RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	Nucleoli
BulkPerturb-seq

Description

Ensembl ID	ENSG00000259431	Gene ID	79178	Accession	18987
Symbol	THTPA	Alias	THTP;THTPASE	Full Name	thiamine triphosphatase
Status	Confidence	Length	4265 bases	Strand	Plus strand
Position	14 : 23556007 - 23560271	RNA binding domain	CYTH
Summary	This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000288014	CYTH	PF01928	3e-38	1
ENSP00000384580	CYTH	PF01928	3e-38	1
ENSP00000452281	CYTH	PF01928	6e-23	1
ENSP00000450459	CYTH	PF01928	1.4e-20	1
ENSP00000451835	CYTH	PF01928	1.4e-20	1
ENSP00000452465	CYTH	PF01928	1.5e-20	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
THTPA-205	ENST00000555446	571	No protein	-
THTPA-202	ENST00000404535	1779	230aa	ENSP00000384580
THTPA-208	ENST00000557630	581	122aa	ENSP00000452281
THTPA-206	ENST00000556015	535	105aa	ENSP00000451835
THTPA-204	ENST00000554970	569	140aa	ENSP00000452465
THTPA-201	ENST00000288014	2611	230aa	ENSP00000288014
THTPA-203	ENST00000554789	1595	105aa	ENSP00000450459
THTPA-207	ENST00000556545	339	60aa	ENSP00000452164

Gene Model

Click here to download ENSG00000259431's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
18365	Glucosephosphate Dehydrogenase	9.896e-005	-
18370	Glucosephosphate Dehydrogenase	8.312e-005	-
23758	Muscle, Skeletal	6.5630000E-005	-
24588	Muscle, Skeletal	3.1520000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000259431's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000287	enables magnesium ion binding	2	IBA,ISS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006091	involved_in generation of precursor metabolites and energy	1	NAS	Homo_sapiens(9606)	Process
GO:0006772	involved_in thiamine metabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0016311	involved_in dephosphorylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0016787	enables hydrolase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0042357	involved_in thiamine diphosphate metabolic process	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0050333	enables thiamine triphosphate phosphatase activity	2	IBA,IDA	Homo_sapiens(9606)	Function

Expression