Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerCHIKVSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions TF
Localizations Stress granucleP-body
BulkPerturb-seq DataSet_02_121 DataSet_02_122

Description

Ensembl ID ENSG00000065978 Gene ID 4904 Accession 8014
Symbol YBX1 Alias YB1;BP-8;CSDB;DBPB;YB-1;CBF-A;CSDA2;EFI-A;NSEP1;NSEP-1;MDR-NF1 Full Name Y-box binding protein 1
Status Confidence Length 21388 bases Strand Plus strand
Position 1 : 42682418 - 42703805 RNA binding domain CSD
Summary This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000361626 CSD PF00313 1.9e-25 1
ENSP00000389639 CSD PF00313 5.8e-13 1
ENSP00000405937 CSD PF00313 7.4e-12 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37378715 Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo. Eshita Varma 2023-06-28 Basic research in cardiology
36969033 The lncRNA epigenetics: The significance of m6A and m5C lncRNA modifications in cancer. Ylenia Vincenza Cusenza 2023-01-01 Frontiers in oncology
31358880 Altered transcriptional regulatory proteins in glioblastoma and YBX1 as a potential regulator of tumor invasion. Kumar Manoj Gupta 2019-07-29 Scientific reports
26843810 Beyond the Ribosome: Extra-translational Functions of tRNA Fragments. W Kevin Diebel 2016-01-01 Biomarker insights
29808089 Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases. C A Margherita Pomatto 2018-01-01 International journal of endocrinology
27559612 Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction. J Matthew Shurtleff 2016-08-25 eLife
29712925 The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level. Eunjeong Kwon 2018-04-30 Nature communications
28257101 Exosomes: From Garbage Bins to Promising Therapeutic Targets. Mohammed M H 2017-03-02 International journal of molecular sciences
31355251 Whole Genome Analysis and Prognostic Model Construction Based on Alternative Splicing Events in Endometrial Cancer. Caixia Wang 2019-01-01 BioMed research international
25784054 The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion. Guramrit Singh 2015-01-01 Annual review of biochemistry
35961977 A miR-34a-guided, tRNAiMet-derived, piR_019752-like fragment (tRiMetF31) suppresses migration and angiogenesis of breast cancer cells via targeting PFKFB3. Bo Wang 2022-08-12 Cell death discovery
36387119 Plasma exosomal tRNA-derived fragments as diagnostic biomarkers in non-small cell lung cancer. Baibing Zheng 2022-01-01 Frontiers in oncology
29685978 Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer? J David Hanly 2018-06-05 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
32585856 YBX1 Indirectly Targets Heterochromatin-Repressed Inflammatory Response-Related Apoptosis Genes through Regulating CBX5 mRNA. Andreas Kloetgen 2020-06-23 International journal of molecular sciences
34533860 LncRNA BASP1-AS1 interacts with YBX1 to regulate Notch transcription and drives the malignancy of melanoma. YaLing Li 2021-11-01 Cancer science
33446492 Comprehensive annotation and characterization of planarian tRNA and tRNA-derived fragments (tRFs). Vairavan Lakshmanan 2021-04-01 RNA (New York, N.Y.)
32947897 Long Non-Coding RNAs as Strategic Molecules to Augment the Radiation Therapy in Esophageal Squamous Cell Carcinoma. Uttam Sharma 2020-09-16 International journal of molecular sciences
34465866 YBX1 mediates translation of oncogenic transcripts to control cell competition in AML. Florian Perner 2022-02-01 Leukemia
28872613 Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells. Hsiang-Cheng Chi 2017-09-05 International journal of molecular sciences
37502906 Analysis of small EV proteomes reveals unique functional protein networks regulated by VAP-A. Bahnisikha Barman 2023-07-19 bioRxiv : the preprint server for biology
36389669 RNA m5C regulator-mediated modification patterns and the cross-talk between tumor microenvironment infiltration in gastric cancer. Qiang Zhang 2022-01-01 Frontiers in immunology
32178290 Aurora Kinase A-YBX1 Synergy Fuels Aggressive Oncogenic Phenotypes and Chemoresistance in Castration-Resistant Prostate Cancer. Kumar Nikhil 2020-03-12 Cancers
36642732 Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1. Ruifan Wu 2023-01-16 Cell death & disease
25959498 lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer. Yongchao Liu 2015-05-11 Scientific reports
36533073 Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation. Zhen Yang 2022-01-01 Frontiers in molecular biosciences
29388131 Extracellular RNAs: A New Awareness of Old Perspectives. Noah Sadik 2018-01-01 Methods in molecular biology (Clifton, N.J.)
29180470 ERα Binding by Transcription Factors NFIB and YBX1 Enables FGFR2 Signaling to Modulate Estrogen Responsiveness in Breast Cancer. M Thomas Campbell 2018-01-15 Cancer research
20428086 Pharmacogenomic identification of c-Myc/Max-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell lines. Serkan Sertel 2010-04-22 Molecules (Basel, Switzerland)
32354721 5-methylcytosine modification of an Epstein-Barr virus noncoding RNA decreases its stability. A Belle Henry 2020-08-01 RNA (New York, N.Y.)
