Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions E3 ligaseTransmemebrane
Localizations Stress granucle
BulkPerturb-seq DataSet_01_138

Description

Ensembl ID ENSG00000012048 Gene ID 672 Accession 1100
Symbol BRCA1 Alias IRIS;PSCP;BRCAI;BRCC1;FANCS;PNCA4;RNF53;BROVCA1;PPP1R53 Full Name BRCA1 DNA repair associated
Status Confidence Length 125951 bases Strand Minus strand
Position 17 : 43044295 - 43170245 RNA binding domain N.A.
Summary This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
19010922 Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR. M Jodi Saunus 2008-11-15 Cancer research
17612526 Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression. M Jodi Saunus 2007-07-24 FEBS letters
30323900 MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer. G J Michael Milevskiy 2018-09-11 Oncotarget
35159022 Crosstalk between Long Non Coding RNAs, microRNAs and DNA Damage Repair in Prostate Cancer: New Therapeutic Opportunities? Folake Orafidiya 2022-01-31 Cancers
26412854 A BRCA1-interacting lncRNA regulates homologous recombination. Vivek Sharma 2015-11-01 EMBO reports
26941120 Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. J Sreejith Nair 2016-03-04 Nature communications
34112789 BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage. Jekaterina Vohhodina 2021-06-10 Nature communications
36490315 The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops. Chou-Wei Chang 2022-12-13 Proceedings of the National Academy of Sciences of the United States of America
28196667 Stress granules assembly affects detection of mRNA in living cells by the NanoFlares; an important aspect of the technology. Magdalena Wolczyk 2017-05-01 Biochimica et biophysica acta. General subjects
29596642 The DNA damage response activates HPV16 late gene expression at the level of RNA processing. Kersti Nilsson 2018-06-01 Nucleic acids research
20725763 Targeting poly(ADP-ribose) polymerase activity for cancer therapy. Frédérique Mégnin-Chanet 2010-11-01 Cellular and molecular life sciences : CMLS
24556685 S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability. E N Buckley 2014-02-20 Cell death & disease
23863842 BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers. E Niamh Buckley 2013-10-01 Nucleic acids research
34226554 DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination. Prasun Chakraborty 2021-07-05 Nature communications
30656896 BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters. Katarzyna Piwocka 2018-10-15 Postepy biochemii
32005969 Regulatory R-loops as facilitators of gene expression and genome stability. Christof Niehrs 2020-03-01 Nature reviews. Molecular cell biology
32290274 Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1. Elise Berthel 2020-04-10 Cells

Transcripts

Name Transcript ID bp Protein Translation ID
BRCA1-222 ENST00000497488 6335 1567aa ENSP00000418986
BRCA1-216 ENST00000489037 7056 1837aa ENSP00000420781
BRCA1-214 ENST00000478531 3765 759aa ENSP00000420412
BRCA1-203 ENST00000357654 7088 1863aa ENSP00000350283
BRCA1-211 ENST00000473961 6962 1821aa ENSP00000420201
BRCA1-213 ENST00000477152 7010 1837aa ENSP00000419988
BRCA1-201 ENST00000352993 3668 721aa ENSP00000312236
BRCA1-220 ENST00000493919 3757 713aa ENSP00000418819
BRCA1-221 ENST00000494123 7168 1863aa ENSP00000419103
BRCA1-209 ENST00000471181 7270 1884aa ENSP00000418960
BRCA1-232 ENST00000652672 7320 1816aa ENSP00000498906
BRCA1-228 ENST00000634433 6991 1822aa ENSP00000489431
BRCA1-212 ENST00000476777 7075 1861aa ENSP00000417554
BRCA1-233 ENST00000700081 2851 No protein -
BRCA1-208 ENST00000470026 7147 1863aa ENSP00000419274
BRCA1-226 ENST00000618469 7613 1863aa ENSP00000478114
BRCA1-205 ENST00000461574 7082 1862aa ENSP00000417241
BRCA1-231 ENST00000644555 3921 713aa ENSP00000494614
BRCA1-207 ENST00000468300 3273 699aa ENSP00000417148
BRCA1-234 ENST00000700082 1653 No protein -
BRCA1-230 ENST00000644379 6363 1885aa ENSP00000496570
BRCA1-215 ENST00000484087 2490 717aa ENSP00000419481
BRCA1-223 ENST00000586385 781 173aa ENSP00000465818
BRCA1-224 ENST00000591534 1282 354aa ENSP00000467329
