griseus_chok1gshd	ENSCGRP00001009162	92.8859	86.0403
ENSG00000083544	homo_sapiens	ENSP00000367113	83.871	78.7634	pteropus_vampyrus	ENSPVAP00000009939	95.8525	90.0154
ENSG00000083544	homo_sapiens	ENSP00000367113	87.3656	81.8548	myotis_lucifugus	ENSMLUP00000000216	94.8905	88.9051
ENSG00000083544	homo_sapiens	ENSP00000367113	89.5161	81.8548	vombatus_ursinus	ENSVURP00010018656	89.1566	81.5261
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	90.5914	rhinolophus_ferrumequinum	ENSRFEP00010001622	96.6353	90.7133
ENSG00000083544	homo_sapiens	ENSP00000367113	84.8118	80.5107	neovison_vison	ENSNVIP00000007685	96.9278	92.0123
ENSG00000083544	homo_sapiens	ENSP00000367113	95.2957	91.5323	bos_taurus	ENSBTAP00000066670	95.2957	91.5323
ENSG00000083544	homo_sapiens	ENSP00000367113	94.2204	90.5914	heterocephalus_glaber_female	ENSHGLP00000019723	94.2204	90.5914
ENSG00000083544	homo_sapiens	ENSP00000367113	59.6774	55.914	heterocephalus_glaber_female	ENSHGLP00000013522	91.1704	85.4209
ENSG00000083544	homo_sapiens	ENSP00000367113	95.9677	94.2204	rhinopithecus_bieti	ENSRBIP00000014324	95.3271	93.5915
ENSG00000083544	homo_sapiens	ENSP00000367113	94.3548	90.3226	canis_lupus_dingo	ENSCAFP00020022894	94.9932	90.9337
ENSG00000083544	homo_sapiens	ENSP00000367113	62.5	57.9301	canis_lupus_dingo	ENSCAFP00020019220	93.1864	86.3727
ENSG00000083544	homo_sapiens	ENSP00000367113	92.0699	87.7688	sciurus_vulgaris	ENSSVLP00005003971	93.4516	89.0859
ENSG00000083544	homo_sapiens	ENSP00000367113	88.9785	81.586	phascolarctos_cinereus	ENSPCIP00000014713	88.6212	81.2584
ENSG00000083544	homo_sapiens	ENSP00000367113	76.8817	72.1774	procavia_capensis	ENSPCAP00000013991	88.408	82.9985
ENSG00000083544	homo_sapiens	ENSP00000367113	94.086	89.2473	nannospalax_galili	ENSNGAP00000003750	94.2127	89.3674
ENSG00000083544	homo_sapiens	ENSP00000367113	95.5645	91.3979	bos_grunniens	ENSBGRP00000010611	95.5645	91.3979
ENSG00000083544	homo_sapiens	ENSP00000367113	93.5484	89.5161	chinchilla_lanigera	ENSCLAP00000003721	91.3386	87.4016
ENSG00000083544	homo_sapiens	ENSP00000367113	94.086	89.9194	cervus_hanglu_yarkandensis	ENSCHYP00000022642	95.8904	91.6438
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	92.4731	catagonus_wagneri	ENSCWAP00000022908	96.3758	92.349
ENSG00000083544	homo_sapiens	ENSP00000367113	93.2796	89.7849	ictidomys_tridecemlineatus	ENSSTOP00000020294	95.0685	91.5069
ENSG00000083544	homo_sapiens	ENSP00000367113	96.5054	92.0699	otolemur_garnettii	ENSOGAP00000005273	96.5054	92.0699
ENSG00000083544	homo_sapiens	ENSP00000367113	97.9839	95.5645	cebus_imitator	ENSCCAP00000012197	97.9839	95.5645
ENSG00000083544	homo_sapiens	ENSP00000367113	95.2957	90.9946	moschus_moschiferus	ENSMMSP00000024063	95.2957	90.9946
