Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs diverse
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000023191 Gene ID 6050 Accession 10074
Symbol RNH1 Alias RAI;RNH;IIAE12 Full Name ribonuclease/angiogenin inhibitor 1
Status Confidence Length 12789 bases Strand Minus strand
Position 11 : 494512 - 507300 RNA binding domain N.A.
Summary Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33525475 Angiogenin (ANG)-Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease. Anant Mayuresh Sarangdhar 2021-01-28 International journal of molecular sciences
27806571 Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases. P Sydney Thomas 2016-11-22 Biochemistry
36794853 PARP1 associates with R-loops to promote their resolution and genome stability. Natalie Laspata 2023-03-21 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
RNH1-224 ENST00000534797 2973 461aa ENSP00000433999
RNH1-204 ENST00000397614 1864 461aa ENSP00000380738
RNH1-205 ENST00000397615 2014 461aa ENSP00000380739
RNH1-201 ENST00000354420 1952 461aa ENSP00000346402
RNH1-203 ENST00000397604 1722 461aa ENSP00000380729
RNH1-209 ENST00000525522 3281 No protein -
RNH1-210 ENST00000525701 1794 35aa ENSP00000436022
RNH1-217 ENST00000529768 1019 285aa ENSP00000432170
RNH1-222 ENST00000533410 1829 461aa ENSP00000435594
RNH1-206 ENST00000438658 1725 461aa ENSP00000416589
RNH1-202 ENST00000356187 1791 461aa ENSP00000348515
RNH1-207 ENST00000524464 624 77aa ENSP00000431201
RNH1-214 ENST00000529115 855 No protein -
RNH1-212 ENST00000527485 873 199aa ENSP00000435748
RNH1-216 ENST00000529368 727 194aa ENSP00000435057
RNH1-215 ENST00000529306 870 189aa ENSP00000434947
RNH1-208 ENST00000524780 1059 No protein -
RNH1-218 ENST00000531149 709 181aa ENSP00000435798
RNH1-219 ENST00000531223 572 No protein -
RNH1-213 ENST00000528713 1202 No protein -
RNH1-221 ENST00000532055 704 40aa ENSP00000434971
RNH1-223 ENST00000533592 2344 No protein -
RNH1-220 ENST00000531540 480 8aa ENSP00000432781
RNH1-211 ENST00000526295 488 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
34170Leukoaraiosis7.1451494E-005-
85596Body Mass Index5E-625673413
99093Body Mass Index3E-625673413
106154Body Mass Index8E-625673413

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000023191homo_sapiensENSP0000033495813.1017.73519homo_sapiensENSP0000034640240.780924.0781
ENSG00000023191homo_sapiensENSP0000034046714.28578.5277homo_sapiensENSP0000034640242.516325.3796
ENSG00000023191homo_sapiensENSP0000033198316.11968.24216homo_sapiensENSP0000034640247.939324.5119
ENSG00000023191homo_sapiensENSP0000022146219.681611.1433homo_sapiensENSP0000034640229.501116.7028
ENSG00000023191homo_sapiensENSP00000480036100100homo_sapiensENSP00000346402100100

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000023191homo_sapiensENSP0000034640288.286386.3341nomascus_leucogenysENSNLEP0000001008797.601995.4436
ENSG00000023191homo_sapiensENSP0000034640210098.9154pan_paniscusENSPPAP0000003774810098.9154
ENSG00000023191homo_sapiensENSP0000034640295.661692.8417pongo_abeliiENSPPYP0000003059889.816787.169
ENSG00000023191homo_sapiensENSP0000034640210098.9154pan_troglodytesENSPTRP0000006985010098.9154
ENSG00000023191homo_sapiensENSP0000034640210098.6985gorilla_gorillaENSGGOP0000002353910098.6985
ENSG00000023191homo_sapiensENSP0000034640282.863377.6573gorilla_gorillaENSGGOP0000004784281.449976.3326
