Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000012223 Gene ID 4057 Accession 6720
Symbol LTF Alias LF;HLF2;GIG12;HEL110 Full Name lactotransferrin
Status Confidence Length 49590 bases Strand Minus strand
Position 3 : 46435645 - 46485234 RNA binding domain N.A.
Summary This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
LTF-201 ENST00000231751 2721 710aa ENSP00000231751
LTF-203 ENST00000426532 2494 666aa ENSP00000405719
LTF-202 ENST00000417439 2130 708aa ENSP00000405546
LTF-205 ENST00000443496 2656 696aa ENSP00000397427
LTF-208 ENST00000493056 493 No protein -
LTF-207 ENST00000478874 466 No protein -
LTF-206 ENST00000462667 523 No protein -
LTF-204 ENST00000431944 584 182aa ENSP00000395234
LTF-209 ENST00000498301 469 55aa ENSP00000508000

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
22118Personality4.959e-005-
22136Personality4.959e-005-
34665Platelet Function Tests1.3000000E-007-
35486Platelet Function Tests3.4600000E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001503involved_in ossification1IEAHomo_sapiens(9606)Process
GO:0001530enables lipopolysaccharide binding1IMPHomo_sapiens(9606)Function
GO:0001817involved_in regulation of cytokine production1IDAHomo_sapiens(9606)Process
GO:0001895involved_in retina homeostasis1HEPHomo_sapiens(9606)Process
GO:0002227involved_in innate immune response in mucosa1IDAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0004252enables serine-type endopeptidase activity1IEAHomo_sapiens(9606)Function
GO:0004869enables cysteine-type endopeptidase inhibitor activity1IDAHomo_sapiens(9606)Function
GO:0005506enables iron ion binding1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005615located_in extracellular space3HDA,IBA,IDAHomo_sapiens(9606)Component
GO:0005634located_in nucleus1HDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IMPHomo_sapiens(9606)Component
GO:0005769is_active_in early endosome1IBAHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane1IBAHomo_sapiens(9606)Component
GO:0006508involved_in proteolysis1IEAHomo_sapiens(9606)Process
GO:0006826involved_in iron ion transport1IBAHomo_sapiens(9606)Process
GO:0006959involved_in humoral immune response1TASHomo_sapiens(9606)Process
GO:0008201enables heparin binding1IDAHomo_sapiens(9606)Function
GO:0009986located_in cell surface1IDAHomo_sapiens(9606)Component
GO:0019731involved_in antibacterial humoral response2IBA,IDAHomo_sapiens(9606)Process
GO:0019732involved_in antifungal humoral response1IDAHomo_sapiens(9606)Process
GO:0030141located_in secretory granule1IDAHomo_sapiens(9606)Component
GO:0031640involved_in killing of cells of another organism2IDA,IMPHomo_sapiens(9606)Process
GO:0031665involved_in negative regulation of lipopolysaccharide-mediated signaling pathway1IDAHomo_sapiens(9606)Process
GO:0032680involved_in regulation of tumor necrosis factor production1IDAHomo_sapiens(9606)Process
GO:0032780involved_in negative regulation of ATP-dependent activity1IMPHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0033690involved_in positive regulation of osteoblast proliferation1IDAHomo_sapiens(9606)Process
GO:0034145involved_in positive regulation of toll-like receptor 4 signaling pathway1IMPHomo_sapiens(9606)Process
GO:0034755involved_in iron ion transmembrane transport1IEAHomo_sapiens(9606)Process
GO:0035580located_in specific granule lumen1TASHomo_sapiens(9606)Component
GO:0042581located_in specific granule1IDAHomo_sapiens(9606)Component
GO:0043066involved_in negative regulation of apoptotic process1ISSHomo_sapiens(9606)Process
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:0043539enables protein serine/threonine kinase activator activity1IDAHomo_sapiens(9606)Function
GO:0044793involved_in negative regulation by host of viral process1IMPHomo_sapiens(9606)Process
GO:0045071involved_in negative regulation of viral genome replication1IMPHomo_sapiens(9606)Process
GO:0045669involved_in positive regulation of osteoblast differentiation1IDAHomo_sapiens(9606)Process
GO:0048525involved_in negative regulation of viral process1IMPHomo_sapiens(9606)Process
GO:0050829involved_in defense response to Gram-negative bacterium1IMPHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0055037is_active_in recycling endosome1IBAHomo_sapiens(9606)Component
GO:0060349involved_in bone morphogenesis1IDAHomo_sapiens(9606)Process
GO:0061844involved_in antimicrobial humoral immune response mediated by antimicrobial peptide1IMPHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0071902involved_in positive regulation of protein serine/threonine kinase activity1IDAHomo_sapiens(9606)Process
GO:0097013located_in phagocytic vesicle lumen1TASHomo_sapiens(9606)Component
GO:0140912enables membrane destabilizing activity1IMPHomo_sapiens(9606)Function
GO:1900159involved_in positive regulation of bone mineralization involved in bone maturation1ISSHomo_sapiens(9606)Process
GO:1900229involved_in negative regulation of single-species biofilm formation in or on host organism1IDAHomo_sapiens(9606)Process
GO:1902732involved_in positive regulation of chondrocyte proliferation1IDAHomo_sapiens(9606)Process
GO:1904724located_in tertiary granule lumen1TASHomo_sapiens(9606)Component
GO:2000117involved_in negative regulation of cysteine-type endopeptidase activity1IDAHomo_sapiens(9606)Process
GO:2000308involved_in negative regulation of tumor necrosis factor (ligand) superfamily member 11 production1ISSHomo_sapiens(9606)Process
GO:2001205involved_in negative regulation of osteoclast development1ISSHomo_sapiens(9606)Process

Expression