Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000018510 Gene ID 8540 Accession 327
Symbol AGPS Alias ADAS;ADPS;RCDP3;ADAP-S;ADHAPS;ALDHPSY Full Name alkylglycerone phosphate synthase
Status Confidence Length 174279 bases Strand Plus strand
Position 2 : 177392746 - 177567024 RNA binding domain N.A.
Summary This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
AGPS-215 ENST00000680705 1849 No protein -
AGPS-216 ENST00000680770 3044 624aa ENSP00000505536
AGPS-204 ENST00000637633 2447 629aa ENSP00000490844
AGPS-207 ENST00000679459 2103 638aa ENSP00000506137
AGPS-224 ENST00000681752 7556 122aa ENSP00000504994
AGPS-203 ENST00000460342 2742 No protein -
AGPS-214 ENST00000680677 1143 No protein -
AGPS-218 ENST00000680910 1658 No protein -
AGPS-217 ENST00000680893 7408 251aa ENSP00000505929
AGPS-220 ENST00000681032 7520 245aa ENSP00000505205
AGPS-206 ENST00000679421 8603 No protein -
AGPS-223 ENST00000681565 7784 341aa ENSP00000505620
AGPS-202 ENST00000409888 815 189aa ENSP00000386688
AGPS-201 ENST00000264167 7633 658aa ENSP00000264167
AGPS-205 ENST00000642466 2640 676aa ENSP00000494433
AGPS-212 ENST00000680155 7318 568aa ENSP00000505333
AGPS-208 ENST00000679478 7466 568aa ENSP00000506484
AGPS-222 ENST00000681449 1849 568aa ENSP00000505342
AGPS-225 ENST00000681891 11009 No protein -
AGPS-209 ENST00000679639 1118 No protein -
AGPS-219 ENST00000681028 3257 410aa ENSP00000506323
AGPS-211 ENST00000680028 8738 No protein -
AGPS-210 ENST00000679994 7617 568aa ENSP00000504957
AGPS-213 ENST00000680390 2250 No protein -
AGPS-221 ENST00000681300 2170 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
2992Insulin5.94238606994105E-817903298
9885Echocardiography1.20879885520644E-517903301
45501Platelet Function Tests1.8342300E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005739located_in mitochondrion1HDAHomo_sapiens(9606)Component
GO:0005777is_active_in peroxisome2IBA,IDAHomo_sapiens(9606)Component
GO:0005778located_in peroxisomal membrane1HDAHomo_sapiens(9606)Component
GO:0005782located_in peroxisomal matrix1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0008609enables alkylglycerone-phosphate synthase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0008610involved_in lipid biosynthetic process2IBA,IDAHomo_sapiens(9606)Process
GO:0008611involved_in ether lipid biosynthetic process2IEA,ISSHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0071949enables FAD binding1ISSHomo_sapiens(9606)Function

Expression