RBP Type	Non-canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	ncRNA
Moonlighting functions	E3 ligase
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000074266	Gene ID	8726	Accession	3188
Symbol	EED	Alias	HEED;COGIS;WAIT1	Full Name	embryonic ectoderm development
Status	Confidence	Length	77602 bases	Strand	Plus strand
Position	11 : 86201212 - 86278813	RNA binding domain	N.A.
Summary	This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
28614747	RNA-mediated regulation of heterochromatin.	L Whitney Johnson	2017-06-01	Current opinion in cell biology
9742080	Point mutations in the WD40 domain of Eed block its interaction with Ezh2.	O Denisenko	1998-10-01	Molecular and cellular biology
30833789	RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2.	Qi Zhang	2019-03-01	Nature structural & molecular biology
34027990	LncRNA HBL1 is required for genome-wide PRC2 occupancy and function in cardiogenesis from human pluripotent stem cells.	Juli Liu	2021-07-01	Development (Cambridge, England)
24077223	Promiscuous RNA binding by Polycomb repressive complex 2.	Chen Davidovich	2013-11-01	Nature structural & molecular biology
29185984	Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.	Yicheng Long	2017-11-29	eLife
24882207	Regulatory interactions between RNA and polycomb repressive complex 2.	Catherine Cifuentes-Rojas	2014-07-17	Molecular cell
33769454	Allosteric regulation of histone lysine methyltransferases: from context-specific regulation to selective drugs.	Chen Davidovich	2021-04-30	Biochemical Society transactions
26208723	LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer.	Arunoday Bhan	2015-08-01	Biochimica et biophysica acta
35931079	The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis.	Shuang-Feng Zhang	2022-09-13	Stem cell reports
34547046	The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA.	Jorge Vera-Otarola	2021-09-01	PLoS pathogens

Name	Transcript ID	bp	Protein	Translation ID
EED-214	ENST00000707108	1685	406aa	ENSP00000516737
EED-207	ENST00000528180	1745	361aa	ENSP00000431778
EED-201	ENST00000263360	2088	441aa	ENSP00000263360
EED-212	ENST00000672825	2010	441aa	ENSP00000500834
EED-213	ENST00000673233	1791	501aa	ENSP00000500914
EED-202	ENST00000327320	2033	400aa	ENSP00000315587
EED-203	ENST00000351625	1696	466aa	ENSP00000338186
EED-211	ENST00000534595	713	115aa	ENSP00000436084
EED-205	ENST00000525244	1484	No protein	-
EED-209	ENST00000533228	528	No protein	-
EED-210	ENST00000534564	2767	No protein	-
EED-204	ENST00000524673	1155	No protein	-
EED-206	ENST00000527888	1422	106aa	ENSP00000437318
EED-208	ENST00000528250	1235	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000074266

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	nomascus_leucogenys	ENSNLEP00000019721	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	pan_paniscus	ENSPPAP00000039540	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	pongo_abelii	ENSPPYP00000042598	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	pan_troglodytes	ENSPTRP00000087400	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	gorilla_gorilla	ENSGGOP00000007362	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	97.5057	96.3719	ornithorhynchus_anatinus	ENSOANP00000014144	79.3358	78.4133
ENSG00000074266	homo_sapiens	ENSP00000263360	99.3197	97.9592	sarcophilus_harrisii	ENSSHAP00000041640	86.9048	85.7143
ENSG00000074266	homo_sapiens	ENSP00000263360	76.8708	76.1905	choloepus_hoffmanni	ENSCHOP00000000659	73.2181	72.5702
ENSG00000074266	homo_sapiens	ENSP00000263360	90.9297	90.2494	dasypus_novemcinctus	ENSDNOP00000019786	99.2574	98.5149
ENSG00000074266	homo_sapiens	ENSP00000263360	99.5465	99.093	dasypus_novemcinctus	ENSDNOP00000001262	93.2059	92.7813
