Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs rRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000243147 Gene ID 9553 Accession 14487
Symbol MRPL33 Alias L33mt;bL33m;C2orf1;RPL33L;MRP-L33 Full Name mitochondrial ribosomal protein L33
Status Confidence Length 216371 bases Strand Plus strand
Position 2 : 27771717 - 27988087 RNA binding domain Ribosomal_L33
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000296102 Ribosomal_L33 PF00471 3.8e-06 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
MRPL33-202 ENST00000379666 404 54aa ENSP00000368988
MRPL33-201 ENST00000296102 508 65aa ENSP00000296102
MRPL33-203 ENST00000448427 527 69aa ENSP00000407385
MRPL33-204 ENST00000472192 238 No protein -
MRPL33-206 ENST00000483992 729 No protein -
MRPL33-205 ENST00000476552 587 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
73926Glucose1E-1522581228
73927Body Mass Index1E-1522581228

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000243147

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000243147homo_sapiensENSP0000029610210096.9231nomascus_leucogenysENSNLEP0000001854610096.9231
ENSG00000243147homo_sapiensENSP00000296102100100pan_paniscusENSPPAP00000018671100100
ENSG00000243147homo_sapiensENSP0000029610210096.9231pongo_abeliiENSPPYP0000002955410096.9231
ENSG00000243147homo_sapiensENSP00000296102100100pan_troglodytesENSPTRP00000020231100100
ENSG00000243147homo_sapiensENSP00000296102100100gorilla_gorillaENSGGOP00000037394100100
ENSG00000243147homo_sapiensENSP0000029610286.153870.7692ornithorhynchus_anatinusENSOANP0000002741687.571.875
ENSG00000243147homo_sapiensENSP0000029610289.230876.9231sarcophilus_harrisiiENSSHAP0000004280689.230876.9231
ENSG00000243147homo_sapiensENSP0000029610272.307766.1538erinaceus_europaeusENSEEUP0000000973192.156984.3137
ENSG00000243147homo_sapiensENSP0000029610272.307766.1538erinaceus_europaeusENSEEUP0000000278092.156984.3137
ENSG00000243147homo_sapiensENSP0000029610295.384676.9231echinops_telfairiENSETEP0000000265795.384676.9231
ENSG00000243147homo_sapiensENSP0000029610293.846289.2308callithrix_jacchusENSCJAP0000009261893.846289.2308
ENSG00000243147homo_sapiensENSP0000029610296.923193.8462cercocebus_atysENSCATP0000003015996.923193.8462
ENSG00000243147homo_sapiensENSP0000029610296.923193.8462macaca_fascicularisENSMFAP0000003257435.195534.0782
ENSG00000243147homo_sapiensENSP0000029610296.923193.8462macaca_nemestrinaENSMNEP0000002725396.923193.8462
ENSG00000243147homo_sapiensENSP0000029610296.923193.8462papio_anubisENSPANP0000005887796.923193.8462
ENSG00000243147homo_sapiensENSP0000029610296.923193.8462mandrillus_leucophaeusENSMLEP0000001103696.923193.8462
ENSG00000243147homo_sapiensENSP0000029610295.384683.0769tursiops_truncatusENSTTRP0000001189895.384683.0769
ENSG00000243147homo_sapiensENSP0000029610289.230875.3846vulpes_vulpesENSVVUP0000002109989.230875.3846
ENSG00000243147homo_sapiensENSP0000029610295.384684.6154equus_asinusENSEASP0000505110642.176937.415
ENSG00000243147homo_sapiensENSP0000029610278.461563.0769panthera_leoENSPLOP0000001858977.272762.1212
ENSG00000243147homo_sapiensENSP0000029610293.846281.5385panthera_leoENSPLOP0000000592193.846281.5385
ENSG00000243147homo_sapiensENSP0000029610293.846281.5385ailuropoda_melanoleucaENSAMEP0000000121193.846281.5385
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154bos_indicus_hybridENSBIXP0000501384993.846284.6154
ENSG00000243147homo_sapiensENSP0000029610283.076973.8462bos_indicus_hybridENSBIXP0000504111787.096877.4194
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154bos_indicus_hybridENSBIXP0000502790993.846284.6154