BRCA1-225 ENST00000591849 563 96aa ENSP00000465347
BRCA1-219 ENST00000493795 5732 1816aa ENSP00000418775
BRCA1-204 ENST00000461221 5693 63aa ENSP00000418548
BRCA1-217 ENST00000491747 2379 759aa ENSP00000420705
BRCA1-210 ENST00000472490 561 No protein -
BRCA1-236 ENST00000700182 2269 544aa ENSP00000514849
BRCA1-227 ENST00000621897 375 No protein -
BRCA1-202 ENST00000354071 4497 No protein -
BRCA1-237 ENST00000700183 1778 59aa ENSP00000514850
BRCA1-218 ENST00000492859 1584 59aa ENSP00000420253
BRCA1-229 ENST00000642945 1255 81aa ENSP00000495897
BRCA1-238 ENST00000700184 919 No protein -
BRCA1-206 ENST00000461798 582 63aa ENSP00000417988
BRCA1-235 ENST00000700083 1309 No protein -
BRCA1-239 ENST00000700185 496 No protein -
BRCA1-240 ENST00000700186 737 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000012048

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000012048homo_sapiensENSP0000035028397.208895.8669nomascus_leucogenysENSNLEP0000004220196.125394.7983
ENSG00000012048homo_sapiensENSP0000035028396.940496.35pan_paniscusENSPPAP0000001570297.674497.0795
ENSG00000012048homo_sapiensENSP0000035028397.799296.7794pongo_abeliiENSPPYP0000004122696.709195.7006
ENSG00000012048homo_sapiensENSP0000035028398.711898.2287pan_troglodytesENSPTRP0000007012097.611597.1338
ENSG00000012048homo_sapiensENSP0000035028395.169194.1492gorilla_gorillaENSGGOP0000002392197.203996.1623
ENSG00000012048homo_sapiensENSP0000035028324.798717.767ornithorhynchus_anatinusENSOANP0000003939448.734234.9156
ENSG00000012048homo_sapiensENSP0000035028339.023128.8245notamacropus_eugeniiENSMEUP0000001431439.425229.1215
ENSG00000012048homo_sapiensENSP0000035028367.257160.7622choloepus_hoffmanniENSCHOP0000000479470.117563.3464
ENSG00000012048homo_sapiensENSP0000035028368.59960.6549dasypus_novemcinctusENSDNOP0000001246481.349571.9287
ENSG00000012048homo_sapiensENSP0000035028364.465954.321erinaceus_europaeusENSEEUP0000000249466.280355.8499
ENSG00000012048homo_sapiensENSP0000035028366.720354.643echinops_telfairiENSETEP0000000232270.544857.7753
ENSG00000012048homo_sapiensENSP0000035028392.592687.6543callithrix_jacchusENSCJAP0000002388391.560586.6773
ENSG00000012048homo_sapiensENSP0000035028394.739791.7874cercocebus_atysENSCATP0000004404194.334691.395
ENSG00000012048homo_sapiensENSP0000035028395.974293.1294macaca_fascicularisENSMFAP0000002561394.904592.0913
ENSG00000012048homo_sapiensENSP0000035028396.027993.0757macaca_mulattaENSMMUP0000003438694.957592.0382
ENSG00000012048homo_sapiensENSP0000035028396.188993.2367macaca_nemestrinaENSMNEP0000002112694.614691.7107
ENSG00000012048homo_sapiensENSP0000035028395.115492.1632papio_anubisENSPANP0000002722694.911691.9657
ENSG00000012048homo_sapiensENSP0000035028393.02289.7477mandrillus_leucophaeusENSMLEP0000001464594.031590.7216
ENSG00000012048homo_sapiensENSP0000035028382.71674.3961tursiops_truncatusENSTTRP0000001113984.438475.9452
ENSG00000012048homo_sapiensENSP0000035028383.360274.6108vulpes_vulpesENSVVUP0000003314582.125973.5061
ENSG00000012048homo_sapiensENSP0000035028369.511555.7166mus_spretusMGP_SPRETEiJ_P003150671.389257.2216
ENSG00000012048homo_sapiensENSP0000035028385.775676.5432equus_asinusENSEASP0000501449086.099176.8319
ENSG00000012048homo_sapiensENSP0000035028381.052170.6924capra_hircusENSCHIP0000003301481.931671.4596
ENSG00000012048homo_sapiensENSP0000035028383.467573.9667loxodonta_africanaENSLAFP0000001217783.872774.3258
ENSG00000012048homo_sapiensENSP0000035028384.3875.8991panthera_leoENSPLOP0000001437684.244475.7771
ENSG00000012048homo_sapiensENSP0000035028383.789674.9866ailuropoda_melanoleucaENSAMEP0000000019783.610174.8259
ENSG00000012048homo_sapiensENSP0000035028381.696271.5513bos_indicus_hybridENSBIXP0000502518578.372868.6406
ENSG00000012048homo_sapiensENSP0000035028380.193268.9211oryctolagus_cuniculusENSOCUP0000000336680.669569.3305
ENSG00000012048homo_sapiensENSP0000035028384.3875.0939equus_caballusENSECAP0000003516384.607175.296
ENSG00000012048homo_sapiensENSP0000035028383.091874.1814canis_lupus_familiarisENSCAFP0084500843282.428173.5889