ENSG00000023191homo_sapiensENSP0000034640270.065156.3991ornithorhynchus_anatinusENSOANP0000004083770.98957.1429
ENSG00000023191homo_sapiensENSP0000034640271.366655.0976sarcophilus_harrisiiENSSHAP0000003381063.513549.0347
ENSG00000023191homo_sapiensENSP0000034640240.997831.8872notamacropus_eugeniiENSMEUP0000000534060.383446.9649
ENSG00000023191homo_sapiensENSP0000034640242.082432.538choloepus_hoffmanniENSCHOP0000000225767.595852.2648
ENSG00000023191homo_sapiensENSP0000034640275.271163.7744dasypus_novemcinctusENSDNOP0000002950167.906157.5342
ENSG00000023191homo_sapiensENSP0000034640240.997831.0195echinops_telfairiENSETEP0000001200356.756842.9429
ENSG00000023191homo_sapiensENSP0000034640286.767978.5249callithrix_jacchusENSCJAP0000004488186.956578.6957
ENSG00000023191homo_sapiensENSP0000034640295.444791.757cercocebus_atysENSCATP0000001106996.491292.7632
ENSG00000023191homo_sapiensENSP0000034640295.227891.974macaca_fascicularisENSMFAP0000005807296.483593.1868
ENSG00000023191homo_sapiensENSP0000034640295.444792.1909macaca_mulattaENSMMUP0000007600996.491293.2018
ENSG00000023191homo_sapiensENSP0000034640216.485915.4013macaca_mulattaENSMMUP0000007107490.476284.5238
ENSG00000023191homo_sapiensENSP0000034640282.646478.7419macaca_mulattaENSMMUP0000007562180.891777.0701
ENSG00000023191homo_sapiensENSP0000034640295.444791.757macaca_nemestrinaENSMNEP0000002987396.491292.7632
ENSG00000023191homo_sapiensENSP0000034640291.75787.4187papio_anubisENSPANP0000000855973.05769.6028
ENSG00000023191homo_sapiensENSP0000034640295.444791.974mandrillus_leucophaeusENSMLEP0000001315496.491292.9825
ENSG00000023191homo_sapiensENSP0000034640249.023943.3839tursiops_truncatusENSTTRP0000000573049.45343.7637
ENSG00000023191homo_sapiensENSP0000034640278.741967.8959vulpes_vulpesENSVVUP0000002338680.132569.0949
ENSG00000023191homo_sapiensENSP0000034640281.995769.8482mus_spretusMGP_SPRETEiJ_P008655982.894770.614
ENSG00000023191homo_sapiensENSP0000034640273.969665.7267equus_asinusENSEASP0000504963985.463775.9398
ENSG00000023191homo_sapiensENSP0000034640282.429570.9328capra_hircusENSCHIP0000001473483.333371.7105
ENSG00000023191homo_sapiensENSP0000034640279.392666.8113loxodonta_africanaENSLAFP0000000177579.392666.8113
ENSG00000023191homo_sapiensENSP0000034640279.392668.5466panthera_leoENSPLOP0000002743480.263269.2982
ENSG00000023191homo_sapiensENSP0000034640278.524967.2451ailuropoda_melanoleucaENSAMEP0000004313461.986353.0822
ENSG00000023191homo_sapiensENSP0000034640282.646471.8004bos_indicus_hybridENSBIXP0000504497183.369872.4289
ENSG00000023191homo_sapiensENSP0000034640284.815675.0542equus_caballusENSECAP0000002503857.247450.6589
ENSG00000023191homo_sapiensENSP0000034640279.392668.5466canis_lupus_familiarisENSCAFP0084504117379.912768.9956
ENSG00000023191homo_sapiensENSP0000034640279.826568.7636panthera_pardusENSPPRP0000001574980.701869.5175
ENSG00000023191homo_sapiensENSP0000034640284.164974.4035marmota_marmota_marmotaENSMMMP0000000789685.087775.2193
ENSG00000023191homo_sapiensENSP0000034640281.12871.1497balaenoptera_musculusENSBMSP0001001276481.838171.7724
ENSG00000023191homo_sapiensENSP0000034640275.488163.9913cavia_porcellusENSCPOP0000000798076.315864.693
ENSG00000023191homo_sapiensENSP0000034640280.260368.9805felis_catusENSFCAP0000002996374.596864.1129
ENSG00000023191homo_sapiensENSP0000034640281.344971.3666ursus_americanusENSUAMP0000003632179.113969.4093
