Description

Ensembl ID ENSMUSG00000026917 Gene ID 140858 Accession -
Symbol Wdr5 Alias Big;Big-3;2410008O07Rik Full Name WD repeat domain 5
Status Confidence Length 21379 bases Strand Plus strand
Position 2 : 27405169 - 27426547 RNA binding domain eIF2A
Summary Predicted to enable methylated histone binding activity. Predicted to contribute to histone methyltransferase activity (H3-K4 specific). Acts upstream of or within histone H3-K4 methylation; positive regulation of gluconeogenesis; and skeletal system development. Located in nucleus. Part of ATAC complex. Is expressed in cerebral cortex; testis; and vault of skull. Orthologous to human WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSMUSP00000109585 eIF2A PF08662 2e-11 1
ENSMUSP00000121654 eIF2A PF08662 9.5e-11 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
Wdr5-204 ENSMUST00000144315 798 No protein -
Wdr5-201 ENSMUST00000113952 2890 334aa ENSMUSP00000109585
Wdr5-203 ENSMUST00000140396 1031 281aa ENSMUSP00000121654
Wdr5-202 ENSMUST00000125088 678 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSMUSG00000026917[{"sID": "ENSMUSG00000026917" "sSP": "mus_musculus" "sProtein": "ENSMUSP00000109585" "sPercPos": 87.7245 "sPercID": 78.7425 "tID": "ENSMUSG00000034379" "tSP": "mus_musculus" "tGene": "Wdr5b"

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSMUSG00000026917

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000123part_of histone acetyltransferase complex1ISOMus_musculus(10090)Component
GO:0001501acts_upstream_of_or_within skeletal system development1IDAMus_musculus(10090)Process
GO:0005515enables protein binding1IPIMus_musculus(10090)Function
GO:0005622located_in intracellular anatomical structure1IDAMus_musculus(10090)Component
GO:0005634located_in nucleus2IDA,ISOMus_musculus(10090)Component
GO:0005654located_in nucleoplasm2ISO,TASMus_musculus(10090)Component
GO:0006094acts_upstream_of gluconeogenesis1IGIMus_musculus(10090)Process
GO:0006325acts_upstream_of_or_within chromatin organization1IEAMus_musculus(10090)Process
GO:0006355involved_in regulation of DNA-templated transcription1ISOMus_musculus(10090)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1ISOMus_musculus(10090)Process
GO:0018022acts_upstream_of_or_within peptidyl-lysine methylation1IMPMus_musculus(10090)Process
GO:0031063involved_in regulation of histone deacetylation1ISOMus_musculus(10090)Process
GO:0031175involved_in neuron projection development1ISOMus_musculus(10090)Process
GO:0035064enables methylated histone binding1ISOMus_musculus(10090)Function
GO:0035097part_of histone methyltransferase complex1ISOMus_musculus(10090)Component
GO:0042393enables histone binding1IBAMus_musculus(10090)Function
GO:0042800enables histone H3K4 methyltransferase activity1IMPMus_musculus(10090)Function
GO:0043966involved_in histone H3 acetylation1ISOMus_musculus(10090)Process
GO:0043981involved_in histone H4-K5 acetylation1ISOMus_musculus(10090)Process
GO:0043982involved_in histone H4-K8 acetylation1ISOMus_musculus(10090)Process
GO:0043984involved_in histone H4-K16 acetylation1ISOMus_musculus(10090)Process
GO:0044154involved_in histone H3-K14 acetylation1ISOMus_musculus(10090)Process
GO:0044545part_of NSL complex1ISOMus_musculus(10090)Component
GO:0044665part_of MLL1/2 complex1ISOMus_musculus(10090)Component
GO:0044666part_of MLL3/4 complex1ISOMus_musculus(10090)Component
GO:0045722acts_upstream_of_or_within positive regulation of gluconeogenesis1IGIMus_musculus(10090)Process
GO:0045815involved_in transcription initiation-coupled chromatin remodeling1ISOMus_musculus(10090)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1NASMus_musculus(10090)Process
GO:0045995involved_in regulation of embryonic development1IDAMus_musculus(10090)Process
GO:0048188part_of Set1C/COMPASS complex2IBA,ISOMus_musculus(10090)Component
GO:0051302involved_in regulation of cell division2IDA,ISOMus_musculus(10090)Process
GO:0051568involved_in histone H3-K4 methylation1IBAMus_musculus(10090)Process
GO:0051571involved_in positive regulation of histone H3-K4 methylation1ISOMus_musculus(10090)Process
GO:0051726involved_in regulation of cell cycle2IMP,ISOMus_musculus(10090)Process
GO:0071339part_of MLL1 complex1ISOMus_musculus(10090)Component
GO:0072686located_in mitotic spindle1NASMus_musculus(10090)Component
GO:0090043involved_in regulation of tubulin deacetylation1ISOMus_musculus(10090)Process
GO:0140672part_of ATAC complex2IDA,ISOMus_musculus(10090)Component
GO:1900095involved_in regulation of dosage compensation by inactivation of X chromosome1IDAMus_musculus(10090)Process

Expression