RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000228716	Gene ID	1719	Accession	2861
Symbol	DHFR	Alias	DYR;DHFR1;DHFRP1	Full Name	dihydrofolate reductase
Status	Confidence	Length	28758 bases	Strand	Minus strand
Position	5 : 80626226 - 80654983	RNA binding domain	N.A.
Summary	Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
DHFR-201	ENST00000439211	3919	187aa	ENSP00000396308
DHFR-203	ENST00000505337	1719	187aa	ENSP00000426474
DHFR-205	ENST00000511032	1474	129aa	ENSP00000422732
DHFR-202	ENST00000504396	1447	135aa	ENSP00000421334
DHFR-206	ENST00000513048	994	No protein	-
DHFR-204	ENST00000508282	545	No protein	-
DHFR-207	ENST00000513314	582	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000900	enables mRNA regulatory element binding translation repressor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0003729	enables mRNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0004146	enables dihydrofolate reductase activity	4	IBA,IDA,ISS,NAS	Homo_sapiens(9606)	Function
GO:0005542	enables folic acid binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005739	is_active_in mitochondrion	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006545	involved_in glycine biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006729	involved_in tetrahydrobiopterin biosynthetic process	2	IMP,ISS	Homo_sapiens(9606)	Process
GO:0006730	involved_in one-carbon metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0017148	involved_in negative regulation of translation	1	IDA	Homo_sapiens(9606)	Process
GO:0031103	involved_in axon regeneration	1	ISS	Homo_sapiens(9606)	Process
GO:0031427	involved_in response to methotrexate	1	IEA	Homo_sapiens(9606)	Process
GO:0046452	involved_in dihydrofolate metabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0046653	involved_in tetrahydrofolate metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046654	involved_in tetrahydrofolate biosynthetic process	3	IBA,IDA,IEA	Homo_sapiens(9606)	Process
GO:0046655	involved_in folic acid metabolic process	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0050661	enables NADP binding	1	IBA	Homo_sapiens(9606)	Function
GO:0051000	involved_in positive regulation of nitric-oxide synthase activity	1	ISS	Homo_sapiens(9606)	Process
GO:0070402	enables NADPH binding	1	IDA	Homo_sapiens(9606)	Function
GO:1990825	enables sequence-specific mRNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:2000121	involved_in regulation of removal of superoxide radicals	1	ISS	Homo_sapiens(9606)	Process