Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucleP-body
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000239713 Gene ID 60489 Accession 17357
Symbol APOBEC3G Alias Full Name
Status Confidence Length 10469 bases Strand Plus strand
Position 22 : 39077275 - 39087743 RNA binding domain APOBEC_N , APOBEC_C
Summary

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000385057 APOBEC_N PF08210 2.2e-94 1
ENSP00000385057 APOBEC_N PF08210 2.2e-94 2
ENSP00000385057 APOBEC_C PF05240 5.9e-59 3
ENSP00000385057 APOBEC_C PF05240 5.9e-59 4

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
21123176 Atomic force microscopy studies provide direct evidence for dimerization of the HIV restriction factor APOBEC3G. S Luda Shlyakhtenko 2011-02-04 The Journal of biological chemistry
23431045 Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases. Atsushi Koito 2013-01-01 Frontiers in microbiology
16887808 The anti-HIV-1 editing enzyme APOBEC3G binds HIV-1 RNA and messenger RNAs that shuttle between polysomes and stress granules. L Susan Kozak 2006-09-29 The Journal of biological chemistry
18597676 Characterization of APOBEC3G binding to 7SL RNA. Daniel Bach 2008-07-02 Retrovirology
23301054 Analysis of virion-incorporated host proteins required for herpes simplex virus type 1 infection through a RNA interference screen. Camille Stegen 2013-01-01 PloS one
17083721 The cell biology of HIV-1 and other retroviruses. O Eric Freed 2006-11-03 Retrovirology
18456846 Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation. P Hal Bogerd 2008-06-01 RNA (New York, N.Y.)
23890083 APOBEC3 inhibits DEAD-END function to regulate microRNA activity. Sara Ali 2013-07-26 BMC molecular biology
27548206 The Host RNAs in Retroviral Particles. Alice Telesnitsky 2016-08-19 Viruses
25237741 Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes. M J Benjamin Taylor 2014-09-19 eLife
27974822 The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme. Shraddha Sharma 2016-12-15 Scientific reports
18577210 HIV-1 Vif, APOBEC, and intrinsic immunity. Ritu Goila-Gaur 2008-06-24 Retrovirology
19300495 Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells. Masakazu Kamata 2009-03-01 PLoS pathogens
19149995 Accessories to the crime: recent advances in HIV accessory protein biology. Thomas Gramberg 2009-02-01 Current HIV/AIDS reports
18509452 Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1). Chitralekha Bhattacharya 2008-05-28 PloS one
19273150 RNA-protein interactions in hepadnavirus reverse transcription. Jianming Hu 2009-01-01 Frontiers in bioscience (Landmark edition)
17440614 Model structure of human APOBEC3G. Kun-Lin Zhang 2007-04-18 PloS one
20015971 Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis. Delphine Lavens 2010-04-01 Nucleic acids research
26424853 RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates. Bogdan Polevoda 2015-10-30 Nucleic acids research
22970171 Random mutagenesis MAPPIT analysis identifies binding sites for Vif and Gag in both cytidine deaminase domains of Apobec3G. Isabel Uyttendaele 2012-01-01 PloS one
30254620 Post-translational Modification-Based Regulation of HIV Replication. Lin Chen 2018-01-01 Frontiers in microbiology
17609216 RNA and DNA binding properties of HIV-1 Vif protein: a fluorescence study. Serena Bernacchi 2007-09-07 The Journal of biological chemistry
24424502 Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1. Emma Chan 2014-01-14 Viruses
19776130 Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition. Yannick Bulliard 2009-12-01 Journal of virology
33322756 Deaminase-Independent Mode of Antiretroviral Action in Human and Mouse APOBEC3 Proteins. Yoshiyuki Hakata 2020-12-12 Microorganisms
23686230 The APOBEC3 family of retroelement restriction factors. W Eric Refsland 2013-01-01 Current topics in microbiology and immunology
25974865 RNA-binding residues in the N-terminus of APOBEC3G influence its DNA sequence specificity and retrovirus restriction efficiency. Kasandra Bélanger 2015-09-01 Virology
18302164 Hepatitis B virus-cell interactions and pathogenesis. H David Nguyen 2008-08-01 Journal of cellular physiology
33533523 Host-virus interaction and viral evasion. T Scheilla Strumillo 2021-06-01 Cell biology international
28953888 CG dinucleotide suppression enables antiviral defence targeting non-self RNA. A Matthew Takata 2017-10-05 Nature
26110583 APOBEC3 Interference during Replication of Viral Genomes. Luc Willems 2015-06-11 Viruses
20174454 Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS. F Judd Hultquist 2009-11-01 Future virology
27837013 Partial reconstitution of the RNAi response in human cells using Drosophila gene products. M Edward Kennedy 2017-02-01 RNA (New York, N.Y.)