ENSG00000074266	homo_sapiens	ENSP00000263360	98.4127	97.2789	erinaceus_europaeus	ENSEEUP00000005182	93.3333	92.2581
ENSG00000074266	homo_sapiens	ENSP00000263360	63.0385	63.0385	echinops_telfairi	ENSETEP00000014163	66.5072	66.5072
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	callithrix_jacchus	ENSCJAP00000076781	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	cercocebus_atys	ENSCATP00000016770	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	macaca_fascicularis	ENSMFAP00000028155	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	macaca_mulatta	ENSMMUP00000025774	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	macaca_nemestrina	ENSMNEP00000006578	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	papio_anubis	ENSPANP00000055784	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	mandrillus_leucophaeus	ENSMLEP00000015983	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	87.0748	87.0748	tursiops_truncatus	ENSTTRP00000011635	82.5806	82.5806
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	vulpes_vulpes	ENSVVUP00000024096	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	mus_spretus	MGP_SPRETEiJ_P0083989	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	equus_asinus	ENSEASP00005059468	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.5465	capra_hircus	ENSCHIP00000014508	99.7732	99.5465
ENSG00000074266	homo_sapiens	ENSP00000263360	93.1973	92.517	loxodonta_africana	ENSLAFP00000021138	80.5882	80
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	panthera_leo	ENSPLOP00000025357	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	ailuropoda_melanoleuca	ENSAMEP00000041897	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.7732	bos_indicus_hybrid	ENSBIXP00005010732	94.4206	94.4206
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.7732	oryctolagus_cuniculus	ENSOCUP00000016897	100	99.7732
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	equus_caballus	ENSECAP00000053485	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	canis_lupus_familiaris	ENSCAFP00845010068	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	panthera_pardus	ENSPPRP00000021119	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.7732	marmota_marmota_marmota	ENSMMMP00000005658	100	99.7732
ENSG00000074266	homo_sapiens	ENSP00000263360	96.8254	96.8254	balaenoptera_musculus	ENSBMSP00010002273	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	94.3311	94.3311	cavia_porcellus	ENSCPOP00000001643	99.7602	99.7602
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	felis_catus	ENSFCAP00000001477	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	ursus_americanus	ENSUAMP00000034278	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	99.3197	98.1859	monodelphis_domestica	ENSMODP00000005243	99.3197	98.1859
ENSG00000074266	homo_sapiens	ENSP00000263360	95.9184	95.9184	bison_bison_bison	ENSBBBP00000012571	94.4196	94.4196
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	monodon_monoceros	ENSMMNP00015020165	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	sus_scrofa	ENSSSCP00000051060	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	83.9002	83.6735	microcebus_murinus	ENSMICP00000039292	98.4043	98.1383
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.7732	microcebus_murinus	ENSMICP00000009771	94.6352	94.4206
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.7732	octodon_degus	ENSODEP00000005967	99.7732	99.7732
ENSG00000074266	homo_sapiens	ENSP00000263360	64.6258	61.9048	octodon_degus	ENSODEP00000019148	93.4426	89.5082
ENSG00000074266	homo_sapiens	ENSP00000263360	93.8775	91.8367	octodon_degus	ENSODEP00000012958	96.729	94.6262
ENSG00000074266	homo_sapiens	ENSP00000263360	99.5465	99.5465	jaculus_jaculus	ENSJJAP00000013319	99.5465	99.5465