ENSG00000083544	homo_sapiens	ENSP00000367113	97.8495	96.371	rhinopithecus_roxellana	ENSRROP00000042838	97.8495	96.371
ENSG00000083544	homo_sapiens	ENSP00000367113	93.8172	86.5591	mus_pahari	MGP_PahariEiJ_P0085586	93.8172	86.5591
ENSG00000083544	homo_sapiens	ENSP00000367113	72.3118	68.5484	propithecus_coquereli	ENSPCOP00000016345	97.1119	92.0578
ENSG00000083544	homo_sapiens	ENSP00000367113	33.6021	22.043	caenorhabditis_elegans	Y50D4C.3a.1	41.3223	27.1074
ENSG00000083544	homo_sapiens	ENSP00000367113	45.9677	29.1667	drosophila_melanogaster	FBpp0075441	40.9091	25.9569
ENSG00000083544	homo_sapiens	ENSP00000367113	18.5484	13.3065	ciona_intestinalis	ENSCINP00000032086	60.262	43.2314
ENSG00000083544	homo_sapiens	ENSP00000367113	51.2097	36.828	eptatretus_burgeri	ENSEBUP00000018943	50.1316	36.0526
ENSG00000083544	homo_sapiens	ENSP00000367113	68.5484	54.3011	callorhinchus_milii	ENSCMIP00000007643	67.2823	53.2982
ENSG00000083544	homo_sapiens	ENSP00000367113	72.1774	62.5	latimeria_chalumnae	ENSLACP00000001582	71.9839	62.3324
ENSG00000083544	homo_sapiens	ENSP00000367113	70.5645	56.1828	lepisosteus_oculatus	ENSLOCP00000005587	70.6595	56.2584
ENSG00000083544	homo_sapiens	ENSP00000367113	65.7258	51.7473	clupea_harengus	ENSCHAP00000039059	59.6341	46.9512
ENSG00000083544	homo_sapiens	ENSP00000367113	65.7258	51.6129	danio_rerio	ENSDARP00000149904	66.5306	52.2449
ENSG00000083544	homo_sapiens	ENSP00000367113	65.457	51.2097	carassius_auratus	ENSCARP00000077474	64.8469	50.7324
ENSG00000083544	homo_sapiens	ENSP00000367113	65.9946	51.0753	carassius_auratus	ENSCARP00000126128	65.9946	51.0753
ENSG00000083544	homo_sapiens	ENSP00000367113	38.8441	32.5269	carassius_auratus	ENSCARP00000079687	74.2931	62.2108
ENSG00000083544	homo_sapiens	ENSP00000367113	65.457	51.2097	carassius_auratus	ENSCARP00000046080	65.1941	51.004
ENSG00000083544	homo_sapiens	ENSP00000367113	66.3979	52.1505	astyanax_mexicanus	ENSAMXP00000007043	62.4526	49.0518
ENSG00000083544	homo_sapiens	ENSP00000367113	65.8602	51.8817	ictalurus_punctatus	ENSIPUP00000018202	61.1735	48.1898
ENSG00000083544	homo_sapiens	ENSP00000367113	62.9032	49.0591	esox_lucius	ENSELUP00000048025	50.7042	39.545
ENSG00000083544	homo_sapiens	ENSP00000367113	66.129	51.6129	electrophorus_electricus	ENSEEEP00000006447	62.2785	48.6076
ENSG00000083544	homo_sapiens	ENSP00000367113	64.6505	50	oncorhynchus_kisutch	ENSOKIP00005093012	51.0616	39.4904
ENSG00000083544	homo_sapiens	ENSP00000367113	64.1129	49.4624	oncorhynchus_mykiss	ENSOMYP00000127739	48.9231	37.7436
ENSG00000083544	homo_sapiens	ENSP00000367113	64.2473	49.7312	oncorhynchus_mykiss	ENSOMYP00000108305	50.6893	39.2365
ENSG00000083544	homo_sapiens	ENSP00000367113	54.9731	42.0699	salmo_salar	ENSSSAP00000161429	51.2531	39.2231
