RBP Type	N.A.
Diseases
Drug
Main interacting RNAs
Moonlighting functions
Localizations
BulkPerturb-seq

Ensembl ID	WBGene00004189	Gene ID	176024	Accession	-
Symbol	pars-1	Alias	NA	Full Name	Prolyl-tRNA synthetase
Status	Confidence	Length	2251 bases	Strand	Plus strand
Position	III : 7239027 - 7241277	RNA binding domain	ProRS-C_1 , HGTP_anticodon , tRNA-synt_2b
Summary	Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
T20H4	ProRS-C_1	PF09180	7.1e-21	1
T20H4	tRNA-synt_2b	PF00587	1.5e-16	2
T20H4	tRNA-synt_2b	PF00587	2.4e-16	3
T20H4	HGTP_anticodon	PF03129	2.4e-18	4
T20H4	HGTP_anticodon	PF03129	1.7e-12	5

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
pars-1-202	T20H4	1797	454aa	T20H4

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
WBGene00004189	caenorhabditis_elegans	T27F6.5a.1	24.8899	11.674	caenorhabditis_elegans	T20H4.3a.1	19.4492	9.1222
WBGene00004189	caenorhabditis_elegans	C47D12.6a.1	22.069	11.1724	caenorhabditis_elegans	T20H4.3a.1	27.5387	13.9415
WBGene00004189	caenorhabditis_elegans	Y46H3A.7a.1	12.5424	4.0678	caenorhabditis_elegans	T20H4.3a.1	6.36833	2.0654