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.5465	ovis_aries_rambouillet	ENSOARP00020017083	94.4206	94.206
ENSG00000074266	homo_sapiens	ENSP00000263360	92.9705	92.7438	ursus_maritimus	ENSUMAP00000033153	97.3872	97.1496
ENSG00000074266	homo_sapiens	ENSP00000263360	68.4807	68.254	ochotona_princeps	ENSOPRP00000012632	68.9498	68.7215
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	delphinapterus_leucas	ENSDLEP00000004011	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	physeter_catodon	ENSPCTP00005010470	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	mus_caroli	MGP_CAROLIEiJ_P0080624	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	mus_musculus	ENSMUSP00000159171	88.2	88.2
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	dipodomys_ordii	ENSDORP00000022622	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	mustela_putorius_furo	ENSMPUP00000009987	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	aotus_nancymaae	ENSANAP00000001604	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	saimiri_boliviensis_boliviensis	ENSSBOP00000006870	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	86.1678	85.941	vicugna_pacos	ENSVPAP00000001590	85.9728	85.7466
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	chlorocebus_sabaeus	ENSCSAP00000000026	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	84.5805	84.5805	tupaia_belangeri	ENSTBEP00000007305	80.2151	80.2151
ENSG00000074266	homo_sapiens	ENSP00000263360	81.8594	81.8594	mesocricetus_auratus	ENSMAUP00000021241	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	16.5533	16.5533	mesocricetus_auratus	ENSMAUP00000005256	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	phocoena_sinus	ENSPSNP00000024458	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.7732	camelus_dromedarius	ENSCDRP00005010887	94.6352	94.4206
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	carlito_syrichta	ENSTSYP00000004809	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	91.3832	91.3832	panthera_tigris_altaica	ENSPTIP00000012870	91.3832	91.3832
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	rattus_norvegicus	ENSRNOP00000024082	88.2	88.2
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.7732	prolemur_simus	ENSPSMP00000011830	94.6352	94.4206
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.5465	microtus_ochrogaster	ENSMOCP00000000556	100	99.5465
ENSG00000074266	homo_sapiens	ENSP00000263360	72.7891	72.3356	sorex_araneus	ENSSARP00000002079	92.7746	92.1965
ENSG00000074266	homo_sapiens	ENSP00000263360	99.3197	99.3197	peromyscus_maniculatus_bairdii	ENSPEMP00000021770	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.7732	bos_mutus	ENSBMUP00000025516	94.4206	94.4206
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	mus_spicilegus	ENSMSIP00000002325	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	cricetulus_griseus_chok1gshd	ENSCGRP00001002189	98.4375	98.4375
ENSG00000074266	homo_sapiens	ENSP00000263360	90.4762	90.0227	pteropus_vampyrus	ENSPVAP00000007107	85.6223	85.1931
ENSG00000074266	homo_sapiens	ENSP00000263360	85.941	84.5805	myotis_lucifugus	ENSMLUP00000013370	94.0447	92.5558
ENSG00000074266	homo_sapiens	ENSP00000263360	99.3197	97.9592	vombatus_ursinus	ENSVURP00010007950	99.3197	97.9592
ENSG00000074266	homo_sapiens	ENSP00000263360	99.5465	99.093	rhinolophus_ferrumequinum	ENSRFEP00010020069	94.206	93.7768
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	neovison_vison	ENSNVIP00000004294	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.7732	bos_taurus	ENSBTAP00000010324	99.7732	99.7732
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.7732	heterocephalus_glaber_female	ENSHGLP00000059534	87.8243	87.8243