ENSG00000083544	homo_sapiens	ENSP00000367113	55.2419	42.2043	salmo_salar	ENSSSAP00000128149	52.2236	39.8983
ENSG00000083544	homo_sapiens	ENSP00000367113	64.3817	50	salmo_salar	ENSSSAP00000136007	51.3949	39.9142
ENSG00000083544	homo_sapiens	ENSP00000367113	11.1559	9.13978	salmo_trutta	ENSSTUP00000072045	85.567	70.1031
ENSG00000083544	homo_sapiens	ENSP00000367113	55.3763	44.086	salmo_trutta	ENSSTUP00000072268	58.11	46.2623
ENSG00000083544	homo_sapiens	ENSP00000367113	62.5	48.3871	gadus_morhua	ENSGMOP00000006122	51.7241	40.0445
ENSG00000083544	homo_sapiens	ENSP00000367113	65.3226	50.4032	fundulus_heteroclitus	ENSFHEP00000008337	61.8321	47.7099
ENSG00000083544	homo_sapiens	ENSP00000367113	66.3979	50.9409	poecilia_reticulata	ENSPREP00000031211	62.8499	48.2188
ENSG00000083544	homo_sapiens	ENSP00000367113	66.129	50.8064	xiphophorus_maculatus	ENSXMAP00000021678	61.809	47.4874
ENSG00000083544	homo_sapiens	ENSP00000367113	62.0968	47.7151	oryzias_latipes	ENSORLP00000033958	57.8223	44.4305
ENSG00000083544	homo_sapiens	ENSP00000367113	64.1129	49.5968	cyclopterus_lumpus	ENSCLMP00005009299	60.533	46.8274
ENSG00000083544	homo_sapiens	ENSP00000367113	66.6667	51.4785	oreochromis_niloticus	ENSONIP00000004060	63.5897	49.1026
ENSG00000083544	homo_sapiens	ENSP00000367113	66.9355	51.6129	haplochromis_burtoni	ENSHBUP00000005673	63.8462	49.2308
ENSG00000083544	homo_sapiens	ENSP00000367113	66.9355	51.6129	astatotilapia_calliptera	ENSACLP00000033896	63.8462	49.2308
ENSG00000083544	homo_sapiens	ENSP00000367113	66.8011	50.1344	sparus_aurata	ENSSAUP00010055048	57.7236	43.3217
ENSG00000083544	homo_sapiens	ENSP00000367113	66.9355	51.3441	lates_calcarifer	ENSLCAP00010018633	63.4395	48.6624
ENSG00000083544	homo_sapiens	ENSP00000367113	73.2527	59.9462	xenopus_tropicalis	ENSXETP00000063638	69.5153	56.8878
ENSG00000083544	homo_sapiens	ENSP00000367113	85.6183	76.7473	chrysemys_picta_bellii	ENSCPBP00000038565	84.595	75.83
ENSG00000083544	homo_sapiens	ENSP00000367113	85.0806	76.3441	sphenodon_punctatus	ENSSPUP00000001558	84.6257	75.9358
ENSG00000083544	homo_sapiens	ENSP00000367113	85.2151	76.0753	crocodylus_porosus	ENSCPRP00005027082	84.4208	75.3662
ENSG00000083544	homo_sapiens	ENSP00000367113	64.9194	54.4355	laticauda_laticaudata	ENSLLTP00000005441	74.4222	62.4037
ENSG00000083544	homo_sapiens	ENSP00000367113	80.7796	70.9677	notechis_scutatus	ENSNSUP00000013529	81.4363	71.5447
ENSG00000083544	homo_sapiens	ENSP00000367113	77.2849	68.0107	pseudonaja_textilis	ENSPTXP00000005516	79.6399	70.0831
ENSG00000083544	homo_sapiens	ENSP00000367113	85.4839	76.8817	anas_platyrhynchos_platyrhynchos	ENSAPLP00000014192	85.83	77.193
ENSG00000083544	homo_sapiens	ENSP00000367113	84.9462	75.9409	gallus_gallus	ENSGALP00010003295	85.2901	76.2483