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154oryctolagus_cuniculusENSOCUP0000004598993.846284.6154
ENSG00000243147homo_sapiensENSP0000029610289.230875.3846equus_caballusENSECAP0000006644842.02935.5072
ENSG00000243147homo_sapiensENSP0000029610289.230875.3846canis_lupus_familiarisENSCAFP0084504243689.230875.3846
ENSG00000243147homo_sapiensENSP0000029610292.307780canis_lupus_familiarisENSCAFP0084500898092.307780
ENSG00000243147homo_sapiensENSP0000029610293.846281.5385panthera_pardusENSPPRP0000000599893.846281.5385
ENSG00000243147homo_sapiensENSP0000029610276.923163.0769panthera_pardusENSPPRP0000000207180.645266.129
ENSG00000243147homo_sapiensENSP0000029610290.769278.4615marmota_marmota_marmotaENSMMMP0000002307890.769278.4615
ENSG00000243147homo_sapiensENSP0000029610295.384683.0769balaenoptera_musculusENSBMSP0001001323495.384683.0769
ENSG00000243147homo_sapiensENSP0000029610289.230875.3846cavia_porcellusENSCPOP0000003298489.230875.3846
ENSG00000243147homo_sapiensENSP0000029610276.923161.5385felis_catusENSFCAP0000003596679.365163.4921
ENSG00000243147homo_sapiensENSP0000029610286.153873.8462ursus_americanusENSUAMP0000001134151.376144.0367
ENSG00000243147homo_sapiensENSP0000029610289.230873.8462monodelphis_domesticaENSMODP0000001944889.230873.8462
ENSG00000243147homo_sapiensENSP000002961028069.2308bison_bison_bisonENSBBBP0000001370386.666775
ENSG00000243147homo_sapiensENSP0000029610283.076973.8462bison_bison_bisonENSBBBP0000000961887.096877.4194
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154bison_bison_bisonENSBBBP0000000702193.846284.6154
ENSG00000243147homo_sapiensENSP0000029610290.769275.3846monodon_monocerosENSMMNP0001502933390.769275.3846
ENSG00000243147homo_sapiensENSP0000029610295.384684.6154sus_scrofaENSSSCP0000003499995.384684.6154
ENSG00000243147homo_sapiensENSP0000029610298.461590.7692microcebus_murinusENSMICP0000004804698.461590.7692
ENSG00000243147homo_sapiensENSP0000029610293.846278.4615jaculus_jaculusENSJJAP0000001938393.846278.4615
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154ovis_aries_rambouilletENSOARP0002000532193.846284.6154
ENSG00000243147homo_sapiensENSP0000029610287.692370.7692ochotona_princepsENSOPRP0000001083987.692370.7692
ENSG00000243147homo_sapiensENSP0000029610286.153870.7692delphinapterus_leucasENSDLEP0000002931187.571.875
ENSG00000243147homo_sapiensENSP0000029610292.307776.9231delphinapterus_leucasENSDLEP0000001578092.307776.9231
ENSG00000243147homo_sapiensENSP0000029610287.692373.8462physeter_catodonENSPCTP0000501073164.772754.5455
ENSG00000243147homo_sapiensENSP0000029610290.769276.9231mus_musculusENSMUSP0000003102490.769276.9231
ENSG00000243147homo_sapiensENSP0000029610289.230878.4615dipodomys_ordiiENSDORP0000002469789.230878.4615
ENSG00000243147homo_sapiensENSP0000029610293.846289.2308aotus_nancymaaeENSANAP0000002612693.846289.2308
ENSG00000243147homo_sapiensENSP0000029610295.384689.2308saimiri_boliviensis_boliviensisENSSBOP0000000053895.384689.2308
ENSG00000243147homo_sapiensENSP0000029610284.615472.3077vicugna_pacosENSVPAP0000000312596.491282.4561
ENSG00000243147homo_sapiensENSP0000029610290.769281.5385mesocricetus_auratusENSMAUP0000000648790.769281.5385
ENSG00000243147homo_sapiensENSP0000029610295.384683.0769phocoena_sinusENSPSNP0000000864895.384683.0769
ENSG00000243147homo_sapiensENSP0000029610289.230873.8462phocoena_sinusENSPSNP0000001546889.230873.8462
ENSG00000243147homo_sapiensENSP0000029610295.384683.0769camelus_dromedariusENSCDRP0000501686695.384683.0769
ENSG00000243147homo_sapiensENSP0000029610286.153873.8462carlito_syrichtaENSTSYP0000001740486.153873.8462
