RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000083290	Gene ID	9706	Accession	13480
Symbol	ULK2	Alias	ATG1B;Unc51.2	Full Name	unc-51 like autophagy activating kinase 2
Status	Confidence	Length	97107 bases	Strand	Minus strand
Position	17 : 19770830 - 19867936	RNA binding domain	RIO1
Summary	This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000354877	RIO1	PF01163	0.00012	1
ENSP00000378914	RIO1	PF01163	0.00012	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ULK2-203	ENST00000570983	3096	No protein	-
ULK2-201	ENST00000361658	3908	1036aa	ENSP00000354877
ULK2-202	ENST00000395544	9149	1036aa	ENSP00000378914
ULK2-206	ENST00000571454	562	No protein	-
ULK2-209	ENST00000575432	594	198aa	ENSP00000464892
ULK2-204	ENST00000571137	615	No protein	-
ULK2-211	ENST00000580130	627	No protein	-
ULK2-208	ENST00000574854	493	No protein	-
ULK2-205	ENST00000571177	492	No protein	-
ULK2-207	ENST00000574732	564	21aa	ENSP00000465666
ULK2-210	ENST00000580118	577	49aa	ENSP00000467277

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
179	Parkinson Disease	2.505542E-5	17052657

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000045	involved_in autophagosome assembly	1	IBA	Homo_sapiens(9606)	Process
GO:0000407	is_active_in phagophore assembly site	1	IBA	Homo_sapiens(9606)	Component
GO:0000422	involved_in autophagy of mitochondrion	1	IBA	Homo_sapiens(9606)	Process
GO:0004674	enables protein serine/threonine kinase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005776	is_active_in autophagosome	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	1	IBA	Homo_sapiens(9606)	Component
GO:0006914	involved_in autophagy	2	IDA,IGI	Homo_sapiens(9606)	Process
GO:0007165	involved_in signal transduction	1	IEA	Homo_sapiens(9606)	Process
GO:0010508	involved_in positive regulation of autophagy	1	IBA	Homo_sapiens(9606)	Process
GO:0018105	involved_in peptidyl-serine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0030659	located_in cytoplasmic vesicle membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0034045	is_active_in phagophore assembly site membrane	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0034727	involved_in piecemeal microautophagy of the nucleus	1	IBA	Homo_sapiens(9606)	Process
GO:0042594	involved_in response to starvation	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0044805	involved_in late nucleophagy	1	IBA	Homo_sapiens(9606)	Process
GO:0046777	involved_in protein autophosphorylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0048668	involved_in collateral sprouting	1	IEA	Homo_sapiens(9606)	Process
GO:0048671	involved_in negative regulation of collateral sprouting	1	IBA	Homo_sapiens(9606)	Process
GO:0048675	involved_in axon extension	1	IBA	Homo_sapiens(9606)	Process
GO:0061709	involved_in reticulophagy	1	IBA	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function