RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000068383	Gene ID	3632	Accession	6076
Symbol	INPP5A	Alias	5PTASE	Full Name	inositol polyphosphate-5-phosphatase A
Status	Confidence	Length	245694 bases	Strand	Plus strand
Position	10 : 132537787 - 132783480	RNA binding domain	Exo_endo_phos
Summary	The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000357583	Exo_endo_phos	PF03372	1.9e-20	1
ENSP00000357582	Exo_endo_phos	PF03372	1.9e-17	1
ENSP00000340707	Exo_endo_phos	PF03372	2.1e-15	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
INPP5A-203	ENST00000368594	3000	412aa	ENSP00000357583
INPP5A-202	ENST00000368593	1432	387aa	ENSP00000357582
INPP5A-204	ENST00000423490	416	138aa	ENSP00000390936
INPP5A-201	ENST00000342652	832	278aa	ENSP00000340707
INPP5A-206	ENST00000487614	870	No protein	-
INPP5A-207	ENST00000498337	565	No protein	-
INPP5A-205	ENST00000445580	610	104aa	ENSP00000390749

Gene Model

Click here to download ENSG00000068383's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
51689	Autistic Disorder	8.0093000E-006	-
51778	Autistic Disorder	4.1675000E-005	-
64402	Migraine Disorders	2E-8	27182965
82289	Cholangitis, Sclerosing	1E-8	27992413
86634	Gestational Age	7E-6	27490719
86635	Live Birth	7E-6	27490719
98586	Gestational Age	2E-6	27490719
98587	Live Birth	2E-6	27490719
101327	Gait	3E-6	28077804

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000068383's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004445	enables inositol-polyphosphate 5-phosphatase activity	3	IBA,IDA,NAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005886	located_in plasma membrane	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0016020	located_in membrane	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0030425	located_in dendrite	1	ISS	Homo_sapiens(9606)	Component
GO:0042731	enables PH domain binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043647	involved_in inositol phosphate metabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0046856	involved_in phosphatidylinositol dephosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0048015	involved_in phosphatidylinositol-mediated signaling	1	ISS	Homo_sapiens(9606)	Process
GO:0048016	involved_in inositol phosphate-mediated signaling	1	IBA	Homo_sapiens(9606)	Process
GO:0052658	enables inositol-1,4,5-trisphosphate 5-phosphatase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0052659	enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	1	IEA	Homo_sapiens(9606)	Function

Expression