ENSG00000243147homo_sapiensENSP0000029610283.076973.8462carlito_syrichtaENSTSYP0000000286194.736884.2105
ENSG00000243147homo_sapiensENSP0000029610293.846281.5385panthera_tigris_altaicaENSPTIP0000000059693.846281.5385
ENSG00000243147homo_sapiensENSP000002961028066.1538panthera_tigris_altaicaENSPTIP0000002433583.87169.3548
ENSG00000243147homo_sapiensENSP0000029610283.076969.2308rattus_norvegicusENSRNOP0000003305938.848932.3741
ENSG00000243147homo_sapiensENSP0000029610289.230881.5385prolemur_simusENSPSMP0000000125475.324768.8312
ENSG00000243147homo_sapiensENSP0000029610289.230878.4615microtus_ochrogasterENSMOCP0000001350989.230878.4615
ENSG00000243147homo_sapiensENSP0000029610284.615475.3846peromyscus_maniculatus_bairdiiENSPEMP0000000758588.709779.0323
ENSG00000243147homo_sapiensENSP0000029610290.769278.4615peromyscus_maniculatus_bairdiiENSPEMP0000003373490.769278.4615
ENSG00000243147homo_sapiensENSP0000029610283.076973.8462bos_mutusENSBMUP0000001760287.096877.4194
ENSG00000243147homo_sapiensENSP0000029610283.076973.8462bos_mutusENSBMUP0000001709887.096877.4194
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154bos_mutusENSBMUP0000001235493.846284.6154
ENSG00000243147homo_sapiensENSP0000029610290.769276.9231mus_spicilegusENSMSIP0000002371790.769276.9231
ENSG00000243147homo_sapiensENSP0000029610290.769280cricetulus_griseus_chok1gshdENSCGRP0000102668490.769280
ENSG00000243147homo_sapiensENSP0000029610284.615472.3077cricetulus_griseus_chok1gshdENSCGRP0000100743484.615472.3077
ENSG00000243147homo_sapiensENSP0000029610292.307781.5385pteropus_vampyrusENSPVAP0000000582392.307781.5385
ENSG00000243147homo_sapiensENSP0000029610293.846286.1538myotis_lucifugusENSMLUP0000000016693.846286.1538
ENSG00000243147homo_sapiensENSP0000029610290.769280vombatus_ursinusENSVURP0001002671090.769280
ENSG00000243147homo_sapiensENSP0000029610292.307784.6154rhinolophus_ferrumequinumENSRFEP0001001480092.307784.6154
ENSG00000243147homo_sapiensENSP0000029610283.076972.3077bos_taurusENSBTAP0000006131187.096875.8064
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154bos_taurusENSBTAP0000007028993.846284.6154
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154bos_taurusENSBTAP0000005643493.846284.6154
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154bos_taurusENSBTAP0000005639093.846284.6154
ENSG00000243147homo_sapiensENSP0000029610284.615475.3846heterocephalus_glaber_femaleENSHGLP0000003965241.353436.8421
ENSG00000243147homo_sapiensENSP0000029610298.461595.3846rhinopithecus_bietiENSRBIP0000002681598.461595.3846
ENSG00000243147homo_sapiensENSP0000029610292.307778.4615canis_lupus_dingoENSCAFP0002001741192.307778.4615
ENSG00000243147homo_sapiensENSP0000029610289.230875.3846canis_lupus_dingoENSCAFP0002001719389.230875.3846
ENSG00000243147homo_sapiensENSP0000029610290.769281.5385sciurus_vulgarisENSSVLP0000503267390.769281.5385
ENSG00000243147homo_sapiensENSP0000029610289.230876.9231phascolarctos_cinereusENSPCIP0000003970289.230876.9231
ENSG00000243147homo_sapiensENSP0000029610292.307778.4615nannospalax_galiliENSNGAP0000000708692.307778.4615
ENSG00000243147homo_sapiensENSP0000029610289.230876.9231chinchilla_lanigeraENSCLAP0000001063689.230876.9231
ENSG00000243147homo_sapiensENSP0000029610292.307783.0769cervus_hanglu_yarkandensisENSCHYP0000003109192.307783.0769
ENSG00000243147homo_sapiensENSP0000029610293.846284.6154cervus_hanglu_yarkandensisENSCHYP0000000842493.846284.6154
ENSG00000243147homo_sapiensENSP0000029610290.769278.4615ictidomys_tridecemlineatusENSSTOP0000002494090.769278.4615
