Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases SARS-COV-2
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000082701 Gene ID 2932 Accession 4617
Symbol GSK3B Alias NA Full Name glycogen synthase kinase 3 beta
Status Confidence Length 273674 bases Strand Minus strand
Position 3 : 119821321 - 120094994 RNA binding domain N.A.
Summary The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36649031 High Throughput FISH Screening Identifies Small Molecules That Modulate Oncogenic lncRNA MALAT1 via GSK3B and hnRNPs. Nina Zablowsky 2023-01-03 Non-coding RNA

Transcripts

Name Transcript ID bp Protein Translation ID
GSK3B-201 ENST00000264235 7743 420aa ENSP00000264235
GSK3B-202 ENST00000316626 7000 433aa ENSP00000324806
GSK3B-253 ENST00000678439 6714 470aa ENSP00000503868
GSK3B-216 ENST00000676910 645 141aa ENSP00000504338
GSK3B-268 ENST00000679201 546 108aa ENSP00000502998
GSK3B-242 ENST00000678013 647 142aa ENSP00000503088
GSK3B-206 ENST00000676566 1200 No protein -
GSK3B-229 ENST00000677502 1157 No protein -
GSK3B-205 ENST00000650344 1731 387aa ENSP00000497956
GSK3B-245 ENST00000678159 335 39aa ENSP00000504704
GSK3B-262 ENST00000679068 408 34aa ENSP00000503665
GSK3B-204 ENST00000474830 518 No protein -
GSK3B-269 ENST00000679206 280 45aa ENSP00000502943
GSK3B-240 ENST00000677959 128 No protein -
GSK3B-249 ENST00000678286 384 63aa ENSP00000503449
GSK3B-267 ENST00000679194 489 56aa ENSP00000504842
GSK3B-225 ENST00000677362 206 69aa ENSP00000503882
GSK3B-232 ENST00000677716 417 69aa ENSP00000503671
GSK3B-244 ENST00000678121 1018 No protein -
GSK3B-203 ENST00000473886 215 No protein -
GSK3B-250 ENST00000678342 216 No protein -
GSK3B-243 ENST00000678064 389 37aa ENSP00000503367
GSK3B-217 ENST00000676948 437 40aa ENSP00000503446
GSK3B-214 ENST00000676887 414 56aa ENSP00000502977
GSK3B-255 ENST00000678561 673 224aa ENSP00000503494
GSK3B-246 ENST00000678181 271 90aa ENSP00000504266
GSK3B-213 ENST00000676844 241 37aa ENSP00000503005
GSK3B-219 ENST00000677046 137 46aa ENSP00000504697
GSK3B-247 ENST00000678210 126 No protein -
GSK3B-221 ENST00000677069 448 34aa ENSP00000503344
GSK3B-228 ENST00000677483 502 39aa ENSP00000503402
GSK3B-254 ENST00000678509 392 39aa ENSP00000503753
GSK3B-231 ENST00000677648 460 38aa ENSP00000504426
GSK3B-252 ENST00000678377 325 53aa ENSP00000503164
GSK3B-241 ENST00000677995 422 64aa ENSP00000504203
GSK3B-266 ENST00000679188 207 69aa ENSP00000504252
GSK3B-261 ENST00000679066 180 60aa ENSP00000503626
GSK3B-259 ENST00000678787 290 97aa ENSP00000503398
GSK3B-233 ENST00000677788 2556 No protein -
GSK3B-215 ENST00000676890 284 No protein -
GSK3B-258 ENST00000678754 128 No protein -
GSK3B-263 ENST00000679085 127 No protein -
GSK3B-248 ENST00000678245 1561 No protein -
GSK3B-257 ENST00000678678 330 38aa ENSP00000503962
GSK3B-210 ENST00000676733 340 44aa ENSP00000504716
GSK3B-220 ENST00000677067 136 No protein -
GSK3B-226 ENST00000677400 178 59aa ENSP00000504538
GSK3B-238 ENST00000677885 215 71aa ENSP00000504148
GSK3B-223 ENST00000677169 646 42aa ENSP00000503107
GSK3B-234 ENST00000677804 141 No protein -
GSK3B-209 ENST00000676723 140 No protein -
GSK3B-265 ENST00000679164 140 No protein -
GSK3B-236 ENST00000677875 195 65aa ENSP00000504503
GSK3B-251 ENST00000678350 558 105aa ENSP00000503744
GSK3B-212 ENST00000676775 450 85aa ENSP00000503611
GSK3B-237 ENST00000677878 305 102aa ENSP00000503134
GSK3B-260 ENST00000678967 114 No protein -
GSK3B-235 ENST00000677870 118 No protein -
GSK3B-256 ENST00000678608 450 90aa ENSP00000504562
GSK3B-222 ENST00000677128 599 59aa ENSP00000503177
GSK3B-208 ENST00000676722 4361 No protein -
GSK3B-230 ENST00000677530 1826 No protein -
GSK3B-207 ENST00000676650 1311 No protein -
GSK3B-264 ENST00000679131 224 No protein -
GSK3B-218 ENST00000677034 1343 110aa ENSP00000504055
GSK3B-211 ENST00000676743 355 No protein -
GSK3B-227 ENST00000677423 591 29aa ENSP00000503687
GSK3B-239 ENST00000677903 276 29aa ENSP00000503112
GSK3B-224 ENST00000677338 276 29aa ENSP00000503497