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	27.1945	20.9983	lepisosteus_oculatus	ENSLOCP00000020757	73.4884	56.7442
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	20.4819	13.5972	petromyzon_marinus	ENSPMAP00000000155	56.1321	37.2642
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	23.0637	12.3924	ornithorhynchus_anatinus	ENSOANP00000048351	16.6874	8.96638
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.8348	ailuropoda_melanoleuca	ENSAMEP00000001673	23.9554	12.8134
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	25.9897	13.9415	ochotona_princeps	ENSOPRP00000009323	21.0306	11.2813
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.4905	macaca_fascicularis	ENSMFAP00000014628	23.5213	12.3796
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	25.6454	13.7694	macaca_nemestrina	ENSMNEP00000038134	22.406	12.0301
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	26.6781	14.1136	echinops_telfairi	ENSETEP00000006966	21.648	11.4525
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.3184	papio_anubis	ENSPANP00000011899	23.8162	12.3955
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	27.1945	14.9742	dipodomys_ordii	ENSDORP00000007099	26.2458	14.4518
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	22.3752	11.3597	vicugna_pacos	ENSVPAP00000005042	18.8953	9.59302
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.4905	mandrillus_leucophaeus	ENSMLEP00000012071	23.9554	12.5348
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	16.179	panthera_leo	ENSPLOP00000026457	24.1234	13.1837
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.9157	15.6627	loxodonta_africana	ENSLAFP00000004164	23.301	12.6214
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	16.179	felis_catus	ENSFCAP00000001577	24.1234	13.1837
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.0878	15.1463	cercocebus_atys	ENSCATP00000022463	24.1774	12.5894
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.2599	16.0069	canis_lupus_familiaris	ENSCAFP00845024349	23.6769	12.9526
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.2599	15.4905	sus_scrofa	ENSSSCP00000022087	23.6769	12.5348
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	15.6627	bos_indicus_hybrid	ENSBIXP00005023943	21.7337	11.4322
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.8348	equus_asinus	ENSEASP00005059355	23.7171	12.7601
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	16.179	chinchilla_lanigera	ENSCLAP00000025157	24.3243	13.3713
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	21.1704	11.3597	procavia_capensis	ENSPCAP00000015582	18.4685	9.90991
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	16.179	vulpes_vulpes	ENSVVUP00000015643	23.7171	13.0374
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.9484	15.8348	mus_spretus	MGP_SPRETEiJ_P0061590	24.0664	12.7248
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.2599	16.0069	octodon_degus	ENSODEP00000016137	23.4483	12.8276
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.5714	14.8021	sarcophilus_harrisii	ENSSHAP00000024350	23.2819	12.0617
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.9157	15.6627	heterocephalus_glaber_female	ENSHGLP00000012895	23.4965	12.7273
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.8348	equus_caballus	ENSECAP00000012043	23.7171	12.7601
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	30.1205	16.3511	cricetulus_griseus_chok1gshd	ENSCGRP00001026117	24.2047	13.1397
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	14.9742	pan_paniscus	ENSPPAP00000038656	23.8162	12.117
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	10.6713	5.50775	cavia_porcellus	ENSCPOP00000009506	21.3793	11.0345
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	24.2685	11.8761	erinaceus_europaeus	ENSEEUP00000000160	19.6106	9.59666
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	8.43373	5.16351	erinaceus_europaeus	ENSEEUP00000011533	13.3515	8.17439
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.9484	16.3511	camelus_dromedarius	ENSCDRP00005024755	24.234	13.2312
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.0878	15.1463	sorex_araneus	ENSSARP00000011874	24.0057	12.5
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.8348	physeter_catodon	ENSPCTP00005028565	24.569	13.2184
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	25.9897	13.7694	gorilla_gorilla	ENSGGOP00000006177	24.5528	13.0081
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	15.4905	rhinopithecus_roxellana	ENSRROP00000013429	24.0947	12.5348
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	16.179	balaenoptera_musculus	ENSBMSP00010020294	24.0947	13.0919
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	62.9948	50.7745	eptatretus_burgeri	ENSEBUP00000026111	69.5817	56.0836
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.2599	15.1463	urocitellus_parryii	ENSUPAP00010002672	23.6769	12.2563
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	15.8348	mus_pahari	MGP_PahariEiJ_P0070182	23.9281	12.7248
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	30.1205	16.0069	bos_grunniens	ENSBGRP00000001188	24.0385	12.7747
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.9484	15.6627	mus_spicilegus	ENSMSIP00000008003	24.0664	12.5864
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	30.2926	16.6954	delphinapterus_leucas	ENSDLEP00000013167	14.8024	8.15812
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.6627	ursus_maritimus	ENSUMAP00000004595	23.9554	12.6741
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.6627	dasypus_novemcinctus	ENSDNOP00000004603	24.0559	12.7273
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.8348	ovis_aries_rambouillet	ENSOARP00020010615	23.9554	12.8134
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	18.9329	9.63855	tupaia_belangeri	ENSTBEP00000003458	15.4062	7.84314
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	16.179	panthera_pardus	ENSPPRP00000027855	24.1234	13.1837
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	12.9088	6.0241	choloepus_hoffmanni	ENSCHOP00000000707	16.3755	7.64192
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	23.7522	13.0809	tursiops_truncatus	ENSTTRP00000010074	23.4295	12.9032
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.8348	myotis_lucifugus	ENSMLUP00000011941	23.8558	12.7601
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.8348	phocoena_sinus	ENSPSNP00000002590	23.8162	12.8134
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.7435	15.1463	aotus_nancymaae	ENSANAP00000003567	23.2591	12.2563
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	16.0069	bison_bison_bison	ENSBBBP00000015860	24.0947	12.9526
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	30.1205	16.179	mesocricetus_auratus	ENSMAUP00000006188	24.2047	13.0014