27015120 A comprehensive repertoire of tRNA-derived fragments in prostate cancer. Michael Olvedy 2016-04-26 Oncotarget
26307974 Regulatory Roles of Non-Coding RNAs in Colorectal Cancer. Jun Wang 2015-08-21 International journal of molecular sciences
33391635 RNA packaging into extracellular vesicles: An orchestra of RNA-binding proteins? Fabrizio Fabbiano 2020-12-01 Journal of extracellular vesicles
36881772 LncRNA HOTAIRM1 functions in DNA double-strand break repair via its association with DNA repair and mRNA surveillance factors. Tzu-Wei Chuang 2023-04-24 Nucleic acids research
34660788 Methylation Modification, Alternative Splicing, and Noncoding RNA Play a Role in Cancer Metastasis through Epigenetic Regulation. Bin Yu 2021-01-01 BioMed research international
36754932 YBX1/lncRNA SBF2-AS1 interaction regulates proliferation and tamoxifen sensitivity via PI3K/AKT/MTOR signaling in breast cancer cells. A Shaharbhanu Hussain 2023-04-01 Molecular biology reports
35109938 YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development. Mingtian Deng 2022-02-02 Cell & bioscience
35861369 Genetic variants in RNA m5 C modification genes associated with survival and chemotherapy efficacy of colorectal cancer. Silu Chen 2023-01-01 Cancer medicine
29073095 Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. J Matthew Shurtleff 2017-10-24 Proceedings of the National Academy of Sciences of the United States of America
27216562 Genetically engineered pre-microRNA-34a prodrug suppresses orthotopic osteosarcoma xenograft tumor growth via the induction of apoptosis and cell cycle arrest. Yong Zhao 2016-05-24 Scientific reports

Transcripts

Name Transcript ID bp Protein Translation ID
YBX1-201 ENST00000321358 2979 324aa ENSP00000361626
YBX1-202 ENST00000332220 776 216aa ENSP00000405937
YBX1-203 ENST00000436427 1524 374aa ENSP00000389639
YBX1-204 ENST00000467957 770 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000065978homo_sapiensENSP0000000769949.450640.9341homo_sapiensENSP0000036162655.555645.9877
ENSG00000065978homo_sapiensENSP0000036331450.717735.8852homo_sapiensENSP0000036162632.71623.1481
ENSG00000065978homo_sapiensENSP0000034440145.233.2homo_sapiensENSP0000036162634.876525.6173
ENSG00000065978homo_sapiensENSP0000022825155.91450homo_sapiensENSP0000036162664.197557.4074

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000065978homo_sapiensENSP00000361626100100nomascus_leucogenysENSNLEP00000014964100100
ENSG00000065978homo_sapiensENSP00000361626100100pan_paniscusENSPPAP00000014831100100
ENSG00000065978homo_sapiensENSP00000361626100100pongo_abeliiENSPPYP00000001698100100
ENSG00000065978homo_sapiensENSP0000036162693.209991.0494pan_troglodytesENSPTRP0000007882192.073289.939
ENSG00000065978homo_sapiensENSP0000036162631.790130.5556pan_troglodytesENSPTRP0000007600182.479.2
ENSG00000065978homo_sapiensENSP0000036162693.209991.0494pan_troglodytesENSPTRP0000007856592.073289.939
ENSG00000065978homo_sapiensENSP0000036162690.123588.8889gorilla_gorillaENSGGOP0000002435792.993691.7197
ENSG00000065978homo_sapiensENSP0000036162695.67994.4444ornithorhynchus_anatinusENSOANP0000003917490.116388.9535
ENSG00000065978homo_sapiensENSP0000036162688.580286.4198sarcophilus_harrisiiENSSHAP0000001700087.585.3659
ENSG00000065978homo_sapiensENSP0000036162645.061744.1358notamacropus_eugeniiENSMEUP0000000901059.109357.8947
ENSG00000065978homo_sapiensENSP0000036162689.197588.8889dasypus_novemcinctusENSDNOP0000001782899.655299.3103
ENSG00000065978homo_sapiensENSP00000361626100100callithrix_jacchusENSCJAP00000005817100100
ENSG00000065978homo_sapiensENSP00000361626100100cercocebus_atysENSCATP00000004796100100
ENSG00000065978homo_sapiensENSP0000036162634.876532.4074macaca_fascicularisENSMFAP0000004380990.484
ENSG00000065978homo_sapiensENSP00000361626100100macaca_mulattaENSMMUP00000017257100100
ENSG00000065978homo_sapiensENSP0000036162683.024778.7037macaca_nemestrinaENSMNEP0000002083184.591280.1887
