RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000025800	Gene ID	23633	Accession	6399
Symbol	KPNA6	Alias	IPOA7	Full Name	karyopherin subunit alpha 6
Status	Confidence	Length	68508 bases	Strand	Plus strand
Position	1 : 32108056 - 32176563	RNA binding domain	N.A.
Summary	Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
KPNA6-201	ENST00000373625	7355	536aa	ENSP00000362728
KPNA6-204	ENST00000471599	3941	186aa	ENSP00000474234
KPNA6-203	ENST00000469790	879	No protein	-
KPNA6-202	ENST00000446515	965	321aa	ENSP00000415677

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	is_active_in nucleoplasm	3	IBA,NAS,TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	NAS,TAS	Homo_sapiens(9606)	Component
GO:0006366	involved_in transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process
GO:0006606	involved_in protein import into nucleus	1	ISS	Homo_sapiens(9606)	Process
GO:0006607	involved_in NLS-bearing protein import into nucleus	1	IBA	Homo_sapiens(9606)	Process
GO:0008139	enables nuclear localization sequence binding	1	IBA	Homo_sapiens(9606)	Function
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0019079	involved_in viral genome replication	1	IEA	Homo_sapiens(9606)	Process
GO:0042564	part_of NLS-dependent protein nuclear import complex	1	IPI	Homo_sapiens(9606)	Component
GO:0043657	located_in host cell	1	IEA	Homo_sapiens(9606)	Component
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process
GO:0060135	involved_in maternal process involved in female pregnancy	1	IEA	Homo_sapiens(9606)	Process
GO:0061608	enables nuclear import signal receptor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0075506	acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin	1	IMP	Homo_sapiens(9606)	Process
GO:1900017	involved_in positive regulation of cytokine production involved in inflammatory response	1	IEA	Homo_sapiens(9606)	Process
GO:1903902	acts_upstream_of_or_within positive regulation of viral life cycle	1	IMP	Homo_sapiens(9606)	Process