RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000041880	Gene ID	10039	Accession	273
Symbol	PARP3	Alias	IRT1;ARTD3;ADPRT3;ADPRTL2;ADPRTL3;PADPRT-3	Full Name	poly(ADP-ribose) polymerase family member 3
Status	Confidence	Length	6523 bases	Strand	Plus strand
Position	3 : 51942345 - 51948867	RNA binding domain	PARP
Summary	The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000381740	PARP	PF00644	9.1e-45	1
ENSP00000395951	PARP	PF00644	9.1e-45	1
ENSP00000401511	PARP	PF00644	9.1e-45	1
ENSP00000417396	PARP	PF00644	9.1e-45	1
ENSP00000417625	PARP	PF00644	9.1e-45	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PARP3-203	ENST00000431474	2096	533aa	ENSP00000401511
PARP3-202	ENST00000417220	2472	533aa	ENSP00000395951
PARP3-201	ENST00000398755	2337	533aa	ENSP00000381740
PARP3-206	ENST00000471971	2393	533aa	ENSP00000417396
PARP3-204	ENST00000470601	940	No protein	-
PARP3-209	ENST00000498510	1952	533aa	ENSP00000417625
PARP3-205	ENST00000470749	697	No protein	-
PARP3-207	ENST00000475782	771	No protein	-
PARP3-208	ENST00000486510	443	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
13620	E-Selectin	3.7883000E-005	19729612

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000723	acts_upstream_of_or_within telomere maintenance	1	IMP	Homo_sapiens(9606)	Process
GO:0003824	enables catalytic activity	1	TAS	Homo_sapiens(9606)	Function
GO:0003950	enables NAD+ ADP-ribosyltransferase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005730	is_active_in nucleolus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IEA	Homo_sapiens(9606)	Component
GO:0005814	located_in centriole	1	IEA	Homo_sapiens(9606)	Component
GO:0006302	involved_in double-strand break repair	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0016604	located_in nuclear body	1	IDA	Homo_sapiens(9606)	Component
GO:0016779	enables nucleotidyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0030592	involved_in DNA ADP-ribosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0035861	is_active_in site of double-strand break	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0045171	located_in intercellular bridge	1	IDA	Homo_sapiens(9606)	Component
GO:0045829	involved_in negative regulation of isotype switching	1	ISS	Homo_sapiens(9606)	Process
GO:0051106	acts_upstream_of_or_within positive regulation of DNA ligation	1	IGI	Homo_sapiens(9606)	Process
GO:0060236	acts_upstream_of_or_within regulation of mitotic spindle organization	1	IMP	Homo_sapiens(9606)	Process
GO:0070212	NOT involved_in protein poly-ADP-ribosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0070213	involved_in protein auto-ADP-ribosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0140294	enables NAD DNA ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140804	enables NAD+- protein-lysine ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140806	enables NAD+- protein-aspartate ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140807	enables NAD+-protein-glutamate ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:1905662	involved_in negative regulation of telomerase RNA reverse transcriptase activity	1	IMP	Homo_sapiens(9606)	Process
GO:1990166	acts_upstream_of_or_within protein localization to site of double-strand break	1	IMP	Homo_sapiens(9606)	Process
GO:1990404	enables NAD+-protein ADP-ribosyltransferase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:2001034	involved_in positive regulation of double-strand break repair via nonhomologous end joining	1	IDA	Homo_sapiens(9606)	Process