RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000002746	Gene ID	23072	Accession	22195
Symbol	HECW1	Alias	NEDL1	Full Name	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Status	Confidence	Length	453357 bases	Strand	Plus strand
Position	7 : 43112645 - 43566001	RNA binding domain	N.A.
Summary	Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
HECW1-201	ENST00000395891	9453	1606aa	ENSP00000379228
HECW1-209	ENST00000490954	531	No protein	-
HECW1-203	ENST00000453890	5169	1572aa	ENSP00000407774
HECW1-210	ENST00000492310	2186	No protein	-
HECW1-207	ENST00000471527	497	No protein	-
HECW1-211	ENST00000493057	750	No protein	-
HECW1-205	ENST00000464944	574	No protein	-
HECW1-208	ENST00000481031	412	No protein	-
HECW1-206	ENST00000471043	2888	No protein	-
HECW1-204	ENST00000461842	609	No protein	-
HECW1-202	ENST00000429529	415	138aa	ENSP00000413336

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
13251	Lupus Erythematosus, Systemic	1.17E-5	18204446
16835	Alcoholism	8.52E-05	-
16838	Alcoholism	6.14E-05	-
36729	Platelet Function Tests	1.5900000E-007	-
45254	Platelet Function Tests	8.0003842E-006	-
45295	Platelet Function Tests	3.5862709E-006	-
45300	Platelet Function Tests	3.4007331E-006	-
45380	Platelet Function Tests	1.8312700E-005	-
55860	lycopene	1.7740000E-005	-
55865	lycopene	2.8990000E-005	-
62361	Adenocarcinoma Of Esophagus	5E-6	24121790
67730	3-hydroxy-1-methylpropylmercapturic acid	1E-6	26053186
67731	Smoking	1E-6	26053186
74830	Bone Density	5E-6	27397699
79993	Alzheimer Disease	1E-6	23535033
90791	amyloid beta-protein (1-42)	3E-7	26252872
90792	Cerebrospinal Fluid	3E-7	26252872
102781	Immunoglobulin A	6E-6	28187132
104117	Energy Intake	6E-6	23251661
106473	Diabetes Mellitus, Type 2	4E-6	25102180

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0016567	involved_in protein ubiquitination	2	IBA,IEA	Homo_sapiens(9606)	Process
GO:0048814	involved_in regulation of dendrite morphogenesis	1	IBA	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	2	IBA,TAS	Homo_sapiens(9606)	Function
GO:0090090	involved_in negative regulation of canonical Wnt signaling pathway	1	TAS	Homo_sapiens(9606)	Process
GO:2000650	involved_in negative regulation of sodium ion transmembrane transporter activity	1	IBA	Homo_sapiens(9606)	Process