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RBP World!
Functions and Diseases
| RBP Type | Non-canonical_RBPs |
| Diseases | N.A. |
| Drug | N.A. |
| Main interacting RNAs | snoRNA |
| Moonlighting functions | N.A. |
| Localizations | N.A. |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000273841 | Gene ID | 6880 | Accession | 11542 |
| Symbol | TAF9 | Alias | TAF2G;TAFII31;TAFII32;MGC:5067;TAFII-31;TAFII-32;TAFIID32;STAF31/32 | Full Name | TATA-box binding protein associated factor 9 |
| Status | Confidence | Length | 5271 bases | Strand | Minus strand |
| Position | 5 : 69364743 - 69370013 | RNA binding domain | N.A. | ||
| Summary | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|---|---|---|---|
| 21731475 | Luteolin Regulation of Estrogen Signaling and Cell Cycle Pathway Genes in MCF-7 Human Breast Cancer Cells. | M Barry Markaverich | 2011-01-01 | International journal of biomedical science : IJBS |
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| TAF9-209 | ENST00000685776 | 4640 | No protein | - |
| TAF9-211 | ENST00000687205 | 1331 | No protein | - |
| TAF9-219 | ENST00000693414 | 1254 | 264aa | ENSP00000509848 |
| TAF9-216 | ENST00000691076 | 1348 | 264aa | ENSP00000509913 |
| TAF9-204 | ENST00000504109 | 1339 | 264aa | ENSP00000426283 |
| TAF9-213 | ENST00000688968 | 1296 | 264aa | ENSP00000510364 |
| TAF9-201 | ENST00000217893 | 1163 | 264aa | ENSP00000217893 |
| TAF9-205 | ENST00000506736 | 1180 | 264aa | ENSP00000421873 |
| TAF9-202 | ENST00000328663 | 1461 | 264aa | ENSP00000370193 |
| TAF9-212 | ENST00000687836 | 1193 | 264aa | ENSP00000509753 |
| TAF9-214 | ENST00000689249 | 1112 | 264aa | ENSP00000508645 |
| TAF9-215 | ENST00000690749 | 1629 | 264aa | ENSP00000510605 |
| TAF9-217 | ENST00000691515 | 3155 | 264aa | ENSP00000509452 |
| TAF9-206 | ENST00000508954 | 1705 | 264aa | ENSP00000427617 |
| TAF9-220 | ENST00000693538 | 2165 | No protein | - |
| TAF9-210 | ENST00000686157 | 1818 | No protein | - |
| TAF9-218 | ENST00000691555 | 2285 | 264aa | ENSP00000510101 |
| TAF9-207 | ENST00000509462 | 1057 | 264aa | ENSP00000427343 |
| TAF9-208 | ENST00000512152 | 996 | 264aa | ENSP00000425798 |
| TAF9-203 | ENST00000503245 | 1168 | 264aa | ENSP00000425944 |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0000124 | part_of SAGA complex | 3 | IBA,IDA,NAS | Homo_sapiens(9606) | Component |
| GO:0000492 | involved_in box C/D snoRNP assembly | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0000976 | enables transcription cis-regulatory region binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0002039 | enables p53 binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0003677 | enables DNA binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0003713 | enables transcription coactivator activity | 3 | IBA,IDA,IMP | Homo_sapiens(9606) | Function |
| GO:0004402 | contributes_to histone acetyltransferase activity | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005634 | located_in nucleus | 3 | EXP,IDA,ISS | Homo_sapiens(9606) | Component |
| GO:0005654 | located_in nucleoplasm | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0005669 | part_of transcription factor TFIID complex | 4 | IBA,IDA,IPI,ISS | Homo_sapiens(9606) | Component |
| GO:0006282 | involved_in regulation of DNA repair | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0006338 | involved_in chromatin remodeling | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0006355 | involved_in regulation of DNA-templated transcription | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0006357 | involved_in regulation of transcription by RNA polymerase II | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0006468 | involved_in protein phosphorylation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0006974 | involved_in DNA damage response | 1 | IC | Homo_sapiens(9606) | Process |
| GO:0016251 | contributes_to RNA polymerase II general transcription initiation factor activity | 2 | IBA,IC | Homo_sapiens(9606) | Function |
| GO:0016573 | involved_in histone acetylation | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0032435 | involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0033276 | part_of transcription factor TFTC complex | 3 | IBA,IDA,NAS | Homo_sapiens(9606) | Component |
| GO:0035521 | involved_in monoubiquitinated histone deubiquitination | 2 | IDA,ISS | Homo_sapiens(9606) | Process |
| GO:0035522 | involved_in monoubiquitinated histone H2A deubiquitination | 2 | IDA,ISS | Homo_sapiens(9606) | Process |
| GO:0042789 | involved_in mRNA transcription by RNA polymerase II | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0043066 | involved_in negative regulation of apoptotic process | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0043484 | involved_in regulation of RNA splicing | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0043966 | involved_in histone H3 acetylation | 3 | IBA,IDA,NAS | Homo_sapiens(9606) | Process |
| GO:0045893 | involved_in positive regulation of DNA-templated transcription | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0045944 | involved_in positive regulation of transcription by RNA polymerase II | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0046982 | enables protein heterodimerization activity | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0050821 | involved_in protein stabilization | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0051117 | enables ATPase binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0051123 | involved_in RNA polymerase II preinitiation complex assembly | 3 | IBA,IPI,ISS | Homo_sapiens(9606) | Process |
| GO:0060261 | involved_in positive regulation of transcription initiation by RNA polymerase II | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0060760 | involved_in positive regulation of response to cytokine stimulus | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0070555 | involved_in response to interleukin-1 | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0070742 | enables C2H2 zinc finger domain binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0070761 | part_of pre-snoRNP complex | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0071339 | part_of MLL1 complex | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0140297 | enables DNA-binding transcription factor binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:1902065 | involved_in response to L-glutamate | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:1902166 | involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 1 | IC | Homo_sapiens(9606) | Process |