RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Description

Ensembl ID	WBGene00000196	Gene ID	174749	Accession	-
Symbol	aars-1	Alias	NA	Full Name	Alanine--tRNA ligase, mitochondrial
Status	Confidence	Length	4293 bases	Strand	Minus strand
Position	II : 11460205 - 11464497	RNA binding domain	tRNA-synt_2c , tRNA_SAD
Summary	Predicted to enable several functions, including ATP binding activity; catalytic activity, acting on a tRNA; and tRNA binding activity. Predicted to be involved in alanyl-tRNA aminoacylation and tRNA modification. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 8. Orthologous to human AARS2 (alanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
W02B12	tRNA_SAD	PF07973	1.1e-07	1
W02B12	tRNA-synt_2c	PF01411	7.5e-166	2

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
aars-1-202	W02B12	2356	No protein	-

Gene Model

Click here to download WBGene00000196's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download WBGene00000196's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
WBGene00000196

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
WBGene00000196

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000049	enables tRNA binding	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0000166	enables nucleotide binding	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0002161	enables aminoacyl-tRNA editing activity	1	IBA	Caenorhabditis_elegans(6239)	Function
GO:0003723	enables RNA binding	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0004812	enables aminoacyl-tRNA ligase activity	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0004813	enables alanine-tRNA ligase activity	2	IBA,IEA	Caenorhabditis_elegans(6239)	Function
GO:0005524	enables ATP binding	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0005737	located_in cytoplasm	1	IEA	Caenorhabditis_elegans(6239)	Component
GO:0005739	is_active_in mitochondrion	2	IBA,IEA	Caenorhabditis_elegans(6239)	Component
GO:0006412	involved_in translation	1	IEA	Caenorhabditis_elegans(6239)	Process
GO:0006419	involved_in alanyl-tRNA aminoacylation	2	IBA,IEA	Caenorhabditis_elegans(6239)	Process
GO:0008270	enables zinc ion binding	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0016874	enables ligase activity	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0043039	involved_in tRNA aminoacylation	1	IEA	Caenorhabditis_elegans(6239)	Process
GO:0046872	enables metal ion binding	1	IEA	Caenorhabditis_elegans(6239)	Function
GO:0106074	involved_in aminoacyl-tRNA metabolism involved in translational fidelity	1	IEA	Caenorhabditis_elegans(6239)	Process

Expression