ENSG00000012048homo_sapiensENSP0000035028335.963532.9039panthera_pardusENSPPRP0000000206188.507380.9775
ENSG00000012048homo_sapiensENSP000003502834.347833.97209marmota_marmota_marmotaENSMMMP0000000514488.043580.4348
ENSG00000012048homo_sapiensENSP0000035028317.015615.4053marmota_marmota_marmotaENSMMMP0000000518889.54881.0734
ENSG00000012048homo_sapiensENSP0000035028385.560977.1337balaenoptera_musculusENSBMSP0001001928985.791277.3412
ENSG00000012048homo_sapiensENSP0000035028383.682275.0939felis_catusENSFCAP0000001219383.279974.7329
ENSG00000012048homo_sapiensENSP000003502833.972093.7037ursus_americanusENSUAMP0000001650473.267368.3168
ENSG00000012048homo_sapiensENSP0000035028360.976945.84monodelphis_domesticaENSMODP0000001893361.739146.413
ENSG00000012048homo_sapiensENSP0000035028380.56970.3167bison_bison_bisonENSBBBP0000000274182.066771.6238
ENSG00000012048homo_sapiensENSP0000035028377.670469.6726monodon_monocerosENSMMNP0001502764583.256674.6835
ENSG00000012048homo_sapiensENSP0000035028382.608773.0005sus_scrofaENSSSCP0000003443983.414673.7127
ENSG00000012048homo_sapiensENSP0000035028382.179374.6645microcebus_murinusENSMICP0000004998586.497278.5876
ENSG00000012048homo_sapiensENSP000003502833.864733.22061octodon_degusENSODEP0000002461291.139275.9494
ENSG00000012048homo_sapiensENSP0000035028369.779957.649jaculus_jaculusENSJJAP0000002027973.821760.9881
ENSG00000012048homo_sapiensENSP0000035028381.266871.2292ovis_aries_rambouilletENSOARP0002002687982.104171.9631
ENSG00000012048homo_sapiensENSP000003502834.079443.97209ursus_maritimusENSUMAP0000003495282.608780.4348
ENSG00000012048homo_sapiensENSP0000035028371.229260.1181ochotona_princepsENSOPRP0000000996172.237360.969
ENSG00000012048homo_sapiensENSP0000035028336.339233.7627delphinapterus_leucasENSDLEP0000002285188.496782.2222
ENSG00000012048homo_sapiensENSP0000035028376.650668.5454physeter_catodonENSPCTP0000501696983.950675.0735
ENSG00000012048homo_sapiensENSP000003502838.534628.26624physeter_catodonENSPCTP0000502833792.982590.0585
ENSG00000012048homo_sapiensENSP0000035028369.350555.3408mus_caroliMGP_CAROLIEiJ_P003007871.420756.9928
ENSG00000012048homo_sapiensENSP0000035028369.457955.7166mus_musculusENSMUSP0000001729071.412857.2848
ENSG00000012048homo_sapiensENSP000003502833.596353.16693dipodomys_ordiiENSDORP0000001985184.810174.6835
ENSG00000012048homo_sapiensENSP0000035028335.909832.7429mustela_putorius_furoENSMPUP0000000972287.336879.6345
ENSG00000012048homo_sapiensENSP0000035028391.841187.2786aotus_nancymaaeENSANAP0000000432993.650888.9984
ENSG00000012048homo_sapiensENSP0000035028382.984478.7976saimiri_boliviensis_boliviensisENSSBOP0000002218992.408887.7466
ENSG00000012048homo_sapiensENSP0000035028372.249164.8953vicugna_pacosENSVPAP0000000238075.83168.1127
ENSG00000012048homo_sapiensENSP0000035028333.816432.7429chlorocebus_sabaeusENSCSAP0000001465195.022692.006
ENSG00000012048homo_sapiensENSP0000035028343.102537.5201tupaia_belangeriENSTBEP0000001127445.061739.2256
ENSG00000012048homo_sapiensENSP0000035028347.074637.7348mesocricetus_auratusENSMAUP0000000664367.203153.8697
ENSG00000012048homo_sapiensENSP0000035028384.3875.7917phocoena_sinusENSPSNP0000001917784.289575.7105
ENSG00000012048homo_sapiensENSP0000035028384.111675.1476camelus_dromedariusENSCDRP0000501650485.070676.0043
ENSG00000012048homo_sapiensENSP000003502837.353736.11916carlito_syrichtaENSTSYP0000003137076.111163.3333
ENSG00000012048homo_sapiensENSP000003502833.811063.54267carlito_syrichtaENSTSYP0000003365889.873483.5443
ENSG00000012048homo_sapiensENSP0000035028335.856132.9039panthera_tigris_altaicaENSPTIP0000001424988.243180.9775
ENSG00000012048homo_sapiensENSP0000035028369.618955.7703rattus_norvegicusENSRNOP0000002810971.381457.1822
ENSG00000012048homo_sapiensENSP0000035028336.71533.3333prolemur_simusENSPSMP0000000839489.646181.3893
ENSG00000012048homo_sapiensENSP000003502833.972093.38164microtus_ochrogasterENSMOCP0000001047991.35877.7778
ENSG00000012048homo_sapiensENSP0000035028366.77456.5754sorex_araneusENSSARP0000000420069.458458.8498
ENSG00000012048homo_sapiensENSP0000035028371.551357.5953peromyscus_maniculatus_bairdiiENSPEMP0000001826773.001158.7623