ENSG00000083544	homo_sapiens	ENSP00000367113	83.7366	74.5968	meleagris_gallopavo	ENSMGAP00000029101	81.1198	72.2656
ENSG00000083544	homo_sapiens	ENSP00000367113	84.9462	75.1344	serinus_canaria	ENSSCAP00000020867	85.2901	75.4386
ENSG00000083544	homo_sapiens	ENSP00000367113	83.871	74.5968	parus_major	ENSPMJP00000018471	82.649	73.5099
ENSG00000083544	homo_sapiens	ENSP00000367113	81.4516	72.8495	anolis_carolinensis	ENSACAP00000004832	82.449	73.7415
ENSG00000083544	homo_sapiens	ENSP00000367113	66.9355	51.6129	neolamprologus_brichardi	ENSNBRP00000024570	63.8462	49.2308
ENSG00000083544	homo_sapiens	ENSP00000367113	80.914	71.1021	naja_naja	ENSNNAP00000023630	81.5718	71.6802
ENSG00000083544	homo_sapiens	ENSP00000367113	81.1828	73.1183	podarcis_muralis	ENSPMRP00000012561	82.4011	74.2156
ENSG00000083544	homo_sapiens	ENSP00000367113	84.4086	75.4032	geospiza_fortis	ENSGFOP00000006348	84.7503	75.7085
ENSG00000083544	homo_sapiens	ENSP00000367113	83.6021	74.5968	taeniopygia_guttata	ENSTGUP00000015450	79.1349	70.6107
ENSG00000083544	homo_sapiens	ENSP00000367113	70.4301	56.3172	erpetoichthys_calabaricus	ENSECRP00000026890	70.3356	56.2416
ENSG00000083544	homo_sapiens	ENSP00000367113	65.9946	51.0753	kryptolebias_marmoratus	ENSKMAP00000029507	62.3888	48.2846
ENSG00000083544	homo_sapiens	ENSP00000367113	82.2581	73.3871	salvator_merianae	ENSSMRP00000000566	83.1522	74.1848
ENSG00000083544	homo_sapiens	ENSP00000367113	63.8441	50.2688	oryzias_javanicus	ENSOJAP00000030918	63.1649	49.734
ENSG00000083544	homo_sapiens	ENSP00000367113	67.2043	51.7473	amphilophus_citrinellus	ENSACIP00000030906	63.9386	49.2327
ENSG00000083544	homo_sapiens	ENSP00000367113	64.7849	49.1936	dicentrarchus_labrax	ENSDLAP00005024270	62.1936	47.2258
ENSG00000083544	homo_sapiens	ENSP00000367113	63.0376	46.9086	amphiprion_percula	ENSAPEP00000032180	61.1473	45.502
ENSG00000083544	homo_sapiens	ENSP00000367113	66.2634	50.9409	oryzias_sinensis	ENSOSIP00000030519	63.2863	48.6521
ENSG00000083544	homo_sapiens	ENSP00000367113	74.328	66.8011	pelodiscus_sinensis	ENSPSIP00000015457	84.9462	76.3441
ENSG00000083544	homo_sapiens	ENSP00000367113	85.8871	76.3441	gopherus_evgoodei	ENSGEVP00005000028	85.8871	76.3441
ENSG00000083544	homo_sapiens	ENSP00000367113	85.0806	75.672	chelonoidis_abingdonii	ENSCABP00000028397	84.0637	74.7676
ENSG00000083544	homo_sapiens	ENSP00000367113	67.3387	51.7473	seriola_dumerili	ENSSDUP00000006210	63.6595	48.9199
ENSG00000083544	homo_sapiens	ENSP00000367113	63.5753	48.9247	cottoperca_gobio	ENSCGOP00000030844	60.641	46.6667
ENSG00000083544	homo_sapiens	ENSP00000367113	83.7366	74.5968	struthio_camelus_australis	ENSSCUP00000005373	83.8493	74.6972