ENSG00000243147homo_sapiensENSP0000029610295.384693.8462cebus_imitatorENSCCAP0000000467795.384693.8462
ENSG00000243147homo_sapiensENSP0000029610290.769278.4615urocitellus_parryiiENSUPAP0001000718290.769278.4615
ENSG00000243147homo_sapiensENSP0000029610276.923167.6923moschus_moschiferusENSMMSP0000002554368.493160.274
ENSG00000243147homo_sapiensENSP0000029610293.846283.0769moschus_moschiferusENSMMSP0000001122993.846283.0769
ENSG00000243147homo_sapiensENSP0000029610298.461595.3846rhinopithecus_roxellanaENSRROP0000002135398.461595.3846
ENSG00000243147homo_sapiensENSP0000029610293.846286.1538propithecus_coquereliENSPCOP0000001730393.846286.1538
ENSG00000243147homo_sapiensENSP0000029610281.538566.1538callorhinchus_miliiENSCMIP0000003708681.538566.1538
ENSG00000243147homo_sapiensENSP0000029610281.538567.6923latimeria_chalumnaeENSLACP0000002290281.538567.6923
ENSG00000243147homo_sapiensENSP0000029610272.307763.0769clupea_harengusENSCHAP0000004710171.212162.1212
ENSG00000243147homo_sapiensENSP0000029610278.461567.6923danio_rerioENSDARP0000014027578.461567.6923
ENSG00000243147homo_sapiensENSP0000029610272.307753.8462carassius_auratusENSCARP0000005656761.842146.0526
ENSG00000243147homo_sapiensENSP0000029610281.538564.6154ictalurus_punctatusENSIPUP0000001511270.666756
ENSG00000243147homo_sapiensENSP0000029610283.076964.6154electrophorus_electricusENSEEEP0000001231783.076964.6154
ENSG00000243147homo_sapiensENSP0000029610273.846261.5385oncorhynchus_kisutchENSOKIP000050500798066.6667
ENSG00000243147homo_sapiensENSP0000029610273.846261.5385oncorhynchus_mykissENSOMYP000000584178066.6667
ENSG00000243147homo_sapiensENSP0000029610275.384661.5385salmo_truttaENSSTUP0000007631281.666766.6667
ENSG00000243147homo_sapiensENSP0000029610272.307758.4615gadus_morhuaENSGMOP0000004675178.333363.3333
ENSG00000243147homo_sapiensENSP0000029610275.384658.4615fundulus_heteroclitusENSFHEP0000000813377.777860.3175
ENSG00000243147homo_sapiensENSP0000029610267.692356.9231poecilia_reticulataENSPREP0000000703072.131160.6557
ENSG00000243147homo_sapiensENSP0000029610269.230856.9231xiphophorus_maculatusENSXMAP0000001847473.770560.6557
ENSG00000243147homo_sapiensENSP0000029610275.384663.0769oryzias_latipesENSORLP0000004153881.666768.3333
ENSG00000243147homo_sapiensENSP0000029610270.769253.8462cyclopterus_lumpusENSCLMP0000501960970.769253.8462
ENSG00000243147homo_sapiensENSP0000029610270.769255.3846oreochromis_niloticusENSONIP0000005195756.097643.9024
ENSG00000243147homo_sapiensENSP0000029610272.307760astatotilapia_callipteraENSACLP0000003829878.333365
ENSG00000243147homo_sapiensENSP0000029610276.923161.5385sparus_aurataENSSAUP0001005497976.923161.5385
ENSG00000243147homo_sapiensENSP0000029610273.846255.3846lates_calcariferENSLCAP000100471588060
ENSG00000243147homo_sapiensENSP0000029610275.384666.1538chrysemys_picta_belliiENSCPBP0000003657775.384666.1538
ENSG00000243147homo_sapiensENSP0000029610275.384667.6923crocodylus_porosusENSCPRP0000501394671.014563.7681
ENSG00000243147homo_sapiensENSP000002961028064.6154neolamprologus_brichardiENSNBRP000000147378064.6154
ENSG00000243147homo_sapiensENSP0000029610267.692349.2308erpetoichthys_calabaricusENSECRP0000000309269.841350.7937
ENSG00000243147homo_sapiensENSP0000029610264.615453.8462kryptolebias_marmoratusENSKMAP0000000513568.852557.377
ENSG00000243147homo_sapiensENSP0000029610283.076969.2308oryzias_javanicusENSOJAP0000004352383.076969.2308
ENSG00000243147homo_sapiensENSP0000029610275.384661.5385amphilophus_citrinellusENSACIP0000001419375.384661.5385
ENSG00000243147homo_sapiensENSP0000029610273.846256.9231dicentrarchus_labraxENSDLAP000050461708061.6667
