RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Description

Ensembl ID	ENSG00000074201	Gene ID	1207	Accession	2080
Symbol	CLNS1A	Alias	CLCI;ICln;CLNS1B	Full Name	chloride nucleotide-sensitive channel 1A
Status	Confidence	Length	122859 bases	Strand	Minus strand
Position	11 : 77514936 - 77637794	RNA binding domain	N.A.
Summary	This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
CLNS1A-206	ENST00000526761	415	22aa	ENSP00000475218
CLNS1A-212	ENST00000533957	369	No protein	-
CLNS1A-204	ENST00000525428	2982	237aa	ENSP00000433919
CLNS1A-201	ENST00000263309	1172	203aa	ENSP00000263309
CLNS1A-202	ENST00000525064	1121	179aa	ENSP00000433741
CLNS1A-205	ENST00000526009	747	23aa	ENSP00000436245
CLNS1A-211	ENST00000532069	898	167aa	ENSP00000434963
CLNS1A-210	ENST00000528364	953	237aa	ENSP00000434311
CLNS1A-209	ENST00000527299	387	No protein	-
CLNS1A-207	ENST00000527133	667	49aa	ENSP00000432570
CLNS1A-203	ENST00000525359	283	No protein	-
CLNS1A-208	ENST00000527265	620	No protein	-

Gene Model

Click here to download ENSG00000074201's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000074201's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000387	involved_in spliceosomal snRNP assembly	3	IBA,IDA,NAS	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005681	part_of spliceosomal complex	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005856	located_in cytoskeleton	1	IEA	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0006821	involved_in chloride transport	1	IEA	Homo_sapiens(9606)	Process
GO:0006884	involved_in cell volume homeostasis	1	IEA	Homo_sapiens(9606)	Process
GO:0034709	part_of methylosome	1	IDA	Homo_sapiens(9606)	Component
GO:0034715	part_of pICln-Sm protein complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0043985	involved_in histone H4-R3 methylation	1	NAS	Homo_sapiens(9606)	Process
GO:0045292	involved_in mRNA cis splicing, via spliceosome	1	IBA	Homo_sapiens(9606)	Process
GO:0048026	involved_in positive regulation of mRNA splicing, via spliceosome	1	NAS	Homo_sapiens(9606)	Process

Expression