ENSG00000083544	homo_sapiens	ENSP00000367113	85.3495	77.2849	anser_brachyrhynchus	ENSABRP00000012810	85.695	77.5978
ENSG00000083544	homo_sapiens	ENSP00000367113	62.7688	49.7312	gasterosteus_aculeatus	ENSGACP00000020132	61.2058	48.4928
ENSG00000083544	homo_sapiens	ENSP00000367113	65.3226	49.5968	cynoglossus_semilaevis	ENSCSEP00000000963	62.8719	47.7361
ENSG00000083544	homo_sapiens	ENSP00000367113	65.7258	50.5376	poecilia_formosa	ENSPFOP00000024918	62.2137	47.8372
ENSG00000083544	homo_sapiens	ENSP00000367113	67.0699	53.0914	myripristis_murdjan	ENSMMDP00005020544	62.5313	49.4987
ENSG00000083544	homo_sapiens	ENSP00000367113	66.3979	51.2097	sander_lucioperca	ENSSLUP00000047789	62.6109	48.289
ENSG00000083544	homo_sapiens	ENSP00000367113	84.6774	75.8064	strigops_habroptila	ENSSHBP00005004344	85.0202	76.1134
ENSG00000083544	homo_sapiens	ENSP00000367113	67.6075	51.2097	amphiprion_ocellaris	ENSAOCP00000029281	63.8325	48.3503
ENSG00000083544	homo_sapiens	ENSP00000367113	86.0215	77.4194	terrapene_carolina_triunguis	ENSTMTP00000020981	86.0215	77.4194
ENSG00000083544	homo_sapiens	ENSP00000367113	86.0215	77.5538	terrapene_carolina_triunguis	ENSTMTP00000010315	86.0215	77.5538
ENSG00000083544	homo_sapiens	ENSP00000367113	10.3495	8.33333	hucho_hucho	ENSHHUP00000007457	72.6415	58.4906
ENSG00000083544	homo_sapiens	ENSP00000367113	66.2634	50.8064	betta_splendens	ENSBSLP00000013629	62.8827	48.2143
ENSG00000083544	homo_sapiens	ENSP00000367113	66.5323	52.4194	pygocentrus_nattereri	ENSPNAP00000019593	62.579	49.3047
ENSG00000083544	homo_sapiens	ENSP00000367113	67.6075	52.2849	anabas_testudineus	ENSATEP00000020962	63.9136	49.4282
ENSG00000083544	homo_sapiens	ENSP00000367113	62.5	47.4462	seriola_lalandi_dorsalis	ENSSLDP00000003907	61.1038	46.3863
ENSG00000083544	homo_sapiens	ENSP00000367113	62.3656	47.3118	labrus_bergylta	ENSLBEP00000015109	61.7843	46.8708
ENSG00000083544	homo_sapiens	ENSP00000367113	66.8011	51.4785	pundamilia_nyererei	ENSPNYP00000001961	63.7179	49.1026
ENSG00000083544	homo_sapiens	ENSP00000367113	67.3387	51.0753	mastacembelus_armatus	ENSMAMP00000005874	63.8217	48.4076
ENSG00000083544	homo_sapiens	ENSP00000367113	67.8763	51.2097	stegastes_partitus	ENSSPAP00000006943	64.0863	48.3503
ENSG00000083544	homo_sapiens	ENSP00000367113	68.1452	50.8064	acanthochromis_polyacanthus	ENSAPOP00000013294	64.3401	47.9695
ENSG00000083544	homo_sapiens	ENSP00000367113	84.9462	76.2097	aquila_chrysaetos_chrysaetos	ENSACCP00020021800	85.2901	76.5182
ENSG00000083544	homo_sapiens	ENSP00000367113	60.6183	46.371	nothobranchius_furzeri	ENSNFUP00015022986	59.8938	45.8167
ENSG00000083544	homo_sapiens	ENSP00000367113	12.3656	10.2151	cyprinodon_variegatus	ENSCVAP00000006422	79.3103	65.5172
ENSG00000083544	homo_sapiens	ENSP00000367113	62.3656	47.7151	cyprinodon_variegatus	ENSCVAP00000012988	61.1331	46.7721
