RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Description

Ensembl ID	ENSMUSG00000027810	Gene ID	229317	Accession	-
Symbol	Eif2a	Alias	D030048D22;D3Ertd194e	Full Name	eukaryotic translation initiation factor 2A
Status	Confidence	Length	31681 bases	Strand	Plus strand
Position	3 : 58433242 - 58464922	RNA binding domain	eIF2A
Summary	Predicted to enable RNA binding activity and ribosome binding activity. Acts upstream of or within SREBP signaling pathway; cellular protein metabolic process; and positive regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be part of cytosolic small ribosomal subunit and eukaryotic translation initiation factor 2 complex. Is expressed in brain; early conceptus; lens; liver; and ovary. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSMUSP00000029387	eIF2A	PF08662	3.3e-78	1
ENSMUSP00000120901	eIF2A	PF08662	1.1e-16	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
Eif2a-201	ENSMUST00000029387	2299	581aa	ENSMUSP00000029387
Eif2a-203	ENSMUST00000137469	1035	No protein	-
Eif2a-202	ENSMUST00000135876	1561	60aa	ENSMUSP00000122375
Eif2a-207	ENSMUST00000154219	1945	59aa	ENSMUSP00000121236
Eif2a-205	ENSMUST00000138848	913	251aa	ENSMUSP00000120901
Eif2a-204	ENSMUST00000138827	2258	No protein	-
Eif2a-206	ENSMUST00000148251	3432	No protein	-

Gene Model

Click here to download ENSMUSG00000027810's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSMUSG00000027810's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSMUSG00000027810

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSMUSG00000027810

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000049	enables tRNA binding	2	IBA,ISO	Mus_musculus(10090)	Function
GO:0003729	enables mRNA binding	1	IBA	Mus_musculus(10090)	Function
GO:0003743	enables translation initiation factor activity	2	IBA,ISO	Mus_musculus(10090)	Function
GO:0005737	located_in cytoplasm	1	ISO	Mus_musculus(10090)	Component
GO:0005850	part_of eukaryotic translation initiation factor 2 complex	1	ISO	Mus_musculus(10090)	Component
GO:0006412	acts_upstream_of_or_within translation	1	IDA	Mus_musculus(10090)	Process
GO:0006413	involved_in translational initiation	1	ISO	Mus_musculus(10090)	Process
GO:0006417	involved_in regulation of translation	1	ISO	Mus_musculus(10090)	Process
GO:0006468	acts_upstream_of_or_within protein phosphorylation	1	IDA	Mus_musculus(10090)	Process
GO:0009967	acts_upstream_of_or_within positive regulation of signal transduction	1	IDA	Mus_musculus(10090)	Process
GO:0017148	involved_in negative regulation of translation	1	TAS	Mus_musculus(10090)	Process
GO:0022627	part_of cytosolic small ribosomal subunit	1	IBA	Mus_musculus(10090)	Component
GO:0030968	involved_in endoplasmic reticulum unfolded protein response	1	TAS	Mus_musculus(10090)	Process
GO:0032933	acts_upstream_of_or_within SREBP signaling pathway	1	IDA	Mus_musculus(10090)	Process
GO:0042255	involved_in ribosome assembly	1	ISO	Mus_musculus(10090)	Process
GO:0043022	enables ribosome binding	2	IBA,ISO	Mus_musculus(10090)	Function
GO:1904294	involved_in positive regulation of ERAD pathway	1	TAS	Mus_musculus(10090)	Process
GO:1990928	involved_in response to amino acid starvation	1	ISO	Mus_musculus(10090)	Process

Expression