Transcripts

Name Transcript ID bp Protein Translation ID
APOBEC3G-203 ENST00000463934 1081 No protein -
APOBEC3G-204 ENST00000480000 812 No protein -
APOBEC3G-202 ENST00000461827 803 No protein -
APOBEC3G-201 ENST00000407997 1564 384aa ENSP00000385057
APOBEC3G-206 ENST00000486357 543 No protein -
APOBEC3G-207 ENST00000494150 2775 No protein -
APOBEC3G-205 ENST00000481958 2337 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000239713homo_sapiensENSP0000022933555.555640.9091homo_sapiensENSP0000038505728.645821.0938
ENSG00000239713homo_sapiensENSP0000041175453.551933.8798homo_sapiensENSP0000038505725.520816.1458
ENSG00000239713homo_sapiensENSP0000030974965.683650.4021homo_sapiensENSP0000038505763.802148.9583
ENSG00000239713homo_sapiensENSP0000021609956.217641.4508homo_sapiensENSP0000038505756.510441.6667
ENSG00000239713homo_sapiensENSP0000035534057.368440.5263homo_sapiensENSP0000038505728.385420.0521
ENSG00000239713homo_sapiensENSP0000024911671.356863.3166homo_sapiensENSP0000038505736.979232.8125
ENSG00000239713homo_sapiensENSP0000032745969.371756.5445homo_sapiensENSP0000038505769.010456.25
ENSG00000239713homo_sapiensENSP0000022930438.983124.5763homo_sapiensENSP0000038505723.958315.1042
ENSG00000239713homo_sapiensENSP0000024466945.535729.9107homo_sapiensENSP0000038505726.562517.4479

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000239713homo_sapiensENSP0000038505761.979257.5521nomascus_leucogenysENSNLEP0000003135084.098978.0919
ENSG00000239713homo_sapiensENSP0000038505786.718883.5938pan_paniscusENSPPAP0000002014180.629577.724
ENSG00000239713homo_sapiensENSP0000038505791.406286.7188pongo_abeliiENSPPYP0000001320088.19183.6683
ENSG00000239713homo_sapiensENSP0000038505796.87595.0521pan_troglodytesENSPTRP0000002478696.87595.0521
ENSG00000239713homo_sapiensENSP0000038505793.229291.6667gorilla_gorillaENSGGOP0000002196595.212893.617
ENSG00000239713homo_sapiensENSP0000038505719.531212.2396sarcophilus_harrisiiENSSHAP0000004312326.041716.3194
ENSG00000239713homo_sapiensENSP0000038505724.739617.1875dasypus_novemcinctusENSDNOP0000002619842.792829.7297
ENSG00000239713homo_sapiensENSP0000038505777.864666.6667callithrix_jacchusENSCJAP0000008983357.610849.3256
ENSG00000239713homo_sapiensENSP0000038505775.781264.3229callithrix_jacchusENSCJAP0000008412361.006351.782
ENSG00000239713homo_sapiensENSP0000038505777.604266.4062callithrix_jacchusENSCJAP0000002290777.604266.4062
ENSG00000239713homo_sapiensENSP0000038505776.822965.625callithrix_jacchusENSCJAP0000004186475.64164.6154
ENSG00000239713homo_sapiensENSP0000038505710.15625.46875cercocebus_atysENSCATP0000000947349.367126.5823
ENSG00000239713homo_sapiensENSP0000038505783.593875.5208macaca_mulattaENSMMUP0000006998964.258
ENSG00000239713homo_sapiensENSP0000038505782.552175macaca_nemestrinaENSMNEP0000003087273.549966.8213
ENSG00000239713homo_sapiensENSP0000038505783.854277.8646papio_anubisENSPANP0000004977360.186955.8879
ENSG00000239713homo_sapiensENSP0000038505783.593877.6042mandrillus_leucophaeusENSMLEP0000000560280.653374.8744
ENSG00000239713homo_sapiensENSP0000038505731.510424.2188tursiops_truncatusENSTTRP0000000890462.694348.1865
ENSG00000239713homo_sapiensENSP0000038505720.572914.3229vulpes_vulpesENSVVUP0000003095236.073125.1142
ENSG00000239713homo_sapiensENSP0000038505730.989626.0417equus_asinusENSEASP0000504599354.587245.8716
ENSG00000239713homo_sapiensENSP0000038505731.2525.7812equus_asinusENSEASP0000504458441.095933.9041