ENSG00000023191homo_sapiensENSP0000034640214.316711.2798monodelphis_domesticaENSMODP0000006045574.157358.427
ENSG00000023191homo_sapiensENSP0000034640273.318964.2082bison_bison_bisonENSBBBP0000002610281.445871.3253
ENSG00000023191homo_sapiensENSP0000034640281.12871.3666monodon_monocerosENSMMNP0001502981981.838171.9912
ENSG00000023191homo_sapiensENSP0000034640282.429573.102sus_scrofaENSSSCP0000005815983.15173.7418
ENSG00000023191homo_sapiensENSP0000034640286.117177.4403microcebus_murinusENSMICP0000004658387.061478.2895
ENSG00000023191homo_sapiensENSP0000034640276.138864.6421octodon_degusENSODEP0000001941071.486860.6925
ENSG00000023191homo_sapiensENSP0000034640283.73172.6681jaculus_jaculusENSJJAP0000002456678.455368.0894
ENSG00000023191homo_sapiensENSP0000034640282.646471.1497ovis_aries_rambouilletENSOARP0002002008183.369871.7724
ENSG00000023191homo_sapiensENSP0000034640216.485914.3167ursus_maritimusENSUMAP0000000708188.372176.7442
ENSG00000023191homo_sapiensENSP0000034640281.344971.3666delphinapterus_leucasENSDLEP0000000412282.236872.1491
ENSG00000023191homo_sapiensENSP0000034640281.12871.1497physeter_catodonENSPCTP0000502535681.838171.7724
ENSG00000023191homo_sapiensENSP0000034640281.344969.8482mus_caroliMGP_CAROLIEiJ_P008313982.236870.614
ENSG00000023191homo_sapiensENSP0000034640281.995770.4989mus_musculusENSMUSP0000014792876.829366.0569
ENSG00000023191homo_sapiensENSP0000034640237.96132.1041dipodomys_ordiiENSDORP0000002761676.08764.3478
ENSG00000023191homo_sapiensENSP0000034640272.88560.3037mustela_putorius_furoENSMPUP0000000867577.598264.2032
ENSG00000023191homo_sapiensENSP0000034640291.323284.8156aotus_nancymaaeENSANAP0000000705491.323284.8156
ENSG00000023191homo_sapiensENSP0000034640286.334179.8265aotus_nancymaaeENSANAP0000000310479.282973.3068
ENSG00000023191homo_sapiensENSP0000034640280.043472.885saimiri_boliviensis_boliviensisENSSBOP0000002565191.336683.1683
ENSG00000023191homo_sapiensENSP0000034640294.143290.6725chlorocebus_sabaeusENSCSAP0000000725595.175491.6667
ENSG00000023191homo_sapiensENSP0000034640247.939342.7332tupaia_belangeriENSTBEP0000000618059.891653.3875
ENSG00000023191homo_sapiensENSP0000034640282.429571.8004mesocricetus_auratusENSMAUP0000002294577.235867.2764
ENSG00000023191homo_sapiensENSP0000034640281.344971.1497phocoena_sinusENSPSNP0000001126167.32558.8869
ENSG00000023191homo_sapiensENSP0000034640274.837364.6421camelus_dromedariusENSCDRP0000501038072.025162.2129
ENSG00000023191homo_sapiensENSP0000034640275.921965.7267panthera_tigris_altaicaENSPTIP0000002490676.754466.4474
ENSG00000023191homo_sapiensENSP0000034640278.30868.3297rattus_norvegicusENSRNOP0000006991075.681366.0377
ENSG00000023191homo_sapiensENSP0000034640286.767978.7419prolemur_simusENSPSMP0000000963887.719379.6053
ENSG00000023191homo_sapiensENSP0000034640283.514171.3666microtus_ochrogasterENSMOCP0000000264578.25266.8699
ENSG00000023191homo_sapiensENSP0000034640252.060745.5531sorex_araneusENSSARP0000000610756.206149.1803
ENSG00000023191homo_sapiensENSP0000034640283.297273.102peromyscus_maniculatus_bairdiiENSPEMP0000000982678.048868.4959
ENSG00000023191homo_sapiensENSP0000034640282.863372.2343bos_mutusENSBMUP0000000788973.745264.2857
ENSG00000023191homo_sapiensENSP0000034640281.995770.4989mus_spicilegusENSMSIP0000001610776.829366.0569
ENSG00000023191homo_sapiensENSP0000034640268.763657.9176mus_spicilegusENSMSIP0000003174770.917259.7315
