RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000065485	Gene ID	10954	Accession	24811
Symbol	PDIA5	Alias	PDIR	Full Name	protein disulfide isomerase family A member 5
Status	Confidence	Length	158203 bases	Strand	Plus strand
Position	3 : 123067025 - 123225227	RNA binding domain	N.A.
Summary	This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PDIA5-207	ENST00000489923	1651	262aa	ENSP00000417520
PDIA5-201	ENST00000316218	1844	519aa	ENSP00000323313
PDIA5-205	ENST00000484644	667	64aa	ENSP00000419946
PDIA5-208	ENST00000495004	563	No protein	-
PDIA5-204	ENST00000472319	395	No protein	-
PDIA5-202	ENST00000467157	2232	No protein	-
PDIA5-206	ENST00000485208	499	No protein	-
PDIA5-203	ENST00000469649	722	83aa	ENSP00000417199

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
53319	Triiodothyronine	2.7670000E-005	-
96996	Fibrinogen	2E-8	26561523
97191	Fibrinogen	1E-7	28107422
103775	Fibrinogen	8E-9	28107422
103823	Platelet Count	4E-9	22139419

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003756	enables protein disulfide isomerase activity	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005783	is_active_in endoplasmic reticulum	1	IBA	Homo_sapiens(9606)	Component
GO:0005788	located_in endoplasmic reticulum lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0006457	involved_in protein folding	3	IBA,IDA,TAS	Homo_sapiens(9606)	Process
GO:0015035	enables protein-disulfide reductase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0016491	enables oxidoreductase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0022900	involved_in electron transport chain	1	TAS	Homo_sapiens(9606)	Process