ENSG00000239713homo_sapiensENSP0000038505726.041720.8333equus_asinusENSEASP0000505375425.906720.7254
ENSG00000239713homo_sapiensENSP0000038505732.552126.3021equus_asinusENSEASP0000503963055.803645.0893
ENSG00000239713homo_sapiensENSP0000038505731.770826.0417equus_asinusENSEASP0000505422057.547247.1698
ENSG00000239713homo_sapiensENSP0000038505733.072923.9583capra_hircusENSCHIP0000001003859.624443.1925
ENSG00000239713homo_sapiensENSP0000038505731.770825.2604loxodonta_africanaENSLAFP000000074646148.5
ENSG00000239713homo_sapiensENSP0000038505745.572932.8125loxodonta_africanaENSLAFP0000001572744.642932.1429
ENSG00000239713homo_sapiensENSP0000038505732.291725.5208loxodonta_africanaENSLAFP0000000441868.888954.4444
ENSG00000239713homo_sapiensENSP0000038505730.468824.4792ailuropoda_melanoleucaENSAMEP0000001136159.090947.4747
ENSG00000239713homo_sapiensENSP0000038505732.812525bos_indicus_hybridENSBIXP0000504389368.108151.8919
ENSG00000239713homo_sapiensENSP0000038505729.947922.6562oryctolagus_cuniculusENSOCUP000000179414634.8
ENSG00000239713homo_sapiensENSP0000038505730.468825.5208equus_caballusENSECAP0000003422938.741732.4503
ENSG00000239713homo_sapiensENSP0000038505730.729223.1771canis_lupus_familiarisENSCAFP0084503090459.898545.1777
ENSG00000239713homo_sapiensENSP0000038505730.729223.1771canis_lupus_familiarisENSCAFP0084503096759.898545.1777
ENSG00000239713homo_sapiensENSP0000038505732.812526.0417balaenoptera_musculusENSBMSP0001001382750.806440.3226
ENSG00000239713homo_sapiensENSP0000038505720.312512.2396monodelphis_domesticaENSMODP000000405053018.0769
ENSG00000239713homo_sapiensENSP0000038505732.291723.9583bison_bison_bisonENSBBBP000000116216246
ENSG00000239713homo_sapiensENSP0000038505732.812525monodon_monocerosENSMMNP0001502747364.948549.4845
ENSG00000239713homo_sapiensENSP0000038505735.416728.125microcebus_murinusENSMICP0000004603767.326753.4653
ENSG00000239713homo_sapiensENSP0000038505734.37526.8229microcebus_murinusENSMICP0000004590470.212854.7872
ENSG00000239713homo_sapiensENSP0000038505731.770823.1771ovis_aries_rambouilletENSOARP0002001478165.945948.1081
ENSG00000239713homo_sapiensENSP0000038505729.687524.2188ursus_maritimusENSUMAP0000001975357.575846.9697
ENSG00000239713homo_sapiensENSP0000038505729.687524.4792ursus_maritimusENSUMAP0000000255355.609845.8537
ENSG00000239713homo_sapiensENSP0000038505727.864622.3958ochotona_princepsENSOPRP0000000214559.11647.5138
ENSG00000239713homo_sapiensENSP0000038505732.812525.5208delphinapterus_leucasENSDLEP0000001485264.948550.5155
ENSG00000239713homo_sapiensENSP0000038505732.552125.2604physeter_catodonENSPCTP0000501231654.347842.1739
ENSG00000239713homo_sapiensENSP0000038505729.687523.9583mustela_putorius_furoENSMPUP0000001313759.685948.1675
ENSG00000239713homo_sapiensENSP0000038505779.687568.75aotus_nancymaaeENSANAP0000002697280.104769.1099
ENSG00000239713homo_sapiensENSP0000038505769.010459.8958aotus_nancymaaeENSANAP0000002035676.811666.6667
ENSG00000239713homo_sapiensENSP000003850577563.5417aotus_nancymaaeENSANAP0000002124177.419465.5914
ENSG00000239713homo_sapiensENSP0000038505766.406257.0312saimiri_boliviensis_boliviensisENSSBOP0000001807377.743966.7683
ENSG00000239713homo_sapiensENSP0000038505775.260463.2812saimiri_boliviensis_boliviensisENSSBOP0000000894674.67762.7907
ENSG00000239713homo_sapiensENSP0000038505780.468869.2708saimiri_boliviensis_boliviensisENSSBOP0000001341864.779955.7652
ENSG00000239713homo_sapiensENSP0000038505763.281252.8646saimiri_boliviensis_boliviensisENSSBOP0000000396977.388564.6497