ENSG00000012048homo_sapiensENSP0000035028380.139670.1557bos_mutusENSBMUP0000002664081.67471.4989
ENSG00000012048homo_sapiensENSP0000035028369.243255.3945mus_spicilegusENSMSIP0000000810871.113656.8909
ENSG00000012048homo_sapiensENSP0000035028371.229258.4541cricetulus_griseus_chok1gshdENSCGRP0000101244173.193660.0662
ENSG00000012048homo_sapiensENSP0000035028375.630768.2233pteropus_vampyrusENSPVAP0000000833176.203468.7399
ENSG00000012048homo_sapiensENSP0000035028381.749972.3027myotis_lucifugusENSMLUP0000000377082.235472.7322
ENSG00000012048homo_sapiensENSP000003502833.650033.11326vombatus_ursinusENSVURP000100281378572.5
ENSG00000012048homo_sapiensENSP0000035028341.331229.898vombatus_ursinusENSVURP0001002814356.617640.9559
ENSG00000012048homo_sapiensENSP000003502837.675796.87064vombatus_ursinusENSVURP0001002813281.714373.1429
ENSG00000012048homo_sapiensENSP0000035028381.749972.5711rhinolophus_ferrumequinumENSRFEP0001001978483.360774.0011
ENSG00000012048homo_sapiensENSP0000035028383.091873.3763neovison_visonENSNVIP0000001800182.648272.9845
ENSG00000012048homo_sapiensENSP0000035028381.588871.4439bos_taurusENSBTAP0000001161682.206671.9849
ENSG00000012048homo_sapiensENSP0000035028370.477756.2534heterocephalus_glaber_femaleENSHGLP0000001650573.43458.613
ENSG00000012048homo_sapiensENSP0000035028391.143387.9764rhinopithecus_bietiENSRBIP0000004118293.399390.154
ENSG00000012048homo_sapiensENSP000003502834.025763.91841canis_lupus_dingoENSCAFP0002001613991.463489.0244
ENSG00000012048homo_sapiensENSP0000035028317.337615.7273canis_lupus_dingoENSCAFP0002001615982.820575.1282
ENSG00000012048homo_sapiensENSP0000035028345.67939.6135canis_lupus_dingoENSCAFP0002001614478.073467.7064
ENSG00000012048homo_sapiensENSP0000035028383.467574.1814sciurus_vulgarisENSSVLP0000500382784.879975.4367
ENSG00000012048homo_sapiensENSP0000035028341.975330.8642phascolarctos_cinereusENSPCIP0000005505955.031740.4645
ENSG00000012048homo_sapiensENSP000003502834.025763.27429phascolarctos_cinereusENSPCIP0000005159088.235371.7647
ENSG00000012048homo_sapiensENSP0000035028357.541648.3092procavia_capensisENSPCAP0000001258459.29249.7788
ENSG00000012048homo_sapiensENSP0000035028368.27755.3408nannospalax_galiliENSNGAP0000001296173.271959.3894
ENSG00000012048homo_sapiensENSP0000035028381.910971.7123bos_grunniensENSBGRP0000000958782.264272.0216
ENSG00000012048homo_sapiensENSP0000035028363.231350.1879chinchilla_lanigeraENSCLAP0000002506469.457655.1297
ENSG00000012048homo_sapiensENSP0000035028383.789674.4498catagonus_wagneriENSCWAP0000002492084.060374.6904
ENSG00000012048homo_sapiensENSP0000035028317.015615.4589ictidomys_tridecemlineatusENSSTOP0000000044989.801781.5864
ENSG00000012048homo_sapiensENSP0000035028390.928686.205cebus_imitatorENSCCAP0000001723292.568387.7596
ENSG00000012048homo_sapiensENSP0000035028316.478814.7611urocitellus_parryiiENSUPAP0001001281986.968877.9037
ENSG00000012048homo_sapiensENSP0000035028381.213170.9071moschus_moschiferusENSMMSP0000002705381.82871.444
ENSG00000012048homo_sapiensENSP0000035028392.055888.1911rhinopithecus_roxellanaENSRROP0000003352493.409689.488
ENSG00000012048homo_sapiensENSP0000035028370.155756.7364mus_pahariMGP_PahariEiJ_P003680372.050758.269
ENSG00000012048homo_sapiensENSP000003502834.025763.75738propithecus_coquereliENSPCOP0000001234293.7587.5
ENSG00000012048homo_sapiensENSP000003502838.051537.56844propithecus_coquereliENSPCOP0000002339295.541489.8089
ENSG00000012048homo_sapiensENSP000003502832.308111.23457caenorhabditis_elegansF42A6.5.142.156922.549
ENSG00000012048homo_sapiensENSP000003502837.675793.43532ciona_intestinalisENSCINP0000002017346.278320.712
ENSG00000012048homo_sapiensENSP0000035028328.770814.2244eptatretus_burgeriENSEBUP0000001483332.722816.1783
ENSG00000012048homo_sapiensENSP0000035028330.703218.2501callorhinchus_miliiENSCMIP0000001083734.94220.7697
ENSG00000012048homo_sapiensENSP0000035028344.337127.3215latimeria_chalumnaeENSLACP0000000674044.100427.1757
ENSG00000012048homo_sapiensENSP0000035028333.923819.8604lepisosteus_oculatusENSLOCP0000001400744.413226.0014