ENSG00000065978homo_sapiensENSP0000036162680.555678.3951macaca_nemestrinaENSMNEP0000003742890.62588.1944
ENSG00000065978homo_sapiensENSP00000361626100100papio_anubisENSPANP00000011056100100
ENSG00000065978homo_sapiensENSP0000036162672.839570.3704mandrillus_leucophaeusENSMLEP0000003292884.285781.4286
ENSG00000065978homo_sapiensENSP0000036162675.308670.3704mandrillus_leucophaeusENSMLEP0000002707186.524880.8511
ENSG00000065978homo_sapiensENSP0000036162698.765498.7654equus_asinusENSEASP0000504774481.424981.4249
ENSG00000065978homo_sapiensENSP0000036162699.691499.3827capra_hircusENSCHIP0000001240899.691499.3827
ENSG00000065978homo_sapiensENSP0000036162695.987795.3704capra_hircusENSCHIP0000000145099.679599.0385
ENSG00000065978homo_sapiensENSP00000361626100100panthera_leoENSPLOP00000014332100100
ENSG00000065978homo_sapiensENSP00000361626100100bos_indicus_hybridENSBIXP00005001416100100
ENSG00000065978homo_sapiensENSP0000036162638.580238.2716oryctolagus_cuniculusENSOCUP0000003417798.425297.6378
ENSG00000065978homo_sapiensENSP0000036162671.604969.1358equus_caballusENSECAP0000003422080.276877.5087
ENSG00000065978homo_sapiensENSP0000036162693.209992.5926canis_lupus_familiarisENSCAFP0084502894094.968694.3396
ENSG00000065978homo_sapiensENSP00000361626100100canis_lupus_familiarisENSCAFP00845022602100100
ENSG00000065978homo_sapiensENSP00000361626100100panthera_pardusENSPPRP00000024323100100
ENSG00000065978homo_sapiensENSP00000361626100100balaenoptera_musculusENSBMSP00010014258100100
ENSG00000065978homo_sapiensENSP0000036162650.925944.1358felis_catusENSFCAP0000005816661.567253.3582
ENSG00000065978homo_sapiensENSP0000036162668.827264.5062ursus_americanusENSUAMP0000002380371.704267.2026
ENSG00000065978homo_sapiensENSP0000036162698.765497.8395monodelphis_domesticaENSMODP0000002148098.765497.8395
ENSG00000065978homo_sapiensENSP00000361626100100monodon_monocerosENSMMNP00015010297100100
ENSG00000065978homo_sapiensENSP0000036162659.876555.5556sus_scrofaENSSSCP0000008032970.545565.4545
ENSG00000065978homo_sapiensENSP0000036162691.975391.0494microcebus_murinusENSMICP0000004109191.975391.0494
ENSG00000065978homo_sapiensENSP0000036162687.345785.1852microcebus_murinusENSMICP0000004613089.55787.3418
ENSG00000065978homo_sapiensENSP0000036162683.950681.7901octodon_degusENSODEP0000000542290.365488.0399
ENSG00000065978homo_sapiensENSP0000036162674.074171.6049jaculus_jaculusENSJJAP0000001774390.56687.5472
ENSG00000065978homo_sapiensENSP0000036162675.308672.5309jaculus_jaculusENSJJAP0000000187786.832783.6299
ENSG00000065978homo_sapiensENSP0000036162610099.6914ovis_aries_rambouilletENSOARP0002000027210099.6914
ENSG00000065978homo_sapiensENSP0000036162690.123589.8148ovis_aries_rambouilletENSOARP0002002332665.470965.2466
ENSG00000065978homo_sapiensENSP00000361626100100physeter_catodonENSPCTP00005028082100100
ENSG00000065978homo_sapiensENSP0000036162630.555629.321aotus_nancymaaeENSANAP0000003371593.396289.6226
ENSG00000065978homo_sapiensENSP0000036162636.728436.4198aotus_nancymaaeENSANAP0000002766994.444493.6508
ENSG00000065978homo_sapiensENSP0000036162633.64233.0247aotus_nancymaaeENSANAP0000003591993.162491.453
ENSG00000065978homo_sapiensENSP0000036162678.086475.6173aotus_nancymaaeENSANAP0000002663989.084586.2676
ENSG00000065978homo_sapiensENSP0000036162633.950632.0988saimiri_boliviensis_boliviensisENSSBOP0000002294994.017188.8889
ENSG00000065978homo_sapiensENSP0000036162699.691499.6914phocoena_sinusENSPSNP0000000206399.691499.6914
ENSG00000065978homo_sapiensENSP0000036162699.691499.6914phocoena_sinusENSPSNP0000001513899.691499.6914
ENSG00000065978homo_sapiensENSP0000036162676.234674.6914camelus_dromedariusENSCDRP0000501198893.916492.0152
ENSG00000065978homo_sapiensENSP0000036162670.987766.358carlito_syrichtaENSTSYP0000001372487.786382.0611
ENSG00000065978homo_sapiensENSP0000036162662.03758.9506rattus_norvegicusENSRNOP0000007993772.563268.9531
ENSG00000065978homo_sapiensENSP0000036162671.604970.0617prolemur_simusENSPSMP0000002550388.888986.9732