ENSG00000083544	homo_sapiens	ENSP00000367113	66.3979	52.0161	denticeps_clupeoides	ENSDCDP00000024571	61.596	48.2544
ENSG00000083544	homo_sapiens	ENSP00000367113	67.0699	51.7473	larimichthys_crocea	ENSLCRP00005000697	63.3249	48.8579
ENSG00000083544	homo_sapiens	ENSP00000367113	64.9194	50.5376	takifugu_rubripes	ENSTRUP00000044051	62.0026	48.267
ENSG00000083544	homo_sapiens	ENSP00000367113	83.7366	74.7312	ficedula_albicollis	ENSFALP00000026680	82.8457	73.9362
ENSG00000083544	homo_sapiens	ENSP00000367113	62.7688	48.1183	hippocampus_comes	ENSHCOP00000001215	61.7725	47.3545
ENSG00000083544	homo_sapiens	ENSP00000367113	63.5753	50.2688	cyprinus_carpio_carpio	ENSCCRP00000136532	63.0667	49.8667
ENSG00000083544	homo_sapiens	ENSP00000367113	65.9946	51.8817	cyprinus_carpio_carpio	ENSCCRP00000135436	65.8177	51.7426
ENSG00000083544	homo_sapiens	ENSP00000367113	84.6774	75.672	coturnix_japonica	ENSCJPP00005024914	85.0202	75.9784
ENSG00000083544	homo_sapiens	ENSP00000367113	61.4247	46.6398	poecilia_latipinna	ENSPLAP00000027621	61.2601	46.5147
ENSG00000083544	homo_sapiens	ENSP00000367113	12.3656	10.4839	poecilia_latipinna	ENSPLAP00000028697	77.3109	65.5462
ENSG00000083544	homo_sapiens	ENSP00000367113	61.828	48.3871	sinocyclocheilus_grahami	ENSSGRP00000107162	63.8889	50
ENSG00000083544	homo_sapiens	ENSP00000367113	62.2312	48.9247	sinocyclocheilus_grahami	ENSSGRP00000025220	62.9932	49.5238
ENSG00000083544	homo_sapiens	ENSP00000367113	66.9355	51.6129	maylandia_zebra	ENSMZEP00005005878	63.8462	49.2308
ENSG00000083544	homo_sapiens	ENSP00000367113	65.457	49.8656	tetraodon_nigroviridis	ENSTNIP00000007906	63.9947	48.7516
ENSG00000083544	homo_sapiens	ENSP00000367113	62.5	48.7903	paramormyrops_kingsleyae	ENSPKIP00000026378	66.0511	51.5625
ENSG00000083544	homo_sapiens	ENSP00000367113	63.4409	49.4624	scleropages_formosus	ENSSFOP00015007884	63.3557	49.396
ENSG00000083544	homo_sapiens	ENSP00000367113	77.2849	64.1129	leptobrachium_leishanense	ENSLLEP00000005037	77.0778	63.941
ENSG00000083544	homo_sapiens	ENSP00000367113	66.129	50.2688	scophthalmus_maximus	ENSSMAP00000041318	63.6481	48.3829
ENSG00000083544	homo_sapiens	ENSP00000367113	66.5323	51.7473	oryzias_melastigma	ENSOMEP00000031052	63.543	49.4223

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003682	enables chromatin binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003713	enables transcription coactivator activity	1	IDA	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006325	involved_in chromatin organization	1	IEA	Homo_sapiens(9606)	Process
GO:0035064	enables methylated histone binding	1	IDA	Homo_sapiens(9606)	Function
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process