ENSG00000012048homo_sapiensENSP0000035028331.669316.4251clupea_harengusENSCHAP0000000656529.150215.1186
ENSG00000012048homo_sapiensENSP0000035028332.367118.4112astyanax_mexicanusENSAMXP0000004547938.188721.7226
ENSG00000012048homo_sapiensENSP0000035028329.414916.3178ictalurus_punctatusENSIPUP0000003265740.029222.206
ENSG00000012048homo_sapiensENSP0000035028329.468617.1766esox_luciusENSELUP0000000610335.079920.4473
ENSG00000012048homo_sapiensENSP0000035028330.220117.7134oncorhynchus_kisutchENSOKIP0000501812835.565420.8465
ENSG00000012048homo_sapiensENSP0000035028330.005417.6597oncorhynchus_mykissENSOMYP0000002206835.833321.0897
ENSG00000012048homo_sapiensENSP0000035028329.89817.8744salmo_salarENSSSAP0000017120435.075620.9698
ENSG00000012048homo_sapiensENSP0000035028328.287716.4788salmo_truttaENSSTUP000000431463419.8065
ENSG00000012048homo_sapiensENSP0000035028327.804616.1567salmo_truttaENSSTUP0000010195434.718520.1743
ENSG00000012048homo_sapiensENSP0000035028329.629617.0156gadus_morhuaENSGMOP0000005321535.820920.5711
ENSG00000012048homo_sapiensENSP0000035028328.985516.9082fundulus_heteroclitusENSFHEP0000002669539.793723.213
ENSG00000012048homo_sapiensENSP0000035028328.448717.7134poecilia_reticulataENSPREP0000003307639.434524.5536
ENSG00000012048homo_sapiensENSP0000035028327.536216.6398xiphophorus_maculatusENSXMAP0000000996337.445322.6277
ENSG00000012048homo_sapiensENSP0000035028329.683317.445oryzias_latipesENSORLP0000000576342.801925.1548
ENSG00000012048homo_sapiensENSP0000035028325.389214.5464cyclopterus_lumpusENSCLMP0000500355837.870321.6974
ENSG00000012048homo_sapiensENSP000003502833.166932.52281cyclopterus_lumpusENSCLMP0000500355457.281645.6311
ENSG00000012048homo_sapiensENSP0000035028329.73717.4987oreochromis_niloticusENSONIP0000002055639.798923.4195
ENSG00000012048homo_sapiensENSP0000035028329.683317.445haplochromis_burtoniENSHBUP0000000310439.841523.415
ENSG00000012048homo_sapiensENSP0000035028328.824516.9082astatotilapia_callipteraENSACLP0000001358238.997822.8758
ENSG00000012048homo_sapiensENSP0000035028328.717116.5862sparus_aurataENSSAUP0001005406437.676121.7606
ENSG00000012048homo_sapiensENSP0000035028330.05917.1766lates_calcariferENSLCAP0001000627639.688222.679
ENSG00000012048homo_sapiensENSP0000035028335.909821.9538xenopus_tropicalisENSXETP0000006300940.42324.713
ENSG00000012048homo_sapiensENSP0000035028349.973235.3731chrysemys_picta_belliiENSCPBP0000002276848.974234.666
ENSG00000012048homo_sapiensENSP0000035028313.580210.1449sphenodon_punctatusENSSPUP0000000578558.837243.9535
ENSG00000012048homo_sapiensENSP000003502836.548583.489crocodylus_porosusENSCPRP0000501125440.939621.8121
ENSG00000012048homo_sapiensENSP0000035028346.001131.562crocodylus_porosusENSCPRP0000501167051.533435.3578
ENSG00000012048homo_sapiensENSP0000035028327.643616.6935pseudonaja_textilisENSPTXP0000002417841.599425.1212
ENSG00000012048homo_sapiensENSP0000035028346.859932.2061anas_platyrhynchos_platyrhynchosENSAPLP0000002665447.291432.5027
ENSG00000012048homo_sapiensENSP0000035028343.156227.5362gallus_gallusENSGALP0001003712446.608729.7391
ENSG00000012048homo_sapiensENSP000003502836.226525.04563meleagris_gallopavoENSMGAP0000002826270.30356.9697
ENSG00000012048homo_sapiensENSP0000035028339.023124.4767meleagris_gallopavoENSMGAP0000001796944.437727.8729
ENSG00000012048homo_sapiensENSP0000035028344.766529.5223serinus_canariaENSSCAP0000000891046.410730.6066
ENSG00000012048homo_sapiensENSP0000035028346.645230.1664parus_majorENSPMJP0000000257148.14431.1357
ENSG00000012048homo_sapiensENSP0000035028340.579726.8384anolis_carolinensisENSACAP0000001316744.549229.4638
ENSG00000012048homo_sapiensENSP0000035028327.375216.2104neolamprologus_brichardiENSNBRP0000002271642.358825.0831
ENSG00000012048homo_sapiensENSP0000035028329.092917.9818podarcis_muralisENSPMRP0000001712442.146226.0498
ENSG00000012048homo_sapiensENSP0000035028345.8430.2201geospiza_fortisENSGFOP0000000551547.603131.3824
ENSG00000012048homo_sapiensENSP0000035028346.591530.7032taeniopygia_guttataENSTGUP0000000295548.14231.7249
ENSG00000012048homo_sapiensENSP0000035028327.697316.2104erpetoichthys_calabaricusENSECRP0000003240647.080327.5547