ENSG00000065978homo_sapiensENSP0000036162687.03783.9506sorex_araneusENSSARP0000001140485.196482.1752
ENSG00000065978homo_sapiensENSP0000036162680.555678.7037peromyscus_maniculatus_bairdiiENSPEMP0000001065393.214391.0714
ENSG00000065978homo_sapiensENSP0000036162636.728435.8025peromyscus_maniculatus_bairdiiENSPEMP0000003598793.700891.3386
ENSG00000065978homo_sapiensENSP0000036162636.419835.1852mus_spicilegusENSMSIP0000000227295.161391.9355
ENSG00000065978homo_sapiensENSP0000036162699.074198.7654cricetulus_griseus_chok1gshdENSCGRP0000100236099.689499.3789
ENSG00000065978homo_sapiensENSP0000036162629.012326.5432vombatus_ursinusENSVURP0001002829978.991672.2689
ENSG00000065978homo_sapiensENSP00000361626100100rhinolophus_ferrumequinumENSRFEP00010008720100100
ENSG00000065978homo_sapiensENSP00000361626100100bos_taurusENSBTAP00000023094100100
ENSG00000065978homo_sapiensENSP0000036162671.296367.284rhinopithecus_bietiENSRBIP0000002167985.873681.0409
ENSG00000065978homo_sapiensENSP0000036162683.950683.642canis_lupus_dingoENSCAFP0002003207498.550798.1884
ENSG00000065978homo_sapiensENSP00000361626100100canis_lupus_dingoENSCAFP0002003088499.082699.0826
ENSG00000065978homo_sapiensENSP0000036162698.765497.8395phascolarctos_cinereusENSPCIP0000001139298.765497.8395
ENSG00000065978homo_sapiensENSP0000036162670.987767.5926nannospalax_galiliENSNGAP0000000151787.452583.27
ENSG00000065978homo_sapiensENSP0000036162689.506289.5062cervus_hanglu_yarkandensisENSCHYP0000003145185.545785.5457
ENSG00000065978homo_sapiensENSP0000036162664.197560.1852otolemur_garnettiiENSOGAP0000001631175.636470.9091
ENSG00000065978homo_sapiensENSP0000036162657.71654.321otolemur_garnettiiENSOGAP0000001791485.779880.7339
ENSG00000065978homo_sapiensENSP0000036162685.185282.716cebus_imitatorENSCCAP0000001366688.178985.623
ENSG00000065978homo_sapiensENSP0000036162678.395175.9259moschus_moschiferusENSMMSP0000002253284.385481.7276
ENSG00000065978homo_sapiensENSP0000036162671.913667.9012rhinopithecus_roxellanaENSRROP0000001167586.296381.4815
ENSG00000065978homo_sapiensENSP0000036162668.827265.4321rhinopithecus_roxellanaENSRROP0000000976885.769281.5385
ENSG00000065978homo_sapiensENSP0000036162632.098832.0988propithecus_coquereliENSPCOP0000000635883.87183.871
ENSG00000065978homo_sapiensENSP0000036162641.049431.1728caenorhabditis_elegansY39A1C.3.145.238134.3537
ENSG00000065978homo_sapiensENSP0000036162634.876524.6914caenorhabditis_elegansF46F11.2.142.322129.9625
ENSG00000065978homo_sapiensENSP0000036162637.345725.6173caenorhabditis_elegansM01E11.5.145.660431.3208
ENSG00000065978homo_sapiensENSP0000036162625.308616.6667drosophila_melanogasterFBpp007679842.051327.6923
ENSG00000065978homo_sapiensENSP0000036162624.382715.7407ciona_intestinalisENSCINP0000003271540.721626.2887
ENSG00000065978homo_sapiensENSP0000036162644.753140.7407eptatretus_burgeriENSEBUP0000001176339.083635.5795
ENSG00000065978homo_sapiensENSP0000036162673.765466.0494callorhinchus_miliiENSCMIP0000001707978.360770.1639
ENSG00000065978homo_sapiensENSP0000036162681.481576.2346latimeria_chalumnaeENSLACP0000002063986.557480.9836
ENSG00000065978homo_sapiensENSP0000036162679.938373.7654lepisosteus_oculatusENSLOCP0000000298583.279776.8489
ENSG00000065978homo_sapiensENSP0000036162679.32170.9877danio_rerioENSDARP0000001048283.171574.4337
ENSG00000065978homo_sapiensENSP0000036162679.32171.2963carassius_auratusENSCARP0000005257182.371874.0385
ENSG00000065978homo_sapiensENSP0000036162677.469169.1358carassius_auratusENSCARP0000008386878.193169.7819
ENSG00000065978homo_sapiensENSP0000036162679.32171.6049astyanax_mexicanusENSAMXP0000001489882.371874.359
ENSG00000065978homo_sapiensENSP0000036162678.086471.6049ictalurus_punctatusENSIPUP0000003243381.350574.5981
ENSG00000065978homo_sapiensENSP0000036162670.987764.5062esox_luciusENSELUP0000000532175.657968.75
ENSG00000065978homo_sapiensENSP0000036162677.777870.0617electrophorus_electricusENSEEEP0000004105080.769272.7564
ENSG00000065978homo_sapiensENSP0000036162669.753162.3457oncorhynchus_kisutchENSOKIP0000504667063.128556.4246