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
16161Stroke3.9946703E-00519369658
96434Cholesterol, HDL1E-824097068

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001837involved_in epithelial to mesenchymal transition1IMPHomo_sapiens(9606)Process
GO:0001954involved_in positive regulation of cell-matrix adhesion1IMPHomo_sapiens(9606)Process
GO:0002020enables protease binding1IPIHomo_sapiens(9606)Function
GO:0002039enables p53 binding1IDAHomo_sapiens(9606)Function
GO:0004672enables protein kinase activity2IMP,TASHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity6IBA,IDA,IMP,ISS,NAS,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus3IBA,IDA,ISSHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IBA,IDA,ISSHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IEAHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0005977involved_in glycogen metabolic process1IDAHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation3IDA,IMP,TASHomo_sapiens(9606)Process
GO:0006983acts_upstream_of_or_within ER overload response1IDAHomo_sapiens(9606)Process
GO:0007212involved_in dopamine receptor signaling pathway1NASHomo_sapiens(9606)Process
GO:0007623involved_in circadian rhythm1ISSHomo_sapiens(9606)Process
GO:0008013enables beta-catenin binding2IBA,IPIHomo_sapiens(9606)Function
GO:0008286involved_in insulin receptor signaling pathway1IBAHomo_sapiens(9606)Process
GO:0010508involved_in positive regulation of autophagy1ISSHomo_sapiens(9606)Process
GO:0010628acts_upstream_of positive regulation of gene expression2IMP,ISSHomo_sapiens(9606)Process
GO:0010629acts_upstream_of negative regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0010822involved_in positive regulation of mitochondrion organization1IMPHomo_sapiens(9606)Process
GO:0010975involved_in regulation of neuron projection development1IBAHomo_sapiens(9606)Process
GO:0016301enables kinase activity1IDAHomo_sapiens(9606)Function
GO:0018105acts_upstream_of_or_within peptidyl-serine phosphorylation3IDA,IGIHomo_sapiens(9606)Process
GO:0018107involved_in peptidyl-threonine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0019082involved_in viral protein processing1TASHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0021766involved_in hippocampus development1IMPHomo_sapiens(9606)Process
GO:0030010involved_in establishment of cell polarity2ISS,TASHomo_sapiens(9606)Process
GO:0030011involved_in maintenance of cell polarity2ISS,TASHomo_sapiens(9606)Process
GO:0030424is_active_in axon2IBA,ISSHomo_sapiens(9606)Component
GO:0030425located_in dendrite1ISSHomo_sapiens(9606)Component
GO:0030516involved_in regulation of axon extension1ISSHomo_sapiens(9606)Process
GO:0030877part_of beta-catenin destruction complex4IBA,IDA,NAS,TASHomo_sapiens(9606)Component
GO:0031175involved_in neuron projection development1IDAHomo_sapiens(9606)Process
GO:0031333involved_in negative regulation of protein-containing complex assembly1IMPHomo_sapiens(9606)Process
GO:0031334involved_in positive regulation of protein-containing complex assembly1IDAHomo_sapiens(9606)Process
GO:0031398involved_in positive regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0032091involved_in negative regulation of protein binding1IDAHomo_sapiens(9606)Process
GO:0032092involved_in positive regulation of protein binding1ISSHomo_sapiens(9606)Process
GO:0032436involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process3IC,IDA,IMPHomo_sapiens(9606)Process
GO:0032515involved_in negative regulation of phosphoprotein phosphatase activity1TASHomo_sapiens(9606)Process
GO:0032886involved_in regulation of microtubule-based process1IMPHomo_sapiens(9606)Process
GO:0034236enables protein kinase A catalytic subunit binding1IPIHomo_sapiens(9606)Function
GO:0034452enables dynactin binding1IPIHomo_sapiens(9606)Function
GO:0035556acts_upstream_of_or_within intracellular signal transduction2IDA,TASHomo_sapiens(9606)Process
GO:0036016involved_in cellular response to interleukin-31ISSHomo_sapiens(9606)Process
GO:0042752involved_in regulation of circadian rhythm1ISSHomo_sapiens(9606)Process
GO:0043066acts_upstream_of_or_within negative regulation of apoptotic process1IDAHomo_sapiens(9606)Process
GO:0043161involved_in proteasome-mediated ubiquitin-dependent protein catabolic process1NASHomo_sapiens(9606)Process
