Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
Status
Confidence
Length
2586 bases
Strand
Minus strand
Position
XII : 823828 - 826413
RNA binding domain
IBN_N
Summary
Enables guanyl-nucleotide exchange factor activity and nuclear import signal receptor activity. Involved in several processes, including intracellular protein transport; nuclear pore complex assembly; and regulation of protein desumoylation. Located in cytoplasm and nucleus. Part of NLS-dependent protein nuclear import complex. Orthologous to human KPNB1 (karyopherin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]