ENSG00000243147homo_sapiensENSP0000029610275.384660amphiprion_perculaENSAPEP0000003280881.666765
ENSG00000243147homo_sapiensENSP000002961028067.6923gopherus_evgoodeiENSGEVP0000501720361.904852.381
ENSG00000243147homo_sapiensENSP0000029610281.538569.2308chelonoidis_abingdoniiENSCABP0000001493781.538569.2308
ENSG00000243147homo_sapiensENSP0000029610278.461561.5385gasterosteus_aculeatusENSGACP0000001705478.461561.5385
ENSG00000243147homo_sapiensENSP0000029610284.615463.0769cynoglossus_semilaevisENSCSEP0000000437584.615463.0769
ENSG00000243147homo_sapiensENSP0000029610283.076970.7692poecilia_formosaENSPFOP0000001108783.076970.7692
ENSG00000243147homo_sapiensENSP0000029610273.846255.3846sander_luciopercaENSSLUP0000002690372.727354.5455
ENSG00000243147homo_sapiensENSP0000029610275.384660amphiprion_ocellarisENSAOCP0000001107881.666765
ENSG00000243147homo_sapiensENSP0000029610275.384661.5385hucho_huchoENSHHUP0000003057281.666766.6667
ENSG00000243147homo_sapiensENSP0000029610270.769256.9231hucho_huchoENSHHUP0000008866142.201833.945
ENSG00000243147homo_sapiensENSP0000029610273.846258.4615betta_splendensENSBSLP000000514208063.3333
ENSG00000243147homo_sapiensENSP0000029610273.846258.4615pygocentrus_nattereriENSPNAP000000261538063.3333
ENSG00000243147homo_sapiensENSP0000029610272.307755.3846anabas_testudineusENSATEP0000001592778.333360
ENSG00000243147homo_sapiensENSP0000029610272.307756.9231seriola_lalandi_dorsalisENSSLDP0000002029270.149355.2239
ENSG00000243147homo_sapiensENSP0000029610276.923163.0769labrus_bergyltaENSLBEP0000003057670.422557.7465
ENSG00000243147homo_sapiensENSP0000029610272.307755.3846mastacembelus_armatusENSMAMP0000002143472.307755.3846
ENSG00000243147homo_sapiensENSP0000029610281.538564.6154stegastes_partitusENSSPAP0000001828181.538564.6154
ENSG00000243147homo_sapiensENSP0000029610273.846258.4615stegastes_partitusENSSPAP000000182668063.3333
ENSG00000243147homo_sapiensENSP0000029610273.846261.5385oncorhynchus_tshawytschaENSOTSP000050396438066.6667
ENSG00000243147homo_sapiensENSP0000029610278.461564.6154acanthochromis_polyacanthusENSAPOP0000002841078.461564.6154
ENSG00000243147homo_sapiensENSP0000029610275.384660denticeps_clupeoidesENSDCDP0000000046075.384660
ENSG00000243147homo_sapiensENSP0000029610272.307756.9231larimichthys_croceaENSLCRP0000503661872.307756.9231
ENSG00000243147homo_sapiensENSP0000029610276.923160takifugu_rubripesENSTRUP0000005398483.333365
ENSG00000243147homo_sapiensENSP0000029610275.384663.0769poecilia_latipinnaENSPLAP0000000815081.666768.3333
ENSG00000243147homo_sapiensENSP0000029610283.076967.6923sinocyclocheilus_grahamiENSSGRP0000011236252.427242.7184
ENSG00000243147homo_sapiensENSP0000029610272.307760maylandia_zebraENSMZEP0000501265978.333365
ENSG00000243147homo_sapiensENSP000002961028067.6923tetraodon_nigroviridisENSTNIP000000219528067.6923
ENSG00000243147homo_sapiensENSP0000029610270.769260paramormyrops_kingsleyaeENSPKIP0000000637876.666765
ENSG00000243147homo_sapiensENSP0000029610278.461563.0769scleropages_formosusENSSFOP0001500687669.86356.1644
ENSG00000243147homo_sapiensENSP0000029610272.307758.4615oryzias_melastigmaENSOMEP0000000843936.718829.6875

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003735enables structural constituent of ribosome1IEAHomo_sapiens(9606)Function
GO:0005739is_active_in mitochondrion2IBA,IDAHomo_sapiens(9606)Component
GO:0005743located_in mitochondrial inner membrane2NAS,TASHomo_sapiens(9606)Component
GO:0005762part_of mitochondrial large ribosomal subunit2IDA,NASHomo_sapiens(9606)Component
GO:0032543involved_in mitochondrial translation1NASHomo_sapiens(9606)Process

Expression