GO:0043547involved_in positive regulation of GTPase activity1IMPHomo_sapiens(9606)Process
GO:0045597involved_in positive regulation of cell differentiation1IMPHomo_sapiens(9606)Process
GO:0045719involved_in negative regulation of glycogen biosynthetic process1TASHomo_sapiens(9606)Process
GO:0045724involved_in positive regulation of cilium assembly1ISSHomo_sapiens(9606)Process
GO:0045732involved_in positive regulation of protein catabolic process1ICHomo_sapiens(9606)Process
GO:0046777involved_in protein autophosphorylation1IDAHomo_sapiens(9606)Process
GO:0046825involved_in regulation of protein export from nucleus2IDA,ISSHomo_sapiens(9606)Process
GO:0046827acts_upstream_of_or_within positive regulation of protein export from nucleus1IDAHomo_sapiens(9606)Process
GO:0048156enables tau protein binding1NASHomo_sapiens(9606)Function
GO:0048814involved_in regulation of dendrite morphogenesis1ISSHomo_sapiens(9606)Process
GO:0050321enables tau-protein kinase activity3IBA,IDA,NASHomo_sapiens(9606)Function
GO:0050770involved_in regulation of axonogenesis1ISSHomo_sapiens(9606)Process
GO:0051059enables NF-kappaB binding1IPIHomo_sapiens(9606)Function
GO:0060079involved_in excitatory postsynaptic potential1NASHomo_sapiens(9606)Process
GO:0061629enables RNA polymerase II-specific DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:0070507involved_in regulation of microtubule cytoskeleton organization2IBA,ISSHomo_sapiens(9606)Process
GO:0070885involved_in negative regulation of calcineurin-NFAT signaling cascade1IMPHomo_sapiens(9606)Process
GO:0071109involved_in superior temporal gyrus development1IMPHomo_sapiens(9606)Process
GO:0071300involved_in cellular response to retinoic acid1IMPHomo_sapiens(9606)Process
GO:0090090involved_in negative regulation of canonical Wnt signaling pathway5IBA,IC,IGI,ISS,TASHomo_sapiens(9606)Process
GO:0097191involved_in extrinsic apoptotic signaling pathway1ISSHomo_sapiens(9606)Process
GO:0097192involved_in extrinsic apoptotic signaling pathway in absence of ligand2IBA,ISSHomo_sapiens(9606)Process
GO:0098793located_in presynapse1IEAHomo_sapiens(9606)Component
GO:0098794located_in postsynapse1IEAHomo_sapiens(9606)Component
GO:0098978is_active_in glutamatergic synapse4EXP,IBA,IDA,IMPHomo_sapiens(9606)Component
GO:0099171involved_in presynaptic modulation of chemical synaptic transmission3EXP,IDA,IMPHomo_sapiens(9606)Process
GO:0106027involved_in neuron projection organization1ISSHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IGIHomo_sapiens(9606)Function
GO:0150101involved_in regulation of microtubule anchoring at centrosome1IMPHomo_sapiens(9606)Process
GO:1900034involved_in regulation of cellular response to heat1TASHomo_sapiens(9606)Process
GO:1900181involved_in negative regulation of protein localization to nucleus1ISSHomo_sapiens(9606)Process
GO:1900271involved_in regulation of long-term synaptic potentiation1ISSHomo_sapiens(9606)Process
GO:1901030involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway1ISSHomo_sapiens(9606)Process
GO:1901984involved_in negative regulation of protein acetylation1ISSHomo_sapiens(9606)Process
GO:1902042involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors1IMPHomo_sapiens(9606)Process
GO:1903566involved_in positive regulation of protein localization to cilium1ISSHomo_sapiens(9606)Process
GO:1904339involved_in negative regulation of dopaminergic neuron differentiation1TASHomo_sapiens(9606)Process
GO:1904646involved_in cellular response to amyloid-beta1ISSHomo_sapiens(9606)Process
GO:1904781involved_in positive regulation of protein localization to centrosome1IMPHomo_sapiens(9606)Process
GO:1904886involved_in beta-catenin destruction complex disassembly3IDA,ISS,TASHomo_sapiens(9606)Process
GO:1905240involved_in negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation1IMPHomo_sapiens(9606)Process
GO:1990909part_of Wnt signalosome1TASHomo_sapiens(9606)Component
GO:2000077involved_in negative regulation of type B pancreatic cell development1TASHomo_sapiens(9606)Process
GO:2000466involved_in negative regulation of glycogen (starch) synthase activity1TASHomo_sapiens(9606)Process
GO:2000740involved_in negative regulation of mesenchymal stem cell differentiation1IMPHomo_sapiens(9606)Process

Expression