ENSG00000065978homo_sapiensENSP0000036162670.370463.5802oncorhynchus_kisutchENSOKIP0000506942774.754167.541
ENSG00000065978homo_sapiensENSP0000036162670.67962.037oncorhynchus_mykissENSOMYP0000003793572.012663.2075
ENSG00000065978homo_sapiensENSP000003616267566.358oncorhynchus_mykissENSOMYP0000004608775.700966.9782
ENSG00000065978homo_sapiensENSP0000036162659.567951.8519salmo_salarENSSSAP0000001520269.424560.4317
ENSG00000065978homo_sapiensENSP0000036162675.617368.2099salmo_salarENSSSAP0000007276475.153467.7914
ENSG00000065978homo_sapiensENSP0000036162675.617368.2099salmo_truttaENSSTUP0000009922076.08768.6335
ENSG00000065978homo_sapiensENSP0000036162674.691466.358salmo_truttaENSSTUP0000003808875.389466.9782
ENSG00000065978homo_sapiensENSP0000036162662.96354.9383gadus_morhuaENSGMOP0000003144361.631453.7764
ENSG00000065978homo_sapiensENSP0000036162671.604966.0494fundulus_heteroclitusENSFHEP0000000132576.567770.6271
ENSG00000065978homo_sapiensENSP0000036162673.148166.6667poecilia_reticulataENSPREP0000002529479.264272.2408
ENSG00000065978homo_sapiensENSP0000036162673.148166.6667xiphophorus_maculatusENSXMAP0000001872678.217871.2871
ENSG00000065978homo_sapiensENSP0000036162672.839566.358oryzias_latipesENSORLP0000000529177.124270.2614
ENSG00000065978homo_sapiensENSP0000036162670.987764.8148cyclopterus_lumpusENSCLMP0000500587072.32766.0377
ENSG00000065978homo_sapiensENSP0000036162668.827261.4198oreochromis_niloticusENSONIP0000003772273.114865.2459
ENSG00000065978homo_sapiensENSP0000036162672.530966.358haplochromis_burtoniENSHBUP0000000854577.302670.7237
ENSG00000065978homo_sapiensENSP0000036162678.086470.679astatotilapia_callipteraENSACLP0000003349478.816271.3396
ENSG00000065978homo_sapiensENSP0000036162670.987763.5802sparus_aurataENSSAUP0001000142975.907667.9868
ENSG00000065978homo_sapiensENSP0000036162640.740736.1111sparus_aurataENSSAUP0001006230262.264255.1887
ENSG00000065978homo_sapiensENSP0000036162678.086470.9877lates_calcariferENSLCAP0001005907878.571471.4286
ENSG00000065978homo_sapiensENSP0000036162686.111180.8642xenopus_tropicalisENSXETP0000002944387.187581.875
ENSG00000065978homo_sapiensENSP0000036162655.246946.2963chrysemys_picta_belliiENSCPBP0000000205659.666750
ENSG00000065978homo_sapiensENSP0000036162695.370491.6667sphenodon_punctatusENSSPUP0000001200691.150487.6106
ENSG00000065978homo_sapiensENSP0000036162652.160539.8148crocodylus_porosusENSCPRP0000500353355.592142.4342
ENSG00000065978homo_sapiensENSP0000036162692.592688.5802laticauda_laticaudataENSLLTP0000000608686.705282.948
ENSG00000065978homo_sapiensENSP0000036162692.592688.5802notechis_scutatusENSNSUP0000002597686.705282.948
ENSG00000065978homo_sapiensENSP0000036162692.592688.5802pseudonaja_textilisENSPTXP0000002263286.705282.948
ENSG00000065978homo_sapiensENSP0000036162694.444491.358anas_platyrhynchos_platyrhynchosENSAPLP0000003019579.069876.4858
ENSG00000065978homo_sapiensENSP0000036162691.975389.1975gallus_gallusENSGALP0001002508190.853788.1098
ENSG00000065978homo_sapiensENSP0000036162680.555677.7778meleagris_gallopavoENSMGAP0000000700581.818278.9969
ENSG00000065978homo_sapiensENSP0000036162675.925972.5309serinus_canariaENSSCAP0000002271496.093891.7969
ENSG00000065978homo_sapiensENSP0000036162695.061791.6667parus_majorENSPMJP0000000347896.2592.8125
ENSG00000065978homo_sapiensENSP0000036162672.530966.358neolamprologus_brichardiENSNBRP0000000398978.333371.6667
ENSG00000065978homo_sapiensENSP0000036162694.444491.358podarcis_muralisENSPMRP0000003164585.714382.9132
ENSG00000065978homo_sapiensENSP0000036162638.271636.4198geospiza_fortisENSGFOP0000001522498.412793.6508
ENSG00000065978homo_sapiensENSP0000036162695.061791.6667taeniopygia_guttataENSTGUP0000001754395.061791.6667
ENSG00000065978homo_sapiensENSP0000036162680.246974.6914erpetoichthys_calabaricusENSECRP0000001606782.539776.8254
ENSG00000065978homo_sapiensENSP0000036162673.456866.0494kryptolebias_marmoratusENSKMAP0000001748178.547970.6271
