RBP Type	N.A.
Diseases
Drug
Main interacting RNAs
Moonlighting functions
Localizations
BulkPerturb-seq

Ensembl ID	ENSMUSG00000058594	Gene ID	50755	Accession	-
Symbol	Fbh1	Alias	Fbx18;Fbxo18	Full Name	F-box DNA helicase 1
Status	Confidence	Length	35008 bases	Strand	Minus strand
Position	2 : 11747386 - 11782393	RNA binding domain	UvrD-helicase
Summary	Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination; replication fork processing; and replication fork protection. Acts upstream of or within negative regulation of chromatin binding activity and response to intra-S DNA damage checkpoint signaling. Predicted to be located in chromatin and nucleus. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBH1 (F-box DNA helicase 1). [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSMUSP00000071495	UvrD-helicase	PF00580	2e-11	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
Fbh1-207	ENSMUST00000139292	358	No protein	-
Fbh1-201	ENSMUST00000071564	3567	1042aa	ENSMUSP00000071495
Fbh1-209	ENSMUST00000155604	1064	No protein	-
Fbh1-202	ENSMUST00000123717	4118	No protein	-
Fbh1-205	ENSMUST00000131893	891	297aa	ENSMUSP00000116392
Fbh1-206	ENSMUST00000136633	374	No protein	-
Fbh1-203	ENSMUST00000123723	820	No protein	-
Fbh1-210	ENSMUST00000192171	476	No protein	-
Fbh1-204	ENSMUST00000126543	898	No protein	-
Fbh1-208	ENSMUST00000151402	503	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSMUSG00000058594

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSMUSG00000058594

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000166	enables nucleotide binding	1	IEA	Mus_musculus(10090)	Function
GO:0000724	involved_in double-strand break repair via homologous recombination	1	IBA	Mus_musculus(10090)	Process
GO:0000785	part_of chromatin	1	ISO	Mus_musculus(10090)	Component
GO:0001934	acts_upstream_of_or_within positive regulation of protein phosphorylation	1	ISO	Mus_musculus(10090)	Process
GO:0003677	enables DNA binding	1	IEA	Mus_musculus(10090)	Function
GO:0003678	enables DNA helicase activity	1	ISO	Mus_musculus(10090)	Function
GO:0003690	enables double-stranded DNA binding	1	ISO	Mus_musculus(10090)	Function
GO:0003697	enables single-stranded DNA binding	1	ISO	Mus_musculus(10090)	Function
GO:0004386	enables helicase activity	1	IEA	Mus_musculus(10090)	Function
GO:0005515	enables protein binding	1	IPI	Mus_musculus(10090)	Function
GO:0005524	enables ATP binding	1	IEA	Mus_musculus(10090)	Function
GO:0005634	is_active_in nucleus	2	IBA,ISO	Mus_musculus(10090)	Component
GO:0005694	located_in chromosome	1	IEA	Mus_musculus(10090)	Component
GO:0006281	involved_in DNA repair	1	ISO	Mus_musculus(10090)	Process
GO:0006308	acts_upstream_of_or_within DNA catabolic process	1	ISO	Mus_musculus(10090)	Process
GO:0006974	involved_in DNA damage response	1	ISO	Mus_musculus(10090)	Process
GO:0015616	enables DNA translocase activity	1	ISO	Mus_musculus(10090)	Function
GO:0016567	involved_in protein ubiquitination	1	ISO	Mus_musculus(10090)	Process
GO:0016787	enables hydrolase activity	1	IEA	Mus_musculus(10090)	Function
GO:0016853	enables isomerase activity	1	IEA	Mus_musculus(10090)	Function
GO:0019005	part_of SCF ubiquitin ligase complex	1	ISO	Mus_musculus(10090)	Component
GO:0031297	involved_in replication fork processing	3	IBA,IMP,ISO	Mus_musculus(10090)	Process
GO:0035562	acts_upstream_of_or_within negative regulation of chromatin binding	1	IMP	Mus_musculus(10090)	Process
GO:0043138	enables 3-5 DNA helicase activity	2	IBA,ISO	Mus_musculus(10090)	Function
GO:0072429	acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling	2	IMP,ISO	Mus_musculus(10090)	Process
GO:1902231	acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	1	ISO	Mus_musculus(10090)	Process
GO:2000042	involved_in negative regulation of double-strand break repair via homologous recombination	2	IMP,ISO	Mus_musculus(10090)	Process