RBP Type	Non-canonical_RBPs
Diseases	Dengue
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000005810	Gene ID	23077	Accession	23386
Symbol	MYCBP2	Alias	PAM;Phr;PHR1;Myc-bp2	Full Name	MYC binding protein 2
Status	Confidence	Length	284621 bases	Strand	Minus strand
Position	13 : 77042474 - 77327094	RNA binding domain	N.A.
Summary	This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
MYCBP2-212	ENST00000695078	15315	No protein	-
MYCBP2-210	ENST00000683823	17326	4700aa	ENSP00000507196
MYCBP2-211	ENST00000684354	17128	4634aa	ENSP00000507330
MYCBP2-208	ENST00000682321	17482	4752aa	ENSP00000508023
MYCBP2-213	ENST00000695079	17221	4665aa	ENSP00000511683
MYCBP2-209	ENST00000683697	15359	4772aa	ENSP00000508153
MYCBP2-201	ENST00000357337	15257	4738aa	ENSP00000349892
MYCBP2-207	ENST00000544440	15077	4678aa	ENSP00000444596
MYCBP2-214	ENST00000695080	14539	4609aa	ENSP00000511684
MYCBP2-215	ENST00000695081	14323	4537aa	ENSP00000511685
MYCBP2-216	ENST00000695082	1861	No protein	-
MYCBP2-217	ENST00000695083	4922	No protein	-
MYCBP2-202	ENST00000429715	3660	1061aa	ENSP00000413907
MYCBP2-218	ENST00000695084	2855	No protein	-
MYCBP2-219	ENST00000695085	712	No protein	-
MYCBP2-220	ENST00000695086	8831	No protein	-
MYCBP2-221	ENST00000695087	1109	No protein	-
MYCBP2-205	ENST00000485061	566	No protein	-
MYCBP2-222	ENST00000695088	1729	No protein	-
MYCBP2-203	ENST00000466564	2402	No protein	-
MYCBP2-206	ENST00000486679	5088	No protein	-
MYCBP2-223	ENST00000695089	2885	No protein	-
MYCBP2-224	ENST00000695090	5985	No protein	-
MYCBP2-225	ENST00000695091	2638	No protein	-
MYCBP2-226	ENST00000695092	2106	No protein	-
MYCBP2-227	ENST00000695093	1019	No protein	-
MYCBP2-228	ENST00000695094	3181	No protein	-
MYCBP2-229	ENST00000695095	3214	No protein	-
MYCBP2-204	ENST00000474882	393	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
47528	Intelligence Tests	4.8295800E-005	-
47529	Intelligence Tests	4.8295800E-005	-
97720	Pre-Eclampsia	1E-6	23551011

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005085	enables guanyl-nucleotide exchange factor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IC	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0005886	is_active_in plasma membrane	1	IBA	Homo_sapiens(9606)	Component
GO:0007411	involved_in axon guidance	1	IBA	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0008582	involved_in regulation of synaptic assembly at neuromuscular junction	1	IBA	Homo_sapiens(9606)	Process
GO:0015630	located_in microtubule cytoskeleton	1	IEA	Homo_sapiens(9606)	Component
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016567	involved_in protein ubiquitination	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0021785	involved_in branchiomotor neuron axon guidance	1	IEA	Homo_sapiens(9606)	Process
GO:0021952	involved_in central nervous system projection neuron axonogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0030424	located_in axon	1	IEA	Homo_sapiens(9606)	Component
GO:0031267	enables small GTPase binding	1	IDA	Homo_sapiens(9606)	Function
GO:0031398	involved_in positive regulation of protein ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0032880	involved_in regulation of protein localization	1	IEA	Homo_sapiens(9606)	Process
GO:0032922	involved_in circadian regulation of gene expression	1	IMP	Homo_sapiens(9606)	Process
GO:0042177	involved_in negative regulation of protein catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IEA	Homo_sapiens(9606)	Function
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0050905	involved_in neuromuscular process	1	ISS	Homo_sapiens(9606)	Process
GO:0051493	involved_in regulation of cytoskeleton organization	1	IEA	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0070936	involved_in protein K48-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:1902667	involved_in regulation of axon guidance	1	ISS	Homo_sapiens(9606)	Process