ENSG00000012048homo_sapiensENSP0000035028328.824516.9082kryptolebias_marmoratusENSKMAP0000002439339.660323.2644
ENSG00000012048homo_sapiensENSP0000035028337.895923.7789salvator_merianaeENSSMRP0000000994042.865826.8974
ENSG00000012048homo_sapiensENSP0000035028326.033315.781oryzias_javanicusENSOJAP0000002891144.495426.9725
ENSG00000012048homo_sapiensENSP0000035028325.657514.7075amphilophus_citrinellusENSACIP0000001274639.244722.4959
ENSG00000012048homo_sapiensENSP0000035028330.327418.0891dicentrarchus_labraxENSDLAP0000501440038.911823.2094
ENSG00000012048homo_sapiensENSP0000035028325.872215.7273amphiprion_perculaENSAPEP0000002286141.056224.9574
ENSG00000012048homo_sapiensENSP0000035028328.395116.8545oryzias_sinensisENSOSIP0000002076740.97624.3222
ENSG00000012048homo_sapiensENSP0000035028323.886214.6538pelodiscus_sinensisENSPSIP0000000562142.461826.0496
ENSG00000012048homo_sapiensENSP0000035028348.684934.6753gopherus_evgoodeiENSGEVP0000500688851.563436.7254
ENSG00000012048homo_sapiensENSP0000035028344.605531.2936chelonoidis_abingdoniiENSCABP0000003113849.346834.62
ENSG00000012048homo_sapiensENSP0000035028326.194314.2244seriola_dumeriliENSSDUP0000002989939.008821.1831
ENSG00000012048homo_sapiensENSP0000035028321.524411.8626cottoperca_gobioENSCGOP0000002481134.127718.8085
ENSG00000012048homo_sapiensENSP0000035028346.001131.2936struthio_camelus_australisENSSCUP0000001011647.217632.1212
ENSG00000012048homo_sapiensENSP0000035028346.162131.2936anser_brachyrhynchusENSABRP0000001490046.713731.6676
ENSG00000012048homo_sapiensENSP0000035028327.643616.8009gasterosteus_aculeatusENSGACP0000000844839.074423.7481
ENSG00000012048homo_sapiensENSP0000035028328.663417.284poecilia_formosaENSPFOP0000000469540.577524.4681
ENSG00000012048homo_sapiensENSP0000035028331.078917.767myripristis_murdjanENSMMDP0000503703938.067121.762
ENSG00000012048homo_sapiensENSP000003502834.294152.89855sander_luciopercaENSSLUP0000000007737.914725.5924
ENSG00000012048homo_sapiensENSP0000035028343.639330.0054strigops_habroptilaENSSHBP0000501582447.823532.8824
ENSG00000012048homo_sapiensENSP0000035028330.112717.3913amphiprion_ocellarisENSAOCP0000000048139.094122.5784
ENSG00000012048homo_sapiensENSP0000035028346.698933.226terrapene_carolina_triunguisENSTMTP0000002044050.20235.7184
ENSG00000012048homo_sapiensENSP0000035028327.589915.4053hucho_huchoENSHHUP0000008438434.871119.4708
ENSG00000012048homo_sapiensENSP0000035028329.307616.9619betta_splendensENSBSLP0000003461138.916622.5232
ENSG00000012048homo_sapiensENSP0000035028331.508318.2501pygocentrus_nattereriENSPNAP0000002609237.081521.4782
ENSG00000012048homo_sapiensENSP0000035028328.931817.1766anabas_testudineusENSATEP0000003188838.445122.8245
ENSG00000012048homo_sapiensENSP000003502836.333873.65003ciona_savignyiENSCSAVP0000001088747.967527.6423
ENSG00000012048homo_sapiensENSP0000035028329.683316.4788seriola_lalandi_dorsalisENSSLDP0000002409838.322921.2751
ENSG00000012048homo_sapiensENSP0000035028326.40915.4053labrus_bergyltaENSLBEP0000000704441.694924.322
ENSG00000012048homo_sapiensENSP0000035028326.462715.8347pundamilia_nyerereiENSPNYP0000000120341.779725
ENSG00000012048homo_sapiensENSP0000035028330.166416.9082mastacembelus_armatusENSMAMP0000002369238.973621.8447
ENSG00000012048homo_sapiensENSP0000035028330.112717.445stegastes_partitusENSSPAP0000000360739.75923.0333
ENSG00000012048homo_sapiensENSP0000035028329.790717.606oncorhynchus_tshawytschaENSOTSP0000507867335.691321.0932
ENSG00000012048homo_sapiensENSP0000035028328.824516.5325acanthochromis_polyacanthusENSAPOP0000002373038.688822.1902
ENSG00000012048homo_sapiensENSP0000035028348.201831.8304aquila_chrysaetos_chrysaetosENSACCP0002000073348.124331.7792
ENSG00000012048homo_sapiensENSP0000035028328.448716.6398nothobranchius_furzeriENSNFUP0001501509538.999322.8109
ENSG00000012048homo_sapiensENSP0000035028328.663416.7472cyprinodon_variegatusENSCVAP0000003183540.639323.7443
ENSG00000012048homo_sapiensENSP0000035028319.377311.4332denticeps_clupeoidesENSDCDP0000000303241.069424.2321