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	rhinopithecus_bieti	ENSRBIP00000039087	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	canis_lupus_dingo	ENSCAFP00020022436	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	sciurus_vulgaris	ENSSVLP00005025854	88.0239	88.0239
ENSG00000074266	homo_sapiens	ENSP00000263360	99.3197	98.4127	phascolarctos_cinereus	ENSPCIP00000025112	99.3197	98.4127
ENSG00000074266	homo_sapiens	ENSP00000263360	82.0862	81.8594	procavia_capensis	ENSPCAP00000001290	77.8495	77.6344
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.5465	nannospalax_galili	ENSNGAP00000021026	99.7732	99.5465
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.7732	bos_grunniens	ENSBGRP00000040326	94.4206	94.4206
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	chinchilla_lanigera	ENSCLAP00000021310	100	100
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.7732	cervus_hanglu_yarkandensis	ENSCHYP00000002675	88	88
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	catagonus_wagneri	ENSCWAP00000006494	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.7732	ictidomys_tridecemlineatus	ENSSTOP00000004199	100	99.7732
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.5465	otolemur_garnettii	ENSOGAP00000019762	99.7732	99.5465
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	cebus_imitator	ENSCCAP00000001710	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.7732	urocitellus_parryii	ENSUPAP00010001668	100	99.7732
ENSG00000074266	homo_sapiens	ENSP00000263360	99.7732	99.7732	moschus_moschiferus	ENSMMSP00000014131	99.7732	99.7732
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	rhinopithecus_roxellana	ENSRROP00000018536	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	100	99.7732	mus_pahari	MGP_PahariEiJ_P0017469	100	99.7732
ENSG00000074266	homo_sapiens	ENSP00000263360	100	100	propithecus_coquereli	ENSPCOP00000021053	94.6352	94.6352
ENSG00000074266	homo_sapiens	ENSP00000263360	43.0839	24.263	caenorhabditis_elegans	C09G4.5.1	41.3943	23.3115
ENSG00000074266	homo_sapiens	ENSP00000263360	69.3878	54.195	drosophila_melanogaster	FBpp0079870	66.2338	51.7316
ENSG00000074266	homo_sapiens	ENSP00000263360	67.8005	48.9796	drosophila_melanogaster	FBpp0079907	70.3529	50.8235
ENSG00000074266	homo_sapiens	ENSP00000263360	69.161	53.0612	ciona_intestinalis	ENSCINP00000014284	71.934	55.1887
ENSG00000074266	homo_sapiens	ENSP00000263360	65.7596	59.8639	petromyzon_marinus	ENSPMAP00000001825	90.9091	82.7586
ENSG00000074266	homo_sapiens	ENSP00000263360	84.8073	76.1905	eptatretus_burgeri	ENSEBUP00000024163	85.1936	76.5376
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	90.4762	callorhinchus_milii	ENSCMIP00000033741	94.5946	89.8649
ENSG00000074266	homo_sapiens	ENSP00000263360	96.5986	95.2381	latimeria_chalumnae	ENSLACP00000015473	91.4163	90.1288
ENSG00000074266	homo_sapiens	ENSP00000263360	96.3719	92.9705	lepisosteus_oculatus	ENSLOCP00000011716	96.3719	92.9705
ENSG00000074266	homo_sapiens	ENSP00000263360	95.0113	91.3832	clupea_harengus	ENSCHAP00000051441	93.9462	90.3587
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	90.0227	danio_rerio	ENSDARP00000131820	94.8081	89.6162
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	90.7029	carassius_auratus	ENSCARP00000034509	93.3628	88.4956
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	90.4762	carassius_auratus	ENSCARP00000009076	62.7976	59.375
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	92.0635	carassius_auratus	ENSCARP00000061973	93.3333	90.2222
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	92.7438	astyanax_mexicanus	ENSAMXP00000016363	95.4649	92.7438
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	92.7438	ictalurus_punctatus	ENSIPUP00000020100	95.4751	92.5339
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.1565	esox_lucius	ENSELUP00000026134	95.0226	90.9502