ENSG00000065978homo_sapiensENSP0000036162693.518590.7407salvator_merianaeENSSMRP0000000992887.572384.9711
ENSG00000065978homo_sapiensENSP0000036162678.086470.0617oryzias_javanicusENSOJAP0000003579277.607469.6319
ENSG00000065978homo_sapiensENSP0000036162667.28457.0988amphilophus_citrinellusENSACIP0000002897067.701957.4534
ENSG00000065978homo_sapiensENSP0000036162676.851969.7531dicentrarchus_labraxENSDLAP0000501511976.380469.3252
ENSG00000065978homo_sapiensENSP0000036162669.753163.5802amphiprion_perculaENSAPEP0000002047673.615667.101
ENSG00000065978homo_sapiensENSP0000036162673.148166.358oryzias_sinensisENSOSIP0000001798177.198770.0326
ENSG00000065978homo_sapiensENSP0000036162645.061737.6543pelodiscus_sinensisENSPSIP0000001051266.063355.2036
ENSG00000065978homo_sapiensENSP000003616265041.0494gopherus_evgoodeiENSGEVP0000501691460.447849.6269
ENSG00000065978homo_sapiensENSP0000036162652.777842.9012chelonoidis_abingdoniiENSCABP0000000937858.965547.931
ENSG00000065978homo_sapiensENSP0000036162672.839567.284seriola_dumeriliENSSDUP0000002891778.145772.1854
ENSG00000065978homo_sapiensENSP0000036162670.370463.8889cottoperca_gobioENSCGOP0000000174876.254269.2308
ENSG00000065978homo_sapiensENSP0000036162685.493882.4074struthio_camelus_australisENSSCUP0000000624595.847792.3875
ENSG00000065978homo_sapiensENSP0000036162689.506286.4198anser_brachyrhynchusENSABRP0000000691496.026592.7152
ENSG00000065978homo_sapiensENSP0000036162671.604965.4321gasterosteus_aculeatusENSGACP0000000852376.315869.7368
ENSG00000065978homo_sapiensENSP0000036162663.888956.4815cynoglossus_semilaevisENSCSEP0000003008168.54360.596
ENSG00000065978homo_sapiensENSP0000036162678.395170.679poecilia_formosaENSPFOP0000001145579.127771.3396
ENSG00000065978homo_sapiensENSP0000036162679.938371.6049myripristis_murdjanENSMMDP0000502050280.185871.8266
ENSG00000065978homo_sapiensENSP0000036162677.469169.7531sander_luciopercaENSSLUP0000001981277.469169.7531
ENSG00000065978homo_sapiensENSP0000036162695.987792.9012strigops_habroptilaENSSHBP0000500100996.284893.1889
ENSG00000065978homo_sapiensENSP0000036162677.777870.9877amphiprion_ocellarisENSAOCP0000002321278.260971.4286
ENSG00000065978homo_sapiensENSP0000036162653.703743.2099terrapene_carolina_triunguisENSTMTP0000001080760.416748.6111
ENSG00000065978homo_sapiensENSP0000036162669.753162.3457hucho_huchoENSHHUP0000004508575.333367.3333
ENSG00000065978homo_sapiensENSP0000036162675.617367.9012hucho_huchoENSHHUP0000006072276.08768.323
ENSG00000065978homo_sapiensENSP0000036162673.765466.9753betta_splendensENSBSLP0000000599675.87368.8889
ENSG00000065978homo_sapiensENSP0000036162679.012372.2222pygocentrus_nattereriENSPNAP0000002168483.116975.974
ENSG00000065978homo_sapiensENSP0000036162677.160570.679anabas_testudineusENSATEP0000001803777.881671.3396
ENSG00000065978homo_sapiensENSP0000036162621.296312.963ciona_savignyiENSCSAVP0000001116239.428624
ENSG00000065978homo_sapiensENSP0000036162672.839567.284seriola_lalandi_dorsalisENSSLDP0000003170478.145772.1854
ENSG00000065978homo_sapiensENSP0000036162671.913665.7407labrus_bergyltaENSLBEP0000000712676.897770.297
ENSG00000065978homo_sapiensENSP0000036162672.530966.358pundamilia_nyerereiENSPNYP0000001329478.333371.6667
ENSG00000065978homo_sapiensENSP0000036162678.395171.2963mastacembelus_armatusENSMAMP0000002715678.88271.7391
ENSG00000065978homo_sapiensENSP0000036162678.086470.679stegastes_partitusENSSPAP0000002743478.086470.679
ENSG00000065978homo_sapiensENSP000003616267566.358oncorhynchus_tshawytschaENSOTSP0000508343464.116156.7282
ENSG00000065978homo_sapiensENSP0000036162670.370463.8889oncorhynchus_tshawytschaENSOTSP0000500491675.747568.7708
ENSG00000065978homo_sapiensENSP000003616267566.358oncorhynchus_tshawytschaENSOTSP0000505552564.116156.7282
ENSG00000065978homo_sapiensENSP0000036162672.839566.9753acanthochromis_polyacanthusENSAPOP0000001535877.377171.1475
ENSG00000065978homo_sapiensENSP0000036162695.370492.5926aquila_chrysaetos_chrysaetosENSACCP0002000686796.261793.4579
