RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000004897	Gene ID	996	Accession	1728
Symbol	CDC27	Alias	APC3;HNUC;NUC2;H-NUC;ANAPC3;CDC27Hs;D0S1430E;D17S978E	Full Name	cell division cycle 27
Status	Confidence	Length	71593 bases	Strand	Minus strand
Position	17 : 47117703 - 47189295	RNA binding domain	N.A.
Summary	The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
CDC27-201	ENST00000066544	5830	824aa	ENSP00000066544
CDC27-207	ENST00000531206	3177	830aa	ENSP00000434614
CDC27-211	ENST00000570740	594	33aa	ENSP00000460830
CDC27-210	ENST00000533415	2570	94aa	ENSP00000432211
CDC27-213	ENST00000571643	716	163aa	ENSP00000460279
CDC27-204	ENST00000527547	2579	823aa	ENSP00000437339
CDC27-203	ENST00000526866	1420	343aa	ENSP00000432105
CDC27-214	ENST00000573502	888	113aa	ENSP00000460132
CDC27-202	ENST00000525495	1459	No protein	-
CDC27-216	ENST00000574304	514	59aa	ENSP00000458904
CDC27-218	ENST00000575830	397	No protein	-
CDC27-219	ENST00000576484	548	103aa	ENSP00000459307
CDC27-215	ENST00000573550	583	75aa	ENSP00000460424
CDC27-212	ENST00000570818	656	86aa	ENSP00000460061
CDC27-217	ENST00000575483	781	233aa	ENSP00000460454
CDC27-209	ENST00000532893	515	52aa	ENSP00000466424
CDC27-206	ENST00000528748	859	No protein	-
CDC27-208	ENST00000532575	765	No protein	-
CDC27-205	ENST00000528147	463	No protein	-

Gene Model

Click here to download ENSG00000004897's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
75491	Erythema Nodosum	8E-6	24487271
75492	Inflammatory Bowel Diseases	8E-6	24487271

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000004897's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005680	part_of anaphase-promoting complex	4	IBA,IDA,IPI,NAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005813	located_in centrosome	1	IDA	Homo_sapiens(9606)	Component
GO:0005819	located_in spindle	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0007091	involved_in metaphase/anaphase transition of mitotic cell cycle	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0007346	involved_in regulation of mitotic cell cycle	1	NAS	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	1	IBA	Homo_sapiens(9606)	Process
GO:0019903	enables protein phosphatase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0031145	involved_in anaphase-promoting complex-dependent catabolic process	2	IBA,NAS	Homo_sapiens(9606)	Process
GO:0051301	involved_in cell division	1	IBA	Homo_sapiens(9606)	Process
GO:0051445	involved_in regulation of meiotic cell cycle	1	NAS	Homo_sapiens(9606)	Process
GO:0070979	involved_in protein K11-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0072686	located_in mitotic spindle	1	IDA	Homo_sapiens(9606)	Component

Expression