ENSG00000074266	homo_sapiens	ENSP00000263360	94.7846	91.8367	electrophorus_electricus	ENSEEEP00000024550	94.3567	91.4221
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	90.7029	oncorhynchus_kisutch	ENSOKIP00005104952	94.3439	90.4977
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	90.7029	oncorhynchus_mykiss	ENSOMYP00000020870	90.4555	86.7679
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	90.7029	oncorhynchus_mykiss	ENSOMYP00000020950	89.485	85.8369
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	90.7029	salmo_salar	ENSSSAP00000035934	93.7079	89.8876
ENSG00000074266	homo_sapiens	ENSP00000263360	94.3311	90.4762	salmo_salar	ENSSSAP00000137661	87.5789	84
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	90.7029	salmo_trutta	ENSSTUP00000052243	94.3439	90.4977
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	90.7029	salmo_trutta	ENSSTUP00000091559	94.3439	90.4977
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.61	fundulus_heteroclitus	ENSFHEP00000030949	94.8081	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	91.1565	poecilia_reticulata	ENSPREP00000023484	94.1309	90.7449
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	91.61	xiphophorus_maculatus	ENSXMAP00000008172	95.0339	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.61	oryzias_latipes	ENSORLP00000034781	94.5946	90.991
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.61	oreochromis_niloticus	ENSONIP00000008996	94.8081	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.3832	haplochromis_burtoni	ENSHBUP00000024260	94.8081	90.9707
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.3832	astatotilapia_calliptera	ENSACLP00000016848	94.8081	90.9707
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	91.8367	lates_calcarifer	ENSLCAP00010022305	95.0339	91.4221
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	93.1973	xenopus_tropicalis	ENSXETP00000097103	94.5946	92.5676
ENSG00000074266	homo_sapiens	ENSP00000263360	97.5057	96.1451	chrysemys_picta_bellii	ENSCPBP00000008403	97.0655	95.7111
ENSG00000074266	homo_sapiens	ENSP00000263360	98.1859	96.5986	sphenodon_punctatus	ENSSPUP00000016220	97.7427	96.1625
ENSG00000074266	homo_sapiens	ENSP00000263360	97.7324	96.8254	crocodylus_porosus	ENSCPRP00005023117	97.5113	96.6063
ENSG00000074266	homo_sapiens	ENSP00000263360	84.127	81.4059	laticauda_laticaudata	ENSLLTP00000011641	87.2941	84.4706
ENSG00000074266	homo_sapiens	ENSP00000263360	97.9592	96.3719	notechis_scutatus	ENSNSUP00000025871	94.9451	93.4066
ENSG00000074266	homo_sapiens	ENSP00000263360	97.7324	96.3719	pseudonaja_textilis	ENSPTXP00000000314	86.7203	85.5131
ENSG00000074266	homo_sapiens	ENSP00000263360	97.7324	96.5986	anas_platyrhynchos_platyrhynchos	ENSAPLP00000012752	97.0721	95.9459
ENSG00000074266	homo_sapiens	ENSP00000263360	95.9184	95.2381	gallus_gallus	ENSGALP00010012363	99.0632	98.3607
ENSG00000074266	homo_sapiens	ENSP00000263360	98.1859	96.8254	meleagris_gallopavo	ENSMGAP00000016171	97.5225	96.1712
ENSG00000074266	homo_sapiens	ENSP00000263360	92.517	89.7959	serinus_canaria	ENSSCAP00000001901	92.7273	90
ENSG00000074266	homo_sapiens	ENSP00000263360	97.2789	96.1451	parus_major	ENSPMJP00000002219	96.8397	95.7111
ENSG00000074266	homo_sapiens	ENSP00000263360	97.9592	96.5986	anolis_carolinensis	ENSACAP00000002435	93.913	92.6087
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.61	neolamprologus_brichardi	ENSNBRP00000021516	94.8081	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	23.356	23.1293	naja_naja	ENSNNAP00000009401	97.1698	96.2264
ENSG00000074266	homo_sapiens	ENSP00000263360	23.1293	22.9025	naja_naja	ENSNNAP00000009416	100	99.0196
ENSG00000074266	homo_sapiens	ENSP00000263360	97.7324	96.1451	podarcis_muralis	ENSPMRP00000003247	92.4893	90.9871
