RBP Type	N.A.
Diseases
Drug
Main interacting RNAs
Moonlighting functions
Localizations
BulkPerturb-seq

Ensembl ID	FBgn0023213	Gene ID	43839	Accession	-
Symbol	eIF4G1	Alias	CG10811;deIF4G;DmelCG10811;eIF-4G;eIF4g;eIF4G;Eif4G;EIF4G;EIF4G1;p200	Full Name	eukaryotic translation initiation factor 4G1
Status	Confidence	Length	15419 bases	Strand	Minus strand
Position	4 : 915297 - 930715	RNA binding domain	MIF4G , MA3
Summary	Enables RNA 7-methylguanosine cap binding activity and eukaryotic initiation factor 4E binding activity. Involved in regulation of translation and translation. Located in cytosol. Part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including adult head and gonad. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to several human genes including EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
FBpp0088303	MA3	PF02847	4.8e-23	1
FBpp0088303	MIF4G	PF02854	2.4e-59	2
FBpp0288389	MA3	PF02847	4.8e-23	1
FBpp0288389	MIF4G	PF02854	2.4e-59	2
FBpp0111817	MA3	PF02847	6.4e-23	1
FBpp0111817	MIF4G	PF02854	3.1e-59	2

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
-	FBtr0112904	6335	1919aa	FBpp0111817
-	FBtr0089243	5576	1666aa	FBpp0088303
-	FBtr0289951	5806	1666aa	FBpp0288389

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
FBgn0023213	drosophila_melanogaster	FBpp0306828	28.6962	15.0538	drosophila_melanogaster	FBpp0111817	22.2512	11.6727
FBgn0023213	drosophila_melanogaster	FBpp0310717	39.4788	22.5386	drosophila_melanogaster	FBpp0111817	42.6264	24.3356

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
FBgn0023213	drosophila_melanogaster	FBpp0111817	20.5315	10.7348	caenorhabditis_elegans	M110.4e.1	33.9655	17.7586
FBgn0023213	drosophila_melanogaster	FBpp0111817	8.12923	5.10683	eptatretus_burgeri	ENSEBUP00000009485	41.7112	26.2032
FBgn0023213	drosophila_melanogaster	FBpp0111817	6.61803	3.85618	eptatretus_burgeri	ENSEBUP00000008010	38.3686	22.3565
FBgn0023213	drosophila_melanogaster	FBpp0111817	9.01511	5.31527	eptatretus_burgeri	ENSEBUP00000012521	42.716	25.1852
FBgn0023213	drosophila_melanogaster	FBpp0111817	4.63783	2.44919	eptatretus_burgeri	ENSEBUP00000023589	42.5837	22.488
FBgn0023213	drosophila_melanogaster	FBpp0111817	8.18134	3.69984	ciona_intestinalis	ENSCINP00000010674	36.7682	16.6276
FBgn0023213	drosophila_melanogaster	FBpp0111817	18.1344	10.1094	ciona_savignyi	ENSCSAVP00000018002	40.6542	22.6636

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000278	involved_in mitotic cell cycle	1	HMP	Drosophila_melanogaster(7227)	Process
GO:0000340	enables RNA 7-methylguanosine cap binding	1	IDA	Drosophila_melanogaster(7227)	Function
GO:0003723	enables RNA binding	2	IDA,IEA	Drosophila_melanogaster(7227)	Function
GO:0003729	enables mRNA binding	1	IBA	Drosophila_melanogaster(7227)	Function
GO:0003743	enables translation initiation factor activity	3	IBA,IEA,ISS	Drosophila_melanogaster(7227)	Function
GO:0005829	located_in cytosol	2	HDA,ISS	Drosophila_melanogaster(7227)	Component
GO:0006412	involved_in translation	1	IDA	Drosophila_melanogaster(7227)	Process
GO:0006413	involved_in translational initiation	1	ISS	Drosophila_melanogaster(7227)	Process
GO:0006417	involved_in regulation of translation	1	IMP	Drosophila_melanogaster(7227)	Process
GO:0008190	enables eukaryotic initiation factor 4E binding	1	IPI	Drosophila_melanogaster(7227)	Function
GO:0016281	part_of eukaryotic translation initiation factor 4F complex	3	IBA,IDA,ISS	Drosophila_melanogaster(7227)	Component