ENSG00000065978homo_sapiensENSP0000036162674.074166.9753nothobranchius_furzeriENSNFUP0001505073575.709868.4543
ENSG00000065978homo_sapiensENSP0000036162672.222265.7407cyprinodon_variegatusENSCVAP0000002073678.260971.2375
ENSG00000065978homo_sapiensENSP0000036162661.111155.8642denticeps_clupeoidesENSDCDP0000001822177.952871.2598
ENSG00000065978homo_sapiensENSP0000036162663.888957.0988denticeps_clupeoidesENSDCDP0000002131276.666768.5185
ENSG00000065978homo_sapiensENSP0000036162658.64253.7037denticeps_clupeoidesENSDCDP0000001635076.612970.1613
ENSG00000065978homo_sapiensENSP0000036162641.666738.5802denticeps_clupeoidesENSDCDP0000001332871.052665.7895
ENSG00000065978homo_sapiensENSP0000036162658.950650.3086denticeps_clupeoidesENSDCDP0000002715860.062951.2579
ENSG00000065978homo_sapiensENSP0000036162666.049459.8765denticeps_clupeoidesENSDCDP0000001218874.048467.128
ENSG00000065978homo_sapiensENSP0000036162641.049438.2716denticeps_clupeoidesENSDCDP0000001275464.878160.4878
ENSG00000065978homo_sapiensENSP0000036162637.96336.1111denticeps_clupeoidesENSDCDP0000002033362.755159.6939
ENSG00000065978homo_sapiensENSP0000036162666.975359.8765denticeps_clupeoidesENSDCDP0000001206974.570466.6667
ENSG00000065978homo_sapiensENSP0000036162640.123536.7284denticeps_clupeoidesENSDCDP0000000156163.106857.767
ENSG00000065978homo_sapiensENSP0000036162664.506258.3333denticeps_clupeoidesENSDCDP0000001502769.435262.7907
ENSG00000065978homo_sapiensENSP0000036162667.592660.8025denticeps_clupeoidesENSDCDP0000001487674.237366.7797
ENSG00000065978homo_sapiensENSP0000036162659.876554.0123denticeps_clupeoidesENSDCDP0000005109375.486468.0934
ENSG00000065978homo_sapiensENSP0000036162666.35860.1852denticeps_clupeoidesENSDCDP0000001523773.883267.0103
ENSG00000065978homo_sapiensENSP0000036162678.086471.6049denticeps_clupeoidesENSDCDP0000004557882.142975.3247
ENSG00000065978homo_sapiensENSP0000036162664.814858.3333denticeps_clupeoidesENSDCDP0000001351574.468167.0213
ENSG00000065978homo_sapiensENSP0000036162658.024753.0864denticeps_clupeoidesENSDCDP0000001636075.268.8
ENSG00000065978homo_sapiensENSP0000036162643.209935.1852denticeps_clupeoidesENSDCDP0000000037954.474744.358
ENSG00000065978homo_sapiensENSP0000036162666.975359.8765denticeps_clupeoidesENSDCDP0000005878174.570466.6667
ENSG00000065978homo_sapiensENSP0000036162663.888957.0988denticeps_clupeoidesENSDCDP0000001182576.666768.5185
ENSG00000065978homo_sapiensENSP0000036162667.592661.4198denticeps_clupeoidesENSDCDP0000000289575.257768.3849
ENSG00000065978homo_sapiensENSP0000036162640.432137.963denticeps_clupeoidesENSDCDP0000000136563.902460
ENSG00000065978homo_sapiensENSP0000036162661.111154.9383denticeps_clupeoidesENSDCDP0000003610869.230862.2378
ENSG00000065978homo_sapiensENSP0000036162655.555647.5309denticeps_clupeoidesENSDCDP0000002106955.555647.5309
ENSG00000065978homo_sapiensENSP0000036162655.246947.2222denticeps_clupeoidesENSDCDP0000001361856.289348.1132
ENSG00000065978homo_sapiensENSP0000036162666.975360.1852denticeps_clupeoidesENSDCDP0000001105973.559366.1017
ENSG00000065978homo_sapiensENSP0000036162641.049435.8025denticeps_clupeoidesENSDCDP0000005401072.677663.388
ENSG00000065978homo_sapiensENSP0000036162677.469170.3704larimichthys_croceaENSLCRP0000505123177.950370.8075
ENSG00000065978homo_sapiensENSP0000036162671.296363.8889takifugu_rubripesENSTRUP0000008610371.076963.6923
ENSG00000065978homo_sapiensENSP0000036162676.543272.5309ficedula_albicollisENSFALP0000001075689.208684.5324
ENSG00000065978homo_sapiensENSP0000036162670.061764.5062hippocampus_comesENSHCOP0000001404474.917568.9769
ENSG00000065978homo_sapiensENSP0000036162679.629670.9877cyprinus_carpio_carpioENSCCRP0000005604782.165673.2484
ENSG00000065978homo_sapiensENSP0000036162678.703770.679cyprinus_carpio_carpioENSCCRP0000000234682.792274.3506
ENSG00000065978homo_sapiensENSP0000036162696.296392.5926coturnix_japonicaENSCJPP0000500779495.705592.0245
ENSG00000065978homo_sapiensENSP0000036162673.148166.6667poecilia_latipinnaENSPLAP0000002835578.217871.2871