ENSG00000074266	homo_sapiens	ENSP00000263360	92.517	90.9297	geospiza_fortis	ENSGFOP00000008512	97.6077	95.933
ENSG00000074266	homo_sapiens	ENSP00000263360	97.5057	95.9184	taeniopygia_guttata	ENSTGUP00000013370	96.8468	95.2703
ENSG00000074266	homo_sapiens	ENSP00000263360	96.1451	93.6508	erpetoichthys_calabaricus	ENSECRP00000003765	97.0252	94.508
ENSG00000074266	homo_sapiens	ENSP00000263360	95.0113	90.9297	kryptolebias_marmoratus	ENSKMAP00000004096	95.4442	91.344
ENSG00000074266	homo_sapiens	ENSP00000263360	97.7324	96.1451	salvator_merianae	ENSSMRP00000012110	95.5654	94.0133
ENSG00000074266	homo_sapiens	ENSP00000263360	93.8775	90.0227	oryzias_javanicus	ENSOJAP00000047030	93.0337	89.2135
ENSG00000074266	homo_sapiens	ENSP00000263360	78.0045	75.5102	amphilophus_citrinellus	ENSACIP00000031196	96.3585	93.2773
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	90.2494	dicentrarchus_labrax	ENSDLAP00005062849	95.2055	90.8676
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	91.8367	amphiprion_percula	ENSAPEP00000011360	85.947	82.4847
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	91.8367	oryzias_sinensis	ENSOSIP00000050992	94.8198	91.2162
ENSG00000074266	homo_sapiens	ENSP00000263360	90.7029	90.0227	pelodiscus_sinensis	ENSPSIP00000012241	99.0099	98.2673
ENSG00000074266	homo_sapiens	ENSP00000263360	58.2766	55.7823	gopherus_evgoodei	ENSGEVP00005003116	84.8185	81.1881
ENSG00000074266	homo_sapiens	ENSP00000263360	97.2789	95.9184	chelonoidis_abingdonii	ENSCABP00000026707	96.8397	95.4853
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	91.61	seriola_dumerili	ENSSDUP00000015795	95.0339	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	90.9297	cottoperca_gobio	ENSCGOP00000031293	94.8081	90.5192
ENSG00000074266	homo_sapiens	ENSP00000263360	93.6508	91.61	struthio_camelus_australis	ENSSCUP00000006318	93.6508	91.61
ENSG00000074266	homo_sapiens	ENSP00000263360	90.7029	90.0227	anser_brachyrhynchus	ENSABRP00000005517	99.2556	98.5112
ENSG00000074266	homo_sapiens	ENSP00000263360	92.0635	87.5283	gasterosteus_aculeatus	ENSGACP00000019715	91.4414	86.9369
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	90.9297	cynoglossus_semilaevis	ENSCSEP00000001232	95.2596	90.5192
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.61	poecilia_formosa	ENSPFOP00000014889	94.8081	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.61	myripristis_murdjan	ENSMMDP00005015429	94.8081	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	95.9184	95.2381	strigops_habroptila	ENSSHBP00005018661	99.0632	98.3607
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	91.8367	amphiprion_ocellaris	ENSAOCP00000026563	95.2596	91.4221
ENSG00000074266	homo_sapiens	ENSP00000263360	97.5057	96.1451	terrapene_carolina_triunguis	ENSTMTP00000022830	96.6292	95.2809
ENSG00000074266	homo_sapiens	ENSP00000263360	46.2585	44.6712	terrapene_carolina_triunguis	ENSTMTP00000016879	91.8919	88.7387
ENSG00000074266	homo_sapiens	ENSP00000263360	94.7846	90.9297	hucho_hucho	ENSHHUP00000085094	94.5701	90.724
ENSG00000074266	homo_sapiens	ENSP00000263360	94.7846	90.9297	hucho_hucho	ENSHHUP00000083911	94.5701	90.724
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	90.7029	betta_splendens	ENSBSLP00000001342	95.0339	90.2935
ENSG00000074266	homo_sapiens	ENSP00000263360	95.0113	91.61	pygocentrus_nattereri	ENSPNAP00000005659	95.0113	91.61
ENSG00000074266	homo_sapiens	ENSP00000263360	66.4399	52.6077	ciona_savignyi	ENSCSAVP00000008464	75.5155	59.7938
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	91.61	seriola_lalandi_dorsalis	ENSSLDP00000010803	95.0339	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.1565	labrus_bergylta	ENSLBEP00000008217	94.8081	90.7449
