Description

Ensembl ID ENSMUSG00000058301 Gene ID 19704 Accession -
Symbol Upf1 Alias NORF1;Rent1;Upflp;PNORF-1;B430202H16Rik Full Name UPF1 regulator of nonsense transcripts homolog (yeast)
Status Confidence Length 21754 bases Strand Minus strand
Position 8 : 70784175 - 70805928 RNA binding domain ResIII , UPF1_1B_dom , UPF1_Zn_bind
Summary Predicted to enable RNA helicase activity; chromatin binding activity; and nucleic acid binding activity. Acts upstream of or within dosage compensation by inactivation of X chromosome. Predicted to be located in chromatin; chromosome, telomeric region; and nucleoplasm. Predicted to be part of exon-exon junction complex and supraspliceosomal complex. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer; embryo; and oocyte. Orthologous to human UPF1 (UPF1 RNA helicase and ATPase). [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSMUSP00000148927 ResIII PF04851 5.6e-05 1
ENSMUSP00000148927 UPF1_Zn_bind PF09416 4.9e-77 2
ENSMUSP00000148927 UPF1_1B_dom PF18141 4.2e-32 3
ENSMUSP00000075089 ResIII PF04851 6e-05 1
ENSMUSP00000075089 UPF1_Zn_bind PF09416 5e-77 2
ENSMUSP00000075089 UPF1_1B_dom PF18141 1.3e-28 3

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
Upf1-202 ENSMUST00000215817 4518 1113aa ENSMUSP00000148927
Upf1-201 ENSMUST00000075666 4618 1124aa ENSMUSP00000075089

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSMUSG00000058301[{"sID": "ENSMUSG00000058301" "sSP": "mus_musculus" "sProtein": "ENSMUSP00000075089" "sPercPos": 6.40569 "sPercID": 3.38078 "tID": "ENSMUSG00000079593" "tSP": "mus_musculus" "tGene": "4933416I08Rik"

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSMUSG00000058301

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000166enables nucleotide binding1IEAMus_musculus(10090)Function
GO:0000184involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay2IBA,ISOMus_musculus(10090)Process
GO:0000781located_in chromosome, telomeric region1ISOMus_musculus(10090)Component
GO:0000785part_of chromatin1ISOMus_musculus(10090)Component
GO:0000956involved_in nuclear-transcribed mRNA catabolic process1ISOMus_musculus(10090)Process
GO:0003677enables DNA binding1IEAMus_musculus(10090)Function
GO:0003682enables chromatin binding1ISOMus_musculus(10090)Function
GO:0003723enables RNA binding2IBA,ISOMus_musculus(10090)Function
GO:0003724enables RNA helicase activity2IBA,ISOMus_musculus(10090)Function
GO:0004386enables helicase activity1IEAMus_musculus(10090)Function
GO:0005515enables protein binding1IPIMus_musculus(10090)Function
GO:0005524enables ATP binding1IEAMus_musculus(10090)Function
GO:0005634located_in nucleus1ISOMus_musculus(10090)Component
GO:0005654located_in nucleoplasm1ISOMus_musculus(10090)Component
GO:0005737is_active_in cytoplasm1IBAMus_musculus(10090)Component
GO:0005829located_in cytosol2ISO,TASMus_musculus(10090)Component
GO:0006260involved_in DNA replication1ISOMus_musculus(10090)Process
GO:0006281involved_in DNA repair1ISOMus_musculus(10090)Process
GO:0006449involved_in regulation of translational termination1ISOMus_musculus(10090)Process
GO:0008270enables zinc ion binding1IEAMus_musculus(10090)Function
GO:0016787enables hydrolase activity1IEAMus_musculus(10090)Function
GO:0016887enables ATP hydrolysis activity1ISOMus_musculus(10090)Function
GO:0032201involved_in telomere maintenance via semi-conservative replication1ISOMus_musculus(10090)Process
GO:0032204involved_in regulation of telomere maintenance1ISOMus_musculus(10090)Process
GO:0032508involved_in DNA duplex unwinding1ISOMus_musculus(10090)Process
GO:0035145part_of exon-exon junction complex1ISOMus_musculus(10090)Component
GO:0036121enables double-stranded DNA helicase activity1ISOMus_musculus(10090)Function
GO:0042162enables telomeric DNA binding1ISOMus_musculus(10090)Function
GO:0044530part_of supraspliceosomal complex1ISOMus_musculus(10090)Component
GO:0044770involved_in cell cycle phase transition1ISOMus_musculus(10090)Process
GO:0044877enables protein-containing complex binding1ISOMus_musculus(10090)Function
GO:0046872enables metal ion binding1IEAMus_musculus(10090)Function
GO:0061014involved_in positive regulation of mRNA catabolic process1ISOMus_musculus(10090)Process
GO:0061158involved_in 3-UTR-mediated mRNA destabilization1ISOMus_musculus(10090)Process
GO:0071044involved_in histone mRNA catabolic process1ISOMus_musculus(10090)Process

Expression