ENSG00000239713homo_sapiensENSP0000038505776.302165.8854saimiri_boliviensis_boliviensisENSSBOP0000001991078.342267.6471
ENSG00000239713homo_sapiensENSP0000038505777.864670.8333chlorocebus_sabaeusENSCSAP0000000266874.193667.4938
ENSG00000239713homo_sapiensENSP0000038505731.2523.9583phocoena_sinusENSPSNP0000001327261.855747.4227
ENSG00000239713homo_sapiensENSP0000038505733.854226.5625camelus_dromedariusENSCDRP0000501936867.010352.5773
ENSG00000239713homo_sapiensENSP0000038505735.677128.125carlito_syrichtaENSTSYP0000001752968.554
ENSG00000239713homo_sapiensENSP0000038505733.072925bos_mutusENSBMUP0000000028068.648751.8919
ENSG00000239713homo_sapiensENSP0000038505731.770823.4375pteropus_vampyrusENSPVAP0000001590725.847519.0678
ENSG00000239713homo_sapiensENSP0000038505733.072925.2604pteropus_vampyrusENSPVAP0000000383065.463950
ENSG00000239713homo_sapiensENSP0000038505727.083319.5312myotis_lucifugusENSMLUP0000002237646.222233.3333
ENSG00000239713homo_sapiensENSP0000038505730.468821.875myotis_lucifugusENSMLUP0000001719554.929639.4366
ENSG00000239713homo_sapiensENSP0000038505728.645821.3542myotis_lucifugusENSMLUP0000000046562.546.5909
ENSG00000239713homo_sapiensENSP0000038505738.281228.3854myotis_lucifugusENSMLUP0000000786953.260939.4928
ENSG00000239713homo_sapiensENSP0000038505727.604220.5729myotis_lucifugusENSMLUP0000001325457.608742.9348
ENSG00000239713homo_sapiensENSP0000038505718.7513.8021myotis_lucifugusENSMLUP0000002110656.2541.4062
ENSG00000239713homo_sapiensENSP0000038505742.447928.6458myotis_lucifugusENSMLUP0000002093740.147827.0936
ENSG00000239713homo_sapiensENSP0000038505730.208323.1771myotis_lucifugusENSMLUP0000001810953.703741.2037
ENSG00000239713homo_sapiensENSP0000038505750.781234.8958myotis_lucifugusENSMLUP0000000088752.560636.1186
ENSG00000239713homo_sapiensENSP0000038505745.312533.3333myotis_lucifugusENSMLUP0000001728854.037339.7516
ENSG00000239713homo_sapiensENSP0000038505719.270813.0208vombatus_ursinusENSVURP0001003152424.832216.7785
ENSG00000239713homo_sapiensENSP0000038505732.031225rhinolophus_ferrumequinumENSRFEP0001000240263.076949.2308
ENSG00000239713homo_sapiensENSP0000038505732.552124.7396rhinolophus_ferrumequinumENSRFEP0001000263942.372932.2034
ENSG00000239713homo_sapiensENSP0000038505726.302119.5312neovison_visonENSNVIP0000000185951.26938.0711
ENSG00000239713homo_sapiensENSP0000038505732.031223.9583bos_taurusENSBTAP0000006763360.591145.3202
ENSG00000239713homo_sapiensENSP0000038505775.520867.4479rhinopithecus_bietiENSRBIP0000002304077.95769.6237
ENSG00000239713homo_sapiensENSP0000038505728.12521.875canis_lupus_dingoENSCAFP0002000313646.753236.3636
ENSG00000239713homo_sapiensENSP0000038505728.12521.875canis_lupus_dingoENSCAFP0002000315246.956536.5217
ENSG00000239713homo_sapiensENSP0000038505719.010412.7604phascolarctos_cinereusENSPCIP0000004984428.076918.8462
ENSG00000239713homo_sapiensENSP0000038505746.614633.5938procavia_capensisENSPCAP0000001457338.997828.1046
ENSG00000239713homo_sapiensENSP0000038505723.958318.2292procavia_capensisENSPCAP0000000172467.153351.0949
ENSG00000239713homo_sapiensENSP0000038505732.552124.4792bos_grunniensENSBGRP0000000485447.892736.0153
ENSG00000239713homo_sapiensENSP0000038505732.291722.9167cervus_hanglu_yarkandensisENSCHYP0000002146256.108639.819
ENSG00000239713homo_sapiensENSP0000038505735.937528.9062otolemur_garnettiiENSOGAP0000001978236.125729.0576