ENSG00000012048homo_sapiensENSP0000035028319.806812.0773denticeps_clupeoidesENSDCDP0000000310441.275225.1678
ENSG00000012048homo_sapiensENSP0000035028329.092916.0494larimichthys_croceaENSLCRP0000500187637.691220.7928
ENSG00000012048homo_sapiensENSP0000035028328.448715.7273takifugu_rubripesENSTRUP0000005026939.611421.8984
ENSG00000012048homo_sapiensENSP0000035028345.786430.1127ficedula_albicollisENSFALP0000000082847.257631.0803
ENSG00000012048homo_sapiensENSP0000035028325.550215.2442hippocampus_comesENSHCOP0000001666341.717824.8904
ENSG00000012048homo_sapiensENSP0000035028344.068728.9318coturnix_japonicaENSCJPP0000500583547.021830.8706
ENSG00000012048homo_sapiensENSP0000035028328.663417.445poecilia_latipinnaENSPLAP0000000862540.608424.7148
ENSG00000012048homo_sapiensENSP0000035028329.57617.3913maylandia_zebraENSMZEP0000502841139.668823.3261
ENSG00000012048homo_sapiensENSP0000035028326.08714.5464tetraodon_nigroviridisENSTNIP0000001314738.510321.4739
ENSG00000012048homo_sapiensENSP0000035028329.468617.9818paramormyrops_kingsleyaeENSPKIP0000000645838.151523.2801
ENSG00000012048homo_sapiensENSP0000035028332.957619.5384scleropages_formosusENSSFOP0001501884839.510923.4234
ENSG00000012048homo_sapiensENSP0000035028326.677415.8347scophthalmus_maximusENSSMAP0000003218840.538324.062
ENSG00000012048homo_sapiensENSP0000035028318.196510.1986oryzias_melastigmaENSOMEP0000000333040.309222.5922

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000151part_of ubiquitin ligase complex1NASHomo_sapiens(9606)Component
GO:0000152part_of nuclear ubiquitin ligase complex1IDAHomo_sapiens(9606)Component
GO:0000209involved_in protein polyubiquitination1IDAHomo_sapiens(9606)Process
GO:0000724involved_in double-strand break repair via homologous recombination2IBA,IDAHomo_sapiens(9606)Process
GO:0000800located_in lateral element1IDAHomo_sapiens(9606)Component
GO:0000931part_of gamma-tubulin ring complex1NASHomo_sapiens(9606)Component
GO:0000976enables transcription cis-regulatory region binding1IDAHomo_sapiens(9606)Function
GO:0001673located_in male germ cell nucleus1IEAHomo_sapiens(9606)Component
GO:0001741located_in XY body1IEAHomo_sapiens(9606)Component
GO:0002039enables p53 binding1IDAHomo_sapiens(9606)Function
GO:0003677enables DNA binding1TASHomo_sapiens(9606)Function
GO:0003684enables damaged DNA binding1IEAHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IMPHomo_sapiens(9606)Function
GO:0003723enables RNA binding1IDAHomo_sapiens(9606)Function
GO:0004842enables ubiquitin-protein transferase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005694located_in chromosome1ISSHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane2IBA,IDAHomo_sapiens(9606)Component
GO:0006281involved_in DNA repair1NASHomo_sapiens(9606)Process
GO:0006282involved_in regulation of DNA repair1NASHomo_sapiens(9606)Process
GO:0006301involved_in postreplication repair1IDAHomo_sapiens(9606)Process
GO:0006302involved_in double-strand break repair3IDA,IMP,TASHomo_sapiens(9606)Process
GO:0006349involved_in regulation of gene expression by genomic imprinting1IEAHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1IMPHomo_sapiens(9606)Process
GO:0006633involved_in fatty acid biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1NASHomo_sapiens(9606)Process
GO:0007059involved_in chromosome segregation1IMPHomo_sapiens(9606)Process
GO:0007095involved_in mitotic G2 DNA damage checkpoint signaling1IMPHomo_sapiens(9606)Process
GO:0007098involved_in centrosome cycle1IEAHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0008630acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage1IDAHomo_sapiens(9606)Process
GO:0009048involved_in dosage compensation by inactivation of X chromosome1IBAHomo_sapiens(9606)Process
GO:0010212involved_in response to ionizing radiation1IMPHomo_sapiens(9606)Process
GO:0010575involved_in positive regulation of vascular endothelial growth factor production1IMPHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0015631enables tubulin binding1NASHomo_sapiens(9606)Function
GO:0016567involved_in protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0016604located_in nuclear body1IDAHomo_sapiens(9606)Component