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.3993	14.6299	rhinopithecus_bieti	ENSRBIP00000042513	23.639	12.1777
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.9157	14.9742	callithrix_jacchus	ENSCJAP00000011960	23.3983	12.117
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.2272	15.3184	rhinolophus_ferrumequinum	ENSRFEP00010031138	22.3129	12.1088
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	23.4079	16.179	tetraodon_nigroviridis	ENSTNIP00000004410	59.6491	41.2281
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.8348	capra_hircus	ENSCHIP00000019635	23.9554	12.8134
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	16.0069	bos_mutus	ENSBMUP00000031618	23.9945	12.8988
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.0878	16.0069	panthera_tigris_altaica	ENSPTIP00000006181	23.7027	13.0435
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	27.883	15.3184	saimiri_boliviensis_boliviensis	ENSSBOP00000000346	24.7706	13.6086
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.0878	15.6627	catagonus_wagneri	ENSCWAP00000011251	23.5376	12.6741
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	16.0069	cervus_hanglu_yarkandensis	ENSCHYP00000017991	23.9554	12.9526
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.2272	15.1463	phascolarctos_cinereus	ENSPCIP00000010986	22.8731	12.2734
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.3184	macaca_mulatta	ENSMMUP00000008230	23.8162	12.3955
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.6627	propithecus_coquereli	ENSPCOP00000011471	23.8162	12.6741
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	15.8348	mustela_putorius_furo	ENSMPUP00000004756	23.9945	12.7601
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.9484	16.0069	bos_taurus	ENSBTAP00000004948	24.234	12.9526
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	16.179	moschus_moschiferus	ENSMMSP00000026661	23.9554	13.0919
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	27.7108	14.8021	vombatus_ursinus	ENSVURP00010000610	22.4547	11.9944
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	27.7108	14.8021	vombatus_ursinus	ENSVURP00010019924	22.3922	11.9611
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	4.47504	2.92599	nannospalax_galili	ENSNGAP00000026713	18.3099	11.9718
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	16.0069	jaculus_jaculus	ENSJJAP00000021600	23.783	12.9346
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.9484	15.6627	oryctolagus_cuniculus	ENSOCUP00000046284	24.234	12.6741
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.5714	15.1463	monodelphis_domestica	ENSMODP00000023437	23.152	12.2734
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	15.6627	mus_caroli	MGP_CAROLIEiJ_P0059214	23.9281	12.5864
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.7435	15.1463	ictidomys_tridecemlineatus	ENSSTOP00000007459	23.5543	12.4118
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.3184	pongo_abelii	ENSPPYP00000041602	23.9554	12.3955
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	73.8382	56.2823	poecilia_latipinna	ENSPLAP00000018447	66.5116	50.6977
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.2599	15.4905	rattus_norvegicus	ENSRNOP00000072886	23.5131	12.4481
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	30.2926	16.0069	peromyscus_maniculatus_bairdii	ENSPEMP00000014384	24.3094	12.8453
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.1463	marmota_marmota_marmota	ENSMMMP00000022113	23.8162	12.2563
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.3184	nomascus_leucogenys	ENSNLEP00000012029	23.9554	12.3955
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	16.0069	neovison_vison	ENSNVIP00000021453	24.0947	12.9526
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	16.179	monodon_monoceros	ENSMMNP00015006193	23.9554	13.0919
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	65.5766	49.0534	saccharomyces_cerevisiae	YHR020W	55.3779	41.4244
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	27.5387	14.6299	microcebus_murinus	ENSMICP00000007312	22.567	11.9887
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	24.957	12.7367	ursus_americanus	ENSUAMP00000031269	23.6542	12.0718
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.432	15.3184	chlorocebus_sabaeus	ENSCSAP00000014094	23.8162	12.3955
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.2599	16.0069	canis_lupus_dingo	ENSCAFP00020024978	23.6769	12.9526
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.9484	16.0069	microtus_ochrogaster	ENSMOCP00000020899	24.0664	12.8631
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	28.9157	14.9742	cebus_imitator	ENSCCAP00000032597	23.3983	12.117
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.1463	homo_sapiens	ENSP00000358060	23.9554	12.2563
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	27.1945	14.8021	notamacropus_eugenii	ENSMEUP00000012991	21.975	11.9611
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.7762	15.6627	sciurus_vulgaris	ENSSVLP00005001328	24.0947	12.6741
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.9484	16.0069	carlito_syrichta	ENSTSYP00000023531	24.234	12.9526
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.6041	15.1463	pan_troglodytes	ENSPTRP00000002129	23.9554	12.2563
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	27.0224	14.1136	pteropus_vampyrus	ENSPVAP00000004108	21.8663	11.4206
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.0878	15.4905	prolemur_simus	ENSPSMP00000030630	23.5376	12.5348
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	29.9484	15.8348	mus_musculus	ENSMUSP00000029752	24.0664	12.7248
WBGene00004189	caenorhabditis_elegans	T20H4.3a.1	25.4733	12.2203	otolemur_garnettii	ENSOGAP00000004796	21.5116	10.3198

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000166	enables nucleotide binding	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0004812	enables aminoacyl-tRNA ligase activity	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0004827	enables proline-tRNA ligase activity	2	IBA,IEA	Caenorhabditis_elegans(6239)	Function
GO:0005524	enables ATP binding	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0005737	is_active_in cytoplasm	2	IBA,IEA	Caenorhabditis_elegans(6239)	Component
GO:0006412	involved_in translation	1	IEA	Caenorhabditis_elegans(6239)	Process
GO:0006418	involved_in tRNA aminoacylation for protein translation	1	IEA	Caenorhabditis_elegans(6239)	Process
GO:0006433	involved_in prolyl-tRNA aminoacylation	2	IBA,IEA	Caenorhabditis_elegans(6239)	Process
GO:0016874	enables ligase activity	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0017101	part_of aminoacyl-tRNA synthetase multienzyme complex	1	IBA	Caenorhabditis_elegans(6239)	Component