RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000241058	Gene ID	221078	Accession	23529
Symbol	NSUN6	Alias	NOPD1;ARL5B-AS1;4933414E04Rik	Full Name	NOP2/Sun RNA methyltransferase 6
Status	Confidence	Length	113725 bases	Strand	Minus strand
Position	10 : 18545561 - 18659285	RNA binding domain	Methyltransf_31 , Methyltr_RsmB-F , FtsJ
Summary	Enables tRNA (cytosine-5-)-methyltransferase activity and tRNA binding activity. Involved in tRNA C5-cytosine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000366519	FtsJ	PF01728	2e-06	1
ENSP00000366519	Methyltransf_31	PF13847	2.7e-07	2
ENSP00000366519	Methyltr_RsmB-F	PF01189	1e-44	3

Showing 1 to 3 of 3 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
29636419	CARIC_PMID29636419_Hela_human	Hela	Xichen Bao	2018 Apr 24	doi: 10.1073/pnas.1718406115.?Epub 2018 Apr 10
30352994	eRIC_PMID30352994_Jurkat_human	Jurkat	Joel I Perez-Perri?	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
33332543	FAX.RIC_PMID33332543_Hela_human	Hela	Yongwoo Na	2021 Mar 18	doi: 10.1093/nar/gkaa1194
33693821	PP.enrichment.RIC_PMID33693821_Hela_human	Hela	Zheng Zhang	2021 Jun 21	doi: 10.1093/nar/gkab156
35427468	qRIC_PMID35427468_293T_human	293T	Carlos Henrique Vieira-Vieira	2022 Jun 2	doi: 10.1016/j.molcel.2022.03.024.?Epub 2022 Apr 14
35451177	PhotoCAX.MS_PMID35451177_293T_human	293T	Huixin Luo	2022 Jul 4	doi: 10.1002/anie.202202008
35848924	RIC_PMID35848924_human		Neus Mestre-Farras	2022 Aug 12	doi: 10.1093/nar/gkac605
37421941	RIC_PMID37421941_Hydra10_human		Wenhao Jin	2023 Jul 20	doi: 10.1016/j.molcel.2023.06.019.?Epub 2023 Jul 7

Showing 1 to 9 of 9 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
26160102	NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs.	Sara Haag	2015-09-01	RNA (New York, N.Y.)
28114269	A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.	Chunlai Li	2017-02-01	Nature cell biology
28601226	The Evolution of Substrate Specificity by tRNA Modification Enzymes.	M Katherine McKenney	2017-01-01	The Enzymes
29274663	Long Noncoding RNA in Cancer: Wiring Signaling Circuitry.	Chunru Lin	2018-04-01	Trends in cell biology
30311405	The dynamic RNA modification 5-methylcytosine and its emerging role as an epitranscriptomic mark.	Lukas Trixl	2019-01-01	Wiley interdisciplinary reviews. RNA
30541086	Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.	Jing Li	2019-02-28	Nucleic acids research
32873282	Development and validation of a RNA binding protein gene pair-associated prognostic signature for prediction of overall survival in hepatocellular carcinoma.	Chunmiao Kang	2020-09-01	Biomedical engineering online
33251765	CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators.	Liang Fang	2020-11-01	Molecular systems biology
33330931	Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6.	Tommaso Selmi	2021-01-25	Nucleic acids research
33928086	Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer.	Zhidong Huang	2021-01-01	Frontiers in cell and developmental biology

Showing 1 to 10 of 12 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
NSUN6-201	ENST00000377304	2166	469aa	ENSP00000366519
NSUN6-202	ENST00000414939	637	No protein	-
NSUN6-203	ENST00000444660	524	No protein	-
NSUN6-204	ENST00000449529	689	No protein	-
NSUN6-205	ENST00000456217	392	No protein	-
NSUN6-206	ENST00000493816	315	No protein	-
NSUN6-207	ENST00000606425	578	149aa	ENSP00000476221
NSUN6-208	ENST00000607346	553	35aa	ENSP00000486203

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Gene Model

Click here to download ENSG00000241058's gene model file

ensgID	Trait	pValue	Pubmed ID
No data available in table

GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000241058	rs11015020	10	18588058	Adolescent idiopathic scoliosis	30019117		EFO_0005423
ENSG00000241058	rs4445544	10	18587155	Schizophrenia	30285260	1.074	EFO_0000692

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000241058's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000241058	homo_sapiens	ENSP00000388464	32.8326	18.0258	homo_sapiens	ENSP00000366519	32.6226	17.9104
ENSG00000241058	homo_sapiens	ENSP00000313272	25	14.6552	homo_sapiens	ENSP00000366519	43.2836	25.3731

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000241058	homo_sapiens	ENSP00000366519	100	98.5075	nomascus_leucogenys	ENSNLEP00000015393	100	98.5075
ENSG00000241058	homo_sapiens	ENSP00000366519	99.5736	98.9339	pan_paniscus	ENSPPAP00000039393	99.5736	98.9339
ENSG00000241058	homo_sapiens	ENSP00000366519	99.7868	98.5075	pongo_abelii	ENSPPYP00000002478	99.7868	98.5075
ENSG00000241058	homo_sapiens	ENSP00000366519	95.7356	94.6695	pan_troglodytes	ENSPTRP00000003969	96.7672	95.6897
ENSG00000241058	homo_sapiens	ENSP00000366519	100	99.3603	gorilla_gorilla	ENSGGOP00000009108	100	99.3603
ENSG00000241058	homo_sapiens	ENSP00000366519	68.8699	57.5693	ornithorhynchus_anatinus	ENSOANP00000042723	62.7184	52.4272
ENSG00000241058	homo_sapiens	ENSP00000366519	88.4861	80.597	sarcophilus_harrisii	ENSSHAP00000009609	88.4861	80.597
ENSG00000241058	homo_sapiens	ENSP00000366519	58.6354	53.9446	notamacropus_eugenii	ENSMEUP00000004802	62.0767	57.1106
ENSG00000241058	homo_sapiens	ENSP00000366519	50.5331	47.3348	choloepus_hoffmanni	ENSCHOP00000005758	53.4989	50.1129
ENSG00000241058	homo_sapiens	ENSP00000366519	86.1407	78.8913	dasypus_novemcinctus	ENSDNOP00000011001	86.5096	79.2291

Showing 1 to 10 of 195 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0016428	enables tRNA (cytosine-5-)-methyltransferase activity	2	EXP,IDA	Homo_sapiens(9606)	Function
GO:0000049	enables tRNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0001510	involved_in RNA methylation	1	IBA	Homo_sapiens(9606)	Process
GO:0002946	involved_in tRNA C5-cytosine methylation	1	IDA	Homo_sapiens(9606)	Process
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006400	involved_in tRNA modification	1	TAS	Homo_sapiens(9606)	Process
GO:0030488	involved_in tRNA methylation	1	IDA	Homo_sapiens(9606)	Process

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression