Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases SARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000075142 Gene ID 6717 Accession 11292
Symbol SRI Alias SCN;V19;CP22;CP-22 Full Name sorcin
Status Confidence Length 21879 bases Strand Minus strand
Position 7 : 88205115 - 88226993 RNA binding domain N.A.
Summary This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33664260 The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain. Saikat Bhattacharya 2021-03-04 Nature communications

Transcripts

Name Transcript ID bp Protein Translation ID
SRI-201 ENST00000265729 1972 198aa ENSP00000265729
SRI-203 ENST00000419179 1307 158aa ENSP00000397609
SRI-206 ENST00000472930 903 No protein -
SRI-210 ENST00000490437 570 155aa ENSP00000418512
SRI-202 ENST00000394641 653 183aa ENSP00000378137
SRI-204 ENST00000431660 1418 180aa ENSP00000391148
SRI-205 ENST00000457606 769 72aa ENSP00000415271
SRI-207 ENST00000486860 1024 No protein -
SRI-208 ENST00000488015 588 No protein -
SRI-209 ENST00000489079 557 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
23801Muscle, Skeletal5.0260000E-005-
24621Muscle, Skeletal2.3040000E-005-
38315Platelet Function Tests6.6400000E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001508involved_in action potential1TASHomo_sapiens(9606)Process
GO:0002020enables protease binding1IPIHomo_sapiens(9606)Function
GO:0005102enables signaling receptor binding1TASHomo_sapiens(9606)Function
GO:0005246enables calcium channel regulator activity1TASHomo_sapiens(9606)Function
GO:0005509enables calcium ion binding2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1TASHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0006816involved_in calcium ion transport1IEAHomo_sapiens(9606)Process
GO:0006880involved_in intracellular sequestering of iron ion1TASHomo_sapiens(9606)Process
GO:0006942involved_in regulation of striated muscle contraction1TASHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0007507involved_in heart development1TASHomo_sapiens(9606)Process
GO:0007517involved_in muscle organ development1TASHomo_sapiens(9606)Process
GO:0008016involved_in regulation of heart contraction1TASHomo_sapiens(9606)Process
GO:0010459involved_in negative regulation of heart rate1IMPHomo_sapiens(9606)Process
GO:0010649involved_in regulation of cell communication by electrical coupling1TASHomo_sapiens(9606)Process
GO:0010880involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum1TASHomo_sapiens(9606)Process
GO:0016020located_in membrane1IDAHomo_sapiens(9606)Component
GO:0016529located_in sarcoplasmic reticulum1TASHomo_sapiens(9606)Component
GO:0030018located_in Z disc1IDAHomo_sapiens(9606)Component
GO:0030315located_in T-tubule1TASHomo_sapiens(9606)Component
GO:0033017located_in sarcoplasmic reticulum membrane1IEAHomo_sapiens(9606)Component
GO:0035774involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus1IEAHomo_sapiens(9606)Process
GO:0042584colocalizes_with chromaffin granule membrane1IDAHomo_sapiens(9606)Component
GO:0042994involved_in cytoplasmic sequestering of transcription factor1IEAHomo_sapiens(9606)Process
GO:0044325enables transmembrane transporter binding1TASHomo_sapiens(9606)Function
GO:0046982enables protein heterodimerization activity1IPIHomo_sapiens(9606)Function
GO:0051281involved_in positive regulation of release of sequestered calcium ion into cytosol1IEAHomo_sapiens(9606)Process
GO:0051924involved_in regulation of calcium ion transport1IMPHomo_sapiens(9606)Process
GO:0055118involved_in negative regulation of cardiac muscle contraction1IEAHomo_sapiens(9606)Process
GO:0060315involved_in negative regulation of ryanodine-sensitive calcium-release channel activity1IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome2HDA,IDAHomo_sapiens(9606)Component
GO:0086004involved_in regulation of cardiac muscle cell contraction1IMPHomo_sapiens(9606)Process
GO:0140297enables DNA-binding transcription factor binding1IEAHomo_sapiens(9606)Function
GO:1901077involved_in regulation of relaxation of muscle1IMPHomo_sapiens(9606)Process
GO:1901841involved_in regulation of high voltage-gated calcium channel activity1IMPHomo_sapiens(9606)Process
GO:1901844involved_in regulation of cell communication by electrical coupling involved in cardiac conduction1IMPHomo_sapiens(9606)Process
GO:2000678involved_in negative regulation of transcription regulatory region DNA binding1IEAHomo_sapiens(9606)Process

Expression