ENSG00000065978homo_sapiensENSP0000036162670.370462.3457sinocyclocheilus_grahamiENSSGRP0000006074271.473463.3229
ENSG00000065978homo_sapiensENSP0000036162679.938371.6049sinocyclocheilus_grahamiENSSGRP0000001674380.685472.2741
ENSG00000065978homo_sapiensENSP0000036162672.530966.358maylandia_zebraENSMZEP0000502741378.333371.6667
ENSG00000065978homo_sapiensENSP0000036162670.370464.1975tetraodon_nigroviridisENSTNIP0000001494976.510169.7987
ENSG00000065978homo_sapiensENSP0000036162669.753162.6543paramormyrops_kingsleyaeENSPKIP0000003328759.788453.7037
ENSG00000065978homo_sapiensENSP0000036162677.160569.7531paramormyrops_kingsleyaeENSPKIP0000003236362.344156.3591
ENSG00000065978homo_sapiensENSP0000036162639.814831.7901scleropages_formosusENSSFOP0001504745557.589345.9821
ENSG00000065978homo_sapiensENSP0000036162629.012326.2346leptobrachium_leishanenseENSLLEP0000001194887.850579.4393
ENSG00000065978homo_sapiensENSP0000036162653.703749.3827leptobrachium_leishanenseENSLLEP0000004148774.35968.3761
ENSG00000065978homo_sapiensENSP0000036162682.407475.9259leptobrachium_leishanenseENSLLEP0000001850772.357766.6667
ENSG00000065978homo_sapiensENSP0000036162675.617370.3704leptobrachium_leishanenseENSLLEP0000000565088.447782.3105
ENSG00000065978homo_sapiensENSP0000036162672.222266.358scophthalmus_maximusENSSMAP0000001854577.227770.9571
ENSG00000065978homo_sapiensENSP0000036162673.148166.358oryzias_melastigmaENSOMEP0000002426777.704970.4918

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003676enables nucleic acid binding1IBAHomo_sapiens(9606)Function
GO:0003677enables DNA binding1TASHomo_sapiens(9606)Function
GO:0003690enables double-stranded DNA binding1TASHomo_sapiens(9606)Function
GO:0003723enables RNA binding2HDA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005689part_of U12-type spliceosomal complex1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0006355involved_in regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0006397involved_in mRNA processing1IEAHomo_sapiens(9606)Process
GO:0008380involved_in RNA splicing1IEAHomo_sapiens(9606)Process
GO:0008544involved_in epidermis development1ISSHomo_sapiens(9606)Process
GO:0010468involved_in regulation of gene expression1IBAHomo_sapiens(9606)Process
GO:0010494located_in cytoplasmic stress granule1IDAHomo_sapiens(9606)Component
GO:0017148involved_in negative regulation of translation1ISSHomo_sapiens(9606)Process
GO:0035198enables miRNA binding1IDAHomo_sapiens(9606)Function
GO:0043231located_in intracellular membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0048255involved_in mRNA stabilization1IDAHomo_sapiens(9606)Process
GO:0048598involved_in embryonic morphogenesis1ISSHomo_sapiens(9606)Process
GO:0050658involved_in RNA transport1IMPHomo_sapiens(9606)Process
GO:0051020enables GTPase binding1IPIHomo_sapiens(9606)Function
GO:0051031involved_in tRNA transport1IMPHomo_sapiens(9606)Process
GO:0051781involved_in positive regulation of cell division1IEAHomo_sapiens(9606)Process
GO:0062153enables C5-methylcytidine-containing RNA binding1IDAHomo_sapiens(9606)Function
GO:0070062located_in extracellular exosome2HDA,IDAHomo_sapiens(9606)Component
GO:0070934involved_in CRD-mediated mRNA stabilization2IDA,IMPHomo_sapiens(9606)Process
GO:0070937part_of CRD-mediated mRNA stability complex2IDA,IPIHomo_sapiens(9606)Component
GO:0071204part_of histone pre-mRNA 3end processing complex1ISSHomo_sapiens(9606)Component
GO:1900152involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay1IDAHomo_sapiens(9606)Process
GO:1903608involved_in protein localization to cytoplasmic stress granule1IMPHomo_sapiens(9606)Process
GO:1990124part_of messenger ribonucleoprotein complex1IBAHomo_sapiens(9606)Component
GO:1990428involved_in miRNA transport1IDAHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component
GO:2000767involved_in positive regulation of cytoplasmic translation1IDAHomo_sapiens(9606)Process
GO:2000773involved_in negative regulation of cellular senescence1ISSHomo_sapiens(9606)Process

Expression