ENSG00000023191homo_sapiensENSP0000034640282.863372.2343cricetulus_griseus_chok1gshdENSCGRP0000100503077.642367.6829
ENSG00000023191homo_sapiensENSP0000034640277.223465.5098pteropus_vampyrusENSPVAP0000001324978.241866.3736
ENSG00000023191homo_sapiensENSP0000034640271.583554.2299vombatus_ursinusENSVURP0001000636272.210154.7046
ENSG00000023191homo_sapiensENSP0000034640280.043467.0282rhinolophus_ferrumequinumENSRFEP0001000656662.86252.6405
ENSG00000023191homo_sapiensENSP0000034640277.006565.5098neovison_visonENSNVIP0000000708077.850966.2281
ENSG00000023191homo_sapiensENSP0000034640282.646471.3666bos_taurusENSBTAP0000005947883.552672.1491
ENSG00000023191homo_sapiensENSP0000034640279.175767.8959heterocephalus_glaber_femaleENSHGLP0000000676680.043968.6404
ENSG00000023191homo_sapiensENSP0000034640295.227892.8417rhinopithecus_bietiENSRBIP0000001809096.271993.8596
ENSG00000023191homo_sapiensENSP0000034640279.392668.5466canis_lupus_dingoENSCAFP0002000872780.263269.2982
ENSG00000023191homo_sapiensENSP0000034640284.815674.6204sciurus_vulgarisENSSVLP0000501338385.745675.4386
ENSG00000023191homo_sapiensENSP0000034640272.017454.013phascolarctos_cinereusENSPCIP0000001037363.479947.6099
ENSG00000023191homo_sapiensENSP0000034640283.297273.102nannospalax_galiliENSNGAP0000001864678.048868.4959
ENSG00000023191homo_sapiensENSP0000034640274.620463.7744chinchilla_lanigeraENSCLAP0000000444475.438664.4737
ENSG00000023191homo_sapiensENSP0000034640281.995770.7158cervus_hanglu_yarkandensisENSCHYP0000000870582.894771.4912
ENSG00000023191homo_sapiensENSP0000034640280.477270.7158catagonus_wagneriENSCWAP0000000848581.181671.3348
ENSG00000023191homo_sapiensENSP0000034640284.164974.4035ictidomys_tridecemlineatusENSSTOP0000001518485.087775.2193
ENSG00000023191homo_sapiensENSP0000034640283.080373.9696otolemur_garnettiiENSOGAP0000001027383.624574.4541
ENSG00000023191homo_sapiensENSP0000034640292.190986.1171cebus_imitatorENSCCAP0000002855892.190986.1171
ENSG00000023191homo_sapiensENSP0000034640283.947974.1866urocitellus_parryiiENSUPAP0001002904584.868475
ENSG00000023191homo_sapiensENSP0000034640282.863372.4512moschus_moschiferusENSMMSP0000000419675.944366.4016
ENSG00000023191homo_sapiensENSP0000034640295.661693.0586rhinopithecus_roxellanaENSRROP0000000052580.474478.2847
ENSG00000023191homo_sapiensENSP0000034640282.646471.8004mus_pahariMGP_PahariEiJ_P001991183.552672.5877
ENSG00000023191homo_sapiensENSP0000034640285.466476.5727propithecus_coquereliENSPCOP0000001311086.403577.4123
ENSG00000023191homo_sapiensENSP0000034640231.236417.3536caenorhabditis_elegansK07G5.1.113.63647.57576
ENSG00000023191homo_sapiensENSP0000034640240.56421.4751drosophila_melanogasterFBpp030513112.58416.66218
ENSG00000023191homo_sapiensENSP0000034640236.008717.1367ciona_intestinalisENSCINP0000003344520.44339.72906
ENSG00000023191homo_sapiensENSP0000034640212.58134.33839ciona_intestinalisENSCINP0000003253617.95676.19195
ENSG00000023191homo_sapiensENSP0000034640262.25648.59chrysemys_picta_belliiENSCPBP0000000937762.938649.1228
ENSG00000023191homo_sapiensENSP0000034640263.991345.5531sphenodon_punctatusENSSPUP0000000671860.699643.2099
ENSG00000023191homo_sapiensENSP0000034640262.25645.3362crocodylus_porosusENSCPRP0000501421359.175343.0928
ENSG00000023191homo_sapiensENSP0000034640260.086840.9978laticauda_laticaudataENSLLTP0000001074860.879141.5385
ENSG00000023191homo_sapiensENSP0000034640259.652940.3471notechis_scutatusENSNSUP0000002260060.439640.8791
