Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000257315 Gene ID 100381270 Accession 33273
Symbol ZBED6 Alias MGR Full Name zinc finger BED-type containing 6
Status Confidence Length 58502 bases Strand Plus strand
Position 1 : 203795623 - 203854124 RNA binding domain N.A.
Summary The protein encoded by this transposon-derived intronless gene is a transcriptional repressor that binds to the consensus sequence 5'-GCTCGC-3'. The encoded protein has been shown to repress IGF2 transcription. This gene is located within the first intron of the ZC3H11A gene. [provided by RefSeq, Jul 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ZBED6-201 ENST00000550078 11697 979aa ENSP00000447879

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
81580Breast Neoplasms9E-925038754

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0000976enables transcription cis-regulatory region binding1ISSHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific1ISAHomo_sapiens(9606)Function
GO:0001227enables DNA-binding transcription repressor activity, RNA polymerase II-specific1ISSHomo_sapiens(9606)Function
GO:0001835involved_in blastocyst hatching1IEAHomo_sapiens(9606)Process
GO:0005634is_active_in nucleus3IBA,IDA,ISSHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1ISSHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm2IDA,ISSHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0034451located_in centriolar satellite1IDAHomo_sapiens(9606)Component
GO:0045892involved_in negative regulation of DNA-templated transcription1ISSHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0046983enables protein dimerization activity1IEAHomo_sapiens(9606)Function
GO:0051148involved_in negative regulation of muscle cell differentiation1ISSHomo_sapiens(9606)Process
GO:0061178involved_in regulation of insulin secretion involved in cellular response to glucose stimulus1IEAHomo_sapiens(9606)Process

Expression