RBPWorld - a comprehensive database of RNA Binding Proteins

Welcome to

RBP World!

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000269858	Gene ID	112398	Accession	14660
Symbol	EGLN2	Alias	EIT6;PHD1;EIT-6;HPH-1;HPH-3;HIFPH1;HIF-PH1	Full Name	egl-9 family hypoxia inducible factor 2
Status	Confidence	Length	9439 bases	Strand	Plus strand
Position	19 : 40798996 - 40808434	RNA binding domain	2OG-FeII_Oxy
Summary	The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000472414	2OG-FeII_Oxy	PF03171	0.00019	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
EGLN2-215	ENST00000598654	590	101aa	ENSP00000471568
EGLN2-201	ENST00000303961	2100	407aa	ENSP00000307080
EGLN2-208	ENST00000593972	935	139aa	ENSP00000471546
EGLN2-202	ENST00000406058	2150	407aa	ENSP00000385253
EGLN2-207	ENST00000593726	2821	407aa	ENSP00000469686
EGLN2-210	ENST00000594380	597	87aa	ENSP00000470968
EGLN2-203	ENST00000593397	572	72aa	ENSP00000472146
EGLN2-217	ENST00000601733	584	94aa	ENSP00000469323
EGLN2-206	ENST00000593525	709	77aa	ENSP00000469272
EGLN2-213	ENST00000596517	574	67aa	ENSP00000472870
EGLN2-214	ENST00000597746	459	128aa	ENSP00000472991
EGLN2-209	ENST00000594140	991	125aa	ENSP00000472414
EGLN2-216	ENST00000599579	3894	No protein	-
EGLN2-204	ENST00000593445	3034	No protein	-
EGLN2-205	ENST00000593477	1391	No protein	-
EGLN2-218	ENST00000602166	684	No protein	-
EGLN2-212	ENST00000595621	758	96aa	ENSP00000471944
EGLN2-211	ENST00000595051	477	51aa	ENSP00000471740

Gene Model

Click here to download ENSG00000269858's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
65186	Bronchodilator Agents	3E-6	26634245
65187	Forced Expiratory Volume	3E-6	26634245
68922	Bronchodilator Agents	4E-6	26634245
68923	Forced Expiratory Volume	4E-6	26634245
74945	Bronchodilator Agents	4E-6	26634245
74946	Forced Expiratory Volume	4E-6	26634245
76846	Bronchodilator Agents	4E-6	26634245
76847	Forced Expiratory Volume	4E-6	26634245
96791	Bronchodilator Agents	5E-6	26634245
96792	Forced Expiratory Volume	5E-6	26634245
103180	Smoking	1E-8	20418890

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000269858's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001558	involved_in regulation of cell growth	1	NAS	Homo_sapiens(9606)	Process
GO:0001666	involved_in response to hypoxia	1	IDA	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0008198	enables ferrous iron binding	3	IBA,IDA,NAS	Homo_sapiens(9606)	Function
GO:0016706	enables 2-oxoglutarate-dependent dioxygenase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0018401	involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0019826	enables oxygen sensor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0030520	involved_in intracellular estrogen receptor signaling pathway	1	NAS	Homo_sapiens(9606)	Process
GO:0031418	enables L-ascorbic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0031545	enables peptidyl-proline 4-dioxygenase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0043523	involved_in regulation of neuron apoptotic process	1	IMP	Homo_sapiens(9606)	Process
GO:0045454	involved_in cell redox homeostasis	1	IDA	Homo_sapiens(9606)	Process
GO:0045732	involved_in positive regulation of protein catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0071456	involved_in cellular response to hypoxia	1	IBA	Homo_sapiens(9606)	Process

Expression