ENSG00000023191homo_sapiensENSP0000034640259.869840.564pseudonaja_textilisENSPTXP0000000180460.659341.0989
ENSG00000023191homo_sapiensENSP0000034640255.965339.6963anas_platyrhynchos_platyrhynchosENSAPLP0000000896059.174341.9725
ENSG00000023191homo_sapiensENSP0000034640263.991345.5531gallus_gallusENSGALP0001003864749.915435.533
ENSG00000023191homo_sapiensENSP0000034640263.991345.5531meleagris_gallopavoENSMGAP0000000947162.544.4915
ENSG00000023191homo_sapiensENSP0000034640263.557544.2516serinus_canariaENSSCAP0000002030064.254444.7368
ENSG00000023191homo_sapiensENSP0000034640263.991344.2516parus_majorENSPMJP0000001287264.69344.7368
ENSG00000023191homo_sapiensENSP0000034640262.25643.3839anolis_carolinensisENSACAP0000001460362.938643.8596
ENSG00000023191homo_sapiensENSP0000034640259.869840.9978naja_najaENSNNAP0000000440960.659341.5385
ENSG00000023191homo_sapiensENSP0000034640262.03945.3362podarcis_muralisENSPMRP0000000062562.719345.8333
ENSG00000023191homo_sapiensENSP0000034640263.557543.8178geospiza_fortisENSGFOP0000000988364.254444.2982
ENSG00000023191homo_sapiensENSP0000034640263.123644.4685taeniopygia_guttataENSTGUP0000002151464.096945.1542
ENSG00000023191homo_sapiensENSP0000034640261.171443.167salvator_merianaeENSSMRP0000001734261.842143.6404
ENSG00000023191homo_sapiensENSP0000034640262.689847.0716pelodiscus_sinensisENSPSIP0000001641361.228845.9746
ENSG00000023191homo_sapiensENSP0000034640254.01340.1302gopherus_evgoodeiENSGEVP0000502169556.081141.6667
ENSG00000023191homo_sapiensENSP0000034640256.616139.4794chelonoidis_abingdoniiENSCABP0000000005757.871440.3548
ENSG00000023191homo_sapiensENSP0000034640263.991344.4685struthio_camelus_australisENSSCUP0000001751164.69344.9561
ENSG00000023191homo_sapiensENSP0000034640264.208245.7701anser_brachyrhynchusENSABRP0000001837264.912346.2719
ENSG00000023191homo_sapiensENSP0000034640263.557543.8178strigops_habroptilaENSSHBP0000500162364.254444.2982
ENSG00000023191homo_sapiensENSP0000034640262.25648.59terrapene_carolina_triunguisENSTMTP0000000910759.175346.1856
ENSG00000023191homo_sapiensENSP000003464027.375273.90456ciona_savignyiENSCSAVP0000001951932.075516.9811
ENSG00000023191homo_sapiensENSP000003464026.073752.81996ciona_savignyiENSCSAVP0000001951616.96977.87879
ENSG00000023191homo_sapiensENSP0000034640264.425244.2516aquila_chrysaetos_chrysaetosENSACCP0002001490463.733943.7768
ENSG00000023191homo_sapiensENSP0000034640263.991344.2516ficedula_albicollisENSFALP0000001681753.249136.8231
ENSG00000023191homo_sapiensENSP0000034640263.557545.1193coturnix_japonicaENSCJPP0000502324756.893240.3883

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654is_active_in nucleoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane1IBAHomo_sapiens(9606)Component
GO:0006402involved_in mRNA catabolic process1NASHomo_sapiens(9606)Process
GO:0008428enables ribonuclease inhibitor activity2IBA,IDAHomo_sapiens(9606)Function
GO:0016477involved_in cell migration1IBAHomo_sapiens(9606)Process
GO:0030027is_active_in lamellipodium1IBAHomo_sapiens(9606)Component
GO:0032311part_of angiogenin-PRI complex2IBA,IPIHomo_sapiens(9606)Component
GO:0034315involved_in regulation of Arp2/3 complex-mediated actin nucleation1IBAHomo_sapiens(9606)Process
GO:0045765involved_in regulation of angiogenesis2IBA,IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component

Expression