ENSG00000239713homo_sapiensENSP0000038505734.895826.3021otolemur_garnettiiENSOGAP0000001752965.686349.5098
ENSG00000239713homo_sapiensENSP0000038505773.437564.0625cebus_imitatorENSCCAP0000002897278.116368.144
ENSG00000239713homo_sapiensENSP0000038505773.697963.0208cebus_imitatorENSCCAP0000002850876.902265.7609
ENSG00000239713homo_sapiensENSP0000038505768.7558.0729cebus_imitatorENSCCAP0000003020465.024654.9261
ENSG00000239713homo_sapiensENSP0000038505731.770822.9167moschus_moschiferusENSMMSP0000002112460.696543.7811
ENSG00000239713homo_sapiensENSP0000038505727.604221.875propithecus_coquereliENSPCOP0000001213067.948753.8462
ENSG00000239713homo_sapiensENSP0000038505733.593825.7812propithecus_coquereliENSPCOP0000000990163.861449.0099
ENSG00000239713homo_sapiensENSP0000038505720.833311.4583callorhinchus_miliiENSCMIP0000000496138.095220.9524
ENSG00000239713homo_sapiensENSP0000038505720.312512.5latimeria_chalumnaeENSLACP0000001802022.674413.9535
ENSG00000239713homo_sapiensENSP0000038505721.354213.2812lepisosteus_oculatusENSLOCP0000000425830.036618.6813
ENSG00000239713homo_sapiensENSP0000038505722.135413.0208xenopus_tropicalisENSXETP0000007375838.288322.5225
ENSG00000239713homo_sapiensENSP0000038505720.833312.7604anolis_carolinensisENSACAP0000001826129.739818.2156
ENSG00000239713homo_sapiensENSP0000038505717.708310.9375podarcis_muralisENSPMRP0000003574232.38120
ENSG00000239713homo_sapiensENSP0000038505720.312511.1979erpetoichthys_calabaricusENSECRP0000002101529.885116.4751
ENSG00000239713homo_sapiensENSP0000038505724.479215.625hippocampus_comesENSHCOP0000002105326.111116.6667
ENSG00000239713homo_sapiensENSP0000038505720.312512.2396paramormyrops_kingsleyaeENSPKIP0000002985737.681222.7053
ENSG00000239713homo_sapiensENSP0000038505719.531212.2396scleropages_formosusENSSFOP0001500959637.878823.7374

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000932is_active_in P-body2IBA,IDAHomo_sapiens(9606)Component
GO:0002230involved_in positive regulation of defense response to virus by host1IDAHomo_sapiens(9606)Process
GO:0003723enables RNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0004126enables cytidine deaminase activity2IBA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0008270enables zinc ion binding1IDAHomo_sapiens(9606)Function
GO:0008829enables dCTP deaminase activity1TASHomo_sapiens(9606)Function
GO:0009972involved_in cytidine deamination1IDAHomo_sapiens(9606)Process
GO:0010526involved_in retrotransposon silencing1IDAHomo_sapiens(9606)Process
GO:0016553involved_in base conversion or substitution editing1TASHomo_sapiens(9606)Process
GO:0016554involved_in cytidine to uridine editing1IBAHomo_sapiens(9606)Process
GO:0030895part_of apolipoprotein B mRNA editing enzyme complex1TASHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0045071involved_in negative regulation of viral genome replication1IDAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1IDAHomo_sapiens(9606)Process
GO:0045869involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate2IBA,IDAHomo_sapiens(9606)Process
GO:0047844enables deoxycytidine deaminase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0048525involved_in negative regulation of viral process1IDAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus2IBA,IDAHomo_sapiens(9606)Process
GO:0070383involved_in DNA cytosine deamination2IBA,IDAHomo_sapiens(9606)Process
GO:0080111involved_in DNA demethylation1IBAHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component

Expression