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0030308involved_in negative regulation of cell growth1IMPHomo_sapiens(9606)Process
GO:0031398involved_in positive regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0031436part_of BRCA1-BARD1 complex3IBA,IDA,IPIHomo_sapiens(9606)Component
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0033147involved_in negative regulation of intracellular estrogen receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0035066involved_in positive regulation of histone acetylation2IBA,IDAHomo_sapiens(9606)Process
GO:0035067involved_in negative regulation of histone acetylation1IBAHomo_sapiens(9606)Process
GO:0035518involved_in histone H2A monoubiquitination1NASHomo_sapiens(9606)Process
GO:0035825involved_in homologous recombination1NASHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043009involved_in chordate embryonic development1IBAHomo_sapiens(9606)Process
GO:0043232is_active_in intracellular non-membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0043627involved_in response to estrogen1IDAHomo_sapiens(9606)Process
GO:0044030involved_in regulation of DNA methylation1IEAHomo_sapiens(9606)Process
GO:0044818involved_in mitotic G2/M transition checkpoint1NASHomo_sapiens(9606)Process
GO:0045717involved_in negative regulation of fatty acid biosynthetic process2IBA,IMPHomo_sapiens(9606)Process
GO:0045739involved_in positive regulation of DNA repair1IMPHomo_sapiens(9606)Process
GO:0045766involved_in positive regulation of angiogenesis1IMPHomo_sapiens(9606)Process
GO:0045786involved_in negative regulation of cell cycle1NASHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription2IDA,IMPHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0046600involved_in negative regulation of centriole replication1NASHomo_sapiens(9606)Process
GO:0051179involved_in localization1IDAHomo_sapiens(9606)Process
GO:0051571involved_in positive regulation of histone H3-K4 methylation1IDAHomo_sapiens(9606)Process
GO:0051572involved_in negative regulation of histone H3-K4 methylation1IEAHomo_sapiens(9606)Process
GO:0051573involved_in negative regulation of histone H3-K9 methylation1IDAHomo_sapiens(9606)Process
GO:0051574involved_in positive regulation of histone H3-K9 methylation1IEAHomo_sapiens(9606)Process
GO:0051726acts_upstream_of regulation of cell cycle1IDAHomo_sapiens(9606)Process
GO:0051865involved_in protein autoubiquitination2IDA,NASHomo_sapiens(9606)Process
GO:0070063enables RNA polymerase binding1IDAHomo_sapiens(9606)Function
GO:0070512involved_in positive regulation of histone H4-K20 methylation1IDAHomo_sapiens(9606)Process
GO:0070531part_of BRCA1-A complex3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0070532part_of BRCA1-B complex1IPIHomo_sapiens(9606)Component
GO:0070533part_of BRCA1-C complex1IPIHomo_sapiens(9606)Component
GO:0070537involved_in histone H2A K63-linked deubiquitination1NASHomo_sapiens(9606)Process
GO:0071356involved_in cellular response to tumor necrosis factor1IMPHomo_sapiens(9606)Process
GO:0071479involved_in cellular response to ionizing radiation1IMPHomo_sapiens(9606)Process
GO:0071681involved_in cellular response to indole-3-methanol1IDAHomo_sapiens(9606)Process
GO:0085020involved_in protein K6-linked ubiquitination1IDAHomo_sapiens(9606)Process
GO:0110025involved_in DNA strand resection involved in replication fork processing1NASHomo_sapiens(9606)Process
GO:1902042involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors1IMPHomo_sapiens(9606)Process
GO:1990391part_of DNA repair complex1IPIHomo_sapiens(9606)Component
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component
GO:2000001involved_in regulation of DNA damage checkpoint1NASHomo_sapiens(9606)Process
GO:2000378involved_in negative regulation of reactive oxygen species metabolic process1IMPHomo_sapiens(9606)Process
GO:2000617involved_in positive regulation of histone H3-K9 acetylation1IDAHomo_sapiens(9606)Process
GO:2000620involved_in positive regulation of histone H4-K16 acetylation1IDAHomo_sapiens(9606)Process

Expression