ENSG00000074266	homo_sapiens	ENSP00000263360	86.8481	83.22	pundamilia_nyererei	ENSPNYP00000011012	95.2736	91.2935
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	91.8367	stegastes_partitus	ENSSPAP00000031162	95.0339	91.4221
ENSG00000074266	homo_sapiens	ENSP00000263360	21.542	20.6349	oncorhynchus_tshawytscha	ENSOTSP00005039589	94.0594	90.099
ENSG00000074266	homo_sapiens	ENSP00000263360	86.6213	81.4059	oncorhynchus_tshawytscha	ENSOTSP00005099278	85.0779	79.9555
ENSG00000074266	homo_sapiens	ENSP00000263360	85.941	81.4059	oncorhynchus_tshawytscha	ENSOTSP00005099245	86.5297	81.9635
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	91.8367	acanthochromis_polyacanthus	ENSAPOP00000018226	95.0339	91.4221
ENSG00000074266	homo_sapiens	ENSP00000263360	97.7324	96.3719	aquila_chrysaetos_chrysaetos	ENSACCP00020013249	88.866	87.6289
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	91.61	nothobranchius_furzeri	ENSNFUP00015025283	96.5675	92.4485
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.3832	cyprinodon_variegatus	ENSCVAP00000027768	94.8081	90.9707
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.61	denticeps_clupeoides	ENSDCDP00000061961	88.0503	84.696
ENSG00000074266	homo_sapiens	ENSP00000263360	95.4649	91.61	larimichthys_crocea	ENSLCRP00005055399	92.3246	88.5965
ENSG00000074266	homo_sapiens	ENSP00000263360	90.7029	89.5692	ficedula_albicollis	ENSFALP00000008018	97.561	96.3415
ENSG00000074266	homo_sapiens	ENSP00000263360	94.5578	90.7029	hippocampus_comes	ENSHCOP00000014568	94.1309	90.2935
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.8367	cyprinus_carpio_carpio	ENSCCRP00000095776	89.172	85.9873
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	91.1565	cyprinus_carpio_carpio	ENSCCRP00000001813	96.347	91.7808
ENSG00000074266	homo_sapiens	ENSP00000263360	97.7324	96.3719	coturnix_japonica	ENSCJPP00005004424	97.0721	95.7207
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.61	poecilia_latipinna	ENSPLAP00000008867	94.8081	91.1964
ENSG00000074266	homo_sapiens	ENSP00000263360	95.0113	91.1565	sinocyclocheilus_grahami	ENSSGRP00000012645	93.3185	89.5323
ENSG00000074266	homo_sapiens	ENSP00000263360	23.356	22.449	sinocyclocheilus_grahami	ENSSGRP00000018095	97.1698	93.3962
ENSG00000074266	homo_sapiens	ENSP00000263360	95.2381	91.3832	maylandia_zebra	ENSMZEP00005020638	94.8081	90.9707
ENSG00000074266	homo_sapiens	ENSP00000263360	95.6916	91.3832	tetraodon_nigroviridis	ENSTNIP00000004051	95.045	90.7658
ENSG00000074266	homo_sapiens	ENSP00000263360	95.9184	92.7438	paramormyrops_kingsleyae	ENSPKIP00000011148	95.9184	92.7438
ENSG00000074266	homo_sapiens	ENSP00000263360	95.9184	92.9705	scleropages_formosus	ENSSFOP00015036803	95.0562	92.1348
ENSG00000074266	homo_sapiens	ENSP00000263360	96.3719	94.5578	leptobrachium_leishanense	ENSLLEP00000005956	77.5547	76.0949
ENSG00000074266	homo_sapiens	ENSP00000263360	94.3311	89.3424	scophthalmus_maximus	ENSSMAP00000049666	93.2735	88.3408
ENSG00000074266	homo_sapiens	ENSP00000263360	76.644	74.3764	oryzias_melastigma	ENSOMEP00000018932	94.1504	91.3649

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0001222	enables transcription corepressor binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005694	located_in chromosome	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006338	involved_in chromatin remodeling	1	IEA	Homo_sapiens(9606)	Process
GO:0008047	enables enzyme activator activity	1	IMP	Homo_sapiens(9606)	Function
GO:0021510	involved_in spinal cord development	1	IEA	Homo_sapiens(9606)	Process
GO:0031491	contributes_to nucleosome binding	1	IBA	Homo_sapiens(9606)	Function
GO:0035098	part_of ESC/E(Z) complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0042054	enables histone methyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	